Aila Rissanen

Aila Rissanen

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Aila Rissanen

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Plasma Proteomics Analysis Reveals Dysregulation of Complement Proteins and Inflammation in Acquired Obesity-A Study on Rare BMI-Discordant Monozygotic Twin Pairs.

Proteomics Clin Appl 2019 Jul 5;13(4):e1800173. Epub 2019 Feb 5.

Obesity Research Unit, Research Programs Unit, Diabetes and Obesity Research Program, University of Helsinki, 00014, Helsinki, Finland.

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http://dx.doi.org/10.1002/prca.201800173DOI Listing
July 2019

Increased body fat mass and androgen metabolism - A twin study in healthy young women.

Steroids 2018 12 25;140:24-31. Epub 2018 Aug 25.

University of Helsinki, Research Programs Unit, Diabetes and Obesity, Obesity Research Unit, P.O. Box 63, 00014 University of Helsinki, Finland; Helsinki University Hospital, Endocrinology, Abdominal Center, P.O. Box 340, 00029 HUS, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.steroids.2018.08.006DOI Listing
December 2018

Metabolism of sex steroids is influenced by acquired adiposity-A study of young adult male monozygotic twin pairs.

J Steroid Biochem Mol Biol 2017 09 13;172:98-105. Epub 2017 Jun 13.

University of Helsinki, Research Programs Unit, Diabetes and Obesity, Obesity Research Unit, P.O. Box 63, 00014, University of Helsinki, Finland; Helsinki University Hospital, Endocrinology, Abdominal Center, P.O. Box 340, 00029 HUS, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jsbmb.2017.06.007DOI Listing
September 2017

Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts.

Authors:
Karri Silventoinen Aline Jelenkovic Reijo Sund Yoshie Yokoyama Yoon-Mi Hur Wendy Cozen Amie E Hwang Thomas M Mack Chika Honda Fujio Inui Yoshinori Iwatani Mikio Watanabe Rie Tomizawa Kirsi H Pietiläinen Aila Rissanen Sisira H Siribaddana Matthew Hotopf Athula Sumathipala Fruhling Rijsdijk Qihua Tan Dongfeng Zhang Zengchang Pang Maarit Piirtola Sari Aaltonen Sevgi Y Öncel Fazil Aliev Esther Rebato Jacob B Hjelmborg Kaare Christensen Axel Skytthe Kirsten O Kyvik Judy L Silberg Lindon J Eaves Tessa L Cutler Juan R Ordoñana Juan F Sánchez-Romera Lucia Colodro-Conde Yun-Mi Song Sarah Yang Kayoung Lee Carol E Franz William S Kremen Michael J Lyons Andreas Busjahn Tracy L Nelson Keith E Whitfield Christian Kandler Kerry L Jang Margaret Gatz David A Butler Maria A Stazi Corrado Fagnani Cristina D'Ippolito Glen E Duncan Dedra Buchwald Nicholas G Martin Sarah E Medland Grant W Montgomery Hoe-Uk Jeong Gary E Swan Ruth Krasnow Patrik Ke Magnusson Nancy L Pedersen Anna K Dahl Aslan Tom A McAdams Thalia C Eley Alice M Gregory Per Tynelius Laura A Baker Catherine Tuvblad Gombojav Bayasgalan Danshiitsoodol Narandalai Timothy D Spector Massimo Mangino Genevieve Lachance S Alexandra Burt Kelly L Klump Jennifer R Harris Ingunn Brandt Thomas S Nilsen Robert F Krueger Matt McGue Shandell Pahlen Robin P Corley Brooke M Huibregtse Meike Bartels Catharina Em van Beijsterveldt Gonneke Willemsen Jack H Goldberg Finn Rasmussen Adam D Tarnoki David L Tarnoki Catherine A Derom Robert F Vlietinck Ruth Jf Loos John L Hopper Joohon Sung Hermine H Maes Eric Turkheimer Dorret I Boomsma Thorkild Ia Sørensen Jaakko Kaprio

Am J Clin Nutr 2017 Aug 5;106(2):457-466. Epub 2017 Jul 5.

Public Health, and.

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http://dx.doi.org/10.3945/ajcn.117.153643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525120PMC
August 2017

Cardiorespiratory Fitness and Adiposity as Determinants of Metabolic Health-Pooled Analysis of Two Twin Cohorts.

J Clin Endocrinol Metab 2017 05;102(5):1520-1528

Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, 00290 Helsinki, Finland.

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http://dx.doi.org/10.1210/jc.2016-3435DOI Listing
May 2017

Improved control of blood pressure and albuminuria among patients with type-2 diabetes in Finnish open care.

Blood Press 2017 Apr 16;26(2):67-73. Epub 2016 Jun 16.

a Division of Medicine , Turku University Hospital and University of Turku , Turku , Finland.

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http://dx.doi.org/10.1080/08037051.2016.1190917DOI Listing
April 2017

Mitochondria-related transcriptional signature is downregulated in adipocytes in obesity: a study of young healthy MZ twins.

Diabetologia 2017 01 12;60(1):169-181. Epub 2016 Oct 12.

Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Biomedicum Helsinki, C424b, P.O. Box 63, Haartmaninkatu 8, 00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00125-016-4121-2DOI Listing
January 2017

Association of MMP-8 with obesity, smoking and insulin resistance.

Eur J Clin Invest 2016 Sep;46(9):757-65

Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1111/eci.12649DOI Listing
September 2016

Deep subcutaneous adipose tissue lipid unsaturation associates with intramyocellular lipid content.

Metabolism 2016 Sep 24;65(9):1230-7. Epub 2016 May 24.

FIMM, Institute for Molecular Medicine, University of Helsinki, Helsinki 00014, Finland; Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki 00014, Finland; Endocrinology, Abdominal Center, Helsinki University Central Hospital and University of Helsinki, Helsinki 00290, Finland.

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http://dx.doi.org/10.1016/j.metabol.2016.05.010DOI Listing
September 2016

Weight Loss Is Associated With Increased NAD(+)/SIRT1 Expression But Reduced PARP Activity in White Adipose Tissue.

J Clin Endocrinol Metab 2016 Mar 13;101(3):1263-73. Epub 2016 Jan 13.

Obesity Research Unit (E.R., S.J., S.K., S.H., A.R., K.H.P.), Research Programs Unit, University of Helsinki, 00014 Helsinki, Finland; Research Program for Molecular Neurology (R.R.-T., E.P.), University of Helsinki, 00014 Helsinki, Finland; Helsinki Medical Imaging Center (A.H., J.L., N.L.), Radiology, University of Helsinki, 00290 Helsinki, Finland; Institute for Clinical Diabetology (J.L.), German Diabetes Center, Leibniz Center for Diabetes Research, Heinrich Heine University, 40225 Düsseldorf, Germany; Turku Positron Emission Tomography Center (V.S., K.A.V.), Turku University Hospital and University of Turku, 20521 Turku, Finland; Institute for Molecular Medicine Finland (K.H.P.), Institute for Molecular Medicine Finland, University of Helsinki, 00014 Helsinki, Finland; Endocrinology (K.H.P.), Abdominal Center, Helsinki University Hospital, University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1210/jc.2015-3054DOI Listing
March 2016

Abdominal obesity and circulating metabolites: A twin study approach.

Metabolism 2016 Mar 31;65(3):111-21. Epub 2015 Oct 31.

Obesity Research Unit, Research programs unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland; Department of Medicine, Division of Endocrinology, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.metabol.2015.10.027DOI Listing
March 2016

Obesity Is Associated With Low NAD(+)/SIRT Pathway Expression in Adipose Tissue of BMI-Discordant Monozygotic Twins.

J Clin Endocrinol Metab 2016 Jan 17;101(1):275-83. Epub 2015 Nov 17.

Obesity Research Unit, Research Programs Unit, Diabetes and Obesity (S.J., S.H., J.T.R., E.R., M.T., M.M., A.R., K.H.P.), FIMM, Institute for Molecular Medicine Finland, (J.T.R., J.K., K.H.P.), Molecular Neurology, Research Programs Unit (R.R.T., E.P.), University of Helsinki, Helsinki, Finland, and Helsinki Medical Imaging Center, Radiology (A.H., N.L.), University of Helsinki, Biomedicum Helsinki, Helsinki, Finland 00014; Institute for Clinical Diabetology, German Diabetes Center (J.L.), Leibniz Center for Diabetes Research, Heinrich Heine University, Düsseldorf, Germany; Finnish Twin Cohort Study, Department of Public Health (J.K.), and Department of Health (J.K.), National Institute for Health and Welfare, Helsinki, Finland; and Department of Endocrinology, Abdominal Center (K.H.P.), Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland 00014.

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http://dx.doi.org/10.1210/jc.2015-3095DOI Listing
January 2016

Long-term outcome in anorexia nervosa in the community.

Int J Eat Disord 2015 Nov 8;48(7):851-9. Epub 2015 Jun 8.

Department of Public Health, University of Helsinki, Finland.

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http://dx.doi.org/10.1002/eat.22415DOI Listing
November 2015

Impaired Mitochondrial Biogenesis in Adipose Tissue in Acquired Obesity.

Diabetes 2015 Sep 13;64(9):3135-45. Epub 2015 May 13.

Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland Abdominal Center, Endocrinology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

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http://diabetes.diabetesjournals.org/content/early/2015/05/1
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http://diabetes.diabetesjournals.org/content/64/9/3135.full.
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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db14
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http://dx.doi.org/10.2337/db14-1937DOI Listing
September 2015

Factors associated with recovery from anorexia nervosa: a population-based study.

Int J Eat Disord 2014 Mar 30;47(2):117-23. Epub 2013 Oct 30.

Department of Public Health, University of Helsinki, Helsinki, Finland; Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1002/eat.22168DOI Listing
March 2014

Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans.

Obesity (Silver Spring) 2013 Nov 13;21(11):2279-87. Epub 2013 Jun 13.

Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.

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http://dx.doi.org/10.1002/oby.20456DOI Listing
November 2013

Agreement of bioelectrical impedance with dual-energy X-ray absorptiometry and MRI to estimate changes in body fat, skeletal muscle and visceral fat during a 12-month weight loss intervention.

Br J Nutr 2013 May 31;109(10):1910-6. Epub 2012 Aug 31.

Obesity Research Unit, Department of Medicine, Division of Endocrinology, Helsinki University Central Hospital, University of Helsinki, Biomedicum 1, Haartmaninkatu 8, PO Box 700, FIN-00029 HUCH, Finland.

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http://dx.doi.org/10.1017/S0007114512003698DOI Listing
May 2013

Depression and drive for thinness are associated with persistent bulimia nervosa in the community.

Eur Eat Disord Rev 2013 Mar 20;21(2):121-9. Epub 2012 Jun 20.

Department of Public Health, The Hjelt Institute, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/erv.2182DOI Listing
March 2013

Body mass index and subjective well-being in young adults: a twin population study.

BMC Public Health 2013 Mar 16;13:231. Epub 2013 Mar 16.

Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1186/1471-2458-13-231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691623PMC
March 2013

Genetic influences on physical activity in young adults: a twin study.

Med Sci Sports Exerc 2012 Jul;44(7):1293-301

Hjelt Institute, Twin Research Unit, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1249/MSS.0b013e3182479747DOI Listing
July 2012

Epicardial fat, cardiac dimensions, and low-grade inflammation in young adult monozygotic twins discordant for obesity.

Am J Cardiol 2012 May 10;109(9):1295-302. Epub 2012 Feb 10.

Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Finland.

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http://dx.doi.org/10.1016/j.amjcard.2011.12.023DOI Listing
May 2012

Obesity-related derangements of coagulation and fibrinolysis: a study of obesity-discordant monozygotic twin pairs.

Obesity (Silver Spring) 2012 Jan 29;20(1):88-94. Epub 2011 Sep 29.

Obesity Research Unit, Department of Medicine, Division of Internal Medicine and Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1038/oby.2011.287DOI Listing
January 2012

Circulating anti-Mullerian hormone levels in adult men are under a strong genetic influence.

J Clin Endocrinol Metab 2012 Jan 2;97(1):E161-4. Epub 2011 Nov 2.

Obesity Research Unit, Helsinki University Central Hospital, FI-00029 Helsinki, Finland.

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http://dx.doi.org/10.1210/jc.2011-1697DOI Listing
January 2012

Liver fat but not other adiposity measures influence circulating FGF21 levels in healthy young adult twins.

J Clin Endocrinol Metab 2011 Feb 1;96(2):E351-5. Epub 2010 Dec 1.

Research Program of Molecular Neurology, Biomedicum Helsinki, r.C523B, Haartmaninkatu 8, 00290 Helsinki, Finland.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2010-1326DOI Listing
February 2011

Increased coagulation factor VIII, IX, XI and XII activities in non-alcoholic fatty liver disease.

Liver Int 2011 Feb 7;31(2):176-83. Epub 2010 Dec 7.

Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1111/j.1478-3231.2010.02375.xDOI Listing
February 2011

An investigation into the relationship between soft tissue body composition and bone mineral density in a young adult twin sample.

J Bone Miner Res 2011 Jan;26(1):79-87

The Finnish Twin Cohort Study, Department of Public Health, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/jbmr.192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179317PMC
January 2011

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

Authors:
Iris M Heid Anne U Jackson Joshua C Randall Thomas W Winkler Lu Qi Valgerdur Steinthorsdottir Gudmar Thorleifsson M Carola Zillikens Elizabeth K Speliotes Reedik Mägi Tsegaselassie Workalemahu Charles C White Nabila Bouatia-Naji Tamara B Harris Sonja I Berndt Erik Ingelsson Cristen J Willer Michael N Weedon Jian'an Luan Sailaja Vedantam Tõnu Esko Tuomas O Kilpeläinen Zoltán Kutalik Shengxu Li Keri L Monda Anna L Dixon Christopher C Holmes Lee M Kaplan Liming Liang Josine L Min Miriam F Moffatt Cliona Molony George Nicholson Eric E Schadt Krina T Zondervan Mary F Feitosa Teresa Ferreira Hana Lango Allen Robert J Weyant Eleanor Wheeler Andrew R Wood Karol Estrada Michael E Goddard Guillaume Lettre Massimo Mangino Dale R Nyholt Shaun Purcell Albert Vernon Smith Peter M Visscher Jian Yang Steven A McCarroll James Nemesh Benjamin F Voight Devin Absher Najaf Amin Thor Aspelund Lachlan Coin Nicole L Glazer Caroline Hayward Nancy L Heard-Costa Jouke-Jan Hottenga Asa Johansson Toby Johnson Marika Kaakinen Karen Kapur Shamika Ketkar Joshua W Knowles Peter Kraft Aldi T Kraja Claudia Lamina Michael F Leitzmann Barbara McKnight Andrew P Morris Ken K Ong John R B Perry Marjolein J Peters Ozren Polasek Inga Prokopenko Nigel W Rayner Samuli Ripatti Fernando Rivadeneira Neil R Robertson Serena Sanna Ulla Sovio Ida Surakka Alexander Teumer Sophie van Wingerden Veronique Vitart Jing Hua Zhao Christine Cavalcanti-Proença Peter S Chines Eva Fisher Jennifer R Kulzer Cecile Lecoeur Narisu Narisu Camilla Sandholt Laura J Scott Kaisa Silander Klaus Stark Mari-Liis Tammesoo Tanya M Teslovich Nicholas John Timpson Richard M Watanabe Ryan Welch Daniel I Chasman Matthew N Cooper John-Olov Jansson Johannes Kettunen Robert W Lawrence Niina Pellikka Markus Perola Liesbeth Vandenput Helene Alavere Peter Almgren Larry D Atwood Amanda J Bennett Reiner Biffar Lori L Bonnycastle Stefan R Bornstein Thomas A Buchanan Harry Campbell Ian N M Day Mariano Dei Marcus Dörr Paul Elliott Michael R Erdos Johan G Eriksson Nelson B Freimer Mao Fu Stefan Gaget Eco J C Geus Anette P Gjesing Harald Grallert Jürgen Grässler Christopher J Groves Candace Guiducci Anna-Liisa Hartikainen Neelam Hassanali Aki S Havulinna Karl-Heinz Herzig Andrew A Hicks Jennie Hui Wilmar Igl Pekka Jousilahti Antti Jula Eero Kajantie Leena Kinnunen Ivana Kolcic Seppo Koskinen Peter Kovacs Heyo K Kroemer Vjekoslav Krzelj Johanna Kuusisto Kirsti Kvaloy Jaana Laitinen Olivier Lantieri G Mark Lathrop Marja-Liisa Lokki Robert N Luben Barbara Ludwig Wendy L McArdle Anne McCarthy Mario A Morken Mari Nelis Matt J Neville Guillaume Paré Alex N Parker John F Peden Irene Pichler Kirsi H Pietiläinen Carl G P Platou Anneli Pouta Martin Ridderstråle Nilesh J Samani Jouko Saramies Juha Sinisalo Jan H Smit Rona J Strawbridge Heather M Stringham Amy J Swift Maris Teder-Laving Brian Thomson Gianluca Usala Joyce B J van Meurs Gert-Jan van Ommen Vincent Vatin Claudia B Volpato Henri Wallaschofski G Bragi Walters Elisabeth Widen Sarah H Wild Gonneke Willemsen Daniel R Witte Lina Zgaga Paavo Zitting John P Beilby Alan L James Mika Kähönen Terho Lehtimäki Markku S Nieminen Claes Ohlsson Lyle J Palmer Olli Raitakari Paul M Ridker Michael Stumvoll Anke Tönjes Jorma Viikari Beverley Balkau Yoav Ben-Shlomo Richard N Bergman Heiner Boeing George Davey Smith Shah Ebrahim Philippe Froguel Torben Hansen Christian Hengstenberg Kristian Hveem Bo Isomaa Torben Jørgensen Fredrik Karpe Kay-Tee Khaw Markku Laakso Debbie A Lawlor Michel Marre Thomas Meitinger Andres Metspalu Kristian Midthjell Oluf Pedersen Veikko Salomaa Peter E H Schwarz Tiinamaija Tuomi Jaakko Tuomilehto Timo T Valle Nicholas J Wareham Alice M Arnold Jacques S Beckmann Sven Bergmann Eric Boerwinkle Dorret I Boomsma Mark J Caulfield Francis S Collins Gudny Eiriksdottir Vilmundur Gudnason Ulf Gyllensten Anders Hamsten Andrew T Hattersley Albert Hofman Frank B Hu Thomas Illig Carlos Iribarren Marjo-Riitta Jarvelin W H Linda Kao Jaakko Kaprio Lenore J Launer Patricia B Munroe Ben Oostra Brenda W Penninx Peter P Pramstaller Bruce M Psaty Thomas Quertermous Aila Rissanen Igor Rudan Alan R Shuldiner Nicole Soranzo Timothy D Spector Ann-Christine Syvanen Manuela Uda André Uitterlinden Henry Völzke Peter Vollenweider James F Wilson Jacqueline C Witteman Alan F Wright Gonçalo R Abecasis Michael Boehnke Ingrid B Borecki Panos Deloukas Timothy M Frayling Leif C Groop Talin Haritunians David J Hunter Robert C Kaplan Kari E North Jeffrey R O'Connell Leena Peltonen David Schlessinger David P Strachan Joel N Hirschhorn Themistocles L Assimes H-Erich Wichmann Unnur Thorsteinsdottir Cornelia M van Duijn Kari Stefansson L Adrienne Cupples Ruth J F Loos Inês Barroso Mark I McCarthy Caroline S Fox Karen L Mohlke Cecilia M Lindgren

Nat Genet 2010 Nov 10;42(11):949-60. Epub 2010 Oct 10.

Regensburg University Medical Center, Department of Epidemiology and Preventive Medicine, Regensburg, Germany.

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http://dx.doi.org/10.1038/ng.685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000924PMC
November 2010

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

Authors:
Elizabeth K Speliotes Cristen J Willer Sonja I Berndt Keri L Monda Gudmar Thorleifsson Anne U Jackson Hana Lango Allen Cecilia M Lindgren Jian'an Luan Reedik Mägi Joshua C Randall Sailaja Vedantam Thomas W Winkler Lu Qi Tsegaselassie Workalemahu Iris M Heid Valgerdur Steinthorsdottir Heather M Stringham Michael N Weedon Eleanor Wheeler Andrew R Wood Teresa Ferreira Robert J Weyant Ayellet V Segrè Karol Estrada Liming Liang James Nemesh Ju-Hyun Park Stefan Gustafsson Tuomas O Kilpeläinen Jian Yang Nabila Bouatia-Naji Tõnu Esko Mary F Feitosa Zoltán Kutalik Massimo Mangino Soumya Raychaudhuri Andre Scherag Albert Vernon Smith Ryan Welch Jing Hua Zhao Katja K Aben Devin M Absher Najaf Amin Anna L Dixon Eva Fisher Nicole L Glazer Michael E Goddard Nancy L Heard-Costa Volker Hoesel Jouke-Jan Hottenga Asa Johansson Toby Johnson Shamika Ketkar Claudia Lamina Shengxu Li Miriam F Moffatt Richard H Myers Narisu Narisu John R B Perry Marjolein J Peters Michael Preuss Samuli Ripatti Fernando Rivadeneira Camilla Sandholt Laura J Scott Nicholas J Timpson Jonathan P Tyrer Sophie van Wingerden Richard M Watanabe Charles C White Fredrik Wiklund Christina Barlassina Daniel I Chasman Matthew N Cooper John-Olov Jansson Robert W Lawrence Niina Pellikka Inga Prokopenko Jianxin Shi Elisabeth Thiering Helene Alavere Maria T S Alibrandi Peter Almgren Alice M Arnold Thor Aspelund Larry D Atwood Beverley Balkau Anthony J Balmforth Amanda J Bennett Yoav Ben-Shlomo Richard N Bergman Sven Bergmann Heike Biebermann Alexandra I F Blakemore Tanja Boes Lori L Bonnycastle Stefan R Bornstein Morris J Brown Thomas A Buchanan Fabio Busonero Harry Campbell Francesco P Cappuccio Christine Cavalcanti-Proença Yii-Der Ida Chen Chih-Mei Chen Peter S Chines Robert Clarke Lachlan Coin John Connell Ian N M Day Martin den Heijer Jubao Duan Shah Ebrahim Paul Elliott Roberto Elosua Gudny Eiriksdottir Michael R Erdos Johan G Eriksson Maurizio F Facheris Stephan B Felix Pamela Fischer-Posovszky Aaron R Folsom Nele Friedrich Nelson B Freimer Mao Fu Stefan Gaget Pablo V Gejman Eco J C Geus Christian Gieger Anette P Gjesing Anuj Goel Philippe Goyette Harald Grallert Jürgen Grässler Danielle M Greenawalt Christopher J Groves Vilmundur Gudnason Candace Guiducci Anna-Liisa Hartikainen Neelam Hassanali Alistair S Hall Aki S Havulinna Caroline Hayward Andrew C Heath Christian Hengstenberg Andrew A Hicks Anke Hinney Albert Hofman Georg Homuth Jennie Hui Wilmar Igl Carlos Iribarren Bo Isomaa Kevin B Jacobs Ivonne Jarick Elizabeth Jewell Ulrich John Torben Jørgensen Pekka Jousilahti Antti Jula Marika Kaakinen Eero Kajantie Lee M Kaplan Sekar Kathiresan Johannes Kettunen Leena Kinnunen Joshua W Knowles Ivana Kolcic Inke R König Seppo Koskinen Peter Kovacs Johanna Kuusisto Peter Kraft Kirsti Kvaløy Jaana Laitinen Olivier Lantieri Chiara Lanzani Lenore J Launer Cecile Lecoeur Terho Lehtimäki Guillaume Lettre Jianjun Liu Marja-Liisa Lokki Mattias Lorentzon Robert N Luben Barbara Ludwig Paolo Manunta Diana Marek Michel Marre Nicholas G Martin Wendy L McArdle Anne McCarthy Barbara McKnight Thomas Meitinger Olle Melander David Meyre Kristian Midthjell Grant W Montgomery Mario A Morken Andrew P Morris Rosanda Mulic Julius S Ngwa Mari Nelis Matt J Neville Dale R Nyholt Christopher J O'Donnell Stephen O'Rahilly Ken K Ong Ben Oostra Guillaume Paré Alex N Parker Markus Perola Irene Pichler Kirsi H Pietiläinen Carl G P Platou Ozren Polasek Anneli Pouta Suzanne Rafelt Olli Raitakari Nigel W Rayner Martin Ridderstråle Winfried Rief Aimo Ruokonen Neil R Robertson Peter Rzehak Veikko Salomaa Alan R Sanders Manjinder S Sandhu Serena Sanna Jouko Saramies Markku J Savolainen Susann Scherag Sabine Schipf Stefan Schreiber Heribert Schunkert Kaisa Silander Juha Sinisalo David S Siscovick Jan H Smit Nicole Soranzo Ulla Sovio Jonathan Stephens Ida Surakka Amy J Swift Mari-Liis Tammesoo Jean-Claude Tardif Maris Teder-Laving Tanya M Teslovich John R Thompson Brian Thomson Anke Tönjes Tiinamaija Tuomi Joyce B J van Meurs Gert-Jan van Ommen Vincent Vatin Jorma Viikari Sophie Visvikis-Siest Veronique Vitart Carla I G Vogel Benjamin F Voight Lindsay L Waite Henri Wallaschofski G Bragi Walters Elisabeth Widen Susanna Wiegand Sarah H Wild Gonneke Willemsen Daniel R Witte Jacqueline C Witteman Jianfeng Xu Qunyuan Zhang Lina Zgaga Andreas Ziegler Paavo Zitting John P Beilby I Sadaf Farooqi Johannes Hebebrand Heikki V Huikuri Alan L James Mika Kähönen Douglas F Levinson Fabio Macciardi Markku S Nieminen Claes Ohlsson Lyle J Palmer Paul M Ridker Michael Stumvoll Jacques S Beckmann Heiner Boeing Eric Boerwinkle Dorret I Boomsma Mark J Caulfield Stephen J Chanock Francis S Collins L Adrienne Cupples George Davey Smith Jeanette Erdmann Philippe Froguel Henrik Grönberg Ulf Gyllensten Per Hall Torben Hansen Tamara B Harris Andrew T Hattersley Richard B Hayes Joachim Heinrich Frank B Hu Kristian Hveem Thomas Illig Marjo-Riitta Jarvelin Jaakko Kaprio Fredrik Karpe Kay-Tee Khaw Lambertus A Kiemeney Heiko Krude Markku Laakso Debbie A Lawlor Andres Metspalu Patricia B Munroe Willem H Ouwehand Oluf Pedersen Brenda W Penninx Annette Peters Peter P Pramstaller Thomas Quertermous Thomas Reinehr Aila Rissanen Igor Rudan Nilesh J Samani Peter E H Schwarz Alan R Shuldiner Timothy D Spector Jaakko Tuomilehto Manuela Uda André Uitterlinden Timo T Valle Martin Wabitsch Gérard Waeber Nicholas J Wareham Hugh Watkins James F Wilson Alan F Wright M Carola Zillikens Nilanjan Chatterjee Steven A McCarroll Shaun Purcell Eric E Schadt Peter M Visscher Themistocles L Assimes Ingrid B Borecki Panos Deloukas Caroline S Fox Leif C Groop Talin Haritunians David J Hunter Robert C Kaplan Karen L Mohlke Jeffrey R O'Connell Leena Peltonen David Schlessinger David P Strachan Cornelia M van Duijn H-Erich Wichmann Timothy M Frayling Unnur Thorsteinsdottir Gonçalo R Abecasis Inês Barroso Michael Boehnke Kari Stefansson Kari E North Mark I McCarthy Joel N Hirschhorn Erik Ingelsson Ruth J F Loos

Nat Genet 2010 Nov 10;42(11):937-48. Epub 2010 Oct 10.

Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.

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http://www.genome.gov/pages/research/dir/bmistudy.pdf
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http://www.nature.com/doifinder/10.1038/ng.686
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http://dx.doi.org/10.1038/ng.686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014648PMC
November 2010

Hundreds of variants clustered in genomic loci and biological pathways affect human height.

Authors:
Hana Lango Allen Karol Estrada Guillaume Lettre Sonja I Berndt Michael N Weedon Fernando Rivadeneira Cristen J Willer Anne U Jackson Sailaja Vedantam Soumya Raychaudhuri Teresa Ferreira Andrew R Wood Robert J Weyant Ayellet V Segrè Elizabeth K Speliotes Eleanor Wheeler Nicole Soranzo Ju-Hyun Park Jian Yang Daniel Gudbjartsson Nancy L Heard-Costa Joshua C Randall Lu Qi Albert Vernon Smith Reedik Mägi Tomi Pastinen Liming Liang Iris M Heid Jian'an Luan Gudmar Thorleifsson Thomas W Winkler Michael E Goddard Ken Sin Lo Cameron Palmer Tsegaselassie Workalemahu Yurii S Aulchenko Asa Johansson M Carola Zillikens Mary F Feitosa Tõnu Esko Toby Johnson Shamika Ketkar Peter Kraft Massimo Mangino Inga Prokopenko Devin Absher Eva Albrecht Florian Ernst Nicole L Glazer Caroline Hayward Jouke-Jan Hottenga Kevin B Jacobs Joshua W Knowles Zoltán Kutalik Keri L Monda Ozren Polasek Michael Preuss Nigel W Rayner Neil R Robertson Valgerdur Steinthorsdottir Jonathan P Tyrer Benjamin F Voight Fredrik Wiklund Jianfeng Xu Jing Hua Zhao Dale R Nyholt Niina Pellikka Markus Perola John R B Perry Ida Surakka Mari-Liis Tammesoo Elizabeth L Altmaier Najaf Amin Thor Aspelund Tushar Bhangale Gabrielle Boucher Daniel I Chasman Constance Chen Lachlan Coin Matthew N Cooper Anna L Dixon Quince Gibson Elin Grundberg Ke Hao M Juhani Junttila Lee M Kaplan Johannes Kettunen Inke R König Tony Kwan Robert W Lawrence Douglas F Levinson Mattias Lorentzon Barbara McKnight Andrew P Morris Martina Müller Julius Suh Ngwa Shaun Purcell Suzanne Rafelt Rany M Salem Erika Salvi Serena Sanna Jianxin Shi Ulla Sovio John R Thompson Michael C Turchin Liesbeth Vandenput Dominique J Verlaan Veronique Vitart Charles C White Andreas Ziegler Peter Almgren Anthony J Balmforth Harry Campbell Lorena Citterio Alessandro De Grandi Anna Dominiczak Jubao Duan Paul Elliott Roberto Elosua Johan G Eriksson Nelson B Freimer Eco J C Geus Nicola Glorioso Shen Haiqing Anna-Liisa Hartikainen Aki S Havulinna Andrew A Hicks Jennie Hui Wilmar Igl Thomas Illig Antti Jula Eero Kajantie Tuomas O Kilpeläinen Markku Koiranen Ivana Kolcic Seppo Koskinen Peter Kovacs Jaana Laitinen Jianjun Liu Marja-Liisa Lokki Ana Marusic Andrea Maschio Thomas Meitinger Antonella Mulas Guillaume Paré Alex N Parker John F Peden Astrid Petersmann Irene Pichler Kirsi H Pietiläinen Anneli Pouta Martin Ridderstråle Jerome I Rotter Jennifer G Sambrook Alan R Sanders Carsten Oliver Schmidt Juha Sinisalo Jan H Smit Heather M Stringham G Bragi Walters Elisabeth Widen Sarah H Wild Gonneke Willemsen Laura Zagato Lina Zgaga Paavo Zitting Helene Alavere Martin Farrall Wendy L McArdle Mari Nelis Marjolein J Peters Samuli Ripatti Joyce B J van Meurs Katja K Aben Kristin G Ardlie Jacques S Beckmann John P Beilby Richard N Bergman Sven Bergmann Francis S Collins Daniele Cusi Martin den Heijer Gudny Eiriksdottir Pablo V Gejman Alistair S Hall Anders Hamsten Heikki V Huikuri Carlos Iribarren Mika Kähönen Jaakko Kaprio Sekar Kathiresan Lambertus Kiemeney Thomas Kocher Lenore J Launer Terho Lehtimäki Olle Melander Tom H Mosley Arthur W Musk Markku S Nieminen Christopher J O'Donnell Claes Ohlsson Ben Oostra Lyle J Palmer Olli Raitakari Paul M Ridker John D Rioux Aila Rissanen Carlo Rivolta Heribert Schunkert Alan R Shuldiner David S Siscovick Michael Stumvoll Anke Tönjes Jaakko Tuomilehto Gert-Jan van Ommen Jorma Viikari Andrew C Heath Nicholas G Martin Grant W Montgomery Michael A Province Manfred Kayser Alice M Arnold Larry D Atwood Eric Boerwinkle Stephen J Chanock Panos Deloukas Christian Gieger Henrik Grönberg Per Hall Andrew T Hattersley Christian Hengstenberg Wolfgang Hoffman G Mark Lathrop Veikko Salomaa Stefan Schreiber Manuela Uda Dawn Waterworth Alan F Wright Themistocles L Assimes Inês Barroso Albert Hofman Karen L Mohlke Dorret I Boomsma Mark J Caulfield L Adrienne Cupples Jeanette Erdmann Caroline S Fox Vilmundur Gudnason Ulf Gyllensten Tamara B Harris Richard B Hayes Marjo-Riitta Jarvelin Vincent Mooser Patricia B Munroe Willem H Ouwehand Brenda W Penninx Peter P Pramstaller Thomas Quertermous Igor Rudan Nilesh J Samani Timothy D Spector Henry Völzke Hugh Watkins James F Wilson Leif C Groop Talin Haritunians Frank B Hu Robert C Kaplan Andres Metspalu Kari E North David Schlessinger Nicholas J Wareham David J Hunter Jeffrey R O'Connell David P Strachan H-Erich Wichmann Ingrid B Borecki Cornelia M van Duijn Eric E Schadt Unnur Thorsteinsdottir Leena Peltonen André G Uitterlinden Peter M Visscher Nilanjan Chatterjee Ruth J F Loos Michael Boehnke Mark I McCarthy Erik Ingelsson Cecilia M Lindgren Gonçalo R Abecasis Kari Stefansson Timothy M Frayling Joel N Hirschhorn

Nature 2010 Oct 29;467(7317):832-8. Epub 2010 Sep 29.

Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter EX1 2LU, UK.

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April 2010

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November 2009

Cardiac repolarization and striatal dopamine transporter function are interrelated.

Nucl Med Commun 2009 Sep;30(9):713-7

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September 2009

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Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland.

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HDL subspecies in young adult twins: heritability and impact of overweight.

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Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Finnish Twin Cohort Study, Department of Public Health, University of Helsinki, Helsinki, Finland.

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June 2009

Association of smoking in adolescence with abdominal obesity in adulthood: a follow-up study of 5 birth cohorts of Finnish twins.

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Department of Public Health, University of Helsinki, Helsinki, Finland.

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Columbia University, New York State Psychiatric Institute, 1051 Riverside Dr., Unit 23, New York, NY 10032, USA.

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December 2008

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September 2008

Long-term effect of CB1 blockade with rimonabant on cardiometabolic risk factors: two year results from the RIO-Europe Study.

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July 2008

Lifetime anorexia nervosa in young men in the community: five cases and their co-twins.

Int J Eat Disord 2008 Jul;41(5):458-63

Department of Public Health, University of Helsinki, Helsinki, Finland.

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July 2008

Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity.

Am J Physiol Endocrinol Metab 2008 Jul 6;295(1):E148-54. Epub 2008 May 6.

Department of Laboratory Medicine, Division of Clinical Physiology and Nuclear Medicine, Helsinki University Central Hospital, Helsinki, Finland.

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July 2008

Genetic influences on growth traits of BMI: a longitudinal study of adult twins.

Obesity (Silver Spring) 2008 Apr 31;16(4):847-52. Epub 2008 Jan 31.

Statistics and Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark.

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April 2008

Serotonin transporter binding and acquired obesity -- an imaging study of monozygotic twin pairs.

Physiol Behav 2008 Mar 3;93(4-5):724-32. Epub 2007 Dec 3.

Department of Clinical Physiology and Nuclear Medicine, HUSLAB/Helsinki University Central Hospital, Helsinki, Finland.

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March 2008

Weight loss larger than 10% is needed for general improvement of levels of circulating adiponectin and markers of inflammation in obese subjects: a 3-year weight loss study.

Eur J Endocrinol 2008 Feb;158(2):179-87

Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansensgade 2, DK-8000 Aarhus C, Denmark.

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February 2008

Effect of orlistat on eating behavior among participants in a 3-year weight maintenance trial.

Obesity (Silver Spring) 2008 Feb;16(2):327-33

Department of Preventive Cardiology, Ullevål University Hospital, Oslo, Norway.

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February 2008

Physical inactivity and obesity: a vicious circle.

Obesity (Silver Spring) 2008 Feb;16(2):409-14

Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2249563PMC
February 2008

Genetic and environmental contributions to food use patterns of young adult twins.

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Department of Food Technology, University of Helsinki, P.O. Box 66, FI-00014 University of Helsinki, Finland.

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January 2008

Epidemiology and course of anorexia nervosa in the community.

Am J Psychiatry 2007 Aug;164(8):1259-65

Department of Epidemiology, Columbia University, New York, NY, USA.

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August 2007

Recurrent dieting and smoking among Finnish men and women.

Obesity (Silver Spring) 2007 Jul;15(7):1851-9

Department of Public Health, PO Box 41, University of Helsinki, and Department of Psychiatry, Helsinki University Hospital, Finland.

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July 2007

Serotonin transporter binding of [123I]ADAM in bulimic women, their healthy twin sisters, and healthy women: a SPET study.

BMC Psychiatry 2007 May 21;7:19. Epub 2007 May 21.

Department of Clinical Physiology and Nuclear Medicine, HUSLAB/Helsinki University Central Hospital, Helsinki, Finland.

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Energy substrate metabolism among habitually violent alcoholic offenders having antisocial personality disorder.

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Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland.

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April 2007

Reliability of self-reported eating disorders: Optimizing population screening.

Int J Eat Disord 2006 Dec;39(8):754-62

Department of Epidemiology, Columbia University, New York, New York 10032, USA.

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December 2006

Acquired obesity increases CD68 and tumor necrosis factor-alpha and decreases adiponectin gene expression in adipose tissue: a study in monozygotic twins.

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M.Sc., Obesity Research Unit, Biomedicum Helsinki, C428a, P.O. Box 700, FIN-00029 HUS, Finland.

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July 2006

Muscle dissatisfaction and muscle-enhancing substance use: a population-based twin study in young adult men.

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Department of Public Health, University of Helsinki, Finland.

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June 2006

Effects of acquired obesity on endothelial function in monozygotic twins.

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May 2006

Muscle dissatisfaction in young adult men.

Clin Pract Epidemiol Ment Health 2006 Apr 4;2. Epub 2006 Apr 4.

Department of Public Health, University of Helsinki, Finland.

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