Aiko Sueta

Aiko Sueta

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Aiko Sueta

Aiko Sueta

Publications by authors named "Aiko Sueta"

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Therapeutic predictors of neoadjuvant endocrine therapy response in estrogen receptor-positive breast cancer with reference to optimal gene expression profiling.

Breast Cancer Res Treat 2018 Nov 27;172(2):353-362. Epub 2018 Aug 27.

The Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

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http://dx.doi.org/10.1007/s10549-018-4933-5DOI Listing
November 2018

ESR1 and PIK3CA mutational status in serum and plasma from metastatic breast cancer patients: A comparative study.

Cancer Biomark 2018 ;22(2):345-350

Department of Breast and Endocrine Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.3233/CBM-171161DOI Listing
October 2018

APOBEC3B gene expression as a novel predictive factor for pathological complete response to neoadjuvant chemotherapy in breast cancer.

Oncotarget 2018 Jul 17;9(55):30513-30526. Epub 2018 Jul 17.

Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Sciences, Chuo-Ku, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.18632/oncotarget.25495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078135PMC
July 2018

Clinical significance of plasma cell-free DNA mutations in PIK3CA, AKT1, and ESR1 gene according to treatment lines in ER-positive breast cancer.

Mol Cancer 2018 02 26;17(1):67. Epub 2018 Feb 26.

Department of Breast and Endocrine surgery, Graduate School of Medical Science, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

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http://dx.doi.org/10.1186/s12943-018-0808-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389169PMC
February 2018

Factors involved in early lenvatinib dose reduction: a retrospective analysis.

Med Oncol 2018 Jan 31;35(3):19. Epub 2018 Jan 31.

Graduate School of Life Sciences, Kumamoto University Hospital Cancer Center, Kumamoto, 860-8556, Japan.

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http://dx.doi.org/10.1007/s12032-018-1088-5DOI Listing
January 2018

Prevalence of ESR1 E380Q mutation in tumor tissue and plasma from Japanese breast cancer patients.

BMC Cancer 2017 Nov 22;17(1):786. Epub 2017 Nov 22.

Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto City, 860-8556, Japan.

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-017-3779-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700624PMC
November 2017

Comparison of ESR1 Mutations in Tumor Tissue and Matched Plasma Samples from Metastatic Breast Cancer Patients.

Transl Oncol 2017 Oct 1;10(5):766-771. Epub 2017 Aug 1.

Department of Breast and Endocrine Surgery, Graduate School of Medical Science, Kumamoto University, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19365233173015
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http://dx.doi.org/10.1016/j.tranon.2017.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538967PMC
October 2017

Differential expression of exosomal miRNAs between breast cancer patients with and without recurrence.

Oncotarget 2017 Sep 22;8(41):69934-69944. Epub 2017 Jul 22.

Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.18632/oncotarget.19482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642528PMC
September 2017

Analysis of and mutations in plasma cell-free DNA from ER-positive breast cancer patients.

Oncotarget 2017 Aug 14;8(32):52142-52155. Epub 2017 Jun 14.

Department of Breast and Endocrine Surgery, Graduate School of Medical Science, Kumamoto University, Honjo, Chuo-Ku, Kumamoto, Japan.

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http://www.oncotarget.com/fulltext/18479
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http://dx.doi.org/10.18632/oncotarget.18479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581019PMC
August 2017

Clinical features of lenvatinib treatment in elderly patients with advanced thyroid cancer.

Mol Clin Oncol 2017 Jul 17;7(1):24-26. Epub 2017 May 17.

Kumamoto University Hospital Cancer Center, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.3892/mco.2017.1265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492816PMC
July 2017

Influence of the C5a-C5a receptor system on breast cancer progression and patient prognosis.

Breast Cancer 2016 Nov 22;23(6):876-885. Epub 2015 Oct 22.

Department of Breast and Endocrine Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1007/s12282-015-0654-3DOI Listing
November 2016

Successful ethinylestradiol therapy for a metastatic breast cancer patient with heavily pre-treated with endocrine therapies.

Int Cancer Conf J 2016 Jul 7;5(3):126-130. Epub 2016 Jan 7.

1Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Science, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556 Japan.

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http://dx.doi.org/10.1007/s13691-015-0241-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498252PMC
July 2016

Clinical significance of monitoring ESR1 mutations in circulating cell-free DNA in estrogen receptor positive breast cancer patients.

Oncotarget 2016 May;7(22):32504-18

Department of Breast and Endocrine Surgery, Graduate School of Medical Science, Kumamoto University, Chuo-ku, Kumamoto, 860-8556, Japan.

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http://dx.doi.org/10.18632/oncotarget.8839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078029PMC
May 2016

Droplet digital polymerase chain reaction assay for screening of ESR1 mutations in 325 breast cancer specimens.

Transl Res 2015 Dec 14;166(6):540-553.e2. Epub 2015 Sep 14.

Department of Breast and Endocrine Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.trsl.2015.09.003DOI Listing
December 2015

Associations Between Elastography Findings and Clinicopathological Factors in Breast Cancer.

Medicine (Baltimore) 2015 Dec;94(50):e2290

From the Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan (MH, YY, AS, MT, MY-I, HI); Division of Clinical Pharmacology and Translational Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Tokyo, Japan (MH, AH); Department of Breast and Endocrine Surgery, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan (TK); and Department of Molecular Imaging and Pharmacokinetics, Fundamental Innovative Oncology Core, National Cancer Center Research Institute, Tokyo, Japan (MH, AH).

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https://insights.ovid.com/crossref?an=00005792-201512150-000
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http://dx.doi.org/10.1097/MD.0000000000002290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058935PMC
December 2015

An integrative analysis of PIK3CA mutation, PTEN, and INPP4B expression in terms of trastuzumab efficacy in HER2-positive breast cancer.

PLoS One 2014 26;9(12):e116054. Epub 2014 Dec 26.

Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Science, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116054PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277449PMC
November 2015

Prognostic role of PIK3CA mutations of cell-free DNA in early-stage triple negative breast cancer.

Cancer Sci 2015 Nov 30;106(11):1582-9. Epub 2015 Oct 30.

Department of Breast and Endocrine surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1111/cas.12813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714688PMC
November 2015

C6ORF97-ESR1 breast cancer susceptibility locus: influence on progression and survival in breast cancer patients.

Eur J Hum Genet 2015 Jul 5;23(7):949-56. Epub 2014 Nov 5.

Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1038/ejhg.2014.219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463506PMC
July 2015

Differential role of MACC1 expression and its regulation of the HGF/c‑Met pathway between breast and colorectal cancer.

Int J Oncol 2015 May 25;46(5):2143-53. Epub 2015 Feb 25.

Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860‑8556, Japan.

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http://dx.doi.org/10.3892/ijo.2015.2907DOI Listing
May 2015

Immunohistochemical analysis in ethinylestradiol-treated breast cancers after prior long-term estrogen-deprivation therapy.

Springerplus 2015 5;4:108. Epub 2015 Mar 5.

Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556 Japan.

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http://dx.doi.org/10.1186/s40064-015-0851-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353819PMC
March 2015

Clinical significance of CYLD downregulation in breast cancer.

Breast Cancer Res Treat 2014 Feb 8;143(3):447-57. Epub 2014 Jan 8.

Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1007/s10549-013-2824-3DOI Listing
February 2014

Alcohol and dietary folate intake and the risk of breast cancer: a case-control study in Japan.

Eur J Cancer Prev 2013 Jul;22(4):358-66

Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.

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http://dx.doi.org/10.1097/CEJ.0b013e32835b6a60DOI Listing
July 2013

Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls.

Hum Mol Genet 2013 Jun 27;22(12):2539-50. Epub 2013 Mar 27.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.

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http://dx.doi.org/10.1093/hmg/ddt089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658167PMC
June 2013

Large-scale genotyping identifies 41 new loci associated with breast cancer risk.

Authors:
Kyriaki Michailidou Per Hall Anna Gonzalez-Neira Maya Ghoussaini Joe Dennis Roger L Milne Marjanka K Schmidt Jenny Chang-Claude Stig E Bojesen Manjeet K Bolla Qin Wang Ed Dicks Andrew Lee Clare Turnbull Nazneen Rahman Olivia Fletcher Julian Peto Lorna Gibson Isabel Dos Santos Silva Heli Nevanlinna Taru A Muranen Kristiina Aittomäki Carl Blomqvist Kamila Czene Astrid Irwanto Jianjun Liu Quinten Waisfisz Hanne Meijers-Heijboer Muriel Adank Rob B van der Luijt Rebecca Hein Norbert Dahmen Lars Beckman Alfons Meindl Rita K Schmutzler Bertram Müller-Myhsok Peter Lichtner John L Hopper Melissa C Southey Enes Makalic Daniel F Schmidt Andre G Uitterlinden Albert Hofman David J Hunter Stephen J Chanock Daniel Vincent François Bacot Daniel C Tessier Sander Canisius Lodewyk F A Wessels Christopher A Haiman Mitul Shah Robert Luben Judith Brown Craig Luccarini Nils Schoof Keith Humphreys Jingmei Li Børge G Nordestgaard Sune F Nielsen Henrik Flyger Fergus J Couch Xianshu Wang Celine Vachon Kristen N Stevens Diether Lambrechts Matthieu Moisse Robert Paridaens Marie-Rose Christiaens Anja Rudolph Stefan Nickels Dieter Flesch-Janys Nichola Johnson Zoe Aitken Kirsimari Aaltonen Tuomas Heikkinen Annegien Broeks Laura J Van't Veer C Ellen van der Schoot Pascal Guénel Thérèse Truong Pierre Laurent-Puig Florence Menegaux Frederik Marme Andreas Schneeweiss Christof Sohn Barbara Burwinkel M Pilar Zamora Jose Ignacio Arias Perez Guillermo Pita M Rosario Alonso Angela Cox Ian W Brock Simon S Cross Malcolm W R Reed Elinor J Sawyer Ian Tomlinson Michael J Kerin Nicola Miller Brian E Henderson Fredrick Schumacher Loic Le Marchand Irene L Andrulis Julia A Knight Gord Glendon Anna Marie Mulligan Annika Lindblom Sara Margolin Maartje J Hooning Antoinette Hollestelle Ans M W van den Ouweland Agnes Jager Quang M Bui Jennifer Stone Gillian S Dite Carmel Apicella Helen Tsimiklis Graham G Giles Gianluca Severi Laura Baglietto Peter A Fasching Lothar Haeberle Arif B Ekici Matthias W Beckmann Hermann Brenner Heiko Müller Volker Arndt Christa Stegmaier Anthony Swerdlow Alan Ashworth Nick Orr Michael Jones Jonine Figueroa Jolanta Lissowska Louise Brinton Mark S Goldberg France Labrèche Martine Dumont Robert Winqvist Katri Pylkäs Arja Jukkola-Vuorinen Mervi Grip Hiltrud Brauch Ute Hamann Thomas Brüning Paolo Radice Paolo Peterlongo Siranoush Manoukian Bernardo Bonanni Peter Devilee Rob A E M Tollenaar Caroline Seynaeve Christi J van Asperen Anna Jakubowska Jan Lubinski Katarzyna Jaworska Katarzyna Durda Arto Mannermaa Vesa Kataja Veli-Matti Kosma Jaana M Hartikainen Natalia V Bogdanova Natalia N Antonenkova Thilo Dörk Vessela N Kristensen Hoda Anton-Culver Susan Slager Amanda E Toland Stephen Edge Florentia Fostira Daehee Kang Keun-Young Yoo Dong-Young Noh Keitaro Matsuo Hidemi Ito Hiroji Iwata Aiko Sueta Anna H Wu Chiu-Chen Tseng David Van Den Berg Daniel O Stram Xiao-Ou Shu Wei Lu Yu-Tang Gao Hui Cai Soo Hwang Teo Cheng Har Yip Sze Yee Phuah Belinda K Cornes Mikael Hartman Hui Miao Wei Yen Lim Jen-Hwei Sng Kenneth Muir Artitaya Lophatananon Sarah Stewart-Brown Pornthep Siriwanarangsan Chen-Yang Shen Chia-Ni Hsiung Pei-Ei Wu Shian-Ling Ding Suleeporn Sangrajrang Valerie Gaborieau Paul Brennan James McKay William J Blot Lisa B Signorello Qiuyin Cai Wei Zheng Sandra Deming-Halverson Martha Shrubsole Jirong Long Jacques Simard Montse Garcia-Closas Paul D P Pharoah Georgia Chenevix-Trench Alison M Dunning Javier Benitez Douglas F Easton

Nat Genet 2013 Apr;45(4):353-61, 361e1-2

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

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https://umexpert.um.edu.my/file/publication/00000868_105106.
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http://www.nature.com/doifinder/10.1038/ng.2563
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http://dx.doi.org/10.1038/ng.2563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771688PMC
April 2013

Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers.

Authors:
Juliet D French Maya Ghoussaini Stacey L Edwards Kerstin B Meyer Kyriaki Michailidou Shahana Ahmed Sofia Khan Mel J Maranian Martin O'Reilly Kristine M Hillman Joshua A Betts Thomas Carroll Peter J Bailey Ed Dicks Jonathan Beesley Jonathan Tyrer Ana-Teresa Maia Andrew Beck Nicholas W Knoblauch Constance Chen Peter Kraft Daniel Barnes Anna González-Neira M Rosario Alonso Daniel Herrero Daniel C Tessier Daniel Vincent Francois Bacot Craig Luccarini Caroline Baynes Don Conroy Joe Dennis Manjeet K Bolla Qin Wang John L Hopper Melissa C Southey Marjanka K Schmidt Annegien Broeks Senno Verhoef Sten Cornelissen Kenneth Muir Artitaya Lophatananon Sarah Stewart-Brown Pornthep Siriwanarangsan Peter A Fasching Christian R Loehberg Arif B Ekici Matthias W Beckmann Julian Peto Isabel dos Santos Silva Nichola Johnson Zoe Aitken Elinor J Sawyer Ian Tomlinson Michael J Kerin Nicola Miller Frederik Marme Andreas Schneeweiss Christof Sohn Barbara Burwinkel Pascal Guénel Thérèse Truong Pierre Laurent-Puig Florence Menegaux Stig E Bojesen Børge G Nordestgaard Sune F Nielsen Henrik Flyger Roger L Milne M Pilar Zamora Jose Ignacio Arias Perez Javier Benitez Hoda Anton-Culver Hermann Brenner Heiko Müller Volker Arndt Christa Stegmaier Alfons Meindl Peter Lichtner Rita K Schmutzler Christoph Engel Hiltrud Brauch Ute Hamann Christina Justenhoven Kirsimari Aaltonen Päivi Heikkilä Kristiina Aittomäki Carl Blomqvist Keitaro Matsuo Hidemi Ito Hiroji Iwata Aiko Sueta Natalia V Bogdanova Natalia N Antonenkova Thilo Dörk Annika Lindblom Sara Margolin Arto Mannermaa Vesa Kataja Veli-Matti Kosma Jaana M Hartikainen Anna H Wu Chiu-chen Tseng David Van Den Berg Daniel O Stram Diether Lambrechts Stephanie Peeters Ann Smeets Giuseppe Floris Jenny Chang-Claude Anja Rudolph Stefan Nickels Dieter Flesch-Janys Paolo Radice Paolo Peterlongo Bernardo Bonanni Domenico Sardella Fergus J Couch Xianshu Wang Vernon S Pankratz Adam Lee Graham G Giles Gianluca Severi Laura Baglietto Christopher A Haiman Brian E Henderson Fredrick Schumacher Loic Le Marchand Jacques Simard Mark S Goldberg France Labrèche Martine Dumont Soo Hwang Teo Cheng Har Yip Char-Hong Ng Eranga Nishanthie Vithana Vessela Kristensen Wei Zheng Sandra Deming-Halverson Martha Shrubsole Jirong Long Robert Winqvist Katri Pylkäs Arja Jukkola-Vuorinen Mervi Grip Irene L Andrulis Julia A Knight Gord Glendon Anna Marie Mulligan Peter Devilee Caroline Seynaeve Montserrat García-Closas Jonine Figueroa Stephen J Chanock Jolanta Lissowska Kamila Czene Daniel Klevebring Nils Schoof Maartje J Hooning John W M Martens J Margriet Collée Madeleine Tilanus-Linthorst Per Hall Jingmei Li Jianjun Liu Keith Humphreys Xiao-Ou Shu Wei Lu Yu-Tang Gao Hui Cai Angela Cox Sabapathy P Balasubramanian William Blot Lisa B Signorello Qiuyin Cai Paul D P Pharoah Catherine S Healey Mitul Shah Karen A Pooley Daehee Kang Keun-Young Yoo Dong-Young Noh Mikael Hartman Hui Miao Jen-Hwei Sng Xueling Sim Anna Jakubowska Jan Lubinski Katarzyna Jaworska-Bieniek Katarzyna Durda Suleeporn Sangrajrang Valerie Gaborieau James McKay Amanda E Toland Christine B Ambrosone Drakoulis Yannoukakos Andrew K Godwin Chen-Yang Shen Chia-Ni Hsiung Pei-Ei Wu Shou-Tung Chen Anthony Swerdlow Alan Ashworth Nick Orr Minouk J Schoemaker Bruce A J Ponder Heli Nevanlinna Melissa A Brown Georgia Chenevix-Trench Douglas F Easton Alison M Dunning

Am J Hum Genet 2013 Apr 27;92(4):489-503. Epub 2013 Mar 27.

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia.

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http://dx.doi.org/10.1016/j.ajhg.2013.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617380PMC
April 2013

Differential impact of body mass index and its change on the risk of breast cancer by molecular subtype: A case-control study in Japanese women.

Springerplus 2012 Dec 23;1(1):39. Epub 2012 Oct 23.

Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1, Kanokoden, Chikusa-ku, Nagoya, 464-8681 Japan ; Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Science, 1-1-1, Honjo, Kumamoto, 860-8556 Japan.

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http://dx.doi.org/10.1186/2193-1801-1-39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3550694PMC
December 2012

High recurrence risk and use of adjuvant trastuzumab in patients with small, HER2-positive, node-negative breast cancers.

Int J Clin Oncol 2012 Apr 18;17(2):131-6. Epub 2011 Jun 18.

Department of Breast Oncology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan.

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http://dx.doi.org/10.1007/s10147-011-0269-4DOI Listing
April 2012

A genetic risk predictor for breast cancer using a combination of low-penetrance polymorphisms in a Japanese population.

Breast Cancer Res Treat 2012 Apr 11;132(2):711-21. Epub 2011 Dec 11.

Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1, Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan.

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http://dx.doi.org/10.1007/s10549-011-1904-5DOI Listing
April 2012

Stromal sarcoma of the breast with lung metastases showing a clinical complete response to doxorubicin plus ifosfamide treatment: report of a case.

Surg Today 2011 Aug 20;41(8):1145-9. Epub 2011 Jul 20.

Department of General Surgery, Kumamoto Rousai Hospital, Kumamoto, Japan.

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http://dx.doi.org/10.1007/s00595-010-4406-xDOI Listing
August 2011

[A case of mammary Paget's disease with early systemic recurrence after operation].

Gan To Kagaku Ryoho 2010 Jul;37(7):1329-32

Department of General Surgery, Kumamoto Rousai Hospital.

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July 2010

[A case of spindle cell carcinoma of the breast including metaplastic lesion with poor prognosis].

Gan To Kagaku Ryoho 2009 Jun;36(6):1017-9

Dept. of Breast and Endocrine Surgery, Kumamoto University Hospital, Japan.

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June 2009