Publications by authors named "Aik Choon Tan"

100Publications

Identification of RUNX1T1 as a potential epigenetic modifier in small-cell lung cancer.

Mol Oncol 2021 Jan 27;15(1):195-209. Epub 2020 Nov 27.

Division of Hematology and Oncology, Case Western Reserve University, Cleveland, OH, USA.

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January 2021

Role of mTOR As an Essential Kinase in SCLC.

J Thorac Oncol 2020 Sep 26;15(9):1522-1534. Epub 2020 Jun 26.

Department of Medicine, University of Colorado, Denver, Colorado; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida.

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September 2020

Loss of prdm1a accelerates melanoma onset and progression.

Mol Carcinog 2020 09 20;59(9):1052-1063. Epub 2020 Jun 20.

Department of Craniofacial Biology, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado.

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September 2020

First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer.

Mol Cancer Ther 2020 08 4;19(8):1598-1612. Epub 2020 Jun 4.

The Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences, The University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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August 2020

Leptomeningeal Metastasis from Adrenocortical Carcinoma: A Case Report.

J Endocr Soc 2020 Mar 12;4(3):bvaa017. Epub 2020 Feb 12.

Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado, Aurora, Colorado.

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March 2020

Translational genomics for rare cancers: Challenges and opportunity.

Semin Cancer Biol 2020 04 21;61:iii-iv. Epub 2020 Feb 21.

Division of Molecular Pathology, Institute of Cancer Research, London, UK. Electronic address:

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April 2020

The landscape of tyrosine kinase inhibitors in sarcomas: looking beyond pazopanib.

Expert Rev Anticancer Ther 2019 11 13;19(11):971-991. Epub 2019 Nov 13.

Division of Molecular Pathology, The Institute of Cancer Research, London, UK.

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November 2019

The mutational landscape of mucosal melanoma.

Semin Cancer Biol 2020 04 23;61:139-148. Epub 2019 Oct 23.

Division of Medical Oncology, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80111, USA; Cancer Biology Training Program, Graduate School, University of Colorado Anschutz Medical Campus, Aurora, CO 80111, USA; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL 33612 USA. Electronic address:

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April 2020

Clinical implications of ALDH1A1 and ALDH1A3 mRNA expression in melanoma subtypes.

Chem Biol Interact 2019 Dec 30;314:108822. Epub 2019 Sep 30.

Department of Dermatology, University of Colorado Denver, Aurora, CO, 80045, United States; Denver VA Medical Center, Denver, CO, 80220, United States; Department of Immunology & Microbiology, University of Colorado Denver, Aurora, CO, 80045, United States. Electronic address:

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December 2019

Functional RNAi Screens Define Distinct Protein Kinase Vulnerabilities in EGFR-Dependent HNSCC Cell Lines.

Mol Pharmacol 2019 12 25;96(6):862-870. Epub 2019 Sep 25.

Departments of Craniofacial Biology (T.K.H., E.K.K., K.R.S., J.C., L.A.M., L.E.H.) and Medicine (J.K., A.C.T.), University of Colorado Anschutz Medical Campus, Aurora, Colorado

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December 2019

ReSimNet: drug response similarity prediction using Siamese neural networks.

Bioinformatics 2019 12;35(24):5249-5256

Department of Computer Science and Engineering, Korea University, Seoul 02841, South Korea.

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December 2019

IFITM3 knockdown reduces the expression of CCND1 and CDK4 and suppresses the growth of oral squamous cell carcinoma cells.

Cell Oncol (Dordr) 2019 Aug 4;42(4):477-490. Epub 2019 Apr 4.

Head and Neck Cancer Research Team, Cancer Research Malaysia, 2nd Floor, Outpatient Centre, Subang Jaya Medical Centre, 47500, Subang Jaya, Selangor, Malaysia.

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August 2019

Resistance to Src inhibition alters the BRAF-mutant tumor secretome to promote an invasive phenotype and therapeutic escape through a FAK>p130Cas>c-Jun signaling axis.

Oncogene 2019 04 10;38(14):2565-2579. Epub 2018 Dec 10.

Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, 80045, USA.

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April 2019

GSEA-InContext: identifying novel and common patterns in expression experiments.

Bioinformatics 2018 07;34(13):i555-i564

Computational Bioscience Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

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July 2018

Innate Genetic Evolution of Lung Cancers and Spatial Heterogeneity: Analysis of Treatment-Naïve Lesions.

J Thorac Oncol 2018 10 19;13(10):1496-1507. Epub 2018 Jun 19.

Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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October 2018

Systems Pharmacology-Based Approach of Connecting Disease Genes in Genome-Wide Association Studies with Traditional Chinese Medicine.

Int J Genomics 2018 22;2018:7697356. Epub 2018 Mar 22.

Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

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March 2018

IMPACT web portal: oncology database integrating molecular profiles with actionable therapeutics.

BMC Med Genomics 2018 04 20;11(Suppl 2):26. Epub 2018 Apr 20.

Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

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April 2018

Exploring the molecular mechanisms of Traditional Chinese Medicine components using gene expression signatures and connectivity map.

Comput Methods Programs Biomed 2019 Jun 4;174:33-40. Epub 2018 Apr 4.

Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address:

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June 2019

Genetic Analysis of 779 Advanced Differentiated and Anaplastic Thyroid Cancers.

Clin Cancer Res 2018 07 3;24(13):3059-3068. Epub 2018 Apr 3.

Department of Pharmaceutical Sciences, Skaags School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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July 2018

Deep learning of mutation-gene-drug relations from the literature.

BMC Bioinformatics 2018 01 25;19(1):21. Epub 2018 Jan 25.

Department of Computer Science and Engineering, Korea University, Seoul, South Korea.

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January 2018

A Pilot Study of Biomedical Text Comprehension using an Attention-Based Deep Neural Reader: Design and Experimental Analysis.

JMIR Med Inform 2018 Jan 5;6(1):e2. Epub 2018 Jan 5.

Department of Computer Science and Engineering, College of Informatics, Korea University, Seoul, Republic Of Korea.

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January 2018

PAGER 2.0: an update to the pathway, annotated-list and gene-signature electronic repository for Human Network Biology.

Nucleic Acids Res 2018 01;46(D1):D668-D676

Informatics Institute, School of Medicine, the University of Alabama at Birmingham, AL 35294, USA.

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January 2018

Evaluation of the efficacy of dasatinib, a Src/Abl inhibitor, in colorectal cancer cell lines and explant mouse model.

PLoS One 2017 1;12(11):e0187173. Epub 2017 Nov 1.

Division of Medical Oncology, University of Colorado Denver Anschutz Medical Campus and University of Colorado Cancer Center, Aurora, CO, United States of America.

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December 2017

Molecular Analyses Reveal Inflammatory Mediators in the Solid Component and Cyst Fluid of Human Adamantinomatous Craniopharyngioma.

J Neuropathol Exp Neurol 2017 Sep;76(9):779-788

Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado; Developmental Biology and Cancer Programme, Great Ormond Street UCL Institute of Child Health, London, UK; Department of Neurological Surgery, Columbia University Medical Center, New York, New York; Division of Pediatric Neurosurgery, Department of Neurosurgery, Miami Children's Hospital, University of Miami/Miller School of Medicine, Miami, Florida; Department of Neurosurgery, Stanford University Medical Center, Palo Alto, California; Department of Neurological Surgery, Weill Medical College of Cornell University and Memorial Sloan-Kettering Cancer Center, New York, New York; Department of Neurosurgery, Children's Hospital Alabama, Birmingham, Alabama; Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, Maryland; Department of Pathology; Department of Neurosurgery; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado; Department of Histopathology, Great Ormond Street Hospital, NHS Trust, London, UK; Morgan Adams Foundation Pediatric Brain Tumor Research Program; Pediatric Neurosurgery, Children's Hospital Colorado; and Adult and Child Center for Health Outcomes Research, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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September 2017

Whole-exome sequencing identifies recurrent SF3B1 R625 mutation and comutation of NF1 and KIT in mucosal melanoma.

Melanoma Res 2017 06;27(3):189-199

aDepartment of Medicine, Division of Medical Oncology bDepartment of Pathology cDepartment of Surgery, School of Medicine dDepartment of Biostatistics and Informatics, Colorado School of Public Health eUniversity of Colorado Cancer Center fDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

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June 2017

DeSigN: connecting gene expression with therapeutics for drug repurposing and development.

BMC Genomics 2017 01 25;18(Suppl 1):934. Epub 2017 Jan 25.

Department of Oral & Maxillofacial Clinical Sciences, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia.

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January 2017

A Genome-Wide Loss-of-Function Screen Identifies SLC26A2 as a Novel Mediator of TRAIL Resistance.

Mol Cancer Res 2017 04 20;15(4):382-394. Epub 2017 Jan 20.

Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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April 2017

A Survey of Computational Tools to Analyze and Interpret Whole Exome Sequencing Data.

Int J Genomics 2016 14;2016:7983236. Epub 2016 Dec 14.

Division of Medical Oncology, Department of Medicine, School of Medicine, Aurora, CO 80045, USA; University of Colorado Cancer Center, Aurora, CO 80045, USA; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.

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December 2016

Brusatol overcomes chemoresistance through inhibition of protein translation.

Mol Carcinog 2017 05 8;56(5):1493-1500. Epub 2017 Feb 8.

Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona.

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May 2017

ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.

Proc Natl Acad Sci U S A 2016 10 10;113(43):E6669-E6678. Epub 2016 Oct 10.

Department of Biochemistry and Molecular Genetics, University of Colorado, Aurora, CO 80045; School of Medicine, University of Colorado, Aurora, CO 80045; Integrated Department of Immunology, University of Colorado, Aurora, CO 80045; Cancer Biology Program, University of Colorado, Aurora, CO 80045; Department of Pediatrics, Section of Hematology, Oncology, and Bone Marrow Transplantation, University of Colorado, Aurora, CO 80045

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October 2016

Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2.

J Natl Cancer Inst 2017 01 15;109(1). Epub 2016 Sep 15.

Affiliations of authors: Division of Medical Oncology, Department of Medicine (SBK, PNL, BM, BCJ, JRE, CN, JK, MJG, JJM, NPJ, KG, EW, JR, JJA, WAM, ACT, AJ), Department of Biostatistics and Informatics (JK, DG, ACT), Department of Pathology (HS, XJW), Department of Dermatology (DRR), and Gates Center for Regenerative Medicine (DRR, XJW, AJ), University of Colorado Denver School of Medicine, Denver, CO; Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, MD (BT, LMW); Department of Environmental Health Sciences, Yale School of Public Health, Yale School of Medicine, New Haven, CT (VV).

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January 2017

Big Data Mining and Adverse Event Pattern Analysis in Clinical Drug Trials.

Assay Drug Dev Technol 2016 12 15;14(10):557-566. Epub 2016 Sep 15.

1 Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus , Aurora, Colorado.

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December 2016

Barasertib (AZD1152), a Small Molecule Aurora B Inhibitor, Inhibits the Growth of SCLC Cell Lines In Vitro and In Vivo.

Mol Cancer Ther 2016 10 5;15(10):2314-2322. Epub 2016 Aug 5.

Department of Medicine, University of Colorado Cancer Center, Aurora, Colorado.

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October 2016

HiPub: translating PubMed and PMC texts to networks for knowledge discovery.

Bioinformatics 2016 09 2;32(18):2886-8. Epub 2016 Aug 2.

Department of Computer Science and Engineering, Korea University, Seoul, Korea Interdisciplinary Graduate Program in Bioinformatics, Korea University, Seoul, Korea.

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September 2016

Exploiting receptor tyrosine kinase co-activation for cancer therapy.

Drug Discov Today 2017 01 21;22(1):72-84. Epub 2016 Jul 21.

Division of Cancer Biology, The Institute of Cancer Research, London SW3 6JB, UK. Electronic address:

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January 2017

Integrating heterogeneous drug sensitivity data from cancer pharmacogenomic studies.

Oncotarget 2016 Aug;7(32):51619-51625

Department of Medicine, University of Colorado Cancer Center, University of Colorado School of Medicine, Aurora, CO, USA.

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August 2016

The Mitogen-Activated Protein Kinase Pathway Facilitates Resistance to the Src Inhibitor Dasatinib in Thyroid Cancer.

Mol Cancer Ther 2016 08 24;15(8):1952-63. Epub 2016 May 24.

Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado. University of Colorado Cancer Center, University of Colorado School of Medicine, Aurora, Colorado.

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August 2016

BRONCO: Biomedical entity Relation ONcology COrpus for extracting gene-variant-disease-drug relations.

Database (Oxford) 2016 13;2016. Epub 2016 Apr 13.

Department of Computer Science and Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841 Korea and

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January 2017

IMPACT: a whole-exome sequencing analysis pipeline for integrating molecular profiles with actionable therapeutics in clinical samples.

J Am Med Inform Assoc 2016 07 28;23(4):721-30. Epub 2016 Mar 28.

Division of Medical Oncology, Department of Medicine, School of Medicine Department of Biostatistics and Informatics, Colorado School of Public Health University of Colorado Cancer Center All: University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA

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July 2016

PKCδ regulates integrin αVβ3 expression and transformed growth of K-ras dependent lung cancer cells.

Oncotarget 2016 Apr;7(14):17905-19

The Department of Craniofacial Biology, School of Dental Medicine, Aurora, CO, USA.

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April 2016

A pilot study of cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma.

Oral Oncol 2016 Feb 15;53:74-9. Epub 2015 Dec 15.

Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, United States; Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology. Electronic address:

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February 2016

Expanding the computational toolbox for interrogating cancer kinomes.

Pharmacogenomics 2016 15;17(2):95-7. Epub 2015 Dec 15.

Protein Networks Team, Division of Cancer Biology, The Institute of Cancer Research, London, SW3 6JB, UK.

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September 2016

Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC.

Cancer Res 2015 Oct 10;75(20):4398-406. Epub 2015 Sep 10.

Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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October 2015

Identifying kinase dependency in cancer cells by integrating high-throughput drug screening and kinase inhibition data.

Bioinformatics 2015 Dec 23;31(23):3799-806. Epub 2015 Jul 23.

Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, Department of Medicine, Department of Computer Science and Engineering, Korea University, Seoul, Korea and Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

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December 2015

iCOSSY: An Online Tool for Context-Specific Subnetwork Discovery from Gene Expression Data.

PLoS One 2015 6;10(7):e0131656. Epub 2015 Jul 6.

Department of Computer Science and Engineering, Korea University, Seoul, Korea; Interdisciplinary Graduate Program in Bioinformatics, Korea University, Seoul, Korea.

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April 2016

Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models.

Front Pharmacol 2015 16;6:120. Epub 2015 Jun 16.

Division of Medical Oncology, Department of Internal Medicine, University of Colorado Anschutz Medical Campus Aurora, CO, USA ; University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus Aurora, CO, USA.

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July 2015

Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins.

Cell Rep 2015 Jun 11;11(11):1727-36. Epub 2015 Jun 11.

Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309, USA. Electronic address:

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June 2015

FGFR1 Expression Levels Predict BGJ398 Sensitivity of FGFR1-Dependent Head and Neck Squamous Cell Cancers.

Clin Cancer Res 2015 Oct 26;21(19):4356-64. Epub 2015 May 26.

Section of Prostate Cancer Research, University Hospital of Bonn, Center for Integrated Oncology Cologne-Bonn, Bonn, Germany. Institute of Pathology, University Hospital of Bonn, Center for Integrated Oncology Cologne-Bonn, Bonn, Germany.

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October 2015

DSigDB: drug signatures database for gene set analysis.

Bioinformatics 2015 Sep 19;31(18):3069-71. Epub 2015 May 19.

Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA and Department of Computer Science and Engineering, Korea University, Seoul 136-713, South Korea Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA and Department of Computer Science and Engineering, Korea University, Seoul 136-713, South Korea.

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September 2015

An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases.

PLoS One 2015 6;10(5):e0123600. Epub 2015 May 6.

Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America; Veterans Affairs Eastern Colorado Healthcare System, Denver, Colorado, United States of America.

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February 2016

RIP1 negatively regulates basal autophagic flux through TFEB to control sensitivity to apoptosis.

EMBO Rep 2015 Jun 23;16(6):700-8. Epub 2015 Apr 23.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA University of Colorado Comprehensive Cancer Center, Aurora, CO, USA

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June 2015