Publications by authors named "Ai-Ling Lin"

48Publications

β-amyloid and tau drive early Alzheimer's disease decline while glucose hypometabolism drives late decline.

Commun Biol 2020 Jul 6;3(1):352. Epub 2020 Jul 6.

Sanders-Brown Center on Aging, University of Kentucky, 307 Sanders-Brown Building, 800 S. Limestone Street, Lexington, KY, 40506-0230, USA.

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http://dx.doi.org/10.1038/s42003-020-1079-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338410PMC
July 2020

APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease.

Neurobiol Dis 2020 06 12;139:104834. Epub 2020 Mar 12.

Magnetic Resonance Research Center, Yale University, New Haven, CT, United States of America; Quantitative Neuroscience with Magnetic Resonance Core Center, Yale University, New Haven, CT, United States of America; Department of Diagnostic Radiology, Yale University, New Haven, CT, United States of America; Department of Biomedical Engineering, Yale University, New Haven, CT, United States of America.

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http://dx.doi.org/10.1016/j.nbd.2020.104834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486698PMC
June 2020

Preventable Deaths in Multiple Trauma Patients: The Importance of Auditing and Continuous Quality Improvement.

World J Surg 2020 06;44(6):1835-1843

Department of Surgery, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.

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http://dx.doi.org/10.1007/s00268-020-05423-3DOI Listing
June 2020

Brain-Blood Partition Coefficient and Cerebral Blood Flow in Canines Using Calibrated Short TR Recovery (CaSTRR) Correction Method.

Front Neurosci 2019 5;13:1189. Epub 2019 Nov 5.

F. Joseph Halcomb III, Department of Biomedical Engineering, University of Kentucky, Lexington, KY, United States.

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http://dx.doi.org/10.3389/fnins.2019.01189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848028PMC
November 2019

mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging.

Aging Cell 2020 01 6;19(1):e13057. Epub 2019 Nov 6.

Department of Cellular and Integrative Physiology, Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, Texas.

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http://dx.doi.org/10.1111/acel.13057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974719PMC
January 2020

Chronic Intermittent Hypoxia Induces Robust Astrogliosis in an Alzheimer's Disease-Relevant Mouse Model.

Neuroscience 2019 02 7;398:55-63. Epub 2018 Dec 7.

Spinal Cord & Brain Injury Research Center, University of Kentucky, Lexington, KY, United States; Department of Neuroscience, University of Kentucky, Lexington, KY, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2018.11.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402802PMC
February 2019

A Mild Traumatic Brain Injury in Mice Produces Lasting Deficits in Brain Metabolism.

J Neurotrauma 2018 10 2;35(20):2435-2447. Epub 2018 Jul 2.

1 Spinal Cord & Brain Injury Research Center, University of Kentucky , Lexington Kentucky.

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http://dx.doi.org/10.1089/neu.2018.5663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196750PMC
October 2018

Neuroimaging Biomarkers of Caloric Restriction on Brain Metabolic and Vascular Functions.

Curr Nutr Rep 2017 Mar;6(1):41-48

Sanders-Brown Center on Aging, University of Kentucky, 800 South Limestone Street, Lexington, KY, USA 40536.

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http://dx.doi.org/10.1007/s13668-017-0187-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619257PMC
March 2017

mTOR drives cerebral blood flow and memory deficits in LDLR mice modeling atherosclerosis and vascular cognitive impairment.

J Cereb Blood Flow Metab 2018 01 17;38(1):58-74. Epub 2017 May 17.

1 Department of Cellular and Integrative Physiology and The Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, TX, USA.

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http://dx.doi.org/10.1177/0271678X17705973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757441PMC
January 2018

Targeting mitochondrial dysfunction in CNS injury using Methylene Blue; still a magic bullet?

Neurochem Int 2017 Oct 7;109:117-125. Epub 2017 Apr 7.

Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY, USA; Department of Neuroscience, University of Kentucky, Lexington, KY, USA; Research Physiologist, Lexington VAMC, Lexington, KY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuint.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632129PMC
October 2017

mTOR: Alzheimer's disease prevention for APOE4 carriers.

Oncotarget 2016 07;7(29):44873-44874

Sanders-Brown Center on Aging, Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.

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http://dx.doi.org/10.18632/oncotarget.10349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216689PMC
July 2016

Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer's disease.

J Cereb Blood Flow Metab 2017 01 31;37(1):217-226. Epub 2015 Dec 31.

Geriatric Medicine, University of Oklahoma Health Science Center and Oklahoma City VA Medical Center, Oklahoma City, OK, USA.

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http://dx.doi.org/10.1177/0271678X15621575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167110PMC
January 2017

Early Shifts of Brain Metabolism by Caloric Restriction Preserve White Matter Integrity and Long-Term Memory in Aging Mice.

Front Aging Neurosci 2015 13;7:213. Epub 2015 Nov 13.

Sanders-Brown Center on Aging, University of Kentucky , Lexington, KY , USA ; Department of Pharmacology and Nutritional Sciences, University of Kentucky , Lexington, KY , USA ; Department of Biomedical Engineering, University of Kentucky , Lexington, KY , USA.

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http://dx.doi.org/10.3389/fnagi.2015.00213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643125PMC
November 2015

Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain.

Neurobiol Aging 2015 Jul 25;36(7):2296-2303. Epub 2015 Mar 25.

Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457572PMC
July 2015

Resting-state regional cerebral blood flow during adolescence: associations with initiation of substance use and prediction of future use disorders.

Drug Alcohol Depend 2015 Apr 20;149:40-8. Epub 2015 Jan 20.

Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; Departments of Epidemiology & Biostatistics, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.

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http://dx.doi.org/10.1016/j.drugalcdep.2015.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361292PMC
April 2015

How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story.

Exp Gerontol 2015 Aug 3;68:51-8. Epub 2014 Dec 3.

Banner Sun Health Research Institute, Sun City, AZ 85351, USA; Department of Basic Medical Sciences, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA.

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http://dx.doi.org/10.1016/j.exger.2014.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417920PMC
August 2015

What have novel imaging techniques revealed about metabolism in the aging brain?

Future Neurol 2014 May;9(3):341-354

Magnetic Resonance Research Center, Diagnostic Radiology & Biomedical Engineering, Yale University, New Haven, CT, USA.

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http://dx.doi.org/10.2217/fnl.14.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159180PMC
May 2014

Hypermetabolic state in the 7-month-old triple transgenic mouse model of Alzheimer's disease and the effect of lipoic acid: a 13C-NMR study.

J Cereb Blood Flow Metab 2014 Nov 6;34(11):1749-60. Epub 2014 Aug 6.

Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/jcbfm.2014.137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269751PMC
November 2014

Caloric restriction impedes age-related decline of mitochondrial function and neuronal activity.

J Cereb Blood Flow Metab 2014 Sep 2;34(9):1440-3. Epub 2014 Jul 2.

1] Magnetic Resonance Research Center, Yale University, New Haven, Connecticut, USA [2] Quantitative Neuroscience with Magnetic Resonance Core Center, Yale University, New Haven, Connecticut, USA [3] Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, USA [4] Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/jcbfm.2014.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158670PMC
September 2014

Complex IV-deficient Surf1(-/-) mice initiate mitochondrial stress responses.

Biochem J 2014 Sep;462(2):359-71

*Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78245, U.S.A.

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http://dx.doi.org/10.1042/BJ20140291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145821PMC
September 2014

Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice.

J Cereb Blood Flow Metab 2013 Oct 10;33(10):1605-11. Epub 2013 Jul 10.

1] Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA [2] Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA [3] Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.

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http://dx.doi.org/10.1038/jcbfm.2013.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790931PMC
October 2013

Methylene blue as a cerebral metabolic and hemodynamic enhancer.

PLoS One 2012 9;7(10):e46585. Epub 2012 Oct 9.

Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046585PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467226PMC
June 2013

Blood longitudinal (T1) and transverse (T2) relaxation time constants at 11.7 Tesla.

MAGMA 2012 Jun 10;25(3):245-9. Epub 2011 Nov 10.

Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

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http://dx.doi.org/10.1007/s10334-011-0287-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752414PMC
June 2012

Multimodal MRI neuroimaging biomarkers for cognitive normal adults, amnestic mild cognitive impairment, and Alzheimer's disease.

Neurol Res Int 2012 21;2012:907409. Epub 2011 Sep 21.

Research Imaging Institute, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.

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http://dx.doi.org/10.1155/2012/907409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178148PMC
November 2011

Validation of VASO cerebral blood volume measurement with positron emission tomography.

Magn Reson Med 2011 Mar 2;65(3):744-9. Epub 2010 Dec 2.

Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1002/mrm.22667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059074PMC
March 2011

Functional neuroimaging: a physiological perspective.

Front Neuroenergetics 2010 21;2. Epub 2010 Jul 21.

Research Imaging Institute, University of Texas Health Science Center San Antonio, TX, USA.

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http://dx.doi.org/10.3389/fnene.2010.00017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916670PMC
July 2011

Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex.

Proc Natl Acad Sci U S A 2010 May 19;107(18):8446-51. Epub 2010 Apr 19.

Department of Psychiatry, Research Imaging Institute, University of Texas Health Science Center at San Antonio, TX 78229, USA.

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http://dx.doi.org/10.1073/pnas.0909711107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889577PMC
May 2010

Functional evaluation of therapeutic response for a mouse model of medulloblastoma.

Transgenic Res 2010 Oct 27;19(5):829-40. Epub 2010 Jan 27.

Greehey Children's Cancer Research Institute, University of Texas Health Science Center, 8403 Floyd Curl Drive, MC7784, San Antonio, TX 78229-3900, USA.

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http://dx.doi.org/10.1007/s11248-010-9361-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770905PMC
October 2010

Time-dependent correlation of cerebral blood flow with oxygen metabolism in activated human visual cortex as measured by fMRI.

Neuroimage 2009 Jan 4;44(1):16-22. Epub 2008 Sep 4.

Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2008.08.029DOI Listing
January 2009

Evaluation of MRI models in the measurement of CMRO2 and its relationship with CBF.

Magn Reson Med 2008 Aug;60(2):380-9

Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas, USA.

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http://dx.doi.org/10.1002/mrm.21655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612533PMC
August 2008

[Effect of continuous renal replacement treatment on stress reaction in patients with severe trauma].

Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2004 Feb;16(2):106-8

Intensive Care Unit, Dongguan People's Hospital, Dongguan 523018, Guangdong, China.

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February 2004