Prof. Dr. Ahmed S Attia, Ph.D - Faculty of Pharmacy, Cairo University  - Professor

Prof. Dr. Ahmed S Attia

Ph.D

Faculty of Pharmacy, Cairo University

Professor

Cairo, Cairo | Egypt

Main Specialties: Infectious Disease, Medical Microbiology

Additional Specialties: Microbiology and Immunology

ORCID logohttps://orcid.org/0000-0003-0491-1007


Top Author

Prof. Dr. Ahmed S Attia, Ph.D - Faculty of Pharmacy, Cairo University  - Professor

Prof. Dr. Ahmed S Attia

Ph.D

Introduction

Pharmacy, Cairo University. He obtained his Ph.D. in molecular microbiology from the University of Texas Southwestern Medical, the USA working on the molecular aspects of the microbial resistance to the complement system. Working as a postdoctoral fellow at Vanderbilt University, USA, he identified new microbial therapeutic targets and novel host antimicrobial mechanisms using cutting-edge technologies.
Dr. Attia’s current research focuses on;
i) identifying novel microbial therapeutics targets.
ii) testing and validating new non-conventional antimicrobial agents from both natural and synthetic sources.
iii) development of new diagnostic kits, vaccines, and other biotechnological useful products.
iv) studying the relationship between microbial infections and therapeutic clinical outcomes in non-infectious diseases.
Dr. Attia’s work is highly recognized both on the national and international stage by being awarded many prestigious awards.

Primary Affiliation: Faculty of Pharmacy, Cairo University - Cairo, Cairo , Egypt

Specialties:

Additional Specialties:


View Prof. Dr. Ahmed S Attia’s Resume / CV

Education

May 2006
University of Texas, Southwestern Medical Center in Dallas, USA
Ph. D. in Molecular Microbiology
May 1997
Faculty of Pharmacy, Cairo University, Cairo, Egypt
B.Sc. in Pharmaceutical Sciences
Distinction with Honors

Experience

Jun 2017
Dr. Ikram Abdel Salam Award in Medical Genetics, Faculty of Medicine, Cairo University, Egypt
Winner
Dec 2016
Cairo University Scientific Excellence Award in Advanced Technological Sciences
Winner
Oct 2013
The Saving Lives at Birth Incubator Award
Winner
Jul 2013
Cairo University Encouraging Award in Advanced Technological Sciences, Egypt
Winner
Jun 2013
The State Encouraging Award in Advanced Technological Sciences Serving Medical Sciences, Egypt
Winner
Dec 2011
Misr El-Kheir (MEK) Publication Award
Winner
Jul 2010
Sidney P. Colowick Award for Outstanding Postdoctoral Fellow Vanderbilt University Nashville, TN, USA
Winner

Publications

33Publications

1372Reads

5Profile Views

315PubMed Central Citations

Tracing the dissemination of the international clones of multidrug-resistant Acinetobacter baumannii among cancer patients in Egypt using the PCR-based open reading frame typing (POT) method.

J Glob Antimicrob Resist 2019 12 2;19:210-215. Epub 2019 Aug 2.

Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt. Electronic address:

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http://dx.doi.org/10.1016/j.jgar.2019.07.025DOI Listing
December 2019
55 Reads

The role of α7nAChR in controlling the anti-inflammatory/anti-arthritic action of galantamine.

Biochem Pharmacol 2019 12 10;170:113665. Epub 2019 Oct 10.

Department of Pharmacology, Medical Research Institute, University of Alexandria, Egypt.

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http://dx.doi.org/10.1016/j.bcp.2019.113665DOI Listing
December 2019
5.009 Impact Factor

Comparative proteomics analyses of Acinetobacter baumannii strains ATCC 17978 and AB5075 reveal the differential role of type II secretion system secretomes in lung colonization and ciprofloxacin resistance.

Microb Pathog 2019 Mar 20;128:20-27. Epub 2018 Dec 20.

Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt. Electronic address:

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http://dx.doi.org/10.1016/j.micpath.2018.12.039DOI Listing
March 2019
31 Reads
2.000 Impact Factor

Acinetobacter: an emerging pathogen with a versatile secretome.

Emerg Microbes Infect 2018 Mar 21;7(1):33. Epub 2018 Mar 21.

Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.

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http://dx.doi.org/10.1038/s41426-018-0030-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861075PMC
March 2018
253 Reads

Isogenic mutations in the Moraxella catarrhalis CydDC system display pleiotropic phenotypes and reveal the role of a palindrome sequence in its transcriptional regulation.

Microbiol Res 2017 Sep 9;202:71-79. Epub 2017 Jun 9.

Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt. Electronic address:

Moraxella catarrhalis is becoming an important human respiratory tract pathogen affecting significant proportions from the population. However, still little is known about its physiology and molecular regulation. To this end, the CydDC, which is a heterodimeric ATP binding cassette transporter that has been shown to contribute to the maintenance of the redox homeostasis across the periplasm in other Gram-negative bacteria, is studied here. Amino acids multiple sequence alignments indicated that M. catarrhalis CydC is different from the CydC proteins of the bacterial species in which this system has been previously studied. These findings prompted further interest in studying this system in M. catarrhalis. Isogenic mutant in the CydDC system showed suppression in growth rate, hypersensitivity to oxidative and reductive stress and increased accumulation of intracellular cysteine levels. In addition, the growth of cydC mutant exhibited hypersensitivity to exogenous cysteine; however, it did not display a significant difference from its wild-type counterpart in the murine pulmonary clearance model. Moreover, a palindrome was detected 94bp upstream of the cydD ORF suggesting it might act as a potential regulatory element. Real-time reverse transcription-PCR analysis showed that deletion/change in the palindrome resulted into alterations in the transcription levels of cydC. A better understanding of such system and its regulation helps in developing better ways to combat M. catarrhalis infections.

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http://dx.doi.org/10.1016/j.micres.2017.06.002DOI Listing
September 2017
20 Reads
2.561 Impact Factor

Adaptation to Potassium-Limitation Is Essential for Acinetobacter baumannii Pneumonia Pathogenesis.

J Infect Dis 2016 Dec 5;214(12):2006-2013. Epub 2016 Oct 5.

Department of Microbiology and Immunology, Faculty of Pharmacy.

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http://dx.doi.org/10.1093/infdis/jiw476DOI Listing
December 2016
33 Reads
1 Citation
6.000 Impact Factor

The secretome of Acinetobacter baumannii ATCC 17978 type II secretion system reveals a novel plasmid encoded phospholipase that could be implicated in lung colonization.

Int J Med Microbiol 2016 Dec 1;306(8):633-641. Epub 2016 Oct 1.

Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt. Electronic address:

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http://dx.doi.org/10.1016/j.ijmm.2016.09.006DOI Listing
December 2016
16 Reads
5 Citations
3.614 Impact Factor

Development and validation of LC-MS/MS assay for the simultaneous determination of methotrexate, 6-mercaptopurine and its active metabolite 6-thioguanine in plasma of children with acute lymphoblastic leukemia: Correlation with genetic polymorphism.

J Chromatogr B Analyt Technol Biomed Life Sci 2016 Dec 28;1038:88-94. Epub 2016 Oct 28.

Department of Pediatrics, Hematology-Oncology Division, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.

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http://dx.doi.org/10.1016/j.jchromb.2016.10.035DOI Listing
December 2016
27 Reads
2 Citations
2.730 Impact Factor

Association Between Combined Presence of Hepatitis C Virus and Polymorphisms in Different Genes With Toxicities of Methotrexate and 6-Mercaptopurine in Children With Acute Lymphoblastic Leukemia.

Pediatr Blood Cancer 2016 09 10;63(9):1539-45. Epub 2016 May 10.

Department of Pediatrics, Hematology-Oncology Division, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.

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http://dx.doi.org/10.1002/pbc.26045DOI Listing
September 2016
61 Reads
1 Citation
2.562 Impact Factor

Immunoinformatics Identifies a Lactoferrin Binding Protein A Peptide as a Promising Vaccine With a Global Protective Prospective Against Moraxella catarrhalis.

J Infect Dis 2016 06 10;213(12):1938-45. Epub 2016 Feb 10.

Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Egypt.

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http://dx.doi.org/10.1093/infdis/jiw062DOI Listing
June 2016
56 Reads
2 Citations
6.000 Impact Factor

Mangiferin Mitigates Gastric Ulcer in Ischemia/ Reperfused Rats: Involvement of PPAR-γ, NF-κB and Nrf2/HO-1 Signaling Pathways.

PLoS One 2015 21;10(7):e0132497. Epub 2015 Jul 21.

Department of Pharmacology & Toxicology, Cairo University, Cairo, Egypt.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132497PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509761PMC
May 2016
16 Reads
12 Citations
3.234 Impact Factor

Antidiabetic Effect of Galantamine: Novel Effect for a Known Centrally Acting Drug.

PLoS One 2015 11;10(8):e0134648. Epub 2015 Aug 11.

Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134648PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532414PMC
May 2016
322 Reads
2 Citations
3.234 Impact Factor

Acinetobacter baumannii universal stress protein A plays a pivotal role in stress response and is essential for pneumonia and sepsis pathogenesis.

Int J Med Microbiol 2015 Jan 18;305(1):114-23. Epub 2014 Nov 18.

Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt. Electronic address:

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http://dx.doi.org/10.1016/j.ijmm.2014.11.008DOI Listing
January 2015
19 Reads
8 Citations
3.614 Impact Factor

A sensitive colorimetric assay for identification of Acinetobacter baumannii using unmodified gold nanoparticles.

J Appl Microbiol 2014 Aug 9;117(2):465-71. Epub 2014 Jun 9.

Department of Microbiology, Faculty of Pharmacy, Misr University for Science & Technology, Giza, Egypt.

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http://dx.doi.org/10.1111/jam.12546DOI Listing
August 2014
68 Reads
1 Citation
2.480 Impact Factor

Emergence of carbapenem-resistant Acinetobacter baumannii harboring the OXA-23 carbapenemase in intensive care units of Egyptian hospitals.

Int J Infect Dis 2013 Dec 11;17(12):e1252-4. Epub 2013 Sep 11.

Department of Microbiology, Faculty of Pharmacy, Misr University for Science and Technology, 6(th) of October City, Giza, Egypt.

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http://dx.doi.org/10.1016/j.ijid.2013.07.012DOI Listing
December 2013
36 Reads
12 Citations
2.330 Impact Factor

Menaquinone biosynthesis potentiates haem toxicity in Staphylococcus aureus.

Mol Microbiol 2012 Dec 24;86(6):1376-92. Epub 2012 Oct 24.

Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1111/mmi.12063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524387PMC
December 2012
11 Reads
27 Citations
4.420 Impact Factor

Monitoring the inflammatory response to infection through the integration of MALDI IMS and MRI.

Cell Host Microbe 2012 Jun;11(6):664-73

Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

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http://dx.doi.org/10.1016/j.chom.2012.04.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377982PMC
June 2012
8 Reads
15 Citations
12.330 Impact Factor

Expression and purification of hepatitis B surface antigen S from Escherichia coli; a new simple method.

BMC Res Notes 2012 Mar 1;5:125. Epub 2012 Mar 1.

Department of Microbiology & Immunology, Faculty of Pharmacy, Cairo University, Cairo, Egypt 11562.

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http://dx.doi.org/10.1186/1756-0500-5-125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392745PMC
March 2012
5 Reads
2 Citations

Staphylococcus aureus fur regulates the expression of virulence factors that contribute to the pathogenesis of pneumonia.

Infect Immun 2010 Apr 25;78(4):1618-28. Epub 2010 Jan 25.

Department of Microbiology and Immunology, Vanderbilt University Medical Center, 1161 21st Ave. South, Nashville, Tennessee 37232-2363, USA.

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http://dx.doi.org/10.1128/IAI.01423-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849423PMC
April 2010
27 Reads
62 Citations
3.731 Impact Factor

Membrane damage elicits an immunomodulatory program in Staphylococcus aureus.

PLoS Pathog 2010 Mar 12;6(3):e1000802. Epub 2010 Mar 12.

Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1000802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837406PMC
March 2010
19 Reads
21 Citations

Identification of a bacteriocin and its cognate immunity factor expressed by Moraxella catarrhalis.

BMC Microbiol 2009 Sep 25;9:207. Epub 2009 Sep 25.

Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1186/1471-2180-9-207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761928PMC
September 2009
13 Reads
5 Citations
2.730 Impact Factor

Moraxella catarrhalis binding to host cellular receptors is mediated by sequence-specific determinants not conserved among all UspA1 protein variants.

Infect Immun 2008 Nov 4;76(11):5322-9. Epub 2008 Aug 4.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1128/IAI.00572-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573313PMC
November 2008
19 Reads
19 Citations
3.731 Impact Factor

Modular arrangement of allelic variants explains the divergence in Moraxella catarrhalis UspA protein function.

Infect Immun 2008 Nov 4;76(11):5330-40. Epub 2008 Aug 4.

Department of Molecular Genetics, University of Toronto, Medical Sciences Building, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1128/IAI.00573-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573364PMC
November 2008
33 Reads
10 Citations
3.731 Impact Factor

Moraxella catarrhalis expresses an unusual Hfq protein.

Infect Immun 2008 Jun 24;76(6):2520-30. Epub 2008 Mar 24.

Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9048, USA.

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http://www3.utsouthwestern.edu/sbl/Assets/PDFs/Attia.InfectI
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http://iai.asm.org/content/76/6/2520.full.pdf
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http://iai.asm.org/cgi/doi/10.1128/IAI.01652-07
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http://dx.doi.org/10.1128/IAI.01652-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423088PMC
June 2008
79 Reads
17 Citations
3.731 Impact Factor

A UspA2H-negative variant of Moraxella catarrhalis strain O46E has a deletion in a homopolymeric nucleotide repeat common to uspA2H genes.

Infect Immun 2007 Apr 12;75(4):2035-45. Epub 2007 Jan 12.

Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1128/IAI.00609-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865690PMC
April 2007
11 Reads
5 Citations
3.731 Impact Factor

A conserved tetranucleotide repeat is necessary for wild-type expression of the Moraxella catarrhalis UspA2 protein.

J Bacteriol 2006 Nov 8;188(22):7840-52. Epub 2006 Sep 8.

Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9048, USA.

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http://jb.asm.org/content/188/22/7840.full.pdf
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http://jb.asm.org/cgi/doi/10.1128/JB.01204-06
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http://dx.doi.org/10.1128/JB.01204-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636323PMC
November 2006
13 Reads
12 Citations
2.810 Impact Factor

Binding of vitronectin by the Moraxella catarrhalis UspA2 protein interferes with late stages of the complement cascade.

Infect Immun 2006 Mar;74(3):1597-611

Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9048, USA.

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http://dx.doi.org/10.1128/IAI.74.3.1597-1611.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1418666PMC
March 2006
22 Reads
28 Citations
3.731 Impact Factor

Development of a shuttle vector for Moraxella catarrhalis.

Plasmid 2006 Jan 26;55(1):50-7. Epub 2005 Sep 26.

Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9048, USA.

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http://dx.doi.org/10.1016/j.plasmid.2005.07.004DOI Listing
January 2006
15 Reads
8 Citations
1.580 Impact Factor

The UspA2 protein of Moraxella catarrhalis is directly involved in the expression of serum resistance.

Infect Immun 2005 Apr;73(4):2400-10

Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9048, USA.

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http://dx.doi.org/10.1128/IAI.73.4.2400-2410.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087425PMC
April 2005
9 Reads
27 Citations
3.731 Impact Factor

Top co-authors

Eric J Hansen
Eric J Hansen

University of Texas Southwestern Medical Center

10
Noha M Elhosseiny
Noha M Elhosseiny

Cairo University

9
Wei Wang
Wei Wang

College of Life Science

5
Eric P Skaar
Eric P Skaar

Vanderbilt University Medical Center

5
Jennifer L Sedillo
Jennifer L Sedillo

University of Texas Southwestern Medical Center

4
Nirmeen A Sabry
Nirmeen A Sabry

Cairo University

3
Chad A Brautigam
Chad A Brautigam

The University of Texas Southwestern Medical Center

3
Devin L Stauff
Devin L Stauff

Vanderbilt University Medical Center

3
Victor J Torres
Victor J Torres

New York University School of Medicine

2