Publications by authors named "Ahmed Nokhala"

2 Publications

  • Page 1 of 1

Phytochemicals and biological activity of Linn. Merr. (Dilleniaceae): A short review.

J Pharm Bioallied Sci 2020 Jul-Sep;12(3):217-222. Epub 2020 Jul 18.

Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia (IIUM), Kuantan, Pahang, Malaysia.

is a southeast Asian shrub that belongs to family Dilleniaceae. Over the years, different parts of the plant have been used for the management of different diseases, including diabetes mellitus, hypertension, rheumatism, diarrhea, hepatitis, and inflammation. This variety of medical indications has attracted the attention of many researchers to this plant species, leading to the conduction of many research studies on different parts of the plant. These studies have confirmed some of the aforementioned activities of the plant, whereas other indications remain to be ascertained. This article is an attempt to summarize the studies conducted on and to explore the isolated phytochemicals.
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http://dx.doi.org/10.4103/jpbs.JPBS_192_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574740PMC
July 2020

Investigation of α-Glucosidase Inhibitory Metabolites from Leaves by GC-MS Metabolite Profiling and Docking Studies.

Biomolecules 2020 02 12;10(2). Epub 2020 Feb 12.

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.

Stone leaf () is a Southeast Asian medicinal plant that has been traditionally used for the management of diabetes mellitus. The underlying mechanisms of the antidiabetic activity have not been fully explored yet. Hence, this study aimed to evaluate the α-glucosidase inhibitory potential of the hydromethanolic extracts of leaves and to characterize the metabolites responsible for such activity through gas chromatography-mass spectrometry (GC-MS) metabolomics. Crude hydromethanolic extracts of different strengths were prepared and in vitro assayed for α-glucosidase inhibition. GC-MS analysis was further carried out and the mass spectral data were correlated to the corresponding α-glucosidase inhibitory IC values via an orthogonal partial least squares (OPLS) model. The 100%, 80%, 60% and 40% methanol extracts displayed potent α-glucosidase inhibitory potentials. Moreover, the established model identified 16 metabolites to be responsible for the α-glucosidase inhibitory activity of . The putative α-glucosidase inhibitory metabolites showed moderate to high affinities (binding energies of -5.9 to -9.8 kcal/mol) upon docking into the active site of isomaltase. To sum up, an OPLS model was developed as a rapid method to characterize the α-glucosidase inhibitory metabolites existing in the hydromethanolic extracts of leaves based on GC-MS metabolite profiling.
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http://dx.doi.org/10.3390/biom10020287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072363PMC
February 2020