Ahmed M Gouda

Design, synthesis, and biological evaluation of new series of pyrrol-2(3H)-one and pyridazin-3(2H)-one derivatives as tubulin polymerization inhibitors.

Authors:

Mahmoud S Abdelbaset Mostafa H Abdelrahman Syed Nasir Abbas Bukhari Ahmed M Gouda Bahaa G M Youssif Mohamed Abdel-Aziz Gamal El-Din A Abuo-Rahma

Bioorg Chem 2021 Feb 1;107:104522. Epub 2020 Dec 1.

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, New Minia, Minia, Egypt. Electronic address:

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February 2021

Design and synthesis of novel quinoline/chalcone/1,2,4-triazole hybrids as potent antiproliferative agent targeting EGFR and BRAF kinases.

Authors:

Aliaa M Mohassab Heba A Hassan Dalia Abdelhamid Ahmed M Gouda Bahaa G M Youssif Hiroshi Tateishi Mikako Fujita Masami Otsuka Mohamed Abdel-Aziz

Bioorg Chem 2021 Jan 24;106:104510. Epub 2020 Nov 24.

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt. Electronic address:

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January 2021

Docking studies of sesquiterpene lactones isolated from L. reveals their potential anti-inflammatory and cytotoxic activities.

Authors:

Amira Mohamed Marwa H A Hassan Ahmed M Gouda Sameh AbouZid Dalia El Amir

Nat Prod Res 2020 Nov 19:1-6. Epub 2020 Nov 19.

Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni Suef, Egypt.

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November 2020

Pharmacophore-based virtual screening, synthesis, biological evaluation, and molecular docking study of novel pyrrolizines bearing urea/thiourea moieties with potential cytotoxicity and CDK inhibitory activities.

Authors:

Ahmed M Shawky Nashwa A Ibrahim Mohammed A S Abourehab Ashraf N Abdalla Ahmed M Gouda

J Enzyme Inhib Med Chem 2021 Dec;36(1):15-33

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.

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December 2021

Novel 1,2,4-triazole derivatives as apoptotic inducers targeting p53: Synthesis and antiproliferative activity.

Authors:

Hesham A M Gomaa Hany A M El-Sherief Shaimaa Hussein Ahmed M Gouda Ola I A Salem Khalid Saad Alharbi Alaa M Hayallah Bahaa G M Youssif

Bioorg Chem 2020 12 12;105:104369. Epub 2020 Oct 12.

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Electronic address:

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December 2020

Design and synthesis of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as antiproliferative EGFR and BRAF dual inhibitors.

Authors:

Lamya H Al-Wahaibi Ahmed M Gouda Ola F Abou-Ghadir Ola I A Salem Asmaa T Ali Hatem S Farghaly Mostafa H Abdelrahman Laurent Trembleau Hajjaj H M Abdu-Allah Bahaa G M Youssif

Bioorg Chem 2020 11 3;104:104260. Epub 2020 Sep 3.

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Electronic address:

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November 2020

Design and synthesis of new 1,6-dihydropyrimidin-2-thio derivatives targeting VEGFR-2: Molecular docking and antiproliferative evaluation.

Authors:

Adel A Marzouk Salah A Abdel-Aziz Kamal S Abdelrahman Amira S Wanas Ahmed M Gouda Bahaa G M Youssif Mohamed Abdel-Aziz

Bioorg Chem 2020 09 10;102:104090. Epub 2020 Jul 10.

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt. Electronic address:

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September 2020

Design, synthesis and antitrypanosomal activity of heteroaryl-based 1,2,4-triazole and 1,3,4-oxadiazole derivatives.

Authors:

Montaser Sh Shaykoon Adel A Marzouk Osama M Soltan Amira S Wanas Mohamed M Radwan Ahmed M Gouda Bahaa G M Youssif Mohamed Abdel-Aziz

Bioorg Chem 2020 07 15;100:103933. Epub 2020 May 15.

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt. Electronic address:

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July 2020

Synergistic Anti Leukemia Effect of a Novel Hsp90 and a Pan Cyclin Dependent Kinase Inhibitors.

Authors:

Ashraf N Abdalla Mohamed E Abdallah Akhmed Aslam Ammar Bader Antonio Vassallo Nunziatina De Tommasi Waleed H Malki Ahmed M Gouda Mohammed H Mukhtar Mahmoud Zaki El-Readi Hamad M Alkahtani Alaa A-M Abdel-Aziz Adel S El-Azab

Molecules 2020 May 8;25(9). Epub 2020 May 8.

College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.

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May 2020

Design, synthesis and biological evaluation of novel 5-((substituted quinolin-3-yl/1-naphthyl) methylene)-3-substituted imidazolidin-2,4-dione as HIV-1 fusion inhibitors.

Authors:

Tarek S Ibrahim Riham M Bokhtia Amany M M Al-Mahmoudy Ehab S Taher Mohammed A AlAwadh Mohamed Elagawany Eatedal H Abdel-Aal Siva Panda Ahmed M Gouda Hany Z Asfour Nabil A Alhakamy Bahaa G M Youssif

Bioorg Chem 2020 06 24;99:103782. Epub 2020 Mar 24.

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Electronic address:

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June 2020

Ethyl benzoate bearing pyrrolizine/indolizine moieties: Design, synthesis and biological evaluation of anti-inflammatory and cytotoxic activities.

Authors:

Khalid M Attalah Ashraf N Abdalla Akhmed Aslam Muhammad Ahmed Mohammed A S Abourehab Naser A ElSawy Ahmed M Gouda

Bioorg Chem 2020 01 24;94:103371. Epub 2019 Oct 24.

Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt. Electronic address:

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January 2020

Optimization of pyrrolizine-based Schiff bases with 4-thiazolidinone motif: Design, synthesis and investigation of cytotoxicity and anti-inflammatory potency.

Authors:

Ahmed M Shawky Mohammed A S Abourehab Ashraf N Abdalla Ahmed M Gouda

Eur J Med Chem 2020 Jan 13;185:111780. Epub 2019 Oct 13.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah, 21955, Saudi Arabia; Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt. Electronic address:

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January 2020

Arylpropionic acid-derived NSAIDs: New insights on derivatization, anticancer activity and potential mechanism of action.

Authors:

Ahmed M Gouda Eman A Beshr Faisal A Almalki Hadeel H Halawah Batool Fawzi Taj Athir Faiz Alnafaei Rahaf Sulaiman Alharazi Weam Mahmood Kazi Malak M AlMatrafi

Bioorg Chem 2019 11 27;92:103224. Epub 2019 Aug 27.

B-Pharmacy Program, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.

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November 2019

Pyrrolizine-5-carboxamides: Exploring the impact of various substituents on anti-inflammatory and anticancer activities.

Authors:

Ahmed M Gouda Ahmed H Abdelazeem Ashraf N Abdalla Muhammad Ahmed

Acta Pharm 2018 Sep;68(3):251-273

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.

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September 2018

Structural-based design, synthesis, and antitumor activity of novel alloxazine analogues with potential selective kinase inhibition.

Authors:

Waleed H Malki Ahmed M Gouda Hamdy E A Ali Rabaa Al-Rousan Doaa Samaha Ashraf N Abdalla Juan Bustamante Zakaria Y Abd Elmageed Hamed I Ali

Eur J Med Chem 2018 May 17;152:31-52. Epub 2018 Apr 17.

Rangel College of Pharmacy, Health Science Center, Texas A&M University, Kingsville, TX 78363, United States; Department of Pharmaceutical Chemistry, College of Pharmacy, Helwan University, Cairo 11795, Egypt. Electronic address:

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May 2018

Antitumor activity of pyrrolizines and their Cu(II) complexes: Design, synthesis and cytotoxic screening with potential apoptosis-inducing activity.

Authors:

Ahmed M Gouda Hoda A El-Ghamry Tahani M Bawazeer Thoraya A Farghaly Ashraf N Abdalla Akhmed Aslam

Eur J Med Chem 2018 Feb 6;145:350-359. Epub 2018 Jan 6.

Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia.

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February 2018

Pyrrolizines: Design, synthesis, anticancer evaluation and investigation of the potential mechanism of action.

Authors:

Ahmed M Gouda Ahmed H Abdelazeem Hany A Omar Ashraf N Abdalla Mohammed A S Abourehab Hamed I Ali

Bioorg Med Chem 2017 10 24;25(20):5637-5651. Epub 2017 Aug 24.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Cairo, Egypt; Rangel College of Pharmacy, Health Science Center, Texas A&M University, Kingsville, TX 78363, United States. Electronic address:

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October 2017

An integrated overview on pyrrolizines as potential anti-inflammatory, analgesic and antipyretic agents.

Authors:

Ahmed M Gouda Ahmed H Abdelazeem

Eur J Med Chem 2016 May 1;114:257-92. Epub 2016 Feb 1.

Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt; Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif 21974, Saudi Arabia.

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May 2016