Ahmed Lazrak, PhD - University of Alabama at Birmingham

Ahmed Lazrak

PhD

University of Alabama at Birmingham

United States

Main Specialties: Biology

Additional Specialties: Biophysics

Ahmed Lazrak, PhD - University of Alabama at Birmingham

Ahmed Lazrak

PhD

Introduction

Primary Affiliation: University of Alabama at Birmingham - United States

Specialties:

Additional Specialties:

Research Interests:

Metrics

Number of Publications

28

Publications

Number of Profile Views

110

Profile Views

Number of Article Reads

99

Reads

Number of Citations

573

Citations

Top co-authors

Sadis Matalon
Sadis Matalon

University of Alabama at Birmingham

24
James F Collawn
James F Collawn

University of Alabama at Birmingham

5
Zsuzsanna Bebok
Zsuzsanna Bebok

University of Alabama at Birmingham

5
Bradford A Woodworth
Bradford A Woodworth

Medical University of South Carolina

4
Vedrana Bali
Vedrana Bali

University Hospital Zagreb

4
Gang Liu
Gang Liu

Peking Union Medical College Hospital

4
Lan Chen
Lan Chen

Indiana University School of Medicine

4
Weifeng Song
Weifeng Song

University of Alabama at Birmingham

4
Asta Jurkuvenaite
Asta Jurkuvenaite

University of Alabama at Birmingham

4
Zhihong Yu
Zhihong Yu

Nankai University

3

Publications

28Publications

99Reads

573PubMed Central Citations

Influenza-mediated reduction of lung epithelial ion channel activity leads to dysregulated pulmonary fluid homeostasis.

JCI Insight 2018 Oct 18;3(20). Epub 2018 Oct 18.

Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine.

View Article
October 2018
2 Reads

Influenza virus infection alters ion channel function of airway and alveolar cells: mechanisms and physiological sequelae.

Am J Physiol Lung Cell Mol Physiol 2017 Nov 3;313(5):L845-L858. Epub 2017 Aug 3.

Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and

View Article
November 2017
15 Reads
4 Citations
4.080 Impact Factor

A novel role for primary cilia in airway remodeling.

Am J Physiol Lung Cell Mol Physiol 2017 08 4;313(2):L328-L338. Epub 2017 May 4.

Matrix Biology Group, Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina;

View Article
August 2017
21 Reads
1 Citation
4.080 Impact Factor

Mechanistic Approaches to Improve Correction of the Most Common Disease-Causing Mutation in Cystic Fibrosis.

PLoS One 2016 23;11(5):e0155882. Epub 2016 May 23.

Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.

View Article
July 2017
4 Reads
5 Citations
3.230 Impact Factor

A synonymous codon change alters the drug sensitivity of ΔF508 cystic fibrosis transmembrane conductance regulator.

FASEB J 2016 Jan 3;30(1):201-13. Epub 2015 Sep 3.

*Department of Cell, Developmental, and Integrative Biology, Department of Anesthesiology and Perioperative Medicine, The Lung Injury and Repair Research Center, and The Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA

View Article
January 2016
3 Reads
5 Citations
5.040 Impact Factor

Influenza virus M2 targets cystic fibrosis transmembrane conductance regulator for lysosomal degradation during viral infection.

FASEB J 2015 Jul 20;29(7):2712-25. Epub 2015 Mar 20.

*Department of Anesthesiology, Pulmonary Injury and Repair Center, and Department of Cell, Developmental and Integrative Biology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA; Southern Research Institute, Birmingham, Alabama, USA; and Department of Surgery, Division of Otolaryngology, School of Medicine, University of Alabama, Birmingham, Alabama, USA

View Article
July 2015
4 Reads
10 Citations
5.040 Impact Factor

Chlorine inhalation-induced myocardial depression and failure.

Physiol Rep 2015 Jun;3(6)

Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, Alabama

View Article
June 2015
10 Citations

Hyaluronan mediates airway hyperresponsiveness in oxidative lung injury.

Am J Physiol Lung Cell Mol Physiol 2015 May 6;308(9):L891-903. Epub 2015 Mar 6.

Department of Anesthesiology and Pulmonary Injury and Repair Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama;

View Article
May 2015
2 Reads
19 Citations
4.080 Impact Factor

Sinupret activates CFTR and TMEM16A-dependent transepithelial chloride transport and improves indicators of mucociliary clearance.

PLoS One 2014 12;9(8):e104090. Epub 2014 Aug 12.

Departments of Surgery/Division of Otolaryngology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.

View Article
April 2015
9 Reads
14 Citations
3.230 Impact Factor

The silent codon change I507-ATC->ATT contributes to the severity of the ΔF508 CFTR channel dysfunction.

FASEB J 2013 Nov 1;27(11):4630-45. Epub 2013 Aug 1.

2Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, 1918 University Blvd., MCLM 350A, Birmingham, AL 35294, USA.

View Article
November 2013
2 Reads
22 Citations
5.040 Impact Factor

Influenza matrix protein 2 alters CFTR expression and function through its ion channel activity.

Am J Physiol Lung Cell Mol Physiol 2013 May 1;304(9):L582-92. Epub 2013 Mar 1.

Department of Anesthesiology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USA.

View Article
May 2013
1 Read
14 Citations
4.080 Impact Factor

The CFTR and ENaC debate: how important is ENaC in CF lung disease?

Am J Physiol Lung Cell Mol Physiol 2012 Jun 6;302(11):L1141-6. Epub 2012 Apr 6.

Department of Cell, Developmental and Integrative Biology, School of Medicine, University of Alabama at Birmingham, 35294-0005, USA.

View Article
June 2012
4 Reads
24 Citations
4.080 Impact Factor

Regulation of alveolar epithelial Na+ channels by ERK1/2 in chlorine-breathing mice.

Am J Respir Cell Mol Biol 2012 Mar 13;46(3):342-54. Epub 2011 Oct 13.

Department of Anesthesiology, School of Medicine, University of Alabama at Birmingham, BMR II 224, 901 19th St. South, Birmingham, AL 35205-3703, USA.

View Article
March 2012
23 Citations
3.980 Impact Factor

Enhancement of alveolar epithelial sodium channel activity with decreased cystic fibrosis transmembrane conductance regulator expression in mouse lung.

Am J Physiol Lung Cell Mol Physiol 2011 Oct 8;301(4):L557-67. Epub 2011 Jul 8.

Department of Anesthesiology, School of Medicine, University of Alabama at Birmingham, 35205-3703, USA.

View Article
October 2011
28 Citations
4.080 Impact Factor

Inhibition of lung fluid clearance and epithelial Na+ channels by chlorine, hypochlorous acid, and chloramines.

J Biol Chem 2010 Mar 27;285(13):9716-28. Epub 2010 Jan 27.

Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama 35205, USA.

View Article
March 2010
1 Read
26 Citations
4.570 Impact Factor

Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species.

FASEB J 2009 Nov 13;23(11):3829-42. Epub 2009 Jul 13.

Department of Anesthesiology, Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.

View Article
November 2009
34 Citations
5.040 Impact Factor

Alpha(1)-antitrypsin inhibits epithelial Na+ transport in vitro and in vivo.

Am J Respir Cell Mol Biol 2009 Sep 8;41(3):261-70. Epub 2009 Jan 8.

Department of Anesthesiology, University of Alabama at Birmingham, 224 BMR II, 901 South 19th Street, Birmingham, AL 35205-3703, USA.

View Article
September 2009
3 Reads
19 Citations
3.980 Impact Factor

Respiratory syncytial virus inhibits lung epithelial Na+ channels by up-regulating inducible nitric-oxide synthase.

J Biol Chem 2009 Mar 8;284(11):7294-306. Epub 2009 Jan 8.

Department of Anesthesiology, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.

View Article
March 2009
3 Reads
20 Citations
4.570 Impact Factor

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.

Proc Natl Acad Sci U S A 2006 Jan 20;103(5):1615-20. Epub 2006 Jan 20.

Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8856, USA.

View Article
January 2006
1 Read
71 Citations
9.810 Impact Factor

WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism.

J Biol Chem 2005 Oct 4;280(40):34218-23. Epub 2005 Aug 4.

Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041, USA.

View Article
October 2005
36 Citations
4.570 Impact Factor

WNK1 activates SGK1 to regulate the epithelial sodium channel.

Proc Natl Acad Sci U S A 2005 Jul 8;102(29):10315-20. Epub 2005 Jul 8.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA.

View Article
July 2005
1 Read
63 Citations
9.810 Impact Factor

Novel SIN-1 reactive intermediates modulate chloride secretion across murine airway cells.

Free Radic Biol Med 2003 Sep;35(6):662-75

Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294-2172, USA.

View Article
September 2003
4 Citations
5.740 Impact Factor

cAMP-induced changes of apical membrane potentials of confluent H441 monolayers.

Am J Physiol Lung Cell Mol Physiol 2003 Aug 18;285(2):L443-50. Epub 2003 Apr 18.

Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35205-3703, USA.

View Article
August 2003
33 Citations
4.080 Impact Factor

Invited review: biophysical properties of sodium channels in lung alveolar epithelial cells.

J Appl Physiol (1985) 2002 Nov;93(5):1852-9

Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

View Article
November 2002
43 Citations

cAMP regulation of Cl(-) and HCO(-)(3) secretion across rat fetal distal lung epithelial cells.

Am J Physiol Lung Cell Mol Physiol 2002 Apr;282(4):L650-8

Department of Anesthesiology, University of Alabama at Birmingham, 619 19th Street S., Birmingham, AL 35233, USA.

View Article
April 2002
1 Read
8 Citations
4.080 Impact Factor

Top co-authors

Sadis Matalon
Sadis Matalon

University of Alabama at Birmingham

24
James F Collawn
James F Collawn

University of Alabama at Birmingham

5
Zsuzsanna Bebok
Zsuzsanna Bebok

University of Alabama at Birmingham

5
Bradford A Woodworth
Bradford A Woodworth

Medical University of South Carolina

4
Vedrana Bali
Vedrana Bali

University Hospital Zagreb

4
Gang Liu
Gang Liu

Peking Union Medical College Hospital

4
Lan Chen
Lan Chen

Indiana University School of Medicine

4
Weifeng Song
Weifeng Song

University of Alabama at Birmingham

4
Asta Jurkuvenaite
Asta Jurkuvenaite

University of Alabama at Birmingham

4
Zhihong Yu
Zhihong Yu

Nankai University

3