Publications by authors named "Ahmed F Darweesh"

2 Publications

  • Page 1 of 1

An efficient synthesis of the guaiane sesquiterpene (-)-isoguaiene by domino metathesis.

Beilstein J Org Chem 2019 9;15:858-862. Epub 2019 Apr 9.

Fakult├Ąt Chemie und Lebensmittelchemie, Organische Chemie I, Technische Universit├Ąt Dresden, Bergstrasse 66, 01069 Dresden, Germany.

(-)-Isoguaiene was prepared from ()-citronellal in only 9-10 steps with good overall yields. Either a trienyne or a dienediyne metathesis and highly diastereoselective organocatalytic Michael additions of aldehydes derived from ()-citronellal served as the key transformations.
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http://dx.doi.org/10.3762/bjoc.15.83DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466796PMC
April 2019

Molecular docking simulation and anticancer assessment on human breast carcinoma cell line using novel bis(1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile) and bis(1,4-dihydropyrazolo[4',3':5,6]pyrano[2,3-b]pyridine-6-carbonitrile) derivatives.

Bioorg Chem 2017 04 21;71:19-29. Epub 2017 Jan 21.

Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt. Electronic address:

An efficient route for the synthesis of novel bis(1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile) derivatives is reported. The synthetic pathway involves one pot, synthesis of bis-aldehydes, malononitrile, and pyrazolone in the presence of pyridine. The anticancer activity of the synthesized products against MCF7, HEPG2, and A549 cell lines was assessed. Docking studies were performed and indicated the best binding mode compared to the standard ligand sorafenib.
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http://dx.doi.org/10.1016/j.bioorg.2017.01.009DOI Listing
April 2017
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