Aharon G Freud

Aharon G Freud

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Aharon G Freud

Aharon G Freud

Publications by authors named "Aharon G Freud"

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MicroRNA regulation of natural killer cell development and function in leukemia.

Mol Immunol 2019 11 9;115:12-20. Epub 2018 Aug 9.

Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States; Comprehensive Cancer Center and The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, Ohio, United States. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2018.07.022DOI Listing
November 2019

True Detective: Unraveling Group 1 Innate Lymphocyte Heterogeneity.

Trends Immunol 2019 Oct 6;40(10):909-921. Epub 2019 Sep 6.

Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 900953, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.it.2019.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823149PMC
October 2019

Cellular pathways in the development of human and murine innate lymphoid cells.

Curr Opin Immunol 2019 02 19;56:100-106. Epub 2018 Dec 19.

Department of Hematology, City of Hope National Medical Center, Los Angeles, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2018.11.003DOI Listing
February 2019

SMAD4 promotes TGF-β-independent NK cell homeostasis and maturation and antitumor immunity.

J Clin Invest 2018 11 15;128(11):5123-5136. Epub 2018 Oct 15.

Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1172/JCI121227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205382PMC
November 2018

CD56 Expression Marks Human Group 2 Innate Lymphoid Cell Divergence from a Shared NK Cell and Group 3 Innate Lymphoid Cell Developmental Pathway.

Immunity 2018 09 4;49(3):464-476.e4. Epub 2018 Sep 4.

Department of Pathology, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210 USA; Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210 USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613183035
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http://dx.doi.org/10.1016/j.immuni.2018.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148384PMC
September 2018

Epigenetic and Posttranscriptional Regulation of CD16 Expression during Human NK Cell Development.

J Immunol 2018 01 11;200(2):565-572. Epub 2017 Dec 11.

The Ohio State University Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH 43210;

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http://dx.doi.org/10.4049/jimmunol.1701128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881939PMC
January 2018

The Broad Spectrum of Human Natural Killer Cell Diversity.

Immunity 2017 11;47(5):820-833

Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA; Comprehensive Cancer Center and The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728700PMC
November 2017

Validation of a Targeted RNA Sequencing Assay for Kinase Fusion Detection in Solid Tumors.

J Mol Diagn 2017 09 9;19(5):682-696. Epub 2017 Aug 9.

Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio; Department of Internal Medicine, Division of Medical Oncology, The Ohio State University, Columbus, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2017.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975628PMC
September 2017

Modeling Human Natural Killer Cell Development in the Era of Innate Lymphoid Cells.

Front Immunol 2017 27;8:360. Epub 2017 Mar 27.

Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH, USA; Division of Hematology and Oncology, Department of Internal Medicine, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.3389/fimmu.2017.00360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366880PMC
March 2017

Emerging insights on the pathogenesis and treatment of extranodal NK/T cell lymphomas (ENKTL).

Discov Med 2017 03;23(126):189-199

Division of Hematologic Malignancies and Hematopoietic Stem Cell Transplantation, Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585079PMC
March 2017

Increased Levels of Plasma Epstein Barr Virus DNA Identify a Poor-Risk Subset of Patients With Advanced Stage Cutaneous T-Cell Lymphoma.

Clin Lymphoma Myeloma Leuk 2016 08;16 Suppl:S181-S190.e4

The Comprehensive Cancer Center and The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH; Division of Hematology, The Ohio State University, Columbus, OH. Electronic address:

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http://dx.doi.org/10.1016/j.clml.2016.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999299PMC
August 2016

NKp80 Defines a Critical Step during Human Natural Killer Cell Development.

Cell Rep 2016 07 30;16(2):379-391. Epub 2016 Jun 30.

Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA; Comprehensive Cancer Center and The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/j.celrep.2016.05.095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970225PMC
July 2016

A Progenitor Cell Expressing Transcription Factor RORγt Generates All Human Innate Lymphoid Cell Subsets.

Immunity 2016 05 10;44(5):1140-50. Epub 2016 May 10.

Department of Pathology, The Ohio State University, Columbus, OH 43210, USA; Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893782PMC
May 2016

Myeloid Cell Nuclear Differentiation Antigen (MNDA) Expression Distinguishes Extramedullary Presentations of Myeloid Leukemia From Blastic Plasmacytoid Dendritic Cell Neoplasm.

Am J Surg Pathol 2016 Apr;40(4):502-9

*Department of Pathology, Stanford University, Stanford, CA †Department of Pathology, The Ohio State University, Columbus, OH ‡Department of Pathology, Oregon Health & Science University, Portland, OR.

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http://dx.doi.org/10.1097/PAS.0000000000000595DOI Listing
April 2016

Rapid Column-Free Enrichment of Mononuclear Cells from Solid Tissues.

Sci Rep 2015 Jul 30;5:12490. Epub 2015 Jul 30.

1] Division of Hematopathology, Department of Pathology, The Ohio State University, Columbus, Ohio 43210, USA [2] The Ohio State University Comprehensive Cancer Center, The James Cancer Hospital &Solove Research Center, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1038/srep12490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519776PMC
July 2015

Transcription factor Foxo1 is a negative regulator of natural killer cell maturation and function.

Immunity 2015 Mar 10;42(3):457-70. Epub 2015 Mar 10.

Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43210, USA; The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA; The James Cancer Hospital, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400836PMC
March 2015

The transcription Factor AHR prevents the differentiation of a stage 3 innate lymphoid cell subset to natural killer cells.

Cell Rep 2014 Jul 19;8(1):150-62. Epub 2014 Jun 19.

Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA; Integrated Biomedical Graduate Program, Medical Scientist Program, The Ohio State University, Columbus, OH 43210, USA; Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA; The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.05.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133146PMC
July 2014

Human natural killer cell development in secondary lymphoid tissues.

Semin Immunol 2014 Apr 21;26(2):132-7. Epub 2014 Mar 21.

Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA; Comprehensive Cancer Center and The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2014.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010312PMC
April 2014

Location and cellular stages of natural killer cell development.

Trends Immunol 2013 Dec 19;34(12):573-82. Epub 2013 Sep 19.

Division of Hematology, Department of Internal Medicine, College of Medicine, Ohio State University, Columbus, OH 43210, USA; Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA; James Cancer Hospital and Solove Research Institute, Ohio State University, Columbus, OH 43210, USA. Electronic address:

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http://dx.doi.org/10.1016/j.it.2013.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852183PMC
December 2013

Expression of the activating receptor, NKp46 (CD335), in human natural killer and T-cell neoplasia.

Am J Clin Pathol 2013 Dec;140(6):853-66

Dept of Pathology, The Ohio State University, 892 Biomedical Research Tower, 460 W 12th Ave, Columbus, OH 43210;

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http://dx.doi.org/10.1309/AJCPWGG69MCZOWMMDOI Listing
December 2013

Purification of human NK cell developmental intermediates from lymph nodes and tonsils.

Methods Mol Biol 2010 ;612:1-14

Department of Pathology, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1007/978-1-60761-362-6_1DOI Listing
February 2010

Human natural killer cell development.

Immunol Rev 2006 Dec;214:56-72

Medical Scientist Program, The Ohio State University, Columbus, OH 43210, USA.

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http://doi.wiley.com/10.1111/j.1600-065X.2006.00451.x
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http://dx.doi.org/10.1111/j.1600-065X.2006.00451.xDOI Listing
December 2006

A phase I study of ultra low dose interleukin-2 and stem cell factor in patients with HIV infection or HIV and cancer.

Clin Cancer Res 2006 Jul;12(13):3993-6

Division of Hematology/Oncology, Department of Internal Medicine, Ohio State University, Columbus, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-0268DOI Listing
July 2006

Evidence for discrete stages of human natural killer cell differentiation in vivo.

J Exp Med 2006 Apr 10;203(4):1033-43. Epub 2006 Apr 10.

Medical Scientist Program, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1084/jem.20052507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118285PMC
April 2006

IL-15 but not IL-2 rapidly induces lethal xenogeneic graft-versus-host disease.

Blood 2005 Oct 23;106(7):2433-5. Epub 2005 Jun 23.

Department of Molecular Virology, Immunology, and Medical Genetics, the Medical Scientist Program, the Integrated Biomedical Science Graduate Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.1182/blood-2005-04-1597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895258PMC
October 2005

A human CD34(+) subset resides in lymph nodes and differentiates into CD56bright natural killer cells.

Immunity 2005 Mar;22(3):295-304

Department of Molecular Virology, Immunology, and Medical Genetics, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1016/j.immuni.2005.01.013DOI Listing
March 2005

Failed adoptive immunotherapy with tumor-specific T cells: reversal with low-dose interleukin 15 but not low-dose interleukin 2.

Cancer Res 2004 Nov;64(21):8062-7

Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-1860DOI Listing
November 2004

Safety of interleukin-12 gene therapy against cancer: a murine biodistribution and toxicity study.

Hum Gene Ther 2003 Jul;14(11):1037-48

Department of Human Oncology, University of Wisconsin-Madison, Madison, WI 53792, USA.

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http://dx.doi.org/10.1089/104303403322124765DOI Listing
July 2003