Agnes Viale

Agnes Viale

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Agnes Viale

Agnes Viale

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Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer.

Cancer Cell 2018 01;33(1):125-136.e3

Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Departments of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765991PMC
January 2018

Plasma DNA-based molecular diagnosis, prognostication, and monitoring of patients with fusion-positive sarcomas.

JCO Precis Oncol 2017 23;2017. Epub 2017 May 23.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881916PMC
http://dx.doi.org/10.1200/PO.16.00028DOI Listing
May 2017

KRAS AND THE REALITY OF PERSONALIZED MEDICINE IN NON-SMALL CELL LUNG CANCER.

Mol Med 2016 Sep 7;22:380-387. Epub 2016 Jul 7.

Department of Biological Sciences, Eastern Mediterranean University, Famagusta, North Cyprus, via Mersin-10-Turkey.

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http://dx.doi.org/10.2119/molmed.2016.00151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072415PMC
September 2016

Evaluating Cancer of the Central Nervous System Through Next-Generation Sequencing of Cerebrospinal Fluid.

J Clin Oncol 2016 07 9;34(20):2404-15. Epub 2016 May 9.

Elena I. Pentsova, Ronak H. Shah, Jiabin Tang, Adrienne Boire, Daoqi You, Samuel Briggs, Antonio Omuro, Xuling Lin, Martin Fleisher, Christian Grommes, Katherine S. Panageas, Fanli Meng, S. Duygu Selcuklu, Shahiba Ogilvie, Natalie Distefano, Larisa Shagabayeva, Marc Rosenblum, Lisa M. DeAngelis, Agnes Viale, Ingo K. Mellinghoff, and Michael F. Berger, Memorial Sloan Kettering Cancer Center; Ingo K. Mellinghoff, Weill-Cornell Graduate School of Biomedical Sciences; and Michael F. Berger, Weill-Cornell Medical College, New York, NY.

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http://dx.doi.org/10.1200/JCO.2016.66.6487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981784PMC
July 2016

Massively Parallel Sequencing-Based Clonality Analysis of Synchronous Endometrioid Endometrial and Ovarian Carcinomas.

J Natl Cancer Inst 2016 Jun 1;108(6):djv427. Epub 2016 Feb 1.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY (AMS, CKYN, MRDF, SP, GSM, RAS, RSL, JSRF, BW); Department of Pathology, Hospital Universitario Arnau de Vilanova, University of Lleida, Lleida, Spain (SG, XMG); Department of Pathology, Hospital Universitario Ramón y Cajal, Madrid, Spain (BPM, JCP); Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY (AV, KHH); Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY (JSRF).

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http://jnci.oxfordjournals.org/content/108/6/djv427.full.pdf
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http://jnci.oxfordjournals.org/lookup/doi/10.1093/jnci/djv42
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http://dx.doi.org/10.1093/jnci/djv427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909128PMC
June 2016

Phase II Trial of Sorafenib in Patients with Chemotherapy Refractory Metastatic Esophageal and Gastroesophageal (GE) Junction Cancer.

PLoS One 2015 14;10(8):e0134731. Epub 2015 Aug 14.

Gastrointestinal Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134731PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537304PMC
May 2016

Somatic PIK3CA mutations as a driver of sporadic venous malformations.

Sci Transl Med 2016 Mar;8(332):332ra42

Human Oncology and Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaf1164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962922PMC
March 2016

Extreme Outlier Analysis Identifies Occult Mitogen-Activated Protein Kinase Pathway Mutations in Patients With Low-Grade Serous Ovarian Cancer.

J Clin Oncol 2015 Dec 31;33(34):4099-105. Epub 2015 Aug 31.

Rachel N. Grisham, Brooke E. Sylvester, Helen Won, Deborah DeLair, Zhan Yao, Ronglai Shen, Fanny Dao, Faina Bogomolniy, Vicky Makker, Evis Sala, Tara E. Soumerai, David M. Hyman, Douglas A. Levine, Neal Rosen, Michael F. Berger, David R. Spriggs, Carol A. Aghajanian, David B. Solit, and Gopa Iyer, Memorial Sloan Kettering Cancer Center; Rachel N. Grisham, Gregory McDermott, Vicky Makker, David M. Hyman, Neal Rosen, Michael F. Berger, David R. Spriggs, Carol A. Aghajanian, David B. Solit, and Gopa Iyer, Weill Cornell Medical College; Ricardo Ramirez, Graduate School of Medical Sciences; Nicholas D. Socci and Agnes Viale, Michael F. Berger, and David B. Solit, Marie-Josée and Henry R. Kravis Center for Molecular Oncology, New York, NY; David M. Gershenson, University of Texas MD Anderson Cancer Center, Houston, TX; and John Farley, St Joseph's Hospital and Medical Center, Phoenix, AZ.

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http://jco.ascopubs.org/content/33/34/4099.full.pdf
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2015.62.4726
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http://dx.doi.org/10.1200/JCO.2015.62.4726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669594PMC
December 2015

NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition.

Cancer Discov 2015 Nov 10;5(11):1178-93. Epub 2015 Sep 10.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Medicine, Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642441PMC
November 2015

Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations.

Cancer Res 2015 Sep 24;75(18):3713-9. Epub 2015 Jul 24.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573898PMC
September 2015

Remodeling of the methylation landscape in breast cancer metastasis.

PLoS One 2014 1;9(8):e103896. Epub 2014 Aug 1.

Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America; Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103896PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118917PMC
April 2015

Gene expression profiling of lobular carcinoma in situ reveals candidate precursor genes for invasion.

Mol Oncol 2015 Apr 24;9(4):772-82. Epub 2014 Dec 24.

Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 300 E. 66th St., New York, NY, 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2014.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387062PMC
April 2015

Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia.

Cancer Cell 2015 Apr;27(4):502-15

Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518555PMC
April 2015

Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile.

Nature 2015 Jan 22;517(7533):205-8. Epub 2014 Oct 22.

1] Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA [2] Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA [3] Immunology Program, Sloan-Kettering Institute, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature13828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354891PMC
January 2015

PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors.

Nat Genet 2014 Nov 21;46(11):1227-32. Epub 2014 Sep 21.

1] Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA. [2] Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. [3] Department of Medicine, Weill Cornell Medical College, New York, New York, USA.

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http://dx.doi.org/10.1038/ng.3095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249650PMC
November 2014

Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy.

Cancer Discov 2014 Sep 16;4(9):1014-21. Epub 2014 Jun 16.

Department of Medicine, University of California, San Francisco, California. Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California. Department of Epidemiology and Biostatistics, University of California, San Francisco, California.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155059PMC
September 2014

The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation.

Blood 2014 Aug 17;124(7):1174-82. Epub 2014 Jun 17.

Infectious Disease Service, Department of Medicine, and Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan-Kettering Cancer Center, New York, NY; Weill Cornell Medical College, New York, NY; Immunology Program, Sloan-Kettering Institute, New York, NY.

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http://dx.doi.org/10.1182/blood-2014-02-554725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133489PMC
August 2014

Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins.

Nat Genet 2014 Jun 4;46(6):588-94. Epub 2014 May 4.

1] Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. [2] Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. [3] Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1038/ng.2981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251771PMC
June 2014

Frequent disruption of the RB pathway in indolent follicular lymphoma suggests a new combination therapy.

J Exp Med 2014 Jun 9;211(7):1379-91. Epub 2014 Jun 9.

Cancer Biology & Genetics Program, Computational Biology Program, Department of Medicine, Human Oncology and Pathogenesis Program, Genomics Core Facility, Molecular Pharmacology Program, Department of Pathology, Department of Epidemiology and Biostatistics, and Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065

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http://dx.doi.org/10.1084/jem.20132120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076578PMC
June 2014

Efficacy of intermittent combined RAF and MEK inhibition in a patient with concurrent BRAF- and NRAS-mutant malignancies.

Cancer Discov 2014 May 3;4(5):538-45. Epub 2014 Mar 3.

1Human Oncology and Pathogenesis Program, 2Leukemia Service, 3Gastrointestinal Oncology Service, 4Melanoma and Immunotherapeutics Service, Department of Medicine, 5Molecular Diagnostics Service, Department of Pathology, 6Department of Radiology, 7Center for Molecular Oncology, 8Ludwig Center for Cancer Immunotherapy, and 9Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center; and 10Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-13-1038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850735PMC
May 2014

Tumor genetic analyses of patients with metastatic renal cell carcinoma and extended benefit from mTOR inhibitor therapy.

Clin Cancer Res 2014 Apr 12;20(7):1955-64. Epub 2014 Mar 12.

Authors' Affiliations: Departments of Medicine, Surgery, Pathology, Radiology, and Computational Biology; Human Oncology and Pathogenesis Program; Genomics Core Laboratory, Memorial Sloan-Kettering Cancer Center; and Department of Medicine, Weill Medical College of Cornell University, New York, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140619PMC
April 2014

Genome-wide analysis of the role of copy-number variation in pancreatic cancer risk.

Front Genet 2014 13;5:29. Epub 2014 Feb 13.

Department of Medicine, Memorial Sloan-Kettering Cancer Center New York, NY, USA ; Program in Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center New York, NY, USA.

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https://www.frontiersin.org/articles/10.3389/fgene.2014.0002
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http://journal.frontiersin.org/article/10.3389/fgene.2014.00
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http://dx.doi.org/10.3389/fgene.2014.00029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923159PMC
March 2014

A genome-wide high-resolution array-CGH analysis of cutaneous melanoma and comparison of array-CGH to FISH in diagnostic evaluation.

J Mol Diagn 2013 Sep 22;15(5):581-91. Epub 2013 Jun 22.

Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1016/j.jmoldx.2013.04.001DOI Listing
September 2013

RARγ is essential for retinoic acid induced chromatin remodeling and transcriptional activation in embryonic stem cells.

J Cell Sci 2013 Feb 21;126(Pt 4):999-1008. Epub 2012 Dec 21.

Department of Pharmacology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.119701
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http://dx.doi.org/10.1242/jcs.119701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625813PMC
February 2013

Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer.

Nat Med 2013 Jan 9;19(1):50-6. Epub 2012 Dec 9.

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1038/nm.3029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540187PMC
January 2013

Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice.

J Exp Med 2012 Jul 23;209(8):1445-56. Epub 2012 Jul 23.

Infectious Diseases Service, Department of Medicine, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1084/jem.20120504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409501PMC
July 2012

Including additional controls from public databases improves the power of a genome-wide association study.

Hum Hered 2011 17;72(1):21-34. Epub 2011 Aug 17.

Gerstner Sloan-Kettering Graduate School of Biomedical Sciences, Memorial Sloan-Kettering Cancer Center, New York, USA.

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http://dx.doi.org/10.1159/000330149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171281PMC
January 2012

Profound alterations of intestinal microbiota following a single dose of clindamycin results in sustained susceptibility to Clostridium difficile-induced colitis.

Infect Immun 2012 Jan 17;80(1):62-73. Epub 2011 Oct 17.

Infectious Diseases Service, Department of Medicine, Lucille Castori Center for Microbes, Inflammation and Cancer, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

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http://iai.asm.org/lookup/doi/10.1128/IAI.05496-11
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http://dx.doi.org/10.1128/IAI.05496-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255689PMC
January 2012

A microRNA survival signature (MiSS) for advanced ovarian cancer.

Gynecol Oncol 2011 Jun 26;121(3):444-50. Epub 2011 Feb 26.

Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.ygyno.2011.01.025DOI Listing
June 2011

Epigenomic reorganization of the clustered Hox genes in embryonic stem cells induced by retinoic acid.

J Biol Chem 2011 Feb 18;286(5):3250-60. Epub 2010 Nov 18.

Department of Pharmacology, Weill Cornell Medical College, New York, New York 10065, USA.

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http://dx.doi.org/10.1074/jbc.M110.157545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030330PMC
February 2011

DNA methylation of the first exon is tightly linked to transcriptional silencing.

PLoS One 2011 Jan 18;6(1):e14524. Epub 2011 Jan 18.

Laboratory of Molecular Hematopoiesis, Department of Medicine, Weill Cornell Medical College, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014524PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022582PMC
January 2011

Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor.

Proc Natl Acad Sci U S A 2010 Sep 7;107(39):16759-65. Epub 2010 Sep 7.

Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1073/pnas.1012443107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947883PMC
September 2010