Publications by authors named "Agapios Sachinidis"

100Publications

Enhanced hippocampal type II theta activity AND altered theta architecture in mice lacking the Ca3.2 T-type voltage-gated calcium channel.

Sci Rep 2021 Jan 13;11(1):1099. Epub 2021 Jan 13.

Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany.

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January 2021

ERG1 Plays an Essential Role in Rat Cardiomyocyte Fate Decision by Mediating AKT Signaling.

Stem Cells 2021 Jan 10. Epub 2021 Jan 10.

Key Laboratory of Arrhythmias, Ministry of Education of China, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.

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January 2021

Radiation Response of Murine Embryonic Stem Cells.

Cells 2020 07 9;9(7). Epub 2020 Jul 9.

Institute of Neurophysiology and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert-Koch-Str. 39, 50931 Cologne, Germany.

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July 2020

Cardiotoxicity and Heart Failure: Lessons from Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Anticancer Drugs.

Cells 2020 04 17;9(4). Epub 2020 Apr 17.

Faculty of Medicine, Institute of Neurophysiology, University of Cologne, Robert-Koch-Str. 39, 50931 Cologne, Germany.

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April 2020

Cyclooxygenases Inhibitors Efficiently Induce Cardiomyogenesis in Human Pluripotent Stem Cells.

Cells 2020 02 27;9(3). Epub 2020 Feb 27.

Institute of Neurophysiology, Faculty of Medicine, University of Cologne, Robert-Koch-Str. 39, 50931 Cologne, Germany.

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February 2020

GSK-3β inhibition protects the rat heart from the lipopolysaccharide-induced inflammation injury via suppressing FOXO3A activity.

J Cell Mol Med 2019 11 10;23(11):7796-7809. Epub 2019 Sep 10.

Key Laboratory of Arrhythmias, Ministry of Education, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

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November 2019

Road Map for Development of Stem Cell-Based Alternative Test Methods.

Trends Mol Med 2019 06 23;25(6):470-481. Epub 2019 May 23.

Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund (IfADo), 44139 Dortmund, Germany. Electronic address:

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June 2019

Transcriptional changes associated with advancing stages of heart failure underlie atrial and ventricular arrhythmogenesis.

PLoS One 2019 13;14(5):e0216928. Epub 2019 May 13.

Lankenau Institute for Medical Research, Wynnewood, Pennsylvania, United States of America.

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January 2020

Current Challenges of iPSC-Based Disease Modeling and Therapeutic Implications.

Cells 2019 04 30;8(5). Epub 2019 Apr 30.

Institute of Neurophysiology and Center for Molecular Medicine, University of Cologne, Robert-Koch Str. 39, 50931 Cologne, Germany.

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April 2019

Ca3.2 T-Type Calcium Channels Are Physiologically Mandatory for the Auditory System.

Neuroscience 2019 06 25;409:81-100. Epub 2019 Apr 25.

Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175 Bonn, Germany. Electronic address:

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June 2019

Parabolic, Flight-Induced, Acute Hypergravity and Microgravity Effects on the Beating Rate of Human Cardiomyocytes.

Cells 2019 04 14;8(4). Epub 2019 Apr 14.

Institute of Neurophysiology, Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.

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April 2019

Laminin promotes differentiation of rat embryonic stem cells into cardiomyocytes by activating the integrin/FAK/PI3K p85 pathway.

J Cell Mol Med 2019 05 25;23(5):3629-3640. Epub 2019 Mar 25.

Key Laboratory of Arrhythmias, Ministry of Education, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

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May 2019

Gender specific click and tone burst evoked ABR datasets from mice lacking the Ca3.2 T-type voltage-gated calcium channel.

BMC Res Notes 2019 Mar 20;12(1):157. Epub 2019 Mar 20.

Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany.

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March 2019

Cardiomyocytes facing fibrotic conditions re-express extracellular matrix transcripts.

Acta Biomater 2019 04 9;89:180-192. Epub 2019 Mar 9.

Institute of Neurophysiology, University of Cologne, Cologne, Germany; Department of Pediatric Cardiology, University Hospital Cologne, Cologne, Germany. Electronic address:

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April 2019

Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens.

Front Genet 2018 3;9:558. Epub 2018 Dec 3.

Division of Molecular and Computational Toxicology, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

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December 2018

yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs.

Cell Stem Cell 2019 02 13;24(2):318-327.e8. Epub 2018 Dec 13.

Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany; Institute for Neurophysiology, University of Cologne, 50931 Cologne, Germany; CECAD, Cologne Cluster of Excellence in Cellular Stress Responses in Ageing-Associated Diseases, University of Cologne, 50931 Cologne, Germany. Electronic address:

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February 2019

Gender specific click and tone burst evoked ABR datasets from mice lacking the Ca2.3 R-type voltage-gated calcium channel.

Data Brief 2018 Dec 24;21:1263-1266. Epub 2018 Oct 24.

Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175 Bonn, Germany.

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December 2018

Parallel Genome-wide Profiling of Coding and Non-coding RNAs to Identify Novel Regulatory Elements in Embryonic and Maturated Heart.

Mol Ther Nucleic Acids 2018 Sep 4;12:158-173. Epub 2018 May 4.

University of Cologne (UKK), Institute of Neurophysiology and Center for Molecular Medicine Cologne (CMMC), Robert-Koch-Str. 39, 50931 Cologne, Germany. Electronic address:

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September 2018

Distinct transcriptomic changes in E14.5 mouse skeletal muscle lacking RYR1 or Cav1.1 converge at E18.5.

PLoS One 2018 15;13(3):e0194428. Epub 2018 Mar 15.

Institute of Vegetative Physiology, Center of Physiology and Pathophysiology, University of Cologne, Cologne, Germany.

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July 2018

Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells.

Arch Toxicol 2018 Apr 3;92(4):1507-1524. Epub 2018 Feb 3.

Institute of Neurophysiology and Center for Molecular Medicine Cologne (CMMC), University of Cologne (UKK), Robert-Koch-Str. 39, 50931, Cologne, Germany.

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April 2018

Depletion of Mageb16 induces differentiation of pluripotent stem cells predominantly into mesodermal derivatives.

Sci Rep 2017 10 27;7(1):14285. Epub 2017 Oct 27.

University of Cologne (UKK), Institute of Neurophysiology and Center for Molecular Medicine Cologne (CMMC), Robert-Koch-Str. 39, 50931, Cologne, Germany.

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October 2017

Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes.

Arch Toxicol 2018 Jan 22;92(1):371-381. Epub 2017 Sep 22.

Institute of Neurophysiology and Center for Molecular Medicine Cologne (CMMC), University of Cologne (UKK), Robert-Koch-Str. 39, 50931, Cologne, Germany.

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January 2018

STRIP2 Is Indispensable for the Onset of Embryonic Stem Cell Differentiation.

Mol Ther Methods Clin Dev 2017 Jun 14;5:116-129. Epub 2017 Apr 14.

Institute of Neurophysiology and Center for Molecular Medicine Cologne (CMMC), University of Cologne (UKK), Robert-Koch-Strasse 39, 50931 Cologne, Germany.

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June 2017

Metabolite signatures of doxorubicin induced toxicity in human induced pluripotent stem cell-derived cardiomyocytes.

Amino Acids 2017 Dec 18;49(12):1955-1963. Epub 2017 Apr 18.

Institute of Neurophysiology and Center for Molecular Medicine Cologne (CMMC), University of Cologne (UKK), Robert-Koch-Str. 39, 50931, Cologne, Germany.

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December 2017

Impairment of human neural crest cell migration by prolonged exposure to interferon-beta.

Arch Toxicol 2017 Oct 1;91(10):3385-3402. Epub 2017 Apr 1.

Department of In Vitro Toxicology and Biomedicine, University of Konstanz, Box 657, 78457, Konstanz, Germany.

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October 2017

Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity.

Chem Res Toxicol 2017 04 21;30(4):905-922. Epub 2016 Dec 21.

In Vitro Toxicology and Biomedicine, Department inaugurated by the Doerenkamp-Zbinden Chair Foundation, University of Konstanz , 78457 Konstanz, Germany.

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April 2017

Human Embryonic and Induced Pluripotent Stem Cell Based Toxicity Testing Models: Future Applications in New Drug Discovery.

Curr Med Chem 2016 ;23(30):3495-3509

Institute of Neurophysiology and Centre for Molecular Medicine Cologne (CMMC), Robert-Koch-Str. 39, 50931 Cologne, Germany.

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February 2017

Highlight report: Cardiotoxicity screening.

EXCLI J 2016 22;15:163-5. Epub 2016 Feb 22.

Institute of Neurophysiology and Centre for Molecular Medicine Cologne (CMMC), Robert-Koch-Str. 39, 50931 Cologne, Germany.

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April 2016

The Potential Application of Biomaterials in Cardiac Stem Cell Therapy.

Curr Med Chem 2016 ;23(6):589-602

Institute for Neurophysiology and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert-Koch-Str. 39, 50931, Cologne, Germany.

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November 2016

MicroRNAs as early toxicity signatures of doxorubicin in human-induced pluripotent stem cell-derived cardiomyocytes.

Arch Toxicol 2016 Dec 3;90(12):3087-3098. Epub 2016 Feb 3.

Institute of Neurophysiology, Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931, Cologne, Germany.

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December 2016

Gene profiling of embryonic skeletal muscle lacking type I ryanodine receptor Ca(2+) release channel.

Sci Rep 2016 Feb 1;6:20050. Epub 2016 Feb 1.

Center of Physiology and Pathophysiology, Institute of Vegetative Physiology, Medical Faculty of the University of Cologne, Robert-Koch-Str. 39, Cologne 50931, Germany.

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February 2016

Functional and phenotypic differences of pure populations of stem cell-derived astrocytes and neuronal precursor cells.

Glia 2016 May 22;64(5):695-715. Epub 2015 Dec 22.

The Doerenkamp-Zbinden Chair of in-Vitro Toxicology and Biomedicine/Alternatives to Animal Experimentation, University of Konstanz, Konstanz, Germany.

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May 2016

Toxicogenomics-based prediction of acetaminophen-induced liver injury using human hepatic cell systems.

Toxicol Lett 2016 Jan 20;240(1):50-9. Epub 2015 Oct 20.

Department of In Vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

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January 2016

Transcriptomics of Hepatocytes Treated with Toxicants for Investigating Molecular Mechanisms Underlying Hepatotoxicity.

Methods Mol Biol 2015 ;1250:225-40

Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Robert-Koch-Str. 39, 50931, Cologne, Germany.

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May 2016

Stem cells and differentiation--a synoptic review of patents granted since 2009.

Expert Opin Ther Pat 2015 Jun 2;25(6):663-73. Epub 2015 Mar 2.

University of Cologne, Institute of Neurophysiology and Center for Molecular Medicine Cologne (CMMC), Center of Physiology and Pathophysiology , Robert-Koch-Str 39, 50931, Cologne , Germany +49 0 221 478 7373 ; +49 0 221 478 6965 ;

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June 2015

In vitro assessment of drug-induced liver steatosis based on human dermal stem cell-derived hepatic cells.

Arch Toxicol 2016 Mar 26;90(3):677-89. Epub 2015 Feb 26.

Department of In Vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Center for Pharmaceutical Research, Vrije Universiteit Brussel, Brussels, Belgium.

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March 2016

Signaling molecules, transcription growth factors and other regulators revealed from in-vivo and in-vitro models for the regulation of cardiac development.

Int J Cardiol 2015 Mar 27;183:117-28. Epub 2015 Jan 27.

Center of Physiology and Pathophysiology, Institute of Neurophysiology and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany. Electronic address:

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March 2015

Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors.

Toxicol In Vitro 2015 Sep 24;29(6):1231-9. Epub 2014 Oct 24.

Department of In Vitro Toxicology and Dermato-Cosmetology, Center for Pharmaceutical Research, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium.

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September 2015

A comparative transcriptomic study on the effects of valproic acid on two different hESCs lines in a neural teratogenicity test system.

Toxicol Lett 2014 Nov 2;231(1):38-44. Epub 2014 Sep 2.

Avantea srl, Laboratory of Reproductive Technologies, Via Porcellasco 7f, 26100 Cremona, Italy; Fondazione Avantea, Cremona, Italy. Electronic address:

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November 2014

Lineage-specific regulation of epigenetic modifier genes in human liver and brain.

PLoS One 2014 23;9(7):e102035. Epub 2014 Jul 23.

Doerenkamp-Zbinden Chair for In Vitro Toxicology and Biomedicine, University of Konstanz, Konstanz, Germany.

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April 2015

Unique metabolic features of stem cells, cardiomyocytes, and their progenitors.

Circ Res 2014 Apr;114(8):1346-60

From the Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne, Germany (J.A.G., M.X.D., J.H., A.S.); and Leibniz Research Centre for Working Environment and Human Factors (IfADo), Technical University of Dortmund, Dortmund, Germany (J.G.H., C.C.).

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April 2014

Neuronal-specific deficiency of the splicing factor Tra2b causes apoptosis in neurogenic areas of the developing mouse brain.

PLoS One 2014 19;9(2):e89020. Epub 2014 Feb 19.

Institute of Human Genetics, University of Cologne, Cologne, Germany ; Institute of Genetics, University of Cologne, Cologne, Germany ; Center for Molecular Medicine, University of Cologne, Cologne, Germany.

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January 2015

Human skin-derived stem cells as a novel cell source for in vitro hepatotoxicity screening of pharmaceuticals.

Stem Cells Dev 2014 Jan 21;23(1):44-55. Epub 2013 Sep 21.

1 Department of Toxicology, Center for Pharmaceutical Research, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB) , Brussels, Belgium .

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January 2014

All-trans retinoic acid and basic fibroblast growth factor synergistically direct pluripotent human embryonic stem cells to extraembryonic lineages.

Stem Cell Res 2013 Mar 9;10(2):228-40. Epub 2012 Dec 9.

Center of Physiology and Pathophysiology, Institute of Neurophysiology, Robert-Koch-Str. 39, 50931 Cologne, Germany.

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March 2013

Current status of human pluripotent stem cell based in vitro toxicity tests.

Front Biosci (Schol Ed) 2013 Jan 1;5:118-33. Epub 2013 Jan 1.

Systems toxicology unit, ECVAM, European Centre for the Validation of Alternative Methods, IHCP, JRC, European Commission, Ispra, VA, Italy.

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January 2013

Extensive transcriptional regulation of chromatin modifiers during human neurodevelopment.

PLoS One 2012 9;7(5):e36708. Epub 2012 May 9.

Doerenkamp-Zbinden Department of In Vitro Toxicology and Biomedicine, University of Konstanz, Konstanz, Germany.

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September 2012

Evaluation of developmental toxicants and signaling pathways in a functional test based on the migration of human neural crest cells.

Environ Health Perspect 2012 Aug 9;120(8):1116-22. Epub 2012 May 9.

Doerenkamp-Zbinden Chair of In Vitro Toxicology and Biomedicine, University of Konstanz, Konstanz, Germany.

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August 2012

Gene expression signatures defining fundamental biological processes in pluripotent, early, and late differentiated embryonic stem cells.

Stem Cells Dev 2012 Sep 17;21(13):2471-84. Epub 2012 Apr 17.

Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne, Germany.

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September 2012