Adrienne D Cox

Adrienne D Cox

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Adrienne D Cox

Publications by authors named "Adrienne D Cox"

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KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism.

Cancer Cell 2018 11;34(5):807-822.e7

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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https://www.researchgate.net/publication/325458004_KRAS_Supp
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http://scholar.google.fi/citations?user=_42T_HMAAAAJ&hl=en
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https://www.journals.elsevier.com/cancer-cell/recent-article
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https://linkinghub.elsevier.com/retrieve/pii/S15356108183046
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http://dx.doi.org/10.1016/j.ccell.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321749PMC
November 2018

Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma.

Cancer Cell 2017 02 19;31(2):256-269. Epub 2017 Jan 19.

Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Griffin Cancer Research Building, Room 212, 4500 San Pablo Road, Jacksonville, FL 32224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310966PMC
February 2017

ERK/MAPK Signaling Drives Overexpression of the Rac-GEF, PREX1, in BRAF- and NRAS-Mutant Melanoma.

Mol Cancer Res 2016 10 14;14(10):1009-1018. Epub 2016 Jul 14.

Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Department of Radiation Oncology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-16
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065759PMC
http://dx.doi.org/10.1158/1541-7786.MCR-16-0184DOI Listing
October 2016

The role of wild type RAS isoforms in cancer.

Semin Cell Dev Biol 2016 10 13;58:60-9. Epub 2016 Jul 13.

Department of Pharmacology, Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2016.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028303PMC
October 2016

RPL23 Links Oncogenic RAS Signaling to p53-Mediated Tumor Suppression.

Cancer Res 2016 09 11;76(17):5030-9. Epub 2016 Jul 11.

Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical College, Xuzhou, Jiangsu, China. Curriculum in Genetics and Molecular Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693225PMC
September 2016

Protein Kinase CK2α Maintains Extracellular Signal-regulated Kinase (ERK) Activity in a CK2α Kinase-independent Manner to Promote Resistance to Inhibitors of RAF and MEK but Not ERK in BRAF Mutant Melanoma.

J Biol Chem 2016 08 17;291(34):17804-15. Epub 2016 May 17.

From the Department of Pharmacology, Lineberger Comprehensive Cancer Center, and Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina 27599 and

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http://dx.doi.org/10.1074/jbc.M115.712885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016172PMC
August 2016

INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma.

Genes Dev 2016 06;30(12):1440-53

Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA;

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http://dx.doi.org/10.1101/gad.277178.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926866PMC
June 2016

The C. elegans Chp/Wrch Ortholog CHW-1 Contributes to LIN-18/Ryk and LIN-17/Frizzled Signaling in Cell Polarity.

PLoS One 2015 24;10(7):e0133226. Epub 2015 Jul 24.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, United States of America; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M Health Science Center and College of Medicine, Houston, Texas, 77030, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133226PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514874PMC
May 2016

Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression.

Cancer Cell 2016 Jan 24;29(1):75-89. Epub 2015 Dec 24.

Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816652PMC
January 2016

Targeting -mutant cancers: is ERK the key?

Trends Cancer 2015 Nov;1(3):183-198

Departments of Pharmacology and Radiation Oncology, and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;

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http://dx.doi.org/10.1016/j.trecan.2015.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743050PMC
November 2015

Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases.

J Biol Chem 2015 Sep 27;290(37):22851-61. Epub 2015 Jul 27.

From the Departments of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 and

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http://www.jbc.org/content/290/37/22851.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.656710
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http://dx.doi.org/10.1074/jbc.M115.656710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566255PMC
September 2015

Up-front polytherapy for ALK-positive lung cancer.

Nat Med 2015 Sep;21(9):974-5

Departments of Pharmacology and Radiation Oncology and the Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/nm.3942DOI Listing
September 2015

Nanoparticle formulations of histone deacetylase inhibitors for effective chemoradiotherapy in solid tumors.

Biomaterials 2015 May 19;51:208-215. Epub 2015 Feb 19.

Laboratory of Nano- and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2015.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361776PMC
May 2015

Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?

Clin Cancer Res 2015 Apr;21(8):1819-27

Perlmutter Cancer Institute, New York University School of Medicine, New York, New York.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-14-3214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400837PMC
April 2015

Rho GTPases, oxidation, and cell redox control.

Small GTPases 2014 8;5:e28579. Epub 2014 May 8.

Department of Biochemistry and Biophysics; University of North Carolina; Chapel Hill, NC USA; Lineberger Comprehensive Cancer Center; University of North Carolina; Chapel Hill, NC USA.

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http://dx.doi.org/10.4161/sgtp.28579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114927PMC
February 2015

Redox regulation of Rac1 by thiol oxidation.

Free Radic Biol Med 2015 Feb 5;79:237-50. Epub 2014 Oct 5.

Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599-7260; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7295. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2014.09.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708892PMC
February 2015

K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif.

Proc Natl Acad Sci U S A 2015 Jan 5;112(3):779-84. Epub 2015 Jan 5.

New York University Perlmutter Cancer Institute, New York University School of Medicine, New York, NY 10016;

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http://dx.doi.org/10.1073/pnas.1412811112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311840PMC
January 2015

Drugging the undruggable RAS: Mission possible?

Nat Rev Drug Discov 2014 Nov 17;13(11):828-51. Epub 2014 Oct 17.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1038/nrd4389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355017PMC
November 2014

Effector recruitment method to study spatially regulated activation of Ras and Rho GTPases.

Methods Mol Biol 2014 ;1120:263-83

Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1007/978-1-62703-791-4_18DOI Listing
September 2014

Src-mediated phosphorylation of the tyrosine phosphatase PRL-3 is required for PRL-3 promotion of Rho activation, motility and invasion.

PLoS One 2013 17;8(5):e64309. Epub 2013 May 17.

Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064309PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656837PMC
December 2013

The Role of Ect2 Nuclear RhoGEF Activity in Ovarian Cancer Cell Transformation.

Genes Cancer 2013 Nov;4(11-12):460-75

Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA ; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA ; Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1177/1947601913514851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877668PMC
November 2013

Ras inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosis.

Oncotarget 2013 Feb;4(2):256-68

Department of Neurobiology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712571PMC
http://dx.doi.org/10.18632/oncotarget.844DOI Listing
February 2013

Silencing the killers: paracrine immune suppression in pancreatic cancer.

Cancer Cell 2012 Jun;21(6):715-6

Departments of Radiation Oncology and Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.05.029DOI Listing
June 2012

Phosphorylation by protein kinase Cα regulates RalB small GTPase protein activation, subcellular localization, and effector utilization.

J Biol Chem 2012 Apr 5;287(18):14827-36. Epub 2012 Mar 5.

Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.344986
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http://dx.doi.org/10.1074/jbc.M112.344986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340265PMC
April 2012

The RAF inhibitor paradox revisited.

Cancer Cell 2012 Feb;21(2):147-9

Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285264PMC
February 2012

Folate-targeted polymeric nanoparticle formulation of docetaxel is an effective molecularly targeted radiosensitizer with efficacy dependent on the timing of radiotherapy.

ACS Nano 2011 Nov 28;5(11):8990-8. Epub 2011 Oct 28.

Laboratory of Nano- and Translational Medicine, Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1021/nn203165zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222718PMC
November 2011

RALA and RALBP1 regulate mitochondrial fission at mitosis.

Nat Cell Biol 2011 Aug 7;13(9):1108-15. Epub 2011 Aug 7.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://www.nature.com/articles/ncb2310
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http://dx.doi.org/10.1038/ncb2310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167028PMC
August 2011

Oncogenic synergism between ErbB1, nucleolin, and mutant Ras.

Cancer Res 2011 Mar 21;71(6):2140-51. Epub 2011 Jan 21.

Department of Neurobiology, Tel-Aviv University, Ramat-Aviv, Israel.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-2887DOI Listing
March 2011

TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling.

J Mol Signal 2010 Nov 2;5:18. Epub 2010 Nov 2.

Lineberger Comprehensive Cancer Center and Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill NC 27599-7295, USA.

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http://www.jmolecularsignaling.com/articles/10.1186/1750-218
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http://dx.doi.org/10.1186/1750-2187-5-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990749PMC
November 2010

Regulation of the Rho family small GTPase Wrch-1/RhoU by C-terminal tyrosine phosphorylation requires Src.

Mol Cell Biol 2010 Sep 14;30(17):4324-38. Epub 2010 Jun 14.

Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1128/MCB.01646-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937548PMC
September 2010

Ras-related small GTPases RalA and RalB regulate cellular survival after ionizing radiation.

Int J Radiat Oncol Biol Phys 2010 Sep 7;78(1):205-12. Epub 2010 Jul 7.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2010.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922474PMC
September 2010

Protein localization: Can too much lipid glue stop Ras?

Authors:
Adrienne D Cox

Nat Chem Biol 2010 Jul;6(7):483-5

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http://dx.doi.org/10.1038/nchembio.399DOI Listing
July 2010

Ras history: The saga continues.

Small GTPases 2010 Jul;1(1):2-27

Department of Radiation Oncology; Lineberger Comprehensive Cancer Center; University of North Carolina at Chapel Hill; Chapel Hill, NC USA.

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http://www.tandfonline.com/doi/abs/10.4161/sgtp.1.1.12178
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http://dx.doi.org/10.4161/sgtp.1.1.12178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109476PMC
July 2010

The raf inhibitor paradox: unexpected consequences of targeted drugs.

Cancer Cell 2010 Mar;17(3):221-3

Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.

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http://dx.doi.org/10.1016/j.ccr.2010.02.029DOI Listing
March 2010

Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells.

J Mol Signal 2010 Feb 23;5. Epub 2010 Feb 23.

Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1186/1750-2187-5-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848644PMC
February 2010

Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA.

Mol Cell Biol 2010 Jan 9;30(2):508-23. Epub 2009 Nov 9.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1128/MCB.00916-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798468PMC
January 2010

Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation.

Biochem J 2009 Oct 23;424(1):153-61. Epub 2009 Oct 23.

Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1042/BJ20082377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868966PMC
October 2009

The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis.

Mol Cell Biol 2009 Feb 8;29(4):1035-49. Epub 2008 Dec 8.

Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7512, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00336-08
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http://dx.doi.org/10.1128/MCB.00336-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643799PMC
February 2009

Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification.

J Biol Chem 2008 Sep 9;283(37):25150-63. Epub 2008 Jul 9.

Lineberger Comprehensive Cancer Center, Division of Pharmacotherapy and Experimental Therapeutics, Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1074/jbc.M800882200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533093PMC
September 2008

Use of retrovirus expression of interfering RNA to determine the contribution of activated K-Ras and ras effector expression to human tumor cell growth.

Methods Enzymol 2006 ;407:556-74

Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1016/S0076-6879(05)07045-XDOI Listing
June 2008

Using inhibitors of prenylation to block localization and transforming activity.

Methods Enzymol 2006 ;407:575-97

Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1016/S0076-6879(05)07046-1DOI Listing
June 2008

Use of Caenorhabditis elegans to evaluate inhibitors of Ras function in vivo.

Methods Enzymol 2008 ;439:425-49

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1016/S0076-6879(07)00430-2DOI Listing
June 2008

Inhibitors of chronically active ras: potential for treatment of human malignancies.

Recent Pat Anticancer Drug Discov 2008 Jan;3(1):31-47

Department of Neurobiochemistry, The George S. Wise Faculty of Life Sciences, Tel-Aviv University, 69978 Tel-Aviv, Israel.

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January 2008

Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease.

Cancer Cell 2007 Nov;12(5):467-78

Division of Experimental Hematology, Cincinnati Children's Research Foundation, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.ccr.2007.10.015DOI Listing
November 2007

Geranylgeranyltransferase I as a target for anti-cancer drugs.

J Clin Invest 2007 May;117(5):1223-5

Department of Medicine, NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.

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http://www.jci.org/cgi/doi/10.1172/JCI32108
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http://dx.doi.org/10.1172/JCI32108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857249PMC
May 2007

Biochemical analyses of the Wrch atypical Rho family GTPases.

Methods Enzymol 2006 ;406:11-26

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA.

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http://dx.doi.org/10.1016/S0076-6879(06)06002-2DOI Listing
March 2006

PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility.

Cancer Res 2006 Mar;66(6):3153-61

Department of Radiation Oncology, University of North Carolina at Chapel Hill, North Carolina 27599-7512, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-3116DOI Listing
March 2006

Rac3-mediated transformation requires multiple effector pathways.

Cancer Res 2005 Nov;65(21):9883-90

Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7512, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3116DOI Listing
November 2005

Visual monitoring of post-translational lipid modifications using EGFP-GTPase probes in live cells.

Methods 2005 Oct;37(2):131-37

Department of Pharmacology, University of North Carolina at Chapel Hill, NC 25799, USA.

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http://dx.doi.org/10.1016/j.ymeth.2005.05.023DOI Listing
October 2005

Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif.

J Biol Chem 2005 Sep 26;280(38):33055-65. Epub 2005 Jul 26.

Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, 27599-7512, USA.

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http://dx.doi.org/10.1074/jbc.M507362200DOI Listing
September 2005

Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome.

Proc Natl Acad Sci U S A 2005 Sep 29;102(36):12879-84. Epub 2005 Aug 29.

Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, 50 South Drive, MSC 8004, Bethesda, MD 20892-8004, USA.

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http://dx.doi.org/10.1073/pnas.0506001102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1200293PMC
September 2005

Activation of RalA is critical for Ras-induced tumorigenesis of human cells.

Cancer Cell 2005 Jun;7(6):533-45

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.ccr.2005.04.030DOI Listing
June 2005

Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase.

Curr Biol 2004 Nov;14(22):2052-6

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1016/j.cub.2004.11.011DOI Listing
November 2004

Prenyl-binding domains: potential targets for Ras inhibitors and anti-cancer drugs.

Semin Cancer Biol 2004 Aug;14(4):253-61

Department of Neurobiochemistry, The George S. Wise Faculty of Life Sciences, Tel-Aviv University, 69978 Tel-Aviv, Israel.

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http://dx.doi.org/10.1016/j.semcancer.2004.04.004DOI Listing
August 2004

Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation.

J Biol Chem 2004 Jun 8;279(24):25226-33. Epub 2004 Apr 8.

Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M313792200
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http://dx.doi.org/10.1074/jbc.M313792200DOI Listing
June 2004

Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells.

Oncogene 2004 Jan;23(2):368-78

Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati, College of Medicine, 3125 Eden Ave., Cincinnati, OH 45267-0521, USA.

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http://dx.doi.org/10.1038/sj.onc.1207075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854497PMC
January 2004

The dark side of Ras: regulation of apoptosis.

Oncogene 2003 Dec;22(56):8999-9006

Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1038/sj.onc.1207111DOI Listing
December 2003

Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the Ras oncogene enhances radiation resistance.

Cancer Res 2003 Nov;63(22):7807-14

Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599-7512, USA.

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November 2003

Rac1 and Rac3 are targets for geranylgeranyltransferase I inhibitor-mediated inhibition of signaling, transformation, and membrane ruffling.

Cancer Res 2003 Nov;63(22):7959-67

Departments of Pharmacology and Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7512, USA.

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November 2003

High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors.

J Biol Chem 2003 Oct 25;278(43):41718-27. Epub 2003 Jul 25.

Department of Radiation Oncology and Pharmacology, CB #7512, University of North Carolina, Chapel Hill, NC 27599-7512, USA.

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http://dx.doi.org/10.1074/jbc.M305733200DOI Listing
October 2003

Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1.

Nature 2003 Aug 29;424(6949):694-8. Epub 2003 Jun 29.

Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA.

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http://dx.doi.org/10.1038/nature01806DOI Listing
August 2003

Ras family signaling: therapeutic targeting.

Cancer Biol Ther 2002 Nov-Dec;1(6):599-606

University of North Carolina at Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.4161/cbt.306DOI Listing
June 2003

Farnesyltransferase inhibitors: promises and realities.

Curr Opin Pharmacol 2002 Aug;2(4):388-93

Department of Radiation Oncology CB #7512, 1050 Gravely Building, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7512, USA.

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August 2002

R-Ras C-terminal sequences are sufficient to confer R-Ras specificity to H-Ras.

Oncogene 2002 Jun;21(28):4448-61

Department of Molecular Cell Biology, Institute of Molecular Biology, University of Copenhagen, Øster Farimagsgade 2A, Denmark.

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http://dx.doi.org/10.1038/sj.onc.1205538DOI Listing
June 2002

Ras signalling on the endoplasmic reticulum and the Golgi.

Nat Cell Biol 2002 May;4(5):343-50

Department of Medicine, Cell Biology and Pharmacology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.

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http://dx.doi.org/10.1038/ncb783DOI Listing
May 2002

A distinct class of dominant negative Ras mutants: cytosolic GTP-bound Ras effector domain mutants that inhibit Ras signaling and transformation and enhance cell adhesion.

J Biol Chem 2002 Mar 17;277(13):10813-23. Epub 2002 Jan 17.

Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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March 2002