Adriano Chiò

Adriano Chiò

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Adriano Chiò

Adriano Chiò

Publications by authors named "Adriano Chiò"

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Cognitive impairment across ALS clinical stages in a population-based cohort.

Neurology 2019 Sep 13;93(10):e984-e994. Epub 2019 Aug 13.

From the ALS Center (A. Chiò, C.M., A. Canosa, U.M., R.V., M. Brunetti, M. Barberis, J.P.Z., L.P., B.I., A. Calvo), "Rita Levi Montalcini" Department of Neuroscience, University of Torino; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza of Torino (A. Chiò, C.M., A. Calvo), Turin; Institute of Cognitive Sciences and Technologies (A. Chiò), National Research Council, Rome; Department of Health Sciences Interdisciplinary Research Center of Autoimmune Diseases (L.C., S.D.), "Amedeo Avogadro" University of Eastern Piedmont; ALS Center (E.B., M.F.S., V.S., L.M.), Department of Neurology, Azienda Ospedaliera Universitaria Maggiore della Carità, Novara; and Istituti Clinici Scientifici Maugeri (G.M.), IRCCS Milano, Milan, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000008063DOI Listing
September 2019

Divining progression in Parkinson disease with a blood test: NfL.

Neurology 2019 Sep 16;93(11):471-472. Epub 2019 Aug 16.

From Bellevue Hospital (L.S.B.); New York University School of Medicine (L.S.B.); Albany-Stratton VA Medical Center, NY (L.S.B.); Essentia Health, Duluth, MN (L.S.B.); and "Rita Levi Montalcini" Department of Neuroscience (A.C.), University of Turin, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000008087DOI Listing
September 2019

Multicentre, population-based, case-control study of particulates, combustion products and amyotrophic lateral sclerosis risk.

J Neurol Neurosurg Psychiatry 2019 Aug 8;90(8):854-860. Epub 2019 Mar 8.

Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands

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http://dx.doi.org/10.1136/jnnp-2018-319779DOI Listing
August 2019

Validation of the revised classification of cognitive and behavioural impairment in ALS.

J Neurol Neurosurg Psychiatry 2019 Jul 7;90(7):734-739. Epub 2019 Feb 7.

ALS Center, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Torino, Italy

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http://dx.doi.org/10.1136/jnnp-2018-319696DOI Listing
July 2019

Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis.

Ann Neurol 2019 Apr 13;85(4):470-481. Epub 2019 Mar 13.

Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1002/ana.25431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450729PMC
April 2019

Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials.

Neurology 2019 Apr 8;92(14):e1610-e1623. Epub 2019 Mar 8.

From the Department of Neurology (L.H.v.d.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Neurology (E.S.), Mayo Clinic, Rochester, MN; Department of Neurology (G.G.), University of Kansas Medical Center, Kansas City; Department of Medicine (E.A.M.), Massachusetts General Hospital, Biostatistics Center, Harvard Medical School, Boston; Department of Neurology (J.A., H.M.), Columbia University, Eleanor and Lou Gehrig ALS Center, New York, NY; Department of Neurology (R.H.B.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (M.B.), University of Miami, FL; Neurological Clinical Research Institute (J.D.B.), Massachusetts General Hospital, Boston; Rita Levi Montalcini Department of Neuroscience (A.C.), University of Torino, Italy; Centre Constitutif SLA (P.C.), Université de Tours, France; Department of Neurology (A.G.), Clinical Research Unit, Montreal Neurological Institute, Neurosurgery, McGill University, Montreal, Canada; National Institute of Neurological Disorders and Stroke (A.K.G.), National Institutes of Health, Bethesda, MD; ALS Center (C.L.-H.), University of California San Francisco; Department of Neuroscience (C.J.M.), Sheffield Institute for Translational Neuroscience, University of Sheffield, UK; Department of Neurology (E.P.P.), Section of ALS & Related Disorders, Cleveland Clinic, OH; Department of Neurology (J.R.), The Center for Restorative Neurology, Loma Linda University School of Medicine, CA; Department of Neurology and Laboratory of Neuroscience (V.S.), Istituto Auxologico Italiano, IRCCS, Milan; Department of Pathophysiology and Transplantation (V.S.), "Dino Ferrari" Centre, Università degli Studi di Milano, Milan, Italy; Nuffield Department of Clinical Neurosciences (M.R.T.), University of Oxford, UK; Neuromuscular Diseases Unit/ALS Clinic (M.W.), Kantonsspital St. Gallen, Switzerland; Carolinas Neuromuscular/ALS-MDA Care Center (B.R.B.), Charlotte; Department of Neurology (B.R.B.), Carolinas Medical Center, University of North Carolina School of Medicine, Charlotte; Forbes Norris ALS Treatment and Research Center (R.G.M.), California Pacific Medical Center San Francisco; and Department of Neurosciences (R.G.M.), Stanford University, CA.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000007242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448453PMC
April 2019

A Dynamic Bayesian Network model for the simulation of Amyotrophic Lateral Sclerosis progression.

BMC Bioinformatics 2019 Apr 18;20(Suppl 4):118. Epub 2019 Apr 18.

Department of Information Engineering, University of Padova, Gradenigo 6/b, 35131, Padova, Italy.

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http://dx.doi.org/10.1186/s12859-019-2692-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471677PMC
April 2019

The quest for exogenous risk factors in ALS: Is there a place for physical activity?

Authors:
Adriano Chiò

Amyotroph Lateral Scler Frontotemporal Degener 2016 Jul-Aug;17(5-6):311-2. Epub 2016 May 5.

a 'Rita Levi Montalcini' Department of Neuroscience , University of Torino , Torino , Italy.

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http://dx.doi.org/10.3109/21678421.2016.1172824DOI Listing
March 2019

Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials.

Neurology 2019 Apr 8;92(14):e1610-e1623. Epub 2019 Mar 8.

From the Department of Neurology (L.H.v.d.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Neurology (E.S.), Mayo Clinic, Rochester, MN; Department of Neurology (G.G.), University of Kansas Medical Center, Kansas City; Department of Medicine (E.A.M.), Massachusetts General Hospital, Biostatistics Center, Harvard Medical School, Boston; Department of Neurology (J.A., H.M.), Columbia University, Eleanor and Lou Gehrig ALS Center, New York, NY; Department of Neurology (R.H.B.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (M.B.), University of Miami, FL; Neurological Clinical Research Institute (J.D.B.), Massachusetts General Hospital, Boston; Rita Levi Montalcini Department of Neuroscience (A.C.), University of Torino, Italy; Centre Constitutif SLA (P.C.), Université de Tours, France; Department of Neurology (A.G.), Clinical Research Unit, Montreal Neurological Institute, Neurosurgery, McGill University, Montreal, Canada; National Institute of Neurological Disorders and Stroke (A.K.G.), National Institutes of Health, Bethesda, MD; ALS Center (C.L.-H.), University of California San Francisco; Department of Neuroscience (C.J.M.), Sheffield Institute for Translational Neuroscience, University of Sheffield, UK; Department of Neurology (E.P.P.), Section of ALS & Related Disorders, Cleveland Clinic, OH; Department of Neurology (J.R.), The Center for Restorative Neurology, Loma Linda University School of Medicine, CA; Department of Neurology and Laboratory of Neuroscience (V.S.), Istituto Auxologico Italiano, IRCCS, Milan; Department of Pathophysiology and Transplantation (V.S.), "Dino Ferrari" Centre, Università degli Studi di Milano, Milan, Italy; Nuffield Department of Clinical Neurosciences (M.R.T.), University of Oxford, UK; Neuromuscular Diseases Unit/ALS Clinic (M.W.), Kantonsspital St. Gallen, Switzerland; Carolinas Neuromuscular/ALS-MDA Care Center (B.R.B.), Charlotte; Department of Neurology (B.R.B.), Carolinas Medical Center, University of North Carolina School of Medicine, Charlotte; Forbes Norris ALS Treatment and Research Center (R.G.M.), California Pacific Medical Center San Francisco; and Department of Neurosciences (R.G.M.), Stanford University, CA.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000007242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448453PMC
April 2019

Association between alcohol exposure and the risk of amyotrophic lateral sclerosis in the Euro-MOTOR study.

J Neurol Neurosurg Psychiatry 2019 Jan 3;90(1):11-19. Epub 2018 Aug 3.

'Rita Levi Montalcini' Department of Neurosciences, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1136/jnnp-2018-318559DOI Listing
January 2019

A novel p.Ser108LeufsTer15 SOD1 mutation leading to the formation of a premature stop codon in an apparently sporadic ALS patient: insights into the underlying pathomechanisms.

Neurobiol Aging 2018 12 24;72:189.e11-189.e17. Epub 2018 Aug 24.

ALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Turin, Italy; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, S.C. Neurologia 2 U, Turin, Italy; Neuroscience Institute of Turin (NIT), Turin, Italy; Institute of Cognitive Sciences and Technologies, C.N.R, Rome, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S01974580183030
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http://dx.doi.org/10.1016/j.neurobiolaging.2018.08.014DOI Listing
December 2018

Gene-Environment-Time Interactions in Neurodegenerative Diseases: Hypotheses and Research Approaches.

Ann Neurosci 2018 Dec 4;25(4):261-267. Epub 2018 Dec 4.

Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.

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https://www.karger.com/Article/FullText/495321
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http://dx.doi.org/10.1159/000495321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470336PMC
December 2018

Multicenter validation of [F]-FDG PET and support-vector machine discriminant analysis in automatically classifying patients with amyotrophic lateral sclerosis versus controls.

Amyotroph Lateral Scler Frontotemporal Degener 2018 11 4;19(7-8):570-577. Epub 2018 Jun 4.

a Division of Nuclear Medicine and Department of Imaging and pathology , University Hospitals Leuven and KU Leuven , Leuven , Belgium.

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http://dx.doi.org/10.1080/21678421.2018.1476548DOI Listing
November 2018

Multicentre, cross-cultural, population-based, case-control study of physical activity as risk factor for amyotrophic lateral sclerosis.

J Neurol Neurosurg Psychiatry 2018 08 23;89(8):797-803. Epub 2018 Apr 23.

Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/jnnp-2017-317724DOI Listing
August 2018

The multistep hypothesis of ALS revisited: The role of genetic mutations.

Neurology 2018 08 25;91(7):e635-e642. Epub 2018 Jul 25.

From the "Rita Levi Montalcini" Department of Neuroscience (A. Chiò, A. Canosa, C.M., U.M., M.B., M.B., A. Calvo), University of Torino; Institute of Cognitive Sciences and Technologies (A. Chiò), National Research Council, Rome; ALS Center (L.M., E.B.), Department of Neurology, Azienda Ospedaliera Universitaria Maggiore della Carità; Department of Health Sciences (S.D., L.C.), Interdisciplinary Research Center of Autoimmune Diseases, "Amedeo Avogadro" University of Eastern Piedmont, Novara, Italy; Department of Medical Statistics (N.P.), London School of Hygiene and Tropical Medicine, UK; Centre for Public Health Research (N.P.), Massey University Wellington Campus, New Zealand; Department of Neurology and Neurosurgery (J.H.V., L.H.v.d.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Academic Unit of Neurology (R.M., A.V., O.H., J.R.), Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland; Istituti Clinici Scientifici Maugeri (G.M.), IRCCS Milano, Italy (Gabriele Mora); and King's College London (W.S., A.A.-C.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, UK.

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http://dx.doi.org/10.1212/WNL.0000000000005996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105040PMC
August 2018

Referral bias in ALS epidemiological studies.

PLoS One 2018 16;13(4):e0195821. Epub 2018 Apr 16.

Laboratorio di Malattie Neurologiche, Dipartimento di Neuroscienze, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195821PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901916PMC
July 2018

Amyotrophic lateral sclerosis and food intake.

Amyotroph Lateral Scler Frontotemporal Degener 2018 05 21;19(3-4):267-274. Epub 2017 Dec 21.

a IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri" , Milano , Italy.

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http://dx.doi.org/10.1080/21678421.2017.1418002DOI Listing
May 2018

Multimodal structural MRI in the diagnosis of motor neuron diseases.

Neuroimage Clin 2017 2;16:240-247. Epub 2017 Aug 2.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

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http://dx.doi.org/10.1016/j.nicl.2017.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545829PMC
April 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

Common polymorphisms of chemokine (C-X3-C motif) receptor 1 gene modify amyotrophic lateral sclerosis outcome: A population-based study.

Muscle Nerve 2018 02 25;57(2):212-216. Epub 2017 Apr 25.

"Rita Levi Montalcini" Department of Neuroscience, Neurology II, ALS Center, University of Torino, Via Cherasco 15, I-10126, Torino, Italy.

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http://dx.doi.org/10.1002/mus.25653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912184PMC
February 2018

Network Analysis Identifies Disease-Specific Pathways for Parkinson's Disease.

Mol Neurobiol 2018 01 21;55(1):370-381. Epub 2016 Dec 21.

Laboratory of Biochemistry and Functional Proteomics, Department of Science and High Technology, University of Insubria, via Manara,7, I-21052, Busto Arsizio, VA, Italy.

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http://dx.doi.org/10.1007/s12035-016-0326-0DOI Listing
January 2018

Novel genes associated with amyotrophic lateral sclerosis: diagnostic and clinical implications.

Lancet Neurol 2018 01 16;17(1):94-102. Epub 2017 Nov 16.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA; Department of Neurology, Brain Sciences Institute, Johns Hopkins Hospital, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/S1474-4422(17)30401-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901717PMC
January 2018

Amyotrophic Lateral Sclerosis Incidence and Previous Prescriptions of Drugs for the Nervous System.

Neuroepidemiology 2016 26;47(1):59-66. Epub 2016 Aug 26.

ALS Center, 'Rita Levi Montalcini' Department of Neurosciences, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1159/000448618DOI Listing
December 2017

Genetic screening in sporadic ALS and FTD.

J Neurol Neurosurg Psychiatry 2017 12 22;88(12):1042-1044. Epub 2017 Jun 22.

Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK.

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http://dx.doi.org/10.1136/jnnp-2017-315995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740553PMC
December 2017

Amyotrophic lateral sclerosis.

Lancet 2017 Nov 25;390(10107):2084-2098. Epub 2017 May 25.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(17)31287-4DOI Listing
November 2017

Influence of arterial hypertension, type 2 diabetes and cardiovascular risk factors on ALS outcome: a population-based study.

Amyotroph Lateral Scler Frontotemporal Degener 2017 11 15;18(7-8):590-597. Epub 2017 Jun 15.

a ALS Center, 'Rita Levi Montalcini' Department of Neuroscience , University of Turin , Turin , Italy.

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http://dx.doi.org/10.1080/21678421.2017.1336560DOI Listing
November 2017

A mapping review of international guidance on the management and care of amyotrophic lateral sclerosis (ALS).

Amyotroph Lateral Scler Frontotemporal Degener 2016 Jul-Aug;17(5-6):325-36. Epub 2016 Apr 14.

m Walter Sermeus, KU Leuven Institute for Healthcare Policy, Department of Public Health and Primary Care , University of Leuven - KU Leuven , Leuven , Belgium.

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http://dx.doi.org/10.3109/21678421.2016.1167911DOI Listing
October 2017

Meta-analysis of pharmacogenetic interactions in amyotrophic lateral sclerosis clinical trials.

Neurology 2017 Oct 4;89(18):1915-1922. Epub 2017 Oct 4.

From the Department of Neurology, Brain Centre Rudolf Magnus (R.P.A.v.E., F.P.D., W.v.R., J.H.V., L.H.v.d.B., M.A.v.E.), and Department of Biostatistics and Research Support (M.J.C.E.), University Medical Centre Utrecht, the Netherlands; Maurice Wohl Clinical Neuroscience Institute and United Kingdom Dementia Research Institute Centre (A.R.J., W.S., A.S., C.E.S., A.A.-C.), Department of Basic and Clinical Neuroscience, King's College London; Sheffield Institute for Translational Neuroscience (SITraN) (P.J.S.), University of Sheffield, South Yorkshire; Department of Clinical Neuroscience (P.N.L.), Trafford Centre for Biomedical Research, Brighton and Sussex Medical School, Falmer, Brighton; The Walton Centre NHS Trust (C.A.Y.), Liverpool, UK; Istituti Clinici Scientifici Maugeri IRCSS (G.M.), Milan; Department of Neuroscience (J.M.), Sant'Agostino-Estense Hospital and University of Modena and Reggio Emilia, Modena; Department of Neurology (G.B.), Azienda Universitario Ospedaliera di Cagliari and University of Cagliari; Istituti Clinici Scientifici Maugeri IRCSS (P.V.), Mistretta, Italy; Rijnstate Ziekenhuis (E.V.), Arnhem, the Netherlands; Rita Levi Montalcini' Department of Neuroscience (A.C.), ALS Centre, University of Torino; and Azienda Ospedaliera Città della Salute e della Scienza (A.C.), Turin, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000004606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664299PMC
October 2017

Amyotrophic lateral sclerosis.

Nat Rev Dis Primers 2017 Oct 5;3:17071. Epub 2017 Oct 5.

Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/nrdp.2017.71DOI Listing
October 2017

Novel Compound Heterozygous Spatacsin Mutations in a Greek Kindred with Hereditary Spastic Paraplegia SPG11 and Dementia.

Neurodegener Dis 2016 18;16(5-6):373-81. Epub 2016 Jun 18.

NEURORARE Centre for Rare and Genetic Neurological and Neuromuscular Diseases and Neurogenetics, Athens, Greece.

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http://dx.doi.org/10.1159/000444715DOI Listing
September 2017

A case-control study of hormonal exposures as etiologic factors for ALS in women: Euro-MOTOR.

Neurology 2017 Sep 23;89(12):1283-1290. Epub 2017 Aug 23.

From the Academic Unit of Neurology (J.P.K.R., O.H.), Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland; Department of Neurology and Neurosurgery (A.E.V., J.H.V., L.H.v.d.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Neuroscience (F.D., A.C.), ALS Centre, University of Torino, Turin, Italy; Institute for Risk Assessment Sciences (R.V.), Department of Environmental Epidemiology, University of Utrecht, the Netherlands; Department of Neurosciences (E.B.), IRCSS, Mario Negri Institute of Pharmacological Research, Milan; and Department of Neuroscience (G.L.), University of Bari, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000004390DOI Listing
September 2017

Critical issues in ALS case-control studies: the case of the Euro-MOTOR study.

Amyotroph Lateral Scler Frontotemporal Degener 2017 08 10;18(5-6):411-418. Epub 2017 Feb 10.

f Neurological Diseases Laboratory, Department of Neurosciences , IRCCS Mario Negri , Milano , Italy.

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http://dx.doi.org/10.1080/21678421.2017.1285939DOI Listing
August 2017

The changing picture of amyotrophic lateral sclerosis: lessons from European registers.

J Neurol Neurosurg Psychiatry 2017 07 11;88(7):557-563. Epub 2017 Mar 11.

Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland.

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http://dx.doi.org/10.1136/jnnp-2016-314495DOI Listing
July 2017

A20 in Multiple Sclerosis and Parkinson's Disease: Clue to a Common Dysregulation of Anti-Inflammatory Pathways?

Neurotox Res 2017 Jul 23;32(1):1-7. Epub 2017 Mar 23.

Neurobiology Unit, Neurologia 2 - CReSM (Regional Referring Center Multiple Sclerosis), San Luigi Gonzaga University Hospital & Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano (TO), Italy.

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http://dx.doi.org/10.1007/s12640-017-9724-yDOI Listing
July 2017

C9ORF72 and parkinsonism: Weak link, innocent bystander, or central player in neurodegeneration?

J Neurol Sci 2017 07 17;378:49-51. Epub 2017 Apr 17.

Department of Neuroscience, St. Agostino Estense Hospital, University of Modena and Reggio Emilia, Modena, Italy.

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http://dx.doi.org/10.1016/j.jns.2017.04.027DOI Listing
July 2017

Serum C-Reactive Protein as a Prognostic Biomarker in Amyotrophic Lateral Sclerosis.

JAMA Neurol 2017 06;74(6):660-667

Amyotrophic Lateral Sclerosis Center, "Rita Levi Montalcini" Department of Neuroscience, Neurology II, University of Torino, Turin, Italy9Azienda Ospedaliero-Universitaria Città della Salute e della Scienza, Torino, Italy.

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http://dx.doi.org/10.1001/jamaneurol.2016.6179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822215PMC
June 2017

Incidence of amyotrophic lateral sclerosis in the province of Novara, Italy, and possible role of environmental pollution.

Amyotroph Lateral Scler Frontotemporal Degener 2017 05 2;18(3-4):284-290. Epub 2017 Feb 2.

b Environmental, Genetic, and Nutritional Epidemiology Research Center-CREAGEN, Department of Biomedical, Metabolic and Neural Sciences , University of Modena and Reggio Emilia , Modena , Italy.

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http://dx.doi.org/10.1080/21678421.2017.1281961DOI Listing
May 2017

Age-related penetrance of the C9orf72 repeat expansion.

Sci Rep 2017 05 18;7(1):2116. Epub 2017 May 18.

Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, 20892, USA.

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http://dx.doi.org/10.1038/s41598-017-02364-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437033PMC
May 2017

Acoustic reflex patterns in amyotrophic lateral sclerosis.

Eur Arch Otorhinolaryngol 2017 Feb 30;274(2):679-683. Epub 2016 Aug 30.

Rita Levi Montalcini' Department of Neuroscience, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1007/s00405-016-4284-yDOI Listing
February 2017

Pain in amyotrophic lateral sclerosis.

Lancet Neurol 2017 Feb 8;16(2):144-157. Epub 2016 Dec 8.

Neuroalgology Unit and Motor Neuron Diseases Centre, IRCCS "Carlo Besta" Neurological Institute, Milan, Italy.

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http://dx.doi.org/10.1016/S1474-4422(16)30358-1DOI Listing
February 2017

Phenotypic variability related to C9orf72 mutation in a large Sardinian kindred.

Amyotroph Lateral Scler Frontotemporal Degener 2016 17;17(3-4):245-8. Epub 2015 Nov 17.

a Department of Neurology , Azienda Universitaria-Ospedaliera of Cagliari and University of Cagliari , Cagliari .

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http://dx.doi.org/10.3109/21678421.2015.1111904DOI Listing
January 2017

Use of Genetic Testing in Amyotrophic Lateral Sclerosis by Neurologists.

JAMA Neurol 2017 01;74(1):125-126

Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1001/jamaneurol.2016.4540DOI Listing
January 2017

Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials?

Cytotherapy 2016 12 6;18(12):1471-1475. Epub 2016 Oct 6.

ALS Centre, Department of Neurology, "Maggiore della Carità", University Hospital, Novara, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jcyt.2016.08.005DOI Listing
December 2016

Influence of cigarette smoking on ALS outcome: a population-based study.

J Neurol Neurosurg Psychiatry 2016 Nov 21;87(11):1229-1233. Epub 2016 Sep 21.

'Rita Levi Montalcini' Department of Neuroscience, ALS Center, University of Turin, Turin, Italy Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy Neuroscience Institute of Torino (NIT), Turin, Italy.

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http://dx.doi.org/10.1136/jnnp-2016-313793DOI Listing
November 2016

Curable or treatable? The implications of different definitions of illness when treating patients suffering from amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2015 14;17(1-2):15-20. Epub 2015 Oct 14.

a ' Rita Levi Montalcini' Department of Neuroscience , University of Turin , Italy.

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http://dx.doi.org/10.3109/21678421.2015.1074702DOI Listing
October 2016

Non-self-sufficiency as a primary outcome measure in ALS trials.

Amyotroph Lateral Scler Frontotemporal Degener 2015 16;17(1-2):77-84. Epub 2015 Oct 16.

d Laboratory of Neurological Disorders, Department of Neuroscience , IRCCS Institute for Pharmacological Research Mario Negri , Milan.

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http://dx.doi.org/10.3109/21678421.2015.1074704DOI Listing
October 2016

Amyotrophic lateral sclerosis: moving towards a new classification system.

Lancet Neurol 2016 10;15(11):1182-94

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Netherlands.

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http://dx.doi.org/10.1016/S1474-4422(16)30199-5DOI Listing
October 2016

Genetics of multiple system atrophy: Back to square one?

Neurology 2016 10 14;87(15):1530-1531. Epub 2016 Sep 14.

From Sheffield Institute for Translational Neuroscience (SITraN) (O.B.), University of Sheffield, UK; and Rita Levi Montalcini Department of Neuroscience (A.C.), University of Torino, Turin, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000003215DOI Listing
October 2016

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis.

Nat Genet 2016 09 25;48(9):1037-42. Epub 2016 Jul 25.

Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560030PMC
September 2016

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.

Authors:
Wouter van Rheenen Aleksey Shatunov Annelot M Dekker Russell L McLaughlin Frank P Diekstra Sara L Pulit Rick A A van der Spek Urmo Võsa Simone de Jong Matthew R Robinson Jian Yang Isabella Fogh Perry Tc van Doormaal Gijs H P Tazelaar Max Koppers Anna M Blokhuis William Sproviero Ashley R Jones Kevin P Kenna Kristel R van Eijk Oliver Harschnitz Raymond D Schellevis William J Brands Jelena Medic Androniki Menelaou Alice Vajda Nicola Ticozzi Kuang Lin Boris Rogelj Katarina Vrabec Metka Ravnik-Glavač Blaž Koritnik Janez Zidar Lea Leonardis Leja Dolenc Grošelj Stéphanie Millecamps François Salachas Vincent Meininger Mamede de Carvalho Susana Pinto Jesus S Mora Ricardo Rojas-García Meraida Polak Siddharthan Chandran Shuna Colville Robert Swingler Karen E Morrison Pamela J Shaw John Hardy Richard W Orrell Alan Pittman Katie Sidle Pietro Fratta Andrea Malaspina Simon Topp Susanne Petri Susanne Abdulla Carsten Drepper Michael Sendtner Thomas Meyer Roel A Ophoff Kim A Staats Martina Wiedau-Pazos Catherine Lomen-Hoerth Vivianna M Van Deerlin John Q Trojanowski Lauren Elman Leo McCluskey A Nazli Basak Ceren Tunca Hamid Hamzeiy Yesim Parman Thomas Meitinger Peter Lichtner Milena Radivojkov-Blagojevic Christian R Andres Cindy Maurel Gilbert Bensimon Bernhard Landwehrmeyer Alexis Brice Christine A M Payan Safaa Saker-Delye Alexandra Dürr Nicholas W Wood Lukas Tittmann Wolfgang Lieb Andre Franke Marcella Rietschel Sven Cichon Markus M Nöthen Philippe Amouyel Christophe Tzourio Jean-François Dartigues Andre G Uitterlinden Fernando Rivadeneira Karol Estrada Albert Hofman Charles Curtis Hylke M Blauw Anneke J van der Kooi Marianne de Visser An Goris Markus Weber Christopher E Shaw Bradley N Smith Orietta Pansarasa Cristina Cereda Roberto Del Bo Giacomo P Comi Sandra D'Alfonso Cinzia Bertolin Gianni Sorarù Letizia Mazzini Viviana Pensato Cinzia Gellera Cinzia Tiloca Antonia Ratti Andrea Calvo Cristina Moglia Maura Brunetti Simona Arcuti Rosa Capozzo Chiara Zecca Christian Lunetta Silvana Penco Nilo Riva Alessandro Padovani Massimiliano Filosto Bernard Muller Robbert Jan Stuit Ian Blair Katharine Zhang Emily P McCann Jennifer A Fifita Garth A Nicholson Dominic B Rowe Roger Pamphlett Matthew C Kiernan Julian Grosskreutz Otto W Witte Thomas Ringer Tino Prell Beatrice Stubendorff Ingo Kurth Christian A Hübner P Nigel Leigh Federico Casale Adriano Chio Ettore Beghi Elisabetta Pupillo Rosanna Tortelli Giancarlo Logroscino John Powell Albert C Ludolph Jochen H Weishaupt Wim Robberecht Philip Van Damme Lude Franke Tune H Pers Robert H Brown Jonathan D Glass John E Landers Orla Hardiman Peter M Andersen Philippe Corcia Patrick Vourc'h Vincenzo Silani Naomi R Wray Peter M Visscher Paul I W de Bakker Michael A van Es R Jeroen Pasterkamp Cathryn M Lewis Gerome Breen Ammar Al-Chalabi Leonard H van den Berg Jan H Veldink

Nat Genet 2016 09 25;48(9):1043-8. Epub 2016 Jul 25.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/ng.3622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556360PMC
September 2016

Professor Camillo Negro's Neuropathological Films.

J Hist Neurosci 2016 ;25(1):39-50

b Film-Archive, Museo Nazionale del Cinema , Torino , Italy.

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http://dx.doi.org/10.1080/0964704X.2015.1070034DOI Listing
August 2016

Projected increase in amyotrophic lateral sclerosis from 2015 to 2040.

Nat Commun 2016 08 11;7:12408. Epub 2016 Aug 11.

Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ncomms12408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987527PMC
August 2016

A Multicentric Prospective Incidence Study of Guillain-Barré Syndrome in Italy. The ITANG Study.

Neuroepidemiology 2015 29;45(2):90-9. Epub 2015 Aug 29.

Neurology Unit, Policlinico Borgo Roma, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.

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http://dx.doi.org/10.1159/000438752DOI Listing
July 2016

TBK1 is associated with ALS and ALS-FTD in Sardinian patients.

Neurobiol Aging 2016 07 9;43:180.e1-5. Epub 2016 Apr 9.

"Rita Levi Montalcini" Department of Neuroscience, Amyotrophic Lateral Sclerosis Center, University of Turin, Turin, Italy; Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy; Neuroscience Institute of Torino (NIT), Turin, Italy; Institute of Cognitive Sciences and Technologies, Consiglio Nazionale delle Ricerche, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.03.028DOI Listing
July 2016

Structural brain correlates of cognitive and behavioral impairment in MND.

Hum Brain Mapp 2016 Apr 2;37(4):1614-26. Epub 2016 Feb 2.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

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http://dx.doi.org/10.1002/hbm.23124DOI Listing
April 2016

The Role of APOE in the Occurrence of Frontotemporal Dementia in Amyotrophic Lateral Sclerosis.

JAMA Neurol 2016 Apr;73(4):425-30

ALS Center, "Rita Levi Montalcini" Department of Neuroscience, University of Torino, Torino, Italy2The Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Torino, Italy3The Neuroscience Institute of Torino, Torino, Italy.

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http://dx.doi.org/10.1001/jamaneurol.2015.4773DOI Listing
April 2016

Metabolic spatial connectivity in amyotrophic lateral sclerosis as revealed by independent component analysis.

Hum Brain Mapp 2016 Mar 24;37(3):942-53. Epub 2015 Dec 24.

ALS Center, 'Rita Levi Montalcini' Department of Neuroscience University of Turin, Turin, Italy.

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http://dx.doi.org/10.1002/hbm.23078DOI Listing
March 2016

A new scale for prognostication in Parkinson disease: Of animals and men.

Neurology 2016 Mar 17;86(11):982-3. Epub 2016 Feb 17.

From the "Rita Levi Montalcini" Department of Neuroscience (A.C.), University of Torino; Azienda Università Ospedale Città della Salute e della Scienza (A.C.), Torino; and Department of Basic Medical Sciences, Neuroscience and Sense Organs (G.D.), "Aldo Moro" University of Bari, Italy.

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http://www.neurology.org/content/early/2016/02/17/WNL.000000
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http://dx.doi.org/10.1212/WNL.0000000000002435DOI Listing
March 2016

18F-FDG-PET correlates of cognitive impairment in ALS.

Neurology 2016 Jan 20;86(1):44-9. Epub 2015 Nov 20.

From the ALS Center (A. Canosa, A.M., B.I., S.C., A.I., C.M., A. Calvo, A. Chiò), "Rita Levi Montalcini" Department of Neuroscience, University of Turin; Department of Neurosciences, Ophthalmology, Genetics, Rehabilitation and Child Health (A. Canosa), University of Genoa; Institute of Cognitive Sciences and Technologies (M.P., A. Cistaro, A. Chiò), C.N.R., Rome, Italy; Department of Nuclear Medicine (M.P.), Karolinska Hospital, Stockholm, Sweden; Positron Emission Tomography Centre IRMET S.p.A. (A. Cistaro, P.F.), EuroMedic International, Turin; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino (A. Calvo, A. Chiò), Turin; and the Neuroscience Institute of Turin (NIT) (A. Calvo, A. Chiò), Italy.

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January 2016

Degenerative neuromuscular diseases: crucial gene and cell machinery discoveries.

Lancet Neurol 2016 Jan 8;15(1):12-3. Epub 2015 Dec 8.

Department of Clinical Neurosciences, IRCCS Foundation, "Carlo Besta" Neurological Institute, Milan, Italy.

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http://dx.doi.org/10.1016/S1474-4422(15)00361-0DOI Listing
January 2016

The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease.

Alzheimers Dement 2015 Dec 30;11(12):1407-1416. Epub 2015 Apr 30.

Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany; Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany; Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology, and Medicine, London, UK.

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http://dx.doi.org/10.1016/j.jalz.2014.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627856PMC
December 2015

ATXN2 is a modifier of phenotype in ALS patients of Sardinian ancestry.

Neurobiol Aging 2015 Oct 25;36(10):2906.e1-5. Epub 2015 Jun 25.

ALS Center, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy; Neurology II, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy; Neuroscience Institute of Torino (NIT), Turin, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193218PMC
October 2015

ALS mutant FUS proteins are recruited into stress granules in induced pluripotent stem cell-derived motoneurons.

Dis Model Mech 2015 Jul 23;8(7):755-66. Epub 2015 Apr 23.

Center for Life Nano Science, Istituto Italiano di Tecnologia, Viale Regina Elena 291, Rome 00161, Italy Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, P.le A. Moro 5, Rome 00185, Italy Institute Pasteur Fondazione Cenci-Bolognetti, Sapienza University of Rome, P.le A. Moro 5, Rome 00185, Italy

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http://dx.doi.org/10.1242/dmm.020099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486861PMC
July 2015