Adriano Aguzzi

Adriano Aguzzi

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Adriano Aguzzi

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'Broken access' publishing corrodes quality.

Authors:
Adriano Aguzzi

Nature 2019 06;570(7760):139

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http://dx.doi.org/10.1038/d41586-019-01787-2DOI Listing
June 2019

Unaltered prion disease in mice lacking developmental endothelial locus-1.

Neurobiol Aging 2019 04 11;76:208-213. Epub 2019 Jan 11.

Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.01.003DOI Listing
April 2019

SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease.

J Exp Med 2019 Apr 6;216(4):743-756. Epub 2019 Mar 6.

Institute of Neuropathology, University of Zurich, Zurich, Switzerland

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http://www.jem.org/lookup/doi/10.1084/jem.20171885
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http://dx.doi.org/10.1084/jem.20171885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446871PMC
April 2019

Immunotherapy for neurodegeneration?

Science 2019 04;364(6436):130-131

Institute of Neuropathology, University of Zurich, CH-8091 Zurich, Switzerland.

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http://dx.doi.org/10.1126/science.aaw0685DOI Listing
April 2019

Genome-wide identification of microRNAs regulating the human prion protein.

Brain Pathol 2019 03 21;29(2):232-244. Epub 2018 Dec 21.

Institute of Neuropathology, University of Zürich, Zürich, Switzerland.

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http://doi.wiley.com/10.1111/bpa.12679
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http://dx.doi.org/10.1111/bpa.12679DOI Listing
March 2019

'Forward genetics' and the causes of ALS.

Authors:
Adriano Aguzzi

Nat Rev Mol Cell Biol 2019 Feb;20(2):67

Institute of Neuropathology, University of Zurich,, CH-8002, Zurich, Switzerland.

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http://dx.doi.org/10.1038/s41580-018-0062-6DOI Listing
February 2019

Toxic Protein Spread in Neurodegeneration: Reality versus Fantasy.

Trends Mol Med 2018 12 12;24(12):1007-1020. Epub 2018 Nov 12.

Institute of Neuropathology, University Hospital of Zurich, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2018.09.004DOI Listing
December 2018

Intrinsic Toxicity of Antibodies to the Globular Domain of the Prion Protein.

Biol Psychiatry 2018 10 12;84(7):e51-e52. Epub 2018 Apr 12.

Institute of Neuropathology, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.biopsych.2018.01.028DOI Listing
October 2018

Lymphocyte activation gene 3 (Lag3) expression is increased in prion infections but does not modify disease progression.

Sci Rep 2018 Oct 2;8(1):14600. Epub 2018 Oct 2.

Institute of Neuropathology, University of Zurich, Schmelzbergstrasse 12, CH-8091, Zurich, Switzerland.

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http://www.nature.com/articles/s41598-018-32712-8
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http://dx.doi.org/10.1038/s41598-018-32712-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168446PMC
October 2018

Prions, prionoids and protein misfolding disorders.

Nat Rev Genet 2018 07;19(7):405-418

Institute of Neuropathology, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1038/s41576-018-0011-4DOI Listing
July 2018

Infectious prions do not induce Aβ deposition in an in vivo seeding model.

Acta Neuropathol 2018 06 16;135(6):965-967. Epub 2018 Apr 16.

German Center for Neurodegenerative Diseases (DZNE), Tübingen, 72076, Tübingen, Germany.

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http://dx.doi.org/10.1007/s00401-018-1848-5DOI Listing
June 2018

Structural characterization of POM6 Fab and mouse prion protein complex identifies key regions for prions conformational conversion.

FEBS J 2018 05 14;285(9):1701-1714. Epub 2018 Apr 14.

Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.

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http://dx.doi.org/10.1111/febs.14438DOI Listing
May 2018

Binding of Polythiophenes to Amyloids: Structural Mapping of the Pharmacophore.

ACS Chem Neurosci 2018 03 4;9(3):475-481. Epub 2017 Dec 4.

Physical Chemistry , ETH Zurich , Vladimir-Prelog-Weg 2 , 8093 Zurich , Switzerland.

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http://dx.doi.org/10.1021/acschemneuro.7b00397DOI Listing
March 2018

Toward Therapy of Human Prion Diseases.

Annu Rev Pharmacol Toxicol 2018 01 27;58:331-351. Epub 2017 Sep 27.

Institute of Neuropathology, University of Zurich, CH-8091 Zürich, Switzerland; email:

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http://dx.doi.org/10.1146/annurev-pharmtox-010617-052745DOI Listing
January 2018

A role for astroglia in prion diseases.

J Exp Med 2017 12 21;214(12):3477-3479. Epub 2017 Nov 21.

Institute of Neuropathology, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1084/jem.20172045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716049PMC
December 2017

Strong, generous support for medical research emerges from a large cohort of Swiss patients.

Authors:
Adriano Aguzzi

Swiss Med Wkly 2017 22;147:w14537. Epub 2017 Oct 22.

Institute of Neuropathology, University Hospital of Zurich, Switzerland; Editor in chief, Swiss Medical Weekly.

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http://dx.doi.org/10.4414/smw.2017.14537DOI Listing
November 2017

Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice.

mSphere 2017 Nov-Dec;2(6). Epub 2017 Nov 22.

Prion Research Center, Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.

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http://dx.doi.org/10.1128/mSphereDirect.00493-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700378PMC
November 2017

Scaling behaviour and rate-determining steps in filamentous self-assembly.

Chem Sci 2017 Oct 31;8(10):7087-7097. Epub 2017 Aug 31.

Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , UK . Email: ; Email:

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http://dx.doi.org/10.1039/c7sc01965cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637470PMC
October 2017

Microglia in prion diseases.

J Clin Invest 2017 Sep 17;127(9):3230-3239. Epub 2017 Jul 17.

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http://dx.doi.org/10.1172/JCI90605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669569PMC
September 2017

Modifiers of prion protein biogenesis and recycling identified by a highly parallel endocytosis kinetics assay.

J Biol Chem 2017 05 24;292(20):8356-8368. Epub 2017 Mar 24.

From the Institute of Neuropathology, University of Zurich, CH-8091 Zurich, Switzerland,

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http://dx.doi.org/10.1074/jbc.M116.773283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437241PMC
May 2017

The biological function of the cellular prion protein: an update.

BMC Biol 2017 05 2;15(1):34. Epub 2017 May 2.

Institute of Neuropathology, University of Zurich, Rämistrasse 100, CH-8091, Zürich, Switzerland.

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http://dx.doi.org/10.1186/s12915-017-0375-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412054PMC
May 2017

Extended characterization of the novel co-isogenic C57BL/6J Prnp mouse line.

Amyloid 2017 03;24(sup1):36-37

a Institute of Neuropathology, University Hospital of Zurich , Zurich , Switzerland.

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http://dx.doi.org/10.1080/13506129.2017.1289913DOI Listing
March 2017

Amyloid-β pathology and cerebral amyloid angiopathy are frequent in iatrogenic Creutzfeldt-Jakob disease after dural grafting.

Swiss Med Wkly 2016 26;146:w14287. Epub 2016 Jan 26.

Institute of Neuropathology, University Hospital Zurich, Switzerland; Institute of Neurology, Medical University Vienna, Austria.

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http://dx.doi.org/10.4414/smw.2016.14287DOI Listing
October 2016

Soluble Conformers of Aβ and Tau Alter Selective Proteins Governing Axonal Transport.

J Neurosci 2016 09;36(37):9647-58

Department of Neuroscience, N. Bud Grossman Center for Memory Research and Care, Institute for Translational Neuroscience, University of Minnesota, Minneapolis, Minnesota 55414,

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http://dx.doi.org/10.1523/JNEUROSCI.1899-16.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039246PMC
September 2016

Unaltered Prion Pathogenesis in a Mouse Model of High-Fat Diet-Induced Insulin Resistance.

PLoS One 2015 14;10(12):e0144983. Epub 2015 Dec 14.

Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144983PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677814PMC
August 2016

Phase Separation: Linking Cellular Compartmentalization to Disease.

Trends Cell Biol 2016 07 1;26(7):547-558. Epub 2016 Apr 1.

Department of Molecular Mechanisms of Disease, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2016.03.004DOI Listing
July 2016

New and emerging roles of small RNAs in neurodegeneration, muscle, cardiovascular and inflammatory diseases.

Swiss Med Wkly 2015 16;145:w14192. Epub 2015 Sep 16.

Institute of Molecular Life Sciences, University of Zurich, Switzerland.

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http://dx.doi.org/10.4414/smw.2015.14192DOI Listing
June 2016

Homozygous calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency.

Blood 2016 06 24;127(25):3253-9. Epub 2016 Mar 24.

Division of Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland;

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http://dx.doi.org/10.1182/blood-2016-02-696310DOI Listing
June 2016

A neuroprotective role for microglia in prion diseases.

J Exp Med 2016 05 16;213(6):1047-59. Epub 2016 May 16.

Institute of Neuropathology, University Hospital Zurich, 8091 Zurich, Switzerland

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http://dx.doi.org/10.1084/jem.20151000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886355PMC
May 2016

Strictly co-isogenic C57BL/6J-Prnp-/- mice: A rigorous resource for prion science.

J Exp Med 2016 Mar 29;213(3):313-27. Epub 2016 Feb 29.

Institute of Neuropathology, University Hospital of Zurich, 8091 Zurich, Switzerland

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http://dx.doi.org/10.1084/jem.20151610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813672PMC
March 2016

Prion pathogenesis in the absence of NLRP3/ASC inflammasomes.

PLoS One 2015 11;10(2):e0117208. Epub 2015 Feb 11.

Institute of Neuropathology, University Hospital of Zurich, Zurich, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117208PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324825PMC
January 2016

Cell Biology of Prions and Prionoids: A Status Report.

Trends Cell Biol 2016 Jan 9;26(1):40-51. Epub 2015 Oct 9.

Institute of Neuropathology, University of Zürich, CH-8091 Zürich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2015.08.007DOI Listing
January 2016

Differential Toxicity of Antibodies to the Prion Protein.

PLoS Pathog 2016 Jan 28;12(1):e1005401. Epub 2016 Jan 28.

Institute of Neuropathology, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731068PMC
January 2016

In Vivo Longitudinal (1)H MRS Study of Transgenic Mouse Models of Prion Disease in the Hippocampus and Cerebellum at 14.1 T.

Neurochem Res 2015 Dec 23;40(12):2639-46. Epub 2015 Jul 23.

Centre d'Imagerie Biomedicale, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

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http://dx.doi.org/10.1007/s11064-015-1643-9DOI Listing
December 2015

X-ray structural and molecular dynamical studies of the globular domains of cow, deer, elk and Syrian hamster prion proteins.

J Struct Biol 2015 Oct 28;192(1):37-47. Epub 2015 Aug 28.

Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2H7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jsb.2015.08.014DOI Listing
October 2015

Altered Monoaminergic Systems and Depressive-like Behavior in Congenic Prion Protein Knock-out Mice.

J Biol Chem 2015 Oct;290(43):26350

Institute of Neuropathology, University Hospital of Zurich, Zurich, Switzerland

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http://www.jbc.org/lookup/doi/10.1074/jbc.L115.689117
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http://dx.doi.org/10.1074/jbc.L115.689117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646282PMC
October 2015

Scientific publishing in the times of open access.

Authors:
Adriano Aguzzi

Swiss Med Wkly 2015 4;145:w14118. Epub 2015 Feb 4.

Institute of Neuropathology, University Hospital of Zurich, Switzerland.

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http://dx.doi.org/10.4414/smw.2015.14118DOI Listing
September 2015

Authoring scientific papers: a perspective from the trenches.

Authors:
Adriano Aguzzi

Swiss Med Wkly 2015 21;145:w14107. Epub 2015 Feb 21.

Institute of Neuropathology, University Hospital of Zurich, Switzerland.

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http://dx.doi.org/10.4414/smw.2015.14107DOI Listing
September 2015

PrP charge structure encodes interdomain interactions.

Sci Rep 2015 Sep 1;5:13623. Epub 2015 Sep 1.

Instituto Química-Física "Rocasolano", Consejo Superior de Investigaciones Científicas, Madrid 28006, Spain.

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http://dx.doi.org/10.1038/srep13623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555102PMC
September 2015

Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains.

Neurobiol Aging 2015 May 27;36(5):1994-2003. Epub 2015 Feb 27.

Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.02.019DOI Listing
May 2015

The role of the NADPH oxidase NOX2 in prion pathogenesis.

PLoS Pathog 2014 Dec 11;10(12):e1004531. Epub 2014 Dec 11.

Institute of Neuropathology, University Hospital of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1004531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263757PMC
December 2014

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.

Nat Immunol 2014 Aug 22;15(8):727-37. Epub 2014 Jun 22.

1] Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany. [2] Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. [3] German Center for Neurodegenerative Diseases, Bonn, Germany. [4] Center of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

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http://dx.doi.org/10.1038/ni.2913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116676PMC
August 2014

Neurodegeneration: Alzheimer's disease under strain.

Authors:
Adriano Aguzzi

Nature 2014 Aug;512(7512):32-4

Institute of Neuropathology, University Hospital Zurich, Zurich CH-8091,Switzerland.

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http://dx.doi.org/10.1038/512032aDOI Listing
August 2014

Follicular dendritic cells: origin, phenotype, and function in health and disease.

Trends Immunol 2014 Mar 3;35(3):105-13. Epub 2013 Dec 3.

Garvan Institute of Medical Research, Darlinghurst, New South Wales, Sydney, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.it.2013.11.001DOI Listing
March 2014

Structural basis of prion inhibition by phenothiazine compounds.

Structure 2014 Feb 26;22(2):291-303. Epub 2013 Dec 26.

Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2H7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.str.2013.11.009DOI Listing
February 2014

Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC.

J Neurosci 2014 Jan;34(3):1022-7

Departments of Pathology and Medicine, University of California, San Diego, La Jolla, California 92093, CIC bioGUNE, Parque Tecnológico de Bizkaia, 48160 Derio, Spain, Institut für Molekularbiologie und Biophysik, ETH Zürich, CH-8093 Zürich, Switzerland, Institute of Laboratory Animal Science and Biomodels, University of Veterinary Medicine, 1210 Vienna, Austria, IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain, Department of Integrated Structural and Computational Biology, and Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, California 92037, UniversitätsSpital Zürich, Institute of Neuropathology, CH-8091 Zürich, Switzerland, and Department of Pathology, Immunology, and Microbiology, University of California, Davis, California 95616.

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http://dx.doi.org/10.1523/JNEUROSCI.4636-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891945PMC
January 2014

Prions and lymphoid organs: solved and remaining mysteries.

Prion 2013 Mar-Apr;7(2):157-63. Epub 2013 Jan 28.

Institute of Neuropathology, University Hospital of Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.4161/pri.23536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609124PMC
December 2013

The immunobiology of prion diseases.

Nat Rev Immunol 2013 Dec 5;13(12):888-902. Epub 2013 Nov 5.

Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland.

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http://dx.doi.org/10.1038/nri3553DOI Listing
December 2013

A template for new drugs against Alzheimer's disease.

Cell 2013 Sep;154(6):1182-4

Institute of Neuropathology, University Hospital Zurich, 8091 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2013.08.049DOI Listing
September 2013

Prions, prionoids and pathogenic proteins in Alzheimer disease.

Prion 2013 Jan-Feb;7(1):55-9. Epub 2012 Dec 3.

Department of Neurology, N. Bud Grossman Center for Memory Research and Care, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.4161/pri.23061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609051PMC
August 2013

Superresolution imaging of amyloid fibrils with binding-activated probes.

ACS Chem Neurosci 2013 Jul 22;4(7):1057-61. Epub 2013 Apr 22.

Cell Biology and Biophysics, EMBL Heidelberg, Meyerhofstrasse 1, Heidelberg, Germany.

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http://dx.doi.org/10.1021/cn400091mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715833PMC
July 2013

The crystal structure of an octapeptide repeat of the prion protein in complex with a Fab fragment of the POM2 antibody.

Protein Sci 2013 Jul 31;22(7):893-903. Epub 2013 May 31.

Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada.

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http://dx.doi.org/10.1002/pro.2270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719084PMC
July 2013

Efficient amyloid A clearance in the absence of immunoglobulins and complement factors.

Am J Pathol 2013 Apr 21;182(4):1297-307. Epub 2013 Feb 21.

Institute of Neuropathology, University Hospital of Zurich, 8091 Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.ajpath.2012.12.035DOI Listing
April 2013

Microglia: scapegoat, saboteur, or something else?

Science 2013 Jan;339(6116):156-61

Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8012 Zurich, Switzerland.

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http://dx.doi.org/10.1126/science.1227901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431634PMC
January 2013

Lymphotoxin, but not TNF, is required for prion invasion of lymph nodes.

PLoS Pathog 2012 9;8(8):e1002867. Epub 2012 Aug 9.

Institute of Neuropathology, University Hospital of Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1002867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415451PMC
December 2012

Genetic depletion of complement receptors CD21/35 prevents terminal prion disease in a mouse model of chronic wasting disease.

J Immunol 2012 Nov 21;189(9):4520-7. Epub 2012 Sep 21.

Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Prion Research Center, Fort Collins, CO 80523, USA.

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http://dx.doi.org/10.4049/jimmunol.1201579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478448PMC
November 2012

Structural studies on the folded domain of the human prion protein bound to the Fab fragment of the antibody POM1.

Acta Crystallogr D Biol Crystallogr 2012 Nov 18;68(Pt 11):1501-12. Epub 2012 Oct 18.

Department of Biochemistry, School of Translational Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton AB T6G 2H7, Canada.

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http://dx.doi.org/10.1107/S0907444912037328DOI Listing
November 2012

ZyFISH: a simple, rapid and reliable zygosity assay for transgenic mice.

PLoS One 2012 29;7(5):e37881. Epub 2012 May 29.

Department of Pathology, Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037881PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362593PMC
October 2012

Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells.

Proc Natl Acad Sci U S A 2012 Oct 15;109(44):18150-5. Epub 2012 Oct 15.

German Center for Neurodegenerative Diseases, DZNE, and Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, 72076 Tuebingen, Germany.

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http://dx.doi.org/10.1073/pnas.1210150109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497743PMC
October 2012

Multiple substitutions of methionine 129 in human prion protein reveal its importance in the amyloid fibrillation pathway.

J Biol Chem 2012 Jul 5;287(31):25975-84. Epub 2012 Jun 5.

IFM-Department of Chemistry, Linköping University, SE-581 83 Linköping, Sweden.

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http://dx.doi.org/10.1074/jbc.M112.372136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406681PMC
July 2012

Prion propagation, toxicity and degradation.

Nat Neurosci 2012 Jun 26;15(7):936-9. Epub 2012 Jun 26.

Institute of Neuropathology, University Hospital Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1038/nn.3120DOI Listing
June 2012