Adriana Aguilar-Mahecha

Segal Cancer Center, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montréal, Québec, Canada.

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December 2019

Metastatic Breast Carcinoma-Associated Fibroblasts Have Enhanced Protumorigenic Properties Related to Increased IGF2 Expression.

Authors:

Yirui Gui Adriana Aguilar-Mahecha Urszula Krzemien Abdel Hosein Marguerite Buchanan Josiane Lafleur Michael Pollak Cristiano Ferrario Mark Basik

Clin Cancer Res 2019 12 12;25(23):7229-7242. Epub 2019 Sep 12.

Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Canada.

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December 2019

Precision Medicine Tools to Guide Therapy and Monitor Response to Treatment in a HER-2+ Gastric Cancer Patient: Case Report.

Authors:

Adriana Aguilar-Mahecha Sarah Joseph Luca Cavallone Marguerite Buchanan Urszula Krzemien Gerald Batist Mark Basik

Front Oncol 2019 6;9:698. Epub 2019 Aug 6.

Department of Oncology, Lady Davis Institute, McGill University, Montreal, QC, Canada.

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August 2019

Identification of a Radiosensitivity Molecular Signature Induced by Enzalutamide in Hormone-sensitive and Hormone-resistant Prostate Cancer Cells.

Authors:

Maryam Ghashghaei Tamim M Niazi Adriana Aguilar-Mahecha Kathleen Oros Klein Celia M T Greenwood Mark Basik Thierry M Muanza

Sci Rep 2019 06 20;9(1):8838. Epub 2019 Jun 20.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.

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June 2019

An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy.

Authors:

Cedric Darini Nour Ghaddar Catherine Chabot Gloria Assaker Siham Sabri Shuo Wang Jothilatha Krishnamoorthy Marguerite Buchanan Adriana Aguilar-Mahecha Bassam Abdulkarim Jean Deschenes Jose Torres Josie Ursini-Siegel Mark Basik Antonis E Koromilas

Nat Commun 2019 05 13;10(1):2139. Epub 2019 May 13.

Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, QC, H3T 1E2, Canada.

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May 2019

A Study of Pre-Analytical Variables and Optimization of Extraction Method for Circulating Tumor DNA Measurements by Digital Droplet PCR.

Authors:

Luca Cavallone Mohammed Aldamry Josiane Lafleur Cathy Lan Pablo Gonzalez Ginestet Najmeh Alirezaie Cristiano Ferrario Adriana Aguilar-Mahecha Mark Basik

Cancer Epidemiol Biomarkers Prev 2019 05 1;28(5):909-916. Epub 2019 Mar 1.

Department of Oncology, Lady Davis Institute, McGill University, Montreal, Quebec, Canada.

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May 2019

Immuno-Matrix-Assisted Laser Desorption/Ionization Assays for Quantifying AKT1 and AKT2 in Breast and Colorectal Cancer Cell Lines and Tumors.

Authors:

Robert Popp Huiyan Li André LeBlanc Yassene Mohammed Adriana Aguilar-Mahecha Andrew G Chambers Cathy Lan Oliver Poetz Mark Basik Gerald Batist Christoph H Borchers

Anal Chem 2017 10 20;89(19):10592-10600. Epub 2017 Sep 20.

University of Victoria Genome British Columbia Proteomics Centre, University of Victoria , Victoria, British Columbia V8Z 7X8, Canada.

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October 2017

The identification of challenges in tissue collection for biomarker studies: the Q-CROC-03 neoadjuvant breast cancer translational trial experience.

Authors:

Adriana Aguilar-Mahecha Josiane Lafleur Manuela Pelmus Carole Seguin Cathy Lan Federico Discepola Bojan Kovacina Rosa Christodoulopoulos Ombretta Salvucci Catalin Mihalcioiu Josée-Anne Roy André Robidoux Elizabeth A Marcus Gerald Batist Mark Basik

Mod Pathol 2017 11 28;30(11):1567-1576. Epub 2017 Jul 28.

Department of Oncology, Lady Davis Institute, McGill University, Montreal, QC, Canada.

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November 2017

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer.

Authors:

Fanny Dupuy Sébastien Tabariès Sylvia Andrzejewski Zhifeng Dong Julianna Blagih Matthew G Annis Atilla Omeroglu Dongxia Gao Samuel Leung Eitan Amir Mark Clemons Adriana Aguilar-Mahecha Mark Basik Emma E Vincent Julie St-Pierre Russell G Jones Peter M Siegel

Cell Metab 2015 Oct 10;22(4):577-89. Epub 2015 Sep 10.

Goodman Cancer Research Centre, McGill University, Montréal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montréal, QC H3A 1A3, Canada; Department of Medicine, McGill University, Montréal, QC H3A 1A3, Canada. Electronic address:

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October 2015

Glycoproteomic comparison of clinical triple-negative and luminal breast tumors.

Authors:

Jennifer J Hill Tammy-Lynn Tremblay François Fauteux Jie Li Edwin Wang Adriana Aguilar-Mahecha Mark Basik Maureen O'Connor-McCourt

J Proteome Res 2015 Mar 16;14(3):1376-88. Epub 2015 Feb 16.

Human Health Therapeutics, National Research Council Canada , 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada.

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March 2015

Testing devices or experimental systems? Cancer clinical trials take the genomic turn.

Authors:

Nicole C Nelson Peter Keating Alberto Cambrosio Adriana Aguilar-Mahecha Mark Basik

Soc Sci Med 2014 Jun 12;111:74-83. Epub 2014 Apr 12.

Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Côte-Ste-Catherine, Montreal, Quebec H3T 1E2, Canada. Electronic address:

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June 2014

Biopsies: next-generation biospecimens for tailoring therapy.

Authors:

Mark Basik Adriana Aguilar-Mahecha Caroline Rousseau Zuanel Diaz Sabine Tejpar Alan Spatz Celia M T Greenwood Gerald Batist

Nat Rev Clin Oncol 2013 Aug 25;10(8):437-50. Epub 2013 Jun 25.

Department of Surgery, Jewish General Hospital, McGill University, 3755 Côte Sainte Catherine Road, Montreal, QC H3T 1E2, Canada.

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August 2013

Next-generation biobanking of metastases to enable multidimensional molecular profiling in personalized medicine.

Mod Pathol 2013 Nov 7;26(11):1413-24. Epub 2013 Jun 7.

Quebec Clinical Research Organization in Cancer, Montreal, QC, Canada.

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November 2013

Ultradense array CGH and discovery of micro-copy number alterations and gene fusions in the cancer genome.

Authors:

Ewa Przybytkowski Adriana Aguilar-Mahecha Sheida Nabavi Peter J Tonellato Mark Basik

Methods Mol Biol 2013 ;973:15-38

Department of Oncology, Lady Davis Institute, Sir Mortimer B. Davis, Jewish General Hospital, McGill University, Montreal, QC, Canada.

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July 2013

The effect of pre-analytical variability on the measurement of MRM-MS-based mid- to high-abundance plasma protein biomarkers and a panel of cytokines.

Authors:

Adriana Aguilar-Mahecha Michael A Kuzyk Dominik Domanski Christoph H Borchers Mark Basik

PLoS One 2012 6;7(6):e38290. Epub 2012 Jun 6.

Department of Oncology, Lady Davis Institute, McGill University, Montreal, Quebec, Canada.

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November 2012

CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model.

Authors:

Saima Hassan Marguerite Buchanan Kaushar Jahan Adriana Aguilar-Mahecha Louis Gaboury William J Muller Yaqoob Alsawafi Anna A Mourskaia Peter M Siegel Ombretta Salvucci Mark Basik

Int J Cancer 2011 Jul 12;129(1):225-32. Epub 2010 Nov 12.

Department of Oncology, Lady Davis Institute, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, Canada.

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July 2011

Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent manner.

Authors:

Moutih Rafei Philippe M Campeau Adriana Aguilar-Mahecha Marguerite Buchanan Patrick Williams Elena Birman Shala Yuan Yoon Kow Young Marie-Noëlle Boivin Kathy Forner Mark Basik Jacques Galipeau

J Immunol 2009 May;182(10):5994-6002

Montreal Center for Experimental Therapeutics in Cancer, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada.

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May 2009

Development of reverse phase protein microarrays for the validation of clusterin, a mid-abundant blood biomarker.

Authors:

Adriana Aguilar-Mahecha Christiane Cantin Maureen O'Connor-McCourt Andre Nantel Mark Basik

Proteome Sci 2009 Apr 6;7:15. Epub 2009 Apr 6.

Lady Davis Institute for Biomedical Research, Department of Oncology, Montréal, Québec, H3T 1E2, Canada.

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April 2009

Both t-Darpp and DARPP-32 can cause resistance to trastuzumab in breast cancer cells and are frequently expressed in primary breast cancers.

Authors:

Sophie Hamel Amélie Bouchard Cristiano Ferrario Saima Hassan Adriana Aguilar-Mahecha Marguerite Buchanan Louise Quenneville Wilson Miller Mark Basik

Breast Cancer Res Treat 2010 Feb 20;120(1):47-57. Epub 2009 Mar 20.

Department of Oncology and Surgery, Segal Cancer Center, Sir Mortimer B. Davis Jewish General Hospital, 3755 Cote Ste Catherine, Montreal, QC, H3T 1E2, Canada.

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February 2010

Microarrays as validation strategies in clinical samples: tissue and protein microarrays.

Authors:

Adriana Aguilar-Mahecha Saima Hassan Cristiano Ferrario Mark Basik

OMICS 2006 ;10(3):311-26

Montreal Center for Experimental Therapeutics in Cancer, Lady Davis Institute for Medical Research, The Sir Mortimer B. Davis-Jewish General Hospital, and Department of Oncology, McGill University and Surgery, Montreal, Canada.

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December 2006