Adrian R Krainer

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Adrian R Krainer

Publications by authors named "Adrian R Krainer"

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100Publications

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Mechanism of Nonsense-Mediated mRNA Decay Stimulation by Splicing Factor SRSF1.

Cell Rep 2018 May;23(7):2186-2198

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. Electronic address:

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May 2018

Downregulation of Survivin contributes to cell-cycle arrest during postnatal cardiac development in a severe spinal muscular atrophy mouse model.

Hum Mol Genet 2018 Feb;27(3):486-498

Jiangsu Key Laboratory of Neuropsychiatric Diseases, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China.

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February 2018

A human-specific switch of alternatively spliced isoforms contributes to mutations and tumor recurrence in hepatocellular carcinoma.

Genome Res 2018 Feb 15. Epub 2018 Feb 15.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

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February 2018

A-44G transition in SMN2 intron 6 protects patients with spinal muscular atrophy.

Hum Mol Genet 2017 07;26(14):2768-2780

Department of Pathology, Ohio State University, Columbus, OH 43210, USA.

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July 2017

Splicing-factor alterations in cancers.

RNA 2016 09;22(9):1285-301

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

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September 2016

A Broad Set of Chromatin Factors Influences Splicing.

PLoS Genet 2016 Sep 23;12(9):e1006318. Epub 2016 Sep 23.

Institut Pasteur, Unit of Epigenetic regulation, Paris, France.

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September 2016

Global identification of hnRNP A1 binding sites for SSO-based splicing modulation.

BMC Biol 2016 07 5;14:54. Epub 2016 Jul 5.

Department of Biochemistry and Molecular Biology and The Villum Center for Bioanalytical Sciences, University of Southern Denmark, Campusvej 55, DK-5230, Odense M, Denmark.

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July 2016

Antisense oligonucleotide-directed inhibition of nonsense-mediated mRNA decay.

Nat Biotechnol 2016 Feb 14;34(2):164-6. Epub 2015 Dec 14.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.

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February 2016

Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss.

Genes Dev 2016 Jan 23;30(1):34-51. Epub 2015 Dec 23.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA; Molecular and Cellular Biology Program, Stony Brook University, Stony Brook, New York 11790, USA;

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January 2016

SRSF1-Regulated Alternative Splicing in Breast Cancer.

Mol Cell 2015 Oct;60(1):105-17

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. Electronic address:

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October 2015

The spliceosome, a potential Achilles heel of MYC-driven tumors.

Genome Med 2015 Oct 22;7:107. Epub 2015 Oct 22.

Cold Spring Harbor Laboratory, Bungtown Road, Cold Spring Harbor, NY, 11724, USA.

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October 2015

CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function.

Cell 2015 Aug;162(4):900-10

Center for Comparative Biomedicine, MOE Key Laboratory of Systems Biomedicine, Institute of Systems Biomedicine, Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao Tong University (SJTU), Shanghai 200240, China; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, SJTU, Shanghai 200240, China; Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (MOE), Bio-X Center, School of Life Sciences and Biotechnology, SJTU, Shanghai 200240, China. Electronic address:

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August 2015

Splicing: still so much to learn.

Authors:
Adrian R Krainer

RNA 2015 Apr;21(4):500-1

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA

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April 2015

Motor neuron cell-nonautonomous rescue of spinal muscular atrophy phenotypes in mild and severe transgenic mouse models.

Genes Dev 2015 Feb 12;29(3):288-97. Epub 2015 Jan 12.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA;

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February 2015

RNA splicing. The human splicing code reveals new insights into the genetic determinants of disease.

Science 2015 Jan 18;347(6218):1254806. Epub 2014 Dec 18.

Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario M5S 3G4, Canada. Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada. Program on Genetic Networks and Program on Neural Computation & Adaptive Perception, Canadian Institute for Advanced Research, Toronto, Ontario M5G 1Z8, Canada. Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada. McLaughlin Centre, University of Toronto, Toronto, Ontario M5G 0A4, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada. eScience Group, Microsoft Research, Redmond, WA 98052, USA.

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January 2015

Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer.

Mol Cancer Res 2014 Sep 7;12(9):1195-204. Epub 2014 May 7.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.

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September 2014

Pharmacology of a central nervous system delivered 2'-O-methoxyethyl-modified survival of motor neuron splicing oligonucleotide in mice and nonhuman primates.

J Pharmacol Exp Ther 2014 Jul 30;350(1):46-55. Epub 2014 Apr 30.

Isis Pharmaceuticals, Carlsbad, California (F.R., S.J.C., D.A.N., G.H., S.L., J.M., R.A.F., H.G., J.S.G., S.P.H., C.F.B.); and Cold Spring Harbor Laboratory, Cold Spring Harbor, New York (Y.H., A.R.K.).

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July 2014

HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism.

Cell Rep 2014 Mar 6;6(6):1139-1152. Epub 2014 Mar 6.

Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA. Electronic address:

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March 2014

Splicing factor SRSF6 promotes hyperplasia of sensitized skin.

Nat Struct Mol Biol 2014 Feb 19;21(2):189-97. Epub 2014 Jan 19.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.

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February 2014

Isolated pseudo-RNA-recognition motifs of SR proteins can regulate splicing using a noncanonical mode of RNA recognition.

Proc Natl Acad Sci U S A 2013 Jul 8;110(30):E2802-11. Epub 2013 Jul 8.

Institute for Molecular Biology and Biophysics, Swiss Federal Institute of Technology, 8093 Zurich, Switzerland.

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July 2013

OLego: fast and sensitive mapping of spliced mRNA-Seq reads using small seeds.

Nucleic Acids Res 2013 May 9;41(10):5149-63. Epub 2013 Apr 9.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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May 2013

Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence.

Mol Cell 2013 Apr 7;50(1):56-66. Epub 2013 Mar 7.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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April 2013

Pick one, but be quick: 5' splice sites and the problems of too many choices.

Genes Dev 2013 Jan;27(2):129-44

School of Biological Sciences, Division of Molecular Genetics and Cell Biology, Nanyang Technological University, Singapore.

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January 2013

Antisense-based therapy for the treatment of spinal muscular atrophy.

J Cell Biol 2012 Oct;199(1):21-5

Isis Pharmaceuticals, Carlsbad, CA 92010, USA.

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October 2012

Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides.

Open Biol 2012 Oct;2(10):120133

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724 , USA; Watson School of Biological Sciences, Cold Spring Harbor, NY 11724, USA.

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October 2012

Antisense-mediated exon inclusion.

Methods Mol Biol 2012 ;867:307-23

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.

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July 2012

A generalizable pre-clinical research approach for orphan disease therapy.

Orphanet J Rare Dis 2012 Jun 15;7:39. Epub 2012 Jun 15.

Children's Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, ON, Canada.

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June 2012

Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons.

J Mol Cell Biol 2012 Apr 1;4(2):79-87. Epub 2011 Nov 1.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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April 2012

Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing.

Nat Chem Biol 2012 Apr 15;8(6):555-61. Epub 2012 Apr 15.

Isis Pharmaceuticals, Carlsbad, California, USA.

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April 2012

Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2.

RNA 2012 Feb 19;18(2):274-83. Epub 2011 Dec 19.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

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February 2012

Oncogenic splicing factor SRSF1 is a critical transcriptional target of MYC.

Cell Rep 2012 Feb;1(2):110-7

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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February 2012

The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation.

Nat Struct Mol Biol 2012 Jan 15;19(2):220-8. Epub 2012 Jan 15.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.

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January 2012

RNA therapeutics: beyond RNA interference and antisense oligonucleotides.

Nat Rev Drug Discov 2012 Jan 20;11(2):125-40. Epub 2012 Jan 20.

AVI BioPharma, 3450 Monte Villa Parkway, Bothell, Washington 98021, USA.

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January 2012

SpliceTrap: a method to quantify alternative splicing under single cellular conditions.

Bioinformatics 2011 Nov 6;27(21):3010-6. Epub 2011 Sep 6.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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November 2011

Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model.

Nature 2011 Oct 5;478(7367):123-6. Epub 2011 Oct 5.

Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, New York 11724, USA.

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October 2011

A mutation in a rare type of intron in a sodium-channel gene results in aberrant splicing and causes myotonia.

Hum Mutat 2011 Jul 28;32(7):773-82. Epub 2011 Apr 28.

Department of Neurology, Osaka University Graduate School of Medicine, 2-2 Yamadaoaka, Suita, Osaka, Japan.

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July 2011

Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly.

Proc Natl Acad Sci U S A 2011 May 2;108(20):8233-8. Epub 2011 May 2.

Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093, USA.

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May 2011

Alternative splicing of SLC39A14 in colorectal cancer is regulated by the Wnt pathway.

Mol Cell Proteomics 2011 Jan 11;10(1):M110.002998. Epub 2010 Oct 11.

Department of Molecular Medicine, Aarhus University Hospital, Skejby, DK-8200 Aarhus N, Denmark.

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January 2011

Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model.

Genes Dev 2010 Aug 12;24(15):1634-44. Epub 2010 Jul 12.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

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August 2010

Arginine methylation controls the subcellular localization and functions of the oncoprotein splicing factor SF2/ASF.

Mol Cell Biol 2010 Jun 22;30(11):2762-74. Epub 2010 Mar 22.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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June 2010

A splicing-independent function of SF2/ASF in microRNA processing.

Mol Cell 2010 Apr;38(1):67-77

Department of Cell Biology, Duke University Medical Center, Durham, NC 27708, USA.

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April 2010

SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control.

Nat Struct Mol Biol 2010 Mar 7;17(3):306-12. Epub 2010 Feb 7.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.

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March 2010

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism.

Proc Natl Acad Sci U S A 2010 Feb 19;107(5):1894-9. Epub 2010 Jan 19.

Division of Signal Transduction, Department of Systems Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

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February 2010

Cooperative-binding and splicing-repressive properties of hnRNP A1.

Mol Cell Biol 2009 Oct 10;29(20):5620-31. Epub 2009 Aug 10.

Cold Spring Harbor Laboratory, P.O. Box 100, Cold Spring Harbor, NY 11724, USA.

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October 2009

A positive modifier of spinal muscular atrophy in the SMN2 gene.

Am J Hum Genet 2009 Sep 27;85(3):408-13. Epub 2009 Aug 27.

Department of Pathology, Ohio State University, Columbus, OH 43210, USA.

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September 2009

Splicing therapeutics in SMN2 and APOB.

Curr Opin Mol Ther 2009 Apr;11(2):108-15

University College London Medical School, Department of Endocrinology, Hampstead Campus, London, UK.

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April 2009

A splicing component adapted to gene silencing.

Nat Biotechnol 2009 Mar;27(3):250-1

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March 2009

Recognition of atypical 5' splice sites by shifted base-pairing to U1 snRNA.

Nat Struct Mol Biol 2009 Feb 25;16(2):176-82. Epub 2009 Jan 25.

Cold Spring Harbor Laboratory, PO Box 100, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.

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February 2009

The splicing-factor oncoprotein SF2/ASF activates mTORC1.

Proc Natl Acad Sci U S A 2008 Oct 1;105(40):15323-7. Epub 2008 Oct 1.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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October 2008

Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2.

Genes Dev 2008 Sep;22(18):2550-63

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

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September 2008

Where in the cell is the minor spliceosome?

Proc Natl Acad Sci U S A 2008 Jun 17;105(25):8485-6. Epub 2008 Jun 17.

Yale University and Howard Hughes Medical Institute, New Haven, CT 06536, USA.

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June 2008

Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice.

Am J Hum Genet 2008 Apr 27;82(4):834-48. Epub 2008 Mar 27.

Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, NY 11724, USA.

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April 2008

RNA landscape of evolution for optimal exon and intron discrimination.

Proc Natl Acad Sci U S A 2008 Apr 7;105(15):5797-802. Epub 2008 Apr 7.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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April 2008

Kaposi's sarcoma-associated herpesvirus ORF57 functions as a viral splicing factor and promotes expression of intron-containing viral lytic genes in spliceosome-mediated RNA splicing.

J Virol 2008 Mar 9;82(6):2792-801. Epub 2008 Jan 9.

HIV and AIDS Malignancy Branch, Center for Cancer Research, NCI/NIH, 10 Center Dr., Rm. 6N106, MSC-1868, Bethesda, MD 20892-1868, USA.

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March 2008

Identification of synaptic targets of Drosophila pumilio.

PLoS Comput Biol 2008 Feb 29;4(2):e1000026. Epub 2008 Feb 29.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.

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February 2008

Evolutionary impact of limited splicing fidelity in mammalian genes.

Trends Genet 2007 Oct 24;23(10):484-8. Epub 2007 Aug 24.

Cold Spring Harbor Laboratory, NY 11724, USA.

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October 2007

Deletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing.

PLoS One 2007 Sep 5;2(9):e854. Epub 2007 Sep 5.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America.

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September 2007

Dual-specificity splice sites function alternatively as 5' and 3' splice sites.

Proc Natl Acad Sci U S A 2007 Sep 11;104(38):15028-33. Epub 2007 Sep 11.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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September 2007

Aberrant 5' splice sites in human disease genes: mutation pattern, nucleotide structure and comparison of computational tools that predict their utilization.

Nucleic Acids Res 2007 18;35(13):4250-63. Epub 2007 Jun 18.

International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34012 Trieste, Italy.

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August 2007

The pathology of pre-mRNA splicing: a meeting in the Italian Alps. Workshop on pre-mRNA processing and disease.

EMBO Rep 2007 Aug 13;8(8):730-4. Epub 2007 Jul 13.

MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK.

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August 2007

Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1.

Nat Struct Mol Biol 2007 Jul 17;14(7):630-8. Epub 2007 Jun 17.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.

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July 2007

Splicing remodels messenger ribonucleoprotein architecture via eIF4A3-dependent and -independent recruitment of exon junction complex components.

Proc Natl Acad Sci U S A 2007 Jul 2;104(28):11574-9. Epub 2007 Jul 2.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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July 2007

Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF(65).

PLoS One 2007 Jun 20;2(6):e538. Epub 2007 Jun 20.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America.

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June 2007

SR proteins function in coupling RNAP II transcription to pre-mRNA splicing.

Mol Cell 2007 Jun;26(6):867-81

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

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June 2007

Enhancement of SMN2 exon 7 inclusion by antisense oligonucleotides targeting the exon.

PLoS Biol 2007 Apr;5(4):e73

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America.

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April 2007

The gene encoding the splicing factor SF2/ASF is a proto-oncogene.

Nat Struct Mol Biol 2007 Mar 18;14(3):185-93. Epub 2007 Feb 18.

Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, New York 11724, USA.

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March 2007

Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB.

BMC Mol Biol 2007 Jan 17;8. Epub 2007 Jan 17.

Endocrinology, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

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January 2007

A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B.

J Cell Biol 2006 Nov 30;175(3):389-400. Epub 2006 Oct 30.

Nuclear Function and Dynamics Unit, Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

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November 2006

Comprehensive splice-site analysis using comparative genomics.

Nucleic Acids Res 2006 12;34(14):3955-67. Epub 2006 Aug 12.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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September 2006

An increased specificity score matrix for the prediction of SF2/ASF-specific exonic splicing enhancers.

Hum Mol Genet 2006 Aug 6;15(16):2490-508. Epub 2006 Jul 6.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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August 2006

hnRNP A1 associates with telomere ends and stimulates telomerase activity.

RNA 2006 Jun 7;12(6):1116-28. Epub 2006 Apr 7.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

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June 2006

Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2.

Am J Hum Genet 2006 Jan 16;78(1):63-77. Epub 2005 Nov 16.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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January 2006

The switch in alternative splicing of cyclic AMP-response element modulator protein CREM{tau}2{alpha} (activator) to CREM{alpha} (repressor) in human myometrial cells is mediated by SRp40.

J Biol Chem 2005 Oct 15;280(41):34521-9. Epub 2005 Aug 15.

School of Surgical and Reproductive Sciences, 3rd Floor, William Leech Building, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom.

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October 2005

Distribution of SR protein exonic splicing enhancer motifs in human protein-coding genes.

Nucleic Acids Res 2005 7;33(16):5053-62. Epub 2005 Sep 7.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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September 2005

Determinants of the inherent strength of human 5' splice sites.

RNA 2005 May;11(5):683-98

Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, NY 11724, USA.

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May 2005

Regulation of heterogenous nuclear ribonucleoprotein A1 transport by phosphorylation in cells stressed by osmotic shock.

Proc Natl Acad Sci U S A 2005 Mar 28;102(10):3605-10. Epub 2005 Feb 28.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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March 2005

Functional significance of a deep intronic mutation in the ATM gene and evidence for an alternative exon 28a.

Hum Mutat 2005 Feb;25(2):118-24

Department of Pathology and Laboratory Medicine, The David Geffen School of Medicine, University of California, Los Angeles 90095-1732, USA.

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February 2005

An LKB1 AT-AC intron mutation causes Peutz-Jeghers syndrome via splicing at noncanonical cryptic splice sites.

Nat Struct Mol Biol 2005 Jan 19;12(1):54-9. Epub 2004 Dec 19.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.

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January 2005

Involvement of SR proteins in mRNA surveillance.

Mol Cell 2004 Nov;16(4):597-607

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

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November 2004

Manipulation of alternative splicing by a newly developed inhibitor of Clks.

J Biol Chem 2004 Jun 8;279(23):24246-54. Epub 2004 Mar 8.

Laboratory of Gene Expression, School of Biomedical Science, Department of Functional Genomics, Medical Research Institute, Tokyo Medical & Dental University, Japan.

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June 2004