Adrian P Mander

Adrian P Mander

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Adrian P Mander

Adrian P Mander

Publications by authors named "Adrian P Mander"

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Sample size re-estimation in crossover trials: application to the AIM HY-INFORM study.

Trials 2019 Dec 2;20(1):665. Epub 2019 Dec 2.

Medical Research Council Biostatistics Unit, University of Cambridge, School of Clinical Medicine, Forvie Site, Robinson Way, Cambridge, CB2 0SR, UK.

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http://dx.doi.org/10.1186/s13063-019-3724-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889633PMC
December 2019

Designing and evaluating dose-escalation studies made easy: The MoDEsT web app.

Clin Trials 2019 Dec 19:1740774519890146. Epub 2019 Dec 19.

Department of Mathematics & Statistics, Lancaster University, Lancaster, UK.

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http://dx.doi.org/10.1177/1740774519890146DOI Listing
December 2019

Admissible multiarm stepped-wedge cluster randomized trial designs.

Stat Med 2019 Mar 6;38(7):1103-1119. Epub 2018 Nov 6.

Hub for Trials Methodology Research, MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.

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http://doi.wiley.com/10.1002/sim.8022
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http://dx.doi.org/10.1002/sim.8022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491976PMC
March 2019

A Bayesian model-free approach to combination therapy phase I trials using censored time-to-toxicity data.

J R Stat Soc Ser C Appl Stat 2019 Feb 22;68(2):309-329. Epub 2018 Nov 22.

MRC Biostatistics Unit Hub for Trials Methodology Research, University of Cambridge, UK.

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http://dx.doi.org/10.1111/rssc.12323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420054PMC
February 2019

How to design a dose-finding study using the continual reassessment method.

BMC Med Res Methodol 2019 01 18;19(1):18. Epub 2019 Jan 18.

MRC Biostatistics Unit Hub for Trials Methodology Research, University of Cambridge, Cambridge Institute of Public Health, Forvie Site, Robinson Way, Cambridge Biomedical Campus, Cambridge, CB2 0SR, UK.

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https://bmcmedresmethodol.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12874-018-0638-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339349PMC
January 2019

Re-formulating Gehan's design as a flexible two-stage single-arm trial.

BMC Med Res Methodol 2019 01 28;19(1):22. Epub 2019 Jan 28.

MRC Biostatistics Unit, University of Cambridge, Cambridge, CB2 0SR, UK.

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http://dx.doi.org/10.1186/s12874-019-0659-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350340PMC
January 2019

Group sequential crossover trial designs with strong control of the familywise error rate.

Seq Anal 2018 2;37(2):174-203. Epub 2018 Oct 2.

Hub for Trials Methodology Research, MRC Biostatistics Unit, Cambridge, UK.

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https://www.tandfonline.com/doi/full/10.1080/07474946.2018.1
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http://dx.doi.org/10.1080/07474946.2018.1466528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199128PMC
October 2018

Frequent Monitoring of C-Peptide Levels in Newly Diagnosed Type 1 Subjects Using Dried Blood Spots Collected at Home.

J Clin Endocrinol Metab 2018 09;103(9):3350-3358

University of Cambridge, Department of Paediatrics, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom.

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http://dx.doi.org/10.1210/jc.2018-00500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126892PMC
September 2018

Blinded and unblinded sample size reestimation in crossover trials balanced for period.

Biom J 2018 09 3;60(5):917-933. Epub 2018 Aug 3.

MRC Biostatistics Unit, Cambridge Institute of Public Health, Forvie Site, Robinson Way, Cambridge, UK.

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http://dx.doi.org/10.1002/bimj.201700092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175184PMC
September 2018

Blinded and unblinded sample size reestimation procedures for stepped-wedge cluster randomized trials.

Biom J 2018 09 3;60(5):903-916. Epub 2018 Aug 3.

MRC Biostatistics Unit, Cambridge Institute of Public Health, Forvie Site, Robinson Way, Cambridge Biomedical Campus, Cambridge, UK.

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http://dx.doi.org/10.1002/bimj.201700125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175439PMC
September 2018

An optimised multi-arm multi-stage clinical trial design for unknown variance.

Contemp Clin Trials 2018 04 21;67:116-120. Epub 2018 Feb 21.

Hub for Trials Methodology Research, MRC Biostatistics Unit, Cambridge, UK.

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http://dx.doi.org/10.1016/j.cct.2018.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886309PMC
April 2018

Group sequential designs for stepped-wedge cluster randomised trials.

Clin Trials 2017 Oct 27;14(5):507-517. Epub 2017 Jun 27.

MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge Institute of Public Health, Cambridge, UK.

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http://dx.doi.org/10.1177/1740774517716937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632563PMC
October 2017

AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials.

PLoS One 2016 12;11(7):e0159026. Epub 2016 Jul 12.

MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge Institute of Public Health, Cambridge, United Kingdom.

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https://www.repository.cam.ac.uk/bitstream/handle/1810/25694
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http://dx.plos.org/10.1371/journal.pone.0159026
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0159026PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942070PMC
July 2017

Toxicity-dependent feasibility bounds for the escalation with overdose control approach in phase I cancer trials.

Stat Med 2017 Jul 15;36(16):2499-2513. Epub 2017 Mar 15.

MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge Institute of Public Health, Cambridge, U.K.

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http://dx.doi.org/10.1002/sim.7280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462100PMC
July 2017

Modelling semi-attributable toxicity in dual-agent phase I trials with non-concurrent drug administration.

Stat Med 2017 01 19;36(2):225-241. Epub 2016 Feb 19.

Department of Biostatistics, Mailman School of Public Health, Columbia University, 722 West 168th Street, New York, NY 10032, U.S.A.

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http://doi.wiley.com/10.1002/sim.6912
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http://dx.doi.org/10.1002/sim.6912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157785PMC
January 2017

Stepped wedge cluster randomized controlled trial designs: a review of reporting quality and design features.

Trials 2017 01 21;18(1):33. Epub 2017 Jan 21.

MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge Institute of Public Health, University Forvie Site, Robinson Way, Cambridge, CB2 0SR, UK.

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http://dx.doi.org/10.1186/s13063-017-1783-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5251280PMC
January 2017

Do single-arm trials have a role in drug development plans incorporating randomised trials?

Pharm Stat 2016 Mar-Apr;15(2):143-51. Epub 2015 Nov 26.

MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge, UK.

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http://dx.doi.org/10.1002/pst.1726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855632PMC
December 2016

Assessment of cognitive safety in clinical drug development.

Drug Discov Today 2016 Mar 22;21(3):445-53. Epub 2015 Nov 22.

Department of Psychiatry, University of Cambridge, Cambridge, UK; Cambridge Cognition Limited, Bottisham, Cambridge, UK.

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http://dx.doi.org/10.1016/j.drudis.2015.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863933PMC
March 2016

The choice of test in phase II cancer trials assessing continuous tumour shrinkage when complete responses are expected.

Stat Methods Med Res 2015 Dec 16;24(6):909-19. Epub 2011 Dec 16.

Hub for Trials Methodology Research, MRC Biostatistics Unit, Cambridge, UK.

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http://dx.doi.org/10.1177/0962280211432192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668774PMC
December 2015

Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study.

BMJ Open 2015 Dec 8;5(12):e009799. Epub 2015 Dec 8.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1136/bmjopen-2015-009799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679899PMC
December 2015

A Bayesian adaptive design for biomarker trials with linked treatments.

Br J Cancer 2015 Sep 11;113(5):699-705. Epub 2015 Aug 11.

MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge, UK.

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http://dx.doi.org/10.1038/bjc.2015.278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559835PMC
September 2015

Escalation strategies for combination therapy Phase I trials.

Pharm Stat 2012 May-Jun;11(3):258-66. Epub 2012 Mar 12.

MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, Cambridgeshire, UK.

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http://dx.doi.org/10.1002/pst.1497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573644PMC
July 2015

A product of independent beta probabilities dose escalation design for dual-agent phase I trials.

Stat Med 2015 Apr 29;34(8):1261-76. Epub 2015 Jan 29.

MRC Biostatistics Unit Hub for Trials Methodology Research, Institute of Public Health, University Forvie Site, Cambridge, CB2 0SR, U.K.

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http://dx.doi.org/10.1002/sim.6434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409822PMC
April 2015

Correcting for multiple-testing in multi-arm trials: is it necessary and is it done?

Trials 2014 Sep 17;15:364. Epub 2014 Sep 17.

MRC Biostatistics Unit Hub for Trials Methodology Research, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, UK.

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http://trialsjournal.biomedcentral.com/articles/10.1186/1745
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http://dx.doi.org/10.1186/1745-6215-15-364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177585PMC
September 2014

How to use published complete case results from weight loss studies in a missing data sensitivity analysis.

Obesity (Silver Spring) 2014 Apr 5;22(4):996-1001. Epub 2013 Dec 5.

MRC Biostatistics Unit, Cambridge, UK.

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http://dx.doi.org/10.1002/oby.20635DOI Listing
April 2014

Age and sex differences in the incorporation of EPA and DHA into plasma fractions, cells and adipose tissue in humans.

Br J Nutr 2014 Feb 24;111(4):679-89. Epub 2013 Sep 24.

Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Woodstock Road, Oxford OX2 6GG, UK.

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http://dx.doi.org/10.1017/S0007114513002985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351921PMC
February 2014

Genetic predisposition to an adverse lipid profile limits the improvement in total cholesterol in response to weight loss.

Obesity (Silver Spring) 2013 Dec 29;21(12):2589-95. Epub 2013 May 29.

MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK.

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http://doi.wiley.com/10.1002/oby.20328
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http://dx.doi.org/10.1002/oby.20328DOI Listing
December 2013

Adaptive designs for dual-agent phase I dose-escalation studies.

Nat Rev Clin Oncol 2013 May 19;10(5):277-88. Epub 2013 Mar 19.

Department of Oncology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1038/nrclinonc.2013.35DOI Listing
May 2013

Minimizing the maximum expected sample size in two-stage Phase II clinical trials with continuous outcomes.

J Biopharm Stat 2012 ;22(4):836-52

MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge, United Kingdom.

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http://www.tandfonline.com/doi/abs/10.1080/10543406.2010.528
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http://dx.doi.org/10.1080/10543406.2010.528104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662082PMC
October 2012

Admissible two-stage designs for phase II cancer clinical trials that incorporate the expected sample size under the alternative hypothesis.

Pharm Stat 2012 Mar-Apr;11(2):91-6. Epub 2012 Jan 10.

MRC Biostatistics Unit Hub in Trials Methodology Research, Institute of Public Health, University Forvie Site, Cambridge CB2 0SR, UK.

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http://doi.wiley.com/10.1002/pst.501
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http://dx.doi.org/10.1002/pst.501DOI Listing
July 2012

Optimal multistage designs for randomised clinical trials with continuous outcomes.

Stat Med 2012 Feb 5;31(4):301-12. Epub 2011 Dec 5.

Hub for Trials Methodology Research, MRC Biostatistics Unit, Cambridge, UK.

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http://dx.doi.org/10.1002/sim.4421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499690PMC
February 2012

Reducing sample sizes in two-stage phase II cancer trials by using continuous tumour shrinkage end-points.

Eur J Cancer 2011 May 14;47(7):983-9. Epub 2011 Jan 14.

MRC Biostatistics Unit, Hub for Trials Methodology Research, Cambridge, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S09598049100118
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http://dx.doi.org/10.1016/j.ejca.2010.12.007DOI Listing
May 2011

A phase 2 study of vatalanib in metastatic melanoma patients.

Eur J Cancer 2010 Oct 25;46(15):2671-3. Epub 2010 Aug 25.

Cambridge University Hospitals NHS Foundation Trust (Addenbrookes Hospital), Cambridge, UK.

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http://dx.doi.org/10.1016/j.ejca.2010.07.014DOI Listing
October 2010

Energy-dense, low-fiber, high-fat dietary pattern is associated with increased fatness in childhood.

Am J Clin Nutr 2008 Apr;87(4):846-54

Medical Research Council Human Nutrition Research, Cambridge, United Kingdom.

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http://dx.doi.org/10.1093/ajcn/87.4.846DOI Listing
April 2008

Is sugar-sweetened beverage consumption associated with increased fatness in children?

Nutrition 2007 Jul-Aug;23(7-8):557-63

MRC Human Nutrition Research, Cambridge, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S089990070700151
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http://dx.doi.org/10.1016/j.nut.2007.05.005DOI Listing
September 2007

Use of stable-isotope techniques to validate infant feeding practices reported by Bangladeshi women receiving breastfeeding counseling.

Am J Clin Nutr 2007 Apr;85(4):1075-82

MRC International Nutrition Group, Nutrition & Public Health Interventions Research Unit, London School of Hygiene & Tropical Medicine, London, United Kingdom.

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http://dx.doi.org/10.1093/ajcn/85.4.1075DOI Listing
April 2007