Adrian M Dubuc

Adrian M Dubuc

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Adrian M Dubuc

Adrian M Dubuc

Publications by authors named "Adrian M Dubuc"

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Molecular characterization of localized pleural mesothelioma.

Mod Pathol 2019 Aug 1. Epub 2019 Aug 1.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41379-019-0330-9DOI Listing
August 2019

Characterization of molecular signatures of supratentorial ependymomas.

Mod Pathol 2019 Aug 2. Epub 2019 Aug 2.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41379-019-0329-2DOI Listing
August 2019

ZMYM2-FGFR1 fusion as secondary change in acute myeloid leukemia.

Leuk Lymphoma 2019 02 30;60(2):556-558. Epub 2018 Aug 30.

a Department of Pathology, Brigham and Women's Hospital , Harvard Medical School , Boston ( MA) , USA.

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https://www.tandfonline.com/doi/full/10.1080/10428194.2018.1
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http://dx.doi.org/10.1080/10428194.2018.1493733DOI Listing
February 2019

Nuclear CRX and FOXJ1 Expression Differentiates Non-Germ Cell Pineal Region Tumors and Supports the Ependymal Differentiation of Papillary Tumor of the Pineal Region.

Am J Surg Pathol 2017 Oct;41(10):1410-1421

*Department of Pathology, Brigham and Women's Hospital, Harvard Medical School ‡Department of Pathology, Boston Children's Hospital, Harvard Medical School Departments of §Medical Oncology ¶Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA †Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO ∥East Pathology and Neuropathology Center, East Hospital Group, University Hospital of Lyon Bron, France.

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http://dx.doi.org/10.1097/PAS.0000000000000903DOI Listing
October 2017

Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors.

Neuro Oncol 2017 Jul;19(7):986-996

Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Department of Pathology, Department of Radiology, Department of Neurosurgery, Boston Children's Hospital, Boston, Massachusetts; Department of Medical Oncology, Oncologic Pathology, Department of Pediatric Oncology, Department of Cancer Biology, Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts; Department of Pathology, Department of Neurosurgery, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Pratiti Bandopadhayay, Broad Institute of MIT and Harvard, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/now294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570190PMC
July 2017

The current state of clinical interpretation of sequence variants.

Curr Opin Genet Dev 2017 Feb 31;42:33-39. Epub 2017 Jan 31.

Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine, 65 Landsdowne Str., Cambridge, MA 02115 USA; Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Str., Boston, MA 02115 USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0959437X173000
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http://dx.doi.org/10.1016/j.gde.2017.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446800PMC
February 2017

Reporting of Diagnostic Cytogenetic Results.

Curr Protoc Hum Genet 2016 Apr 1;89:A.1D.1-A.1D.23. Epub 2016 Apr 1.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/0471142905.hg01ds89DOI Listing
April 2016

Somatic cell transfer of c-Myc and Bcl-2 induces large-cell anaplastic medulloblastomas in mice.

J Neurooncol 2016 Feb 30;126(3):415-24. Epub 2015 Oct 30.

Department of Neurosurgery and Huntsman Cancer Institute, University of Utah School of Medicine, 175 North Medical Drive East, Salt Lake City, UT, 84132, USA.

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http://dx.doi.org/10.1007/s11060-015-1985-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733589PMC
February 2016

Integrated Genomic Characterization of a Pineal Parenchymal Tumor of Intermediate Differentiation.

World Neurosurg 2016 Jan 28;85:96-105. Epub 2015 Jul 28.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.wneu.2015.07.032DOI Listing
January 2016

Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma.

Cancer Res 2015 Jan 12;75(1):134-46. Epub 2014 Nov 12.

Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Canada. Division of Neurosurgery, Hospital for Sick Children, Toronto, Canada. Department of Surgery, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-3629DOI Listing
January 2015

Cytogenetic prognostication within medulloblastoma subgroups.

J Clin Oncol 2014 Mar 3;32(9):886-96. Epub 2014 Feb 3.

David J.H. Shih, Marc Remke, Vijay Ramaswamy, Betty Luu, Yuan Yao, Xin Wang, Adrian M. Dubuc, Livia Garzia, John Peacock, Stephen C. Mack, Xiaochong Wu, Adi Rolider, A. Sorana Morrissy, Florence M.G. Cavalli, Claudia C. Faria, Stephen W. Scherer, Uri Tabori, Cynthia E. Hawkins, David Malkin, Eric Bouffet, James T. Rutka, and Michael D. Taylor, Hospital for Sick Children; David J.H. Shih, Marc Remke, Vijay Ramaswamy, Yuan Yao, Xin Wang, Adrian M. Dubuc, John Peacock, Stephen C. Mack, and Michael D. Taylor, University of Toronto, Toronto; Boleslaw Lach, McMaster University, Hamilton, Ontario; Jennifer A. Chan, University of Calgary, Calgary, Alberta; Steffen Albrecht, Adam Fontebasso, and Nada Jabado, McGill University, Montreal, Quebec, Canada; Paul A. Northcott, Andrey Korshunov, Marcel Kool, David T.W. Jones, and Stefan M. Pfister, German Cancer Research Center; Stefan M. Pfister, University Hospital Heidelberg, Heidelberg; Ulrich Schüller, Ludwig-Maximilians-University, Munich; Stefan Rutkowski, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Karel Zitterbart, Masaryk University School of Medicine; Karel Zitterbart and Leos Kren, University Hospital Brno, Brno, Czech Republic; Toshihiro Kumabe and Teiji Tominaga, Tohoku University Graduate School of Medicine, Sendai, Japan; Young Shin Ra, University of Ulsan, Asan Medical Center; Ji-Yeoun Lee, Byung-Kyu Cho, Seung-Ki Kim, and Kyu-Chang Wang, Seoul National University Children's Hospital, Seoul; Shin Jung, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital and Medical School, Chonnam, South Korea; Peter Hauser and Miklós Garami, Semmelweis University, Budapest; László Bognár and Almos Klekner, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary; Shenandoah Robinson, Boston Children's Hospital; Scott L. Pomeroy, Harvard Medical School, Boston, MA; Ali G. Saad, University of Arkansas for Medical Sciences, Little

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http://dx.doi.org/10.1200/JCO.2013.50.9539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948094PMC
March 2014

Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma.

Mol Cancer 2014 Mar 24;13:72. Epub 2014 Mar 24.

Department of Pediatrics and Section of Pediatric Hematology/Oncology/BMT, Children's Hospital Colorado and University of Colorado Denver, Anschutz Medical Campus, 12800 E 19th Ave, Mail Stop 8302, Aurora, CO, 80045, USA.

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http://dx.doi.org/10.1186/1476-4598-13-72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987923PMC
March 2014

Polycomb group gene BMI1 controls invasion of medulloblastoma cells and inhibits BMP-regulated cell adhesion.

Acta Neuropathol Commun 2014 Jan 24;2:10. Epub 2014 Jan 24.

Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK.

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http://dx.doi.org/10.1186/2051-5960-2-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928978PMC
January 2014

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.

Acta Neuropathol 2013 Dec 31;126(6):917-29. Epub 2013 Oct 31.

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00401-013-1198-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830749PMC
December 2013

MyoD is a tumor suppressor gene in medulloblastoma.

Cancer Res 2013 Nov 3;73(22):6828-37. Epub 2013 Oct 3.

Authors' Affiliations: Molecular and Cellular Biology Program, University of Washington; Clinical Research Division, Human Biology Division, and Public Health Sciences Division, Fred Hutchinson Cancer Research Center; Presage Biosciences; Sage Bionetworks; Seattle Children's Hospital, Seattle, Washington; Arthur and Sonia Labatt Brain Tumor Research Center and Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0730-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014678PMC
November 2013

Canonical TGF-β pathway activity is a predictor of SHH-driven medulloblastoma survival and delineates putative precursors in cerebellar development.

Brain Pathol 2013 Mar 11;23(2):178-91. Epub 2012 Oct 11.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/j.1750-3639.2012.00631.xDOI Listing
March 2013

Bmi1 overexpression in the cerebellar granule cell lineage of mice affects cell proliferation and survival without initiating medulloblastoma formation.

Dis Model Mech 2013 Jan 12;6(1):49-63. Epub 2012 Oct 12.

Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK.

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http://dmm.biologists.org/cgi/doi/10.1242/dmm.009506
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http://dx.doi.org/10.1242/dmm.009506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529338PMC
January 2013

Molecular subgroups of medulloblastoma.

Expert Rev Neurother 2012 Jul;12(7):871-84

The Arthur & Sonia Labatt Brain Tumour Research Center, Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1586/ern.12.66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334443PMC
July 2012

The epigenetics of brain tumors.

Methods Mol Biol 2012 ;863:139-53

Department of Laboratory Medicine and Pathobiology, Division of Neurosurgery, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-61779-612-8_8DOI Listing
June 2012

Genome-wide methylation analysis.

Methods Mol Biol 2012 ;863:303-17

Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada.

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http://link.springer.com/10.1007/978-1-61779-612-8_19
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http://dx.doi.org/10.1007/978-1-61779-612-8_19DOI Listing
June 2012

Subgroup-specific alternative splicing in medulloblastoma.

Acta Neuropathol 2012 Apr 23;123(4):485-499. Epub 2012 Feb 23.

Division of Neurosurgery, Arthur & Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1007/s00401-012-0959-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984840PMC
April 2012

The genetics of pediatric brain tumors.

Curr Neurol Neurosci Rep 2010 May;10(3):215-23

Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s11910-010-0103-9DOI Listing
May 2010