Adrian Begg

Adrian Begg

UNVERIFIED PROFILE

Are you Adrian Begg?   Register this Author

Register author
Adrian Begg

Adrian Begg

Publications by authors named "Adrian Begg"

Are you Adrian Begg?   Register this Author

48Publications

434Reads

49Profile Views

The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia.

Radiother Oncol 2013 Sep 9;108(3):529-34. Epub 2013 Jul 9.

Department of Radiation Oncology (Maastro Lab), GROW School for Oncology & Developmental Biology, Maastricht University Medical Center+, Maastricht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.radonc.2013.06.015DOI Listing
September 2013

Investigation of possible endogenous hypoxia markers in colorectal cancer.

Int J Radiat Biol 2013 Jan 24;89(1):9-15. Epub 2012 Aug 24.

Department of Radiation Oncology, UH Gasthuisberg, Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/09553002.2012.715789DOI Listing
January 2013

Predicting outcomes in radiation oncology--multifactorial decision support systems.

Nat Rev Clin Oncol 2013 Jan 20;10(1):27-40. Epub 2012 Nov 20.

Department of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, 6229 ET, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrclinonc.2012.196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555846PMC
January 2013

Predicting recurrence after radiotherapy in head and neck cancer.

Authors:
Adrian C Begg

Semin Radiat Oncol 2012 Apr;22(2):108-18

The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semradonc.2011.12.002DOI Listing
April 2012

5-aminoimidazole-4-carboxamide riboside enhances effect of ionizing radiation in PC3 prostate cancer cells.

Int J Radiat Oncol Biol Phys 2011 Dec 21;81(5):1515-23. Epub 2011 Sep 21.

Department of Radiation Oncology, University Hospitals Leuven Campus Gasthuisberg, and Department of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijrobp.2011.06.1964DOI Listing
December 2011

Strategies to improve radiotherapy with targeted drugs.

Nat Rev Cancer 2011 Apr;11(4):239-53

Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nrc3007
Publisher Site
http://dx.doi.org/10.1038/nrc3007DOI Listing
April 2011

Targeted radiosensitization of cells expressing truncated DNA polymerase {beta}.

Cancer Res 2010 Nov 26;70(21):8706-14. Epub 2010 Oct 26.

Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-09-3901DOI Listing
November 2010

Targeting base excision repair as a sensitization strategy in radiotherapy.

Semin Radiat Oncol 2010 Oct;20(4):241-9

Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semradonc.2010.05.005DOI Listing
October 2010

Predicting response to radiotherapy: evolutions and revolutions.

Authors:
Adrian C Begg

Int J Radiat Biol 2009 ;85(10):825-36

Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
July 2010

POLQ in breast cancer.

Authors:
Adrian Begg

Oncotarget 2010 Jul;1(3):161-2

Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157717PMC
http://dx.doi.org/10.18632/oncotarget.100702DOI Listing
July 2010

HPV and high-risk gene expression profiles predict response to chemoradiotherapy in head and neck cancer, independent of clinical factors.

Radiother Oncol 2010 Jun 24;95(3):365-70. Epub 2010 Mar 24.

Department of Experimental Oncology, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, 1066CX Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.radonc.2010.02.001DOI Listing
June 2010

Radiobiology: state of the present art. A conference report.

Authors:
Adrian C Begg

Int J Radiat Biol 2010 Jan;86(1):71-8

Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/09553000903264549DOI Listing
January 2010

Mechanism of cell killing after ionizing radiation by a dominant negative DNA polymerase beta.

DNA Repair (Amst) 2009 Mar 27;8(3):336-46. Epub 2008 Dec 27.

Department of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2008.11.008DOI Listing
March 2009

Radiotherapy in laryngeal carcinoma: can a panel of 13 markers predict response?

Laryngoscope 2009 Feb;119(2):316-22

Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lary.20069DOI Listing
February 2009

Cell cycle phase dependent role of DNA polymerase beta in DNA repair and survival after ionizing radiation.

Radiother Oncol 2008 Mar 30;86(3):391-8. Epub 2008 Jan 30.

Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.radonc.2008.01.002DOI Listing
March 2008

Clinical radiobiology in 2008.

Radiother Oncol 2008 Mar 3;86(3):295-9. Epub 2008 Mar 3.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.radonc.2008.02.004DOI Listing
March 2008

Heterogeneity of gene expression profiles in head and neck cancer.

Head Neck 2007 Dec;29(12):1083-9

Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hed.20621DOI Listing
December 2007

Gene expression profiling to predict outcome after chemoradiation in head and neck cancer.

Int J Radiat Oncol Biol Phys 2007 Dec 10;69(5):1544-52. Epub 2007 Oct 10.

Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijrobp.2007.08.032DOI Listing
December 2007

Ionizing radiation sensitivity of DNA polymerase lambda-deficient cells.

Radiat Res 2007 Dec;168(6):683-8

Division of Experimental Therapy, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1667/RR1057R.1DOI Listing
December 2007

Involvement of DNA polymerase beta in repair of ionizing radiation damage as measured by in vitro plasmid assays.

Radiat Res 2007 Sep;168(3):281-91

Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1667/RR0750.1DOI Listing
September 2007

Impact of supervised gene signatures of early hypoxia on patient survival.

Radiother Oncol 2007 Jun 25;83(3):374-82. Epub 2007 May 25.

Maastricht Radiation Oncology (Maastro), GROW Research Institute, Maastricht University, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.radonc.2007.05.002DOI Listing
June 2007

Role for DNA polymerase beta in response to ionizing radiation.

DNA Repair (Amst) 2007 Feb 28;6(2):202-12. Epub 2006 Nov 28.

Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2006.09.011DOI Listing
February 2007

Can the severity of normal tissue damage after radiation therapy be predicted?

Authors:
Adrian C Begg

PLoS Med 2006 Oct;3(10):e440

Radboud University Medical Center, Nijmegen, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pmed.0030440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1626559PMC
October 2006

Prediction of treatment outcome by cisplatin-DNA adduct formation in patients with stage III/IV head and neck squamous cell carcinoma, treated by concurrent cisplatin-radiation (RADPLAT).

Int J Cancer 2006 Aug;119(4):750-6

Department of Radiotherapy, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.21919DOI Listing
August 2006

Radiosensitization of squamous cell carcinoma by the alkylphospholipid perifosine in cell culture and xenografts.

Clin Cancer Res 2006 Mar;12(5):1615-22

Division of Experimental Therapy and Cellular Biochemistry, the Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-05-2033DOI Listing
March 2006

Resistance of hypoxic cells to ionizing radiation is influenced by homologous recombination status.

Int J Radiat Oncol Biol Phys 2006 Feb 15;64(2):562-72. Epub 2005 Dec 15.

Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijrobp.2005.09.031DOI Listing
February 2006

Radiosensitization by a dominant negative to DNA polymerase beta is DNA polymerase beta-independent and XRCC1-dependent.

Radiother Oncol 2005 Aug;76(2):123-8

Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.radonc.2005.06.020DOI Listing
August 2005

Hypoxic cell turnover in different solid tumor lines.

Int J Radiat Oncol Biol Phys 2005 Jul;62(4):1157-68

Department of Radiation Oncology, Radboud University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijrobp.2005.03.049DOI Listing
July 2005

Thymidine analogues to assess microperfusion in human tumors.

Int J Radiat Oncol Biol Phys 2005 Jul;62(4):1169-75

Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijrobp.2005.03.063DOI Listing
July 2005

Differentiation-associated staining with anti-pimonidazole antibodies in head and neck tumors.

Radiother Oncol 2004 Jan;70(1):91-7

Division of Experimental Therapy, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.radonc.2003.09.012DOI Listing
January 2004

Towards genetic prediction of radiation responses: ESTRO's GENEPI project.

Radiother Oncol 2003 Nov;69(2):121-5

View Article

Download full-text PDF

Source
November 2003

Is HIF-1alpha a good marker for tumor hypoxia?

Authors:
Adrian C Begg

Int J Radiat Oncol Biol Phys 2003 Jul;56(4):917-9

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0360-3016(03)00286-4DOI Listing
July 2003

Phase 1 study to identify tumour hypoxia in patients with head and neck cancer using technetium-99m BRU 59-21.

Eur J Nucl Med Mol Imaging 2002 Sep 23;29(9):1206-11. Epub 2002 Jul 23.

Department of Radiotherapy, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00259-002-0888-0DOI Listing
September 2002

Editorial radiotherapy and oncology 2002: predictive assays for normal tissue damage.

Radiother Oncol 2002 Aug;64(2):125-9

View Article

Download full-text PDF

Source
August 2002

The role of DNA polymerase beta in determining sensitivity to ionizing radiation in human tumor cells.

Nucleic Acids Res 2002 Jul;30(13):2995-3004

Division of Experimental Therapy and Department of Radiotherapy, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC117058PMC
http://dx.doi.org/10.1093/nar/gkf403DOI Listing
July 2002

Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest.

Oncogene 2002 Jun;21(27):4191-9

MRC Cell Mutation Unit, University of Sussex, Brighton, East Sussex, BN1 9RR, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.onc.1205596DOI Listing
June 2002

Premature chromosome condensation and cell separation studies in biopsies from head and neck tumors for radiosensitivity prediction.

Radiother Oncol 2002 Mar;62(3):335-43

Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
March 2002