Adria Giacca

Adria Giacca

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Adria Giacca

Publications by authors named "Adria Giacca"

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The Distribution of Fatty Acid Biomarkers of Dairy Intake across Serum Lipid Fractions: The Prospective Metabolism and Islet Cell Evaluation (PROMISE) Cohort.

Lipids 2019 10 19;54(10):617-627. Epub 2019 Aug 19.

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 1 King's College Circle, M5S 1A8, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/lipd.12185DOI Listing
October 2019

Glucose-Responsive Composite Microneedle Patch for Hypoglycemia-Triggered Delivery of Native Glucagon.

Adv Mater 2019 Jul 5;31(30):e1901051. Epub 2019 Jun 5.

Advanced Pharmaceutics and Drug Delivery Laboratory, Leslie L. Dan Faculty of Pharmacy, University of Toronto, Toronto, M5S 3M2, Canada.

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http://dx.doi.org/10.1002/adma.201901051DOI Listing
July 2019

NOD1: An Interface Between Innate Immunity and Insulin Resistance.

Endocrinology 2019 05;160(5):1021-1030

Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1210/en.2018-01061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477778PMC
May 2019

Glucose regulation by modified boronic acid-sulfobetaine zwitterionic nanogels - a non-hormonal strategy for the potential treatment of hyperglycemia.

Nanoscale 2019 May;11(21):10167-10171

Advanced Pharmaceutics and Drug Delivery Laboratory, Leslie L. Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1039/c9nr01687bDOI Listing
May 2019

Antipsychotics and glucose metabolism: how brain and body collide.

Am J Physiol Endocrinol Metab 2019 01 3;316(1):E1-E15. Epub 2018 Jul 3.

Centre for Addiction and Mental Health , Toronto, Ontario , Canada.

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https://www.physiology.org/doi/10.1152/ajpendo.00164.2018
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http://dx.doi.org/10.1152/ajpendo.00164.2018DOI Listing
January 2019

Effects of acute olanzapine exposure on central insulin-mediated regulation of whole body fuel selection and feeding.

Psychoneuroendocrinology 2018 12 30;98:127-130. Epub 2018 Jul 30.

Centre for Addiction and Mental Health, 250 College St, Toronto, ON, M5T 1R8, Canada; Institute of Medical Sciences, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8T, Canada; Department of Psychiatry, University of Toronto, 250 College Street, 8th Floor, Toronto, ON, M5T 1R8, Canada; Banting and Best Diabetes Centre, Eaton Building, Room 12E248, 200 Elizabeth St, Toronto, ON M5G 2C4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.psyneuen.2018.07.028DOI Listing
December 2018

Glucose-Induced β-Cell Dysfunction In Vivo: Evidence for a Causal Role of C-jun N-terminal Kinase Pathway.

Endocrinology 2018 11;159(11):3643-3654

Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1210/en.2018-00566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195676PMC
November 2018

Clusters of fatty acids in the serum triacylglyceride fraction associate with the disorders of type 2 diabetes.

J Lipid Res 2018 09 9;59(9):1751-1762. Epub 2018 Jul 9.

Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1194/jlr.P084970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121925PMC
September 2018

Effects of insulin and analogues on carcinogen-induced mammary tumours in high-fat-fed rats.

Endocr Connect 2018 May 24;7(5):739-748. Epub 2018 Apr 24.

Departments of Physiology and MedicineInstitute of Medical Science, Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1530/EC-17-0358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958747PMC
May 2018

Association of NEFA composition with insulin sensitivity and beta cell function in the Prospective Metabolism and Islet Cell Evaluation (PROMISE) cohort.

Diabetologia 2018 04 24;61(4):821-830. Epub 2017 Dec 24.

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, FitzGerald Building, 150 College Street, Toronto, ON, M5S 3E2, Canada.

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http://dx.doi.org/10.1007/s00125-017-4534-6DOI Listing
April 2018

Evaluation of the specific effects of intranasal glucagon on glucose production and lipid concentration in healthy men during a pancreatic clamp.

Diabetes Obes Metab 2018 02 14;20(2):328-334. Epub 2017 Sep 14.

Departments of Medicine and Physiology and the Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/dom.13069DOI Listing
February 2018

In male rats, the ability of central insulin to suppress glucose production is impaired by olanzapine, whereas glucose uptake is left intact.

J Psychiatry Neurosci 2017 11 16;42(6):170092. Epub 2017 Oct 16.

From the Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kowalchuk, Teo, Wilson, Chintoh, Agarwal, Remington, Hahn); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kowalchuk, Giacca, Remington, Hahn); the Department of Psychiatry, University of Toronto, Toronto, Ont., Canada (Chintoh, Remington, Hahn); and the Department of Physiology, University of Toronto, Toronto, Ont., Canada (Lam, Giacca).

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http://dx.doi.org/10.1503/jpn.170092DOI Listing
November 2017

In male rats, the ability of central insulin to suppress glucose production is impaired by olanzapine, whereas glucose uptake is left intact.

J Psychiatry Neurosci 2017 Nov;42(6):424-431

From the Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kowalchuk, Teo, Wilson, Chintoh, Agarwal, Remington, Hahn); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kowalchuk, Giacca, Remington, Hahn); the Department of Psychiatry, University of Toronto, Toronto, Ont., Canada (Chintoh, Remington, Hahn); and the Department of Physiology, University of Toronto, Toronto, Ont., Canada (Lam, Giacca).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662464PMC
November 2017

IKKβ inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents.

Diabetologia 2017 10 20;60(10):2021-2032. Epub 2017 Jul 20.

Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada, M5S 1A8.

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http://dx.doi.org/10.1007/s00125-017-4345-9DOI Listing
October 2017

Enhancing thermal stability of a highly concentrated insulin formulation with Pluronic F-127 for long-term use in microfabricated implantable devices.

Drug Deliv Transl Res 2017 08;7(4):529-543

Advanced Pharmaceutics and Drug Delivery Laboratory, Leslie L. Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, M5S 3M2, Canada.

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http://dx.doi.org/10.1007/s13346-017-0381-8DOI Listing
August 2017

High-dose metformin (420mg/kg daily p.o.) increases insulin sensitivity but does not affect neointimal thickness in the rat carotid balloon injury model of restenosis.

Metabolism 2017 03 10;68:108-118. Epub 2016 Dec 10.

Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8; Department of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada M5S 1A8; Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada M5S 1A8. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2016.12.002DOI Listing
March 2017

Risk factors for colorectal cancer in man induce aberrant crypt foci in rats: Preliminary findings.

Nutr Cancer 2016 28;68(1):94-104. Epub 2015 Dec 28.

h Division of Comparative Medicine and Department of Physiology, Faculty of Medicine, University of Toronto , Toronto , Canada.

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http://dx.doi.org/10.1080/01635581.2016.1115098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784512PMC
December 2016

Relation Between Insulin Sensitivity and Metabolic Abnormalities in Japanese Men With BMI of 23-25 kg/m.

J Clin Endocrinol Metab 2016 10 6;101(10):3676-3684. Epub 2016 Jul 6.

Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.

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http://dx.doi.org/10.1210/jc.2016-1650DOI Listing
October 2016

Insulin decreases atherosclerotic plaque burden and increases plaque stability via nitric oxide synthase in apolipoprotein E-null mice.

Am J Physiol Endocrinol Metab 2016 08 24;311(2):E335-45. Epub 2016 May 24.

Department of Physiology and Medicine, Institute of Medical Science, Banting and Best Diabetes Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1152/ajpendo.00320.2015DOI Listing
August 2016

Longitudinal Associations of Phospholipid and Cholesteryl Ester Fatty Acids With Disorders Underlying Diabetes.

J Clin Endocrinol Metab 2016 Jun 4;101(6):2536-44. Epub 2016 May 4.

Department of Nutritional Sciences (L.W.J., Z.L., R.P.B., A.J.H.), University of Toronto, Toronto, ON M5S 3E2, Canada; Centre for Studies in Family Medicine (S.B.H.), University of Western Ontario, London, ON N6G 2M1, Canada; Division of Endocrinology (R.R., B.Z.), University of Toronto, Toronto, ON M5S 1A8, Canada; Lunenfeld Tanenbaum Research Institute (R.R., B.Z.), Mt Sinai Hospital, Toronto, ON M5T 3L9, Canada; Department of Physiology (A.G.), University of Toronto, Toronto, ON M5S 1A8, Canada; and Dalla Lana School of Public Health (A.J.H.), University of Toronto, Toronto, ON M5T 3M7, Canada.

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http://dx.doi.org/10.1210/jc.2015-4267DOI Listing
June 2016

Metformin attenuates olanzapine-induced hepatic, but not peripheral insulin resistance.

J Endocrinol 2015 Nov 1;227(2):71-81. Epub 2015 Sep 1.

Centre for Addiction and Mental Health250 College Street, Toronto, Ontario, Canada M5T 1R8Institute of Medical ScienceUniversity of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8Department of PsychiatryUniversity of Toronto, 250 College Street, Toronto, Ontario, Canada M5T 1R8Department of PhysiologyUniversity of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8 Centre for Addiction and Mental Health250 College Street, Toronto, Ontario, Canada M5T 1R8Institute of Medical ScienceUniversity of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8Department of PsychiatryUniversity of Toronto, 250 College Street, Toronto, Ontario, Canada M5T 1R8Department of PhysiologyUniversity of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8 Centre for Addiction and Mental Health250 College Street, Toronto, Ontario, Canada M5T 1R8Institute of Medical ScienceUniversity of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8Department of PsychiatryUniversity of Toronto, 250 College Street, Toronto, Ontario, Canada M5T 1R8Department of PhysiologyUniversity of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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http://dx.doi.org/10.1530/JOE-15-0074DOI Listing
November 2015

Resveratrol prevents insulin resistance caused by short-term elevation of free fatty acids in vivo.

Appl Physiol Nutr Metab 2015 Nov 10;40(11):1129-36. Epub 2015 Jul 10.

b Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.

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http://dx.doi.org/10.1139/apnm-2015-0075DOI Listing
November 2015

A low-protein diet combined with low-dose endotoxin leads to changes in glucose homeostasis in weanling rats.

Am J Physiol Endocrinol Metab 2015 Sep 7;309(5):E466-73. Epub 2015 Jul 7.

Department of Physiology, University of Toronto, Toronto, Ontario, Canada; Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Toronto, Ontario, Canada; and Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada.

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http://ajpendo.physiology.org/content/ajpendo/309/5/E466.ful
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http://ajpendo.physiology.org/lookup/doi/10.1152/ajpendo.000
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http://dx.doi.org/10.1152/ajpendo.00090.2015DOI Listing
September 2015

The effect of insulin to decrease neointimal growth after arterial injury is endothelial nitric oxide synthase-dependent.

Atherosclerosis 2015 Jul 25;241(1):111-20. Epub 2015 Apr 25.

Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.04.799DOI Listing
July 2015

Effect of N-acetyl-l-cysteine on insulin resistance caused by prolonged free fatty acid elevation.

J Endocrinol 2015 Apr 21;225(1):1-7. Epub 2015 Jan 21.

Department of PhysiologyUniversity of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8Department of MedicineUniversity of Toronto, Toronto, Ontario, CanadaToronto General Research InstituteUniversity Health Network, Toronto, Ontario, CanadaBanting and Best Diabetes CentreUniversity of Toronto, Toronto, Ontario, CanadaInstitute of Medical ScienceUniversity of Toronto, Toronto, Ontario, CanadaSchool of PharmacyUniversity of Waterloo, Waterloo, Ontario, Canada Department of PhysiologyUniversity of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8Department of MedicineUniversity of Toronto, Toronto, Ontario, CanadaToronto General Research InstituteUniversity Health Network, Toronto, Ontario, CanadaBanting and Best Diabetes CentreUniversity of Toronto, Toronto, Ontario, CanadaInstitute of Medical ScienceUniversity of Toronto, Toronto, Ontario, CanadaSchool of PharmacyUniversity of Waterloo, Waterloo, Ontario, Canada Department of PhysiologyUniversity of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8Department of MedicineUniversity of Toronto, Toronto, Ontario, CanadaToronto General Research InstituteUniversity Health Network, Toronto, Ontario, CanadaBanting and Best Diabetes CentreUniversity of Toronto, Toronto, Ontario, CanadaInstitute of Medical ScienceUniversity of Toronto, Toronto, Ontario, CanadaSchool of PharmacyUniversity of Waterloo, Waterloo, Ontario, Canada Department of PhysiologyUniversity of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8Department of MedicineUniversity of Toronto, Toronto, Ontario, CanadaToronto General Research InstituteUniversity Health Network, Toronto, Ontario, CanadaBanting and Best Diabetes CentreUniversity of Toronto, Toronto, Ontario, CanadaInstitute of Medical ScienceUniversity of Toronto, Toronto, Ontario, CanadaSchool of PharmacyUniversity of Waterloo

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http://dx.doi.org/10.1530/JOE-14-0676DOI Listing
April 2015

In vivo performance and biocompatibility of a subcutaneous implant for real-time glucose-responsive insulin delivery.

Diabetes Technol Ther 2015 Apr 11;17(4):255-67. Epub 2015 Feb 11.

1 Leslie Dan Faculty of Pharmacy, University of Toronto , Toronto, Ontario, Canada .

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http://dx.doi.org/10.1089/dia.2014.0229DOI Listing
April 2015

Microfabricated microporous membranes reduce the host immune response and prolong the functional lifetime of a closed-loop insulin delivery implant in a type 1 diabetic rat model.

Biomaterials 2015 Apr 4;47:51-61. Epub 2015 Feb 4.

Department of Pharmaceutical Science, Leslie L. Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2015.01.005DOI Listing
April 2015

In vivo effects of polyunsaturated, monounsaturated, and saturated fatty acids on hepatic and peripheral insulin sensitivity.

Metabolism 2015 Feb 25;64(2):315-22. Epub 2014 Oct 25.

Department of Physiology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada; Department of Medicine, University of Toronto, 200 Elizabeth Street, Toronto, ON, M5G 2C4, Canada; Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2014.10.019DOI Listing
February 2015

Severe hypoglycemia in a juvenile diabetic rat model: presence and severity of seizures are associated with mortality.

PLoS One 2013 30;8(12):e83168. Epub 2013 Dec 30.

Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada ; Department of Physiology, University of Toronto, Toronto, Ontario, Canada ; Department of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083168PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875447PMC
September 2014

FFA-induced hepatic insulin resistance in vivo is mediated by PKCδ, NADPH oxidase, and oxidative stress.

Am J Physiol Endocrinol Metab 2014 Jul 13;307(1):E34-46. Epub 2014 May 13.

Department of Physiology, University of Toronto, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada; and Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada;

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http://dx.doi.org/10.1152/ajpendo.00436.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080148PMC
July 2014

Effects of intracerebroventricular (ICV) olanzapine on insulin sensitivity and secretion in vivo: an animal model.

Eur Neuropsychopharmacol 2014 Mar 13;24(3):448-58. Epub 2013 Aug 13.

Institute of Medical Sciences, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8; Department of Physiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8.

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http://dx.doi.org/10.1016/j.euroneuro.2013.07.011DOI Listing
March 2014

Acute effects of single-dose olanzapine on metabolic, endocrine, and inflammatory markers in healthy controls.

J Clin Psychopharmacol 2013 Dec;33(6):740-6

From the *Center for Addiction and Mental Health; †Institute of Medical Sciences; ‡Department of Nutritional Sciences, University of Toronto; §Department of Medicine, St. Michael's Hospital; ∥Department of Physiology; ¶Department of Psychology; #Department of Psychiatry, University of Toronto; **University Health Network; and ††Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada.

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https://insights.ovid.com/crossref?an=00004714-201312000-000
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http://dx.doi.org/10.1097/JCP.0b013e31829e8333DOI Listing
December 2013

Local insulin application on the carotid artery inhibits neointima formation.

Can J Physiol Pharmacol 2013 Dec 12;91(12):1086-94. Epub 2013 Sep 12.

a Department of Physiology, Medical Science Building, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.

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http://www.nrcresearchpress.com/doi/10.1139/cjpp-2013-0038
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http://dx.doi.org/10.1139/cjpp-2013-0038DOI Listing
December 2013

In vivo effect of insulin to decrease matrix metalloproteinase-2 and -9 activity after arterial injury.

J Vasc Res 2013 9;50(4):279-88. Epub 2013 Jul 9.

Department of Physiology, University of Toronto, Toronto, Ont., Canada.

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http://dx.doi.org/10.1159/000351611DOI Listing
October 2013

Overexpression of glutathione peroxidase 4 prevents β-cell dysfunction induced by prolonged elevation of lipids in vivo.

Am J Physiol Endocrinol Metab 2013 Jul 21;305(2):E254-62. Epub 2013 May 21.

Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://www.physiology.org/doi/10.1152/ajpendo.00481.2012
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http://dx.doi.org/10.1152/ajpendo.00481.2012DOI Listing
July 2013

Atypical antipsychotics and effects of adrenergic and serotonergic receptor binding on insulin secretion in-vivo: an animal model.

Schizophr Res 2013 May 15;146(1-3):162-9. Epub 2013 Mar 15.

Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto M5S1A8, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S09209964130011
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http://dx.doi.org/10.1016/j.schres.2013.02.023DOI Listing
May 2013

Duration of rise in free fatty acids determines salicylate's effect on hepatic insulin sensitivity.

J Endocrinol 2013 Apr 15;217(1):31-43. Epub 2013 Mar 15.

Department of Physiology, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1530/JOE-12-0214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601809PMC
April 2013

Chronic olanzapine administration in rats: effect of route of administration on weight, food intake and body composition.

Pharmacol Biochem Behav 2013 Feb 9;103(4):717-22. Epub 2012 Dec 9.

Schizophrenia Program, Centre for Addiction and Mental Health (CAMH), Toronto, Canada.

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http://dx.doi.org/10.1016/j.pbb.2012.12.002DOI Listing
February 2013

In vitro and in vivo testing of glucose-responsive insulin-delivery microdevices in diabetic rats.

Lab Chip 2012 Jul 8;12(14):2533-9. Epub 2012 May 8.

Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1039/c2lc40139hDOI Listing
July 2012

Consumption of a high-fat diet rapidly exacerbates the development of fatty liver disease that occurs with chronically elevated glucocorticoids.

Am J Physiol Gastrointest Liver Physiol 2012 Apr 19;302(8):G850-63. Epub 2012 Jan 19.

Muscle Health Research Center and Physical Activity and Chronic Disease Unit, School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada.

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http://www.physiology.org/doi/10.1152/ajpgi.00378.2011
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http://dx.doi.org/10.1152/ajpgi.00378.2011DOI Listing
April 2012

Short-term oral α-lipoic acid does not prevent lipid-induced dysregulation of glucose homeostasis in obese and overweight nondiabetic men.

Am J Physiol Endocrinol Metab 2011 Oct 12;301(4):E736-41. Epub 2011 Jul 12.

Department of Medicine, University of Toronto, Ontario, Canada.

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http://www.physiology.org/doi/10.1152/ajpendo.00183.2011
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http://dx.doi.org/10.1152/ajpendo.00183.2011DOI Listing
October 2011

NOD1 activators link innate immunity to insulin resistance.

Diabetes 2011 Sep 29;60(9):2206-15. Epub 2011 Jun 29.

Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2337/db11-0004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161332PMC
September 2011

Effects of insulin on the vasculature.

Curr Vasc Pharmacol 2011 May;9(3):321-32

Department of Physiology, University of Toronto, Toronto M5S 1A8, Canada.

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http://dx.doi.org/10.2174/157016111795495558DOI Listing
May 2011

Lipid-induced pancreatic β-cell dysfunction: focus on in vivo studies.

Am J Physiol Endocrinol Metab 2011 Feb 30;300(2):E255-62. Epub 2010 Nov 30.

Dept. of Physiology, Univ. of Toronto, ON, Canada.

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http://www.physiology.org/doi/10.1152/ajpendo.00416.2010
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http://dx.doi.org/10.1152/ajpendo.00416.2010DOI Listing
February 2011

Insulin inhibits and oral sucrose increases neointimal growth after arterial injury in rats.

J Vasc Res 2010 6;47(5):412-22. Epub 2010 Feb 6.

Department of Physiology, University of Toronto, Toronto, Ont., Canada.

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http://dx.doi.org/10.1159/000281581DOI Listing
September 2010

Plasma nonesterified Fatty Acid intolerance and hyperglycemia are associated with intravenous lipid-induced impairment of insulin sensitivity and disposition index.

J Clin Endocrinol Metab 2010 Mar 22;95(3):1256-64. Epub 2010 Jan 22.

Division of Endocrinology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Québec, Canada J1H 5N4.

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http://dx.doi.org/10.1210/jc.2009-1932DOI Listing
March 2010

A monolithic polymeric microdevice for pH-responsive drug delivery.

Biomed Microdevices 2009 Dec;11(6):1251-7

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G8, Canada.

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http://dx.doi.org/10.1007/s10544-009-9344-2DOI Listing
December 2009

The effect of high-dose sodium salicylate on chronically elevated plasma nonesterified fatty acid-induced insulin resistance and β-cell dysfunction in overweight and obese nondiabetic men.

Am J Physiol Endocrinol Metab 2009 Nov 15;297(5):E1205-11. Epub 2009 Sep 15.

Departments of Medicine and Physiology, University of Toronto, Toronto, Ontario, Canada.

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http://www.physiology.org/doi/10.1152/ajpendo.00313.2009
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http://dx.doi.org/10.1152/ajpendo.00313.2009DOI Listing
November 2009

Insulin resistance and secretion in vivo: effects of different antipsychotics in an animal model.

Schizophr Res 2009 Mar 20;108(1-3):127-33. Epub 2009 Jan 20.

Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada.

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March 2009

Acute dipeptidyl peptidase-4 inhibition rapidly enhances insulin-mediated suppression of endogenous glucose production in mice.

Endocrinology 2009 Jan 18;150(1):56-62. Epub 2008 Sep 18.

Department of Medicine and Physiology, Division of Endocrinology and Metabolism, University of Toronto,Toronto, Ontario, Canada.

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January 2009

Insulin resistance and decreased glucose-stimulated insulin secretion after acute olanzapine administration.

J Clin Psychopharmacol 2008 Oct;28(5):494-9

Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/JCP.0b013e318184b4c5DOI Listing
October 2008

Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK.

Biochem Biophys Res Commun 2008 Sep 2;374(1):117-22. Epub 2008 Jul 2.

Faculty of Applied Health Sciences, Brock University, St. Catharines, Ont., Canada L2S 3A1.

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http://dx.doi.org/10.1016/j.bbrc.2008.06.104DOI Listing
September 2008

Insulin resistance following continuous, chronic olanzapine treatment: an animal model.

Schizophr Res 2008 Sep;104(1-3):23-30

Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8.

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September 2008

High multivitamin intake by Wistar rats during pregnancy results in increased food intake and components of the metabolic syndrome in male offspring.

Am J Physiol Regul Integr Comp Physiol 2008 Aug 4;295(2):R575-82. Epub 2008 Jun 4.

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College St., Rm. 322, Toronto, ON, Canada M5S 3E2.

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August 2008

UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival.

Proc Natl Acad Sci U S A 2008 Aug 13;105(33):12057-62. Epub 2008 Aug 13.

Departments of Physiology and Medicine, University of Toronto, Toronto, ON, Canada M5S 1A8.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575296PMC
August 2008

Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo.

Diabetes 2007 Nov 6;56(11):2722-31. Epub 2007 Aug 6.

Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2337/db07-0279DOI Listing
November 2007

Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivo.

J Endocrinol 2007 Nov;195(2):323-31

Department of Physiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada.

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http://dx.doi.org/10.1677/JOE-07-0005DOI Listing
November 2007

Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure.

Am J Physiol Endocrinol Metab 2007 Feb 26;292(2):E549-60. Epub 2006 Sep 26.

Department of Physiology, University of Toronto, Toronto, ON, M5S 1A8, Canada.

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February 2007

Direct and indirect effects of insulin on hepatic glucose production in diabetic depancreatized dogs during euglycemia.

J Endocrinol 2006 Sep;190(3):695-702

Departments of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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September 2006

Oleate-induced decrease in hepatocyte insulin binding is mediated by PKC-delta.

Biochem Biophys Res Commun 2006 Aug 9;346(3):931-7. Epub 2006 Jun 9.

Department of Physiology, University of Toronto, Toronto, Ont., Canada M5S 1A8.

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August 2006

Effects of portal free fatty acid elevation on insulin clearance and hepatic glucose flux.

Am J Physiol Endocrinol Metab 2006 Jun 3;290(6):E1089-97. Epub 2006 Jan 3.

Dept. of Physiology, Univ. of Toronto, Medical Sciences Bldg., Rm. 3336, Toronto, ON M5S1A8 Canada.

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http://dx.doi.org/10.1152/ajpendo.00306.2005DOI Listing
June 2006

Hyperinsulinemia, but not other factors associated with insulin resistance, acutely enhances colorectal epithelial proliferation in vivo.

Endocrinology 2006 Apr 12;147(4):1830-7. Epub 2006 Jan 12.

Departments of Nutritional Sciences, University of Toronto, Canada.

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April 2006

Anti-atherogenic effect of insulin in vivo.

J Vasc Res 2005 Nov-Dec;42(6):455-62. Epub 2005 Sep 6.

Department of Physiology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1159/000088099DOI Listing
December 2005

Hyperglycemia after protein ingestion concurrent with injection of a GLP-1 receptor agonist in rats: a possible role for dietary peptides.

Am J Physiol Regul Integr Comp Physiol 2005 Sep 5;289(3):R688-94. Epub 2005 May 5.

Dept. of Nutritional Sciences, Faculty of Medicine, University of Toronto, 3rd floor FitzGerald Bldg., 150 College Street, Toronto, Ontario, Canada M5S 3E2.

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http://dx.doi.org/10.1152/ajpregu.00850.2004DOI Listing
September 2005

N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress.

Am J Physiol Endocrinol Metab 2003 Oct 10;285(4):E744-53. Epub 2003 Jun 10.

Department of Medicine, Mount Sinai Hospital, 60 Murray Street, Toronto, Ontario, Canada M5G 1X5.

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http://dx.doi.org/10.1152/ajpendo.00355.2002DOI Listing
October 2003

Mechanisms of the free fatty acid-induced increase in hepatic glucose production.

Am J Physiol Endocrinol Metab 2003 May;284(5):E863-73

Department of Physiology and Medicine, Medical Science Building, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1152/ajpendo.00033.2003DOI Listing
May 2003

Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites.

Am J Physiol Endocrinol Metab 2003 Feb;284(2):E281-90

Department of Physiology, University of Toronto, Toronto, ON, Canada M5S 1A8.

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http://dx.doi.org/10.1152/ajpendo.00332.2002DOI Listing
February 2003

Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta.

Am J Physiol Endocrinol Metab 2002 Oct;283(4):E682-91

Department of Physiology, University of Toronto, Toronto M5S 1A8, Canada.

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http://dx.doi.org/10.1152/ajpendo.00038.2002DOI Listing
October 2002

The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats.

Diabetes 2002 Jun;51(6):1825-33

Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9135, USA.

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http://dx.doi.org/10.2337/diabetes.51.6.1825DOI Listing
June 2002

The effect of chronic insulin delivery via the intraperitoneal versus the subcutaneous route on hepatic triglyceride secretion rate in streptozotocin diabetic rats.

Atherosclerosis 2002 Apr;161(2):345-52

Department of Physiology, University of Toronto, Medical Sciences Building, Rm. 3363 1 King's College Circle, Toronto Ont., Canada M5S 1A8.

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http://dx.doi.org/10.1016/s0021-9150(01)00659-1DOI Listing
April 2002

Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes.

Endocr Rev 2002 Apr;23(2):201-29

Department of Medicine, Division of Endocrinology, University of Toronto, Canada M5G 2C4.

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April 2002