Adolfo Ferrando

Adolfo Ferrando

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Adolfo Ferrando

Publications by authors named "Adolfo Ferrando"

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Metabolic dependencies and vulnerabilities in leukemia.

Genes Dev 2019 Nov;33(21-22):1460-1474

Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1101/gad.326470.119DOI Listing
November 2019

The Genetics and Mechanisms of T-Cell Acute Lymphoblastic Leukemia.

Cold Spring Harb Perspect Med 2019 Sep 30. Epub 2019 Sep 30.

Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a035246DOI Listing
September 2019

Genetics and mechanisms of NT5C2-driven chemotherapy resistance in relapsed ALL.

Blood 2019 May 25;133(21):2263-2268. Epub 2019 Mar 25.

Institute for Cancer Genetics and.

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http://dx.doi.org/10.1182/blood-2019-01-852392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533602PMC
May 2019

Can one target T-cell ALL?

Authors:
Adolfo Ferrando

Best Pract Res Clin Haematol 2018 12 17;31(4):361-366. Epub 2018 Oct 17.

Institute for Cancer Genetics, Columbia University, 1130 St Nicholas Ave., ICRC 401B, New York, NY, 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.beha.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294319PMC
December 2018

Glucocorticoid Resistance in Acute Lymphoblastic Leukemia: BIM Finally.

Cancer Cell 2018 12;34(6):869-871

Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA; Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA; Department of Systems Biology, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.11.011DOI Listing
December 2018

Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.

Cancer Cell 2018 07;34(1):136-147.e6

Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA; Department of Systems Biology, Columbia University, New York, NY 10032, USA; Department of Pediatrics, Columbia University Medical Center, 1130 St. Nicholas Avenue, ICRC 402, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049837PMC
July 2018

RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis.

Cancer Cell 2018 02 2;33(2):259-273.e7. Epub 2018 Feb 2.

Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University Medical Center, 1130 St Nicholas Avenue, ICRC-401B, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811310PMC
February 2018

Targeted cellular immunotherapy for T cell malignancies.

Nat Med 2017 12;23(12):1402-1403

Institute for Cancer Genetics, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1038/nm.4458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848213PMC
December 2017

Clonal evolution in leukemia.

Nat Med 2017 Oct 6;23(10):1135-1145. Epub 2017 Oct 6.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain.

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http://dx.doi.org/10.1038/nm.4410DOI Listing
October 2017

Common nonmutational activation in chronic lymphocytic leukemia.

Proc Natl Acad Sci U S A 2017 04 17;114(14):E2911-E2919. Epub 2017 Mar 17.

Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032;

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http://dx.doi.org/10.1073/pnas.1702564114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389283PMC
April 2017

The NOTCH1-MYC highway toward T-cell acute lymphoblastic leukemia.

Blood 2017 03 23;129(9):1124-1133. Epub 2017 Jan 23.

Institute for Cancer Genetics.

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http://dx.doi.org/10.1182/blood-2016-09-692582DOI Listing
March 2017

Targeting NOTCH1 in T-ALL: Starving the dragon.

Cell Cycle 2016 11;15(4):483-4. Epub 2016 Feb 11.

a Institute for Cancer Genetics, Columbia University , New York , NY , USA.

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http://dx.doi.org/10.1080/15384101.2015.1128191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056614PMC
December 2016

Tumor Suppressor HIPK2 Regulates Malignant Growth via Phosphorylation of Notch1.

Cancer Res 2016 08 22;76(16):4728-40. Epub 2016 Jun 22.

Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3310DOI Listing
August 2016

MMP-25 Metalloprotease Regulates Innate Immune Response through NF-κB Signaling.

J Immunol 2016 07 3;197(1):296-302. Epub 2016 Jun 3.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain;

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http://dx.doi.org/10.4049/jimmunol.1600094DOI Listing
July 2016

The genetics and mechanisms of T cell acute lymphoblastic leukaemia.

Nat Rev Cancer 2016 07;16(8):494-507

Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA.

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http://dx.doi.org/10.1038/nrc.2016.63DOI Listing
July 2016

How I treat T-cell acute lymphoblastic leukemia in adults.

Blood 2015 Aug 12;126(7):833-41. Epub 2015 May 12.

Department of Pediatrics, Department of Pathology, and Institute for Cancer Genetics, Columbia University Medical Center, New York, NY.

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http://dx.doi.org/10.1182/blood-2014-10-551895DOI Listing
August 2015

Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL.

Nat Med 2015 Jun 11;21(6):563-71. Epub 2015 May 11.

1] Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [2] Pediatric Translational Medicine Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [3] Department of Pharmacology, School of Basic Medicine and Collaborative Innovation Center for Translational Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [4] Collaborative Innovation Center of Systems Biomedicine, National Research Center for Translational Medicine, Shanghai, China.

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http://dx.doi.org/10.1038/nm.3840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670083PMC
June 2015

CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance.

Cancer Cell 2015 Jun;27(6):755-68

Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA; Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461838PMC
June 2015

An oncogenic enhancer enemy (N-Me) in T-ALL.

Cell Cycle 2015 ;14(2):167-8

a Institute for Cancer genetics Columbia University , New York.

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http://dx.doi.org/10.4161/15384101.2014.989129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615101PMC
May 2015

Therapeutic targeting of HES1 transcriptional programs in T-ALL.

Blood 2015 Apr 17;125(18):2806-14. Epub 2015 Mar 17.

Institute for Cancer Genetics, Columbia University, New York, NY; Department of Pathology and Department of Pediatrics, Columbia University Medical Center, New York, NY.

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http://dx.doi.org/10.1182/blood-2014-10-608448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424629PMC
April 2015

Aberrant cytokine production by nonmalignant cells in the pathogenesis of myeloproliferative tumors and response to JAK inhibitor therapies.

Cancer Discov 2015 Mar;5(3):234-6

Institute for Cancer Genetics, Columbia University, New York, New York. Department of Pathology, Columbia University Medical Center, New York, New York. Department of Pediatrics, Columbia University Medical Center, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355913PMC
March 2015

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia.

Nature 2014 Oct 17;514(7523):513-7. Epub 2014 Aug 17.

1] Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, New York, New York 10016, USA [2] NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, New York 10016, USA.

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http://dx.doi.org/10.1038/nature13605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209203PMC
October 2014

A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.

Nat Med 2014 Oct 7;20(10):1130-7. Epub 2014 Sep 7.

1] Institute for Cancer Genetics, Columbia University, New York, New York, USA. [2] Department of Pathology, Columbia University Medical Center, New York, New York, USA. [3] Department of Pediatrics, Columbia University Medical Center, New York, New York, USA.

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http://dx.doi.org/10.1038/nm.3665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192073PMC
October 2014

Small Molecule that Reverses Dexamethasone Resistance in T-cell Acute Lymphoblastic Leukemia (T-ALL).

ACS Med Chem Lett 2014 Jul 25;5(7):754-9. Epub 2014 Apr 25.

Department of Biological Sciences, Department of Chemistry, and Howard Hughes Medical Institute, Columbia University , 1208 Northwest Corner Building, 12th Floor, 550 West 120th Street, MC 4846, New York, New York 10027 United States ; Department of Biological Sciences, Department of Chemistry, and Howard Hughes Medical Institute, Columbia University , 1208 Northwest Corner Building, 12th Floor, 550 West 120th Street, MC 4846, New York, New York 10027 United States ; Department of Biological Sciences, Department of Chemistry, and Howard Hughes Medical Institute, Columbia University , 1208 Northwest Corner Building, 12th Floor, 550 West 120th Street, MC 4846, New York, New York 10027 United States ; Department of Systems Biology, Columbia University Medical Center , and Institute for Cancer Genetics, Columbia University , New York, New York 10032 United States.

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http://dx.doi.org/10.1021/ml500044gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094258PMC
July 2014

Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas.

Nat Genet 2014 Feb 12;46(2):166-70. Epub 2014 Jan 12.

1] Institute for Cancer Genetics, Columbia University, New York, New York, USA. [2] Department of Pathology, Columbia University Medical Center, New York, New York, USA. [3] Department of Pediatrics, Columbia University Medical Center, New York, New York, USA.

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http://dx.doi.org/10.1038/ng.2873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963408PMC
February 2014

Early T-cell precursor acute lymphoblastic leukaemia.

Curr Opin Hematol 2013 Jul;20(4):369-73

Institute for Cancer Genetics and Department of Pediatrics, Columbia University Medical Center, New York, New York 10032, USA.

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http://dx.doi.org/10.1097/MOH.0b013e3283623c61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886681PMC
July 2013

SOX11 is a mantle cell lymphoma oncogene.

Blood 2013 Mar;121(12):2169-70

institute for Cancer Genetics And Departments Of Pediatrics And Pathology, Columbia University, USA.

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http://dx.doi.org/10.1182/blood-2013-02-480418DOI Listing
March 2013

Recent advances on NOTCH signaling in T-ALL.

Curr Top Microbiol Immunol 2012 ;360:163-82

Institute for Cancer Genetics and Graduate Program in Pathobiology and Molecular Medicine, Columbia University Medical Center, New York 10032, USA.

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http://dx.doi.org/10.1007/82_2012_232DOI Listing
January 2013

The molecular basis of T cell acute lymphoblastic leukemia.

J Clin Invest 2012 Oct 1;122(10):3398-406. Epub 2012 Oct 1.

Institute for Cancer Genetics, Department of Pathology, Columbia University Medical Center, New York, New York 10032, USA.

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http://www.jci.org/articles/view/61269
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http://dx.doi.org/10.1172/JCI61269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461904PMC
October 2012

The zebrafish reveals dependence of the mast cell lineage on Notch signaling in vivo.

Blood 2012 Apr 24;119(15):3585-94. Epub 2012 Feb 24.

Izaak Walton Killam Health Centre, Dalhousie University, Halifax, NS, Canada.

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http://dx.doi.org/10.1182/blood-2011-10-385989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375148PMC
April 2012

TLX1-induced T-cell acute lymphoblastic leukemia.

Clin Cancer Res 2011 Oct 24;17(20):6381-6. Epub 2011 Jun 24.

Department of Molecular and Developmental Genetics, VIB, Center for Human Genetics, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-3037DOI Listing
October 2011

ParMap, an algorithm for the identification of small genomic insertions and deletions in nextgen sequencing data.

BMC Res Notes 2010 May 27;3:147. Epub 2010 May 27.

Department of Biomedical Informatics, Columbia University College of Physicians and Surgeons, New York, NY, USA.

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http://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0
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http://dx.doi.org/10.1186/1756-0500-3-147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897800PMC
May 2010

The role of NOTCH1 signaling in T-ALL.

Hematology Am Soc Hematol Educ Program 2009 :353-61

Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1182/asheducation-2009.1.353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847371PMC
March 2010

A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells.

Proc Natl Acad Sci U S A 2010 Mar 10;107(13):5907-12. Epub 2010 Mar 10.

Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Institute for Cancer Genetics, USA.

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http://dx.doi.org/10.1073/pnas.1001647107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851858PMC
March 2010

Therapeutic targeting of NOTCH1 signaling in T-cell acute lymphoblastic leukemia.

Clin Lymphoma Myeloma 2009 ;9 Suppl 3:S205-10

Department of Pathology, Institute for Cancer Genetics, Columbia University, New York, USA.

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http://dx.doi.org/10.3816/CLM.2009.s.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814179PMC
January 2010

ChIP-on-chip significance analysis reveals large-scale binding and regulation by human transcription factor oncogenes.

Proc Natl Acad Sci U S A 2009 Jan 31;106(1):244-9. Epub 2008 Dec 31.

Department of Biomedical Informatics, Joint Centers for Systems Biology, Columbia University, New York, NY 10032, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0806445106
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http://dx.doi.org/10.1073/pnas.0806445106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613038PMC
January 2009

Oncogenic NOTCH1 control of MYC and PI3K: challenges and opportunities for anti-NOTCH1 therapy in T-cell acute lymphoblastic leukemias and lymphomas.

Clin Cancer Res 2008 Sep;14(17):5314-7

Institute for Cancer Genetics-Columbia University, Columbia University Medical Center, New York, New York 10032, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-4864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577004PMC
September 2008

NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL.

Blood 2008 Aug 14;112(3):733-40. Epub 2008 Apr 14.

Division of Pediatric Oncology, Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1182/blood-2007-12-130096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481531PMC
August 2008

The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia.

Cell Cycle 2008 Apr 19;7(8):965-70. Epub 2008 Feb 19.

Institute for Cancer Genetics-Columbia University, New York, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600414PMC
http://dx.doi.org/10.4161/cc.7.8.5753DOI Listing
April 2008

Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice.

Leuk Res 2007 Mar 25;31(3):321-7. Epub 2006 Jul 25.

Department of Medicine, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.leukres.2006.06.009DOI Listing
March 2007

Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.

Nat Med 2007 Jan 17;13(1):70-7. Epub 2006 Dec 17.

Department of Medicine, Section of Rheumatology, University of Chicago, 5841 South Maryland Avenue Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1038/nm1524DOI Listing
January 2007

Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor.

Immunol Rev 2006 Feb;209:159-69

University of Chicago, Department of Medicine, Section of Rheumatology, Committees of Immunology, Cancer and Developmental Biology, Chicago, IL 60637, USA.

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http://doi.wiley.com/10.1111/j.0105-2896.2006.00343.x
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http://dx.doi.org/10.1111/j.0105-2896.2006.00343.xDOI Listing
February 2006

DNA microarrays in the diagnosis and management of acute lymphoblastic leukemia.

Int J Hematol 2004 Dec;80(5):395-400

Harvard Medical School, Pediatric Oncology Department, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1532/ijh97.04137DOI Listing
December 2004

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.

Science 2004 Oct;306(5694):269-71

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1102160DOI Listing
October 2004