Adnane Achour

Adnane Achour

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Adnane Achour

Publications by authors named "Adnane Achour"

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Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin.

Proc Natl Acad Sci U S A 2019 03 26;116(11):5055-5060. Epub 2019 Feb 26.

Science for Life Laboratory, Department of Medicine Solna, Karolinska Institute, and Division of Infectious Diseases, Karolinska University Hospital, Solna, SE-17176 Stockholm, Sweden;

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http://dx.doi.org/10.1073/pnas.1807656116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421438PMC
March 2019

B cell alterations during BAFF inhibition with belimumab in SLE.

EBioMedicine 2019 Feb 26;40:517-527. Epub 2018 Dec 26.

Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.12.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412067PMC
February 2019

Individual and stable autoantibody repertoires in healthy individuals.

Autoimmunity 2019 Feb 5;52(1):1-11. Epub 2019 Mar 5.

a SciLifeLab, Division of Affinity Proteomics, Department of Protein Science , KTH Royal Institute of Technology , Stockholm , Sweden.

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http://dx.doi.org/10.1080/08916934.2019.1581774DOI Listing
February 2019

Bioanalytical advantages of a novel recombinant apyrase enzyme in ATP-based bioluminescence methods.

Anal Chim Acta 2018 Sep 26;1025:118-123. Epub 2018 Apr 26.

Division of Nanobiotechnology, Department of Protein Science, Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2018.04.054DOI Listing
September 2018

Memory T cells specific to citrullinated α-enolase are enriched in the rheumatic joint.

J Autoimmun 2018 08 28;92:47-56. Epub 2018 May 28.

Rheumatology Unit, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183012
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http://dx.doi.org/10.1016/j.jaut.2018.04.004DOI Listing
August 2018

Detecting ligand interactions in real time on living bacterial cells.

Appl Microbiol Biotechnol 2018 May 17;102(9):4193-4201. Epub 2018 Mar 17.

Ridgeview Instruments AB, Vänge, Sweden.

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http://dx.doi.org/10.1007/s00253-018-8919-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895670PMC
May 2018

Structural and functional studies of Spr1654: an essential aminotransferase in teichoic acid biosynthesis in .

Open Biol 2018 04;8(4)

Science for Life Laboratory, Department of Medicine Solna, Karolinska Institute, Solna, 17176 Stockholm, Sweden

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http://dx.doi.org/10.1098/rsob.170248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936713PMC
April 2018

Mass Cytometry Identifies Distinct Lung CD4 T Cell Patterns in Löfgren's Syndrome and Non-Löfgren's Syndrome Sarcoidosis.

Front Immunol 2017 12;8:1130. Epub 2017 Sep 12.

Respiratory Medicine Unit, Department of Medicine, Solna and Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fimmu.2017.01130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601005PMC
September 2017

Nitration of MOG diminishes its encephalitogenicity depending on MHC haplotype.

J Neuroimmunol 2017 02 26;303:1-12. Epub 2016 Nov 26.

Department of Clinical Neuroscience, Applied Immunology & Immunotherapy, Karolinska Institutet, Stockholm, Center for Molecular Medicine, Karolinska University Hospital, Solna, S-17176, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2016.11.008DOI Listing
February 2017

Migratory activation of parasitized dendritic cells by the protozoan Toxoplasma gondii 14-3-3 protein.

Cell Microbiol 2016 Nov 6;18(11):1537-1550. Epub 2016 May 6.

Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 106 09, Stockholm, Sweden.

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http://dx.doi.org/10.1111/cmi.12595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040621PMC
November 2016

The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity.

Mol Microbiol 2016 09 5;101(6):954-67. Epub 2016 Jul 5.

Science for Life Laboratory, Department of Medicine Solna, Karolinska Institutet, and Department of Infectious Diseases, Karolinska University Hospital, Solna, Stockholm, SE, 17176, Sweden.

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http://dx.doi.org/10.1111/mmi.13435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014641PMC
September 2016

The BR domain of PsrP interacts with extracellular DNA to promote bacterial aggregation; structural insights into pneumococcal biofilm formation.

Sci Rep 2016 09 1;6:32371. Epub 2016 Sep 1.

Science for Life Laboratory, Department of Medicine Solna, Karolinska Institute, and Department of Infectious Diseases, Karolinska University Hospital, Solna, SE-17176 Stockholm, Sweden.

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http://dx.doi.org/10.1038/srep32371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007671PMC
September 2016

T-cell receptor-HLA-DRB1 associations suggest specific antigens in pulmonary sarcoidosis.

Eur Respir J 2016 Mar 19;47(3):898-909. Epub 2015 Nov 19.

Respiratory Medicine Unit, Dept of Medicine, Solna and CMM, Karolinska Institutet and Karolinska University Hospital, Solna, Sweden.

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http://dx.doi.org/10.1183/13993003.01209-2015DOI Listing
March 2016

The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer.

J Immunol 2016 Mar 22;196(5):2327-34. Epub 2016 Jan 22.

Science for Life Laboratory, Department of Medicine, Solna, Karolinska Institutet, SE-10450 Stockholm, Sweden; and

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http://dx.doi.org/10.4049/jimmunol.1502249DOI Listing
March 2016

Binding of subdomains 1/2 of PfEMP1-DBL1α to heparan sulfate or heparin mediates Plasmodium falciparum rosetting.

PLoS One 2015 5;10(3):e0118898. Epub 2015 Mar 5.

Science for Life Laboratory, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118898PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351205PMC
January 2016

Viral and cellular proteins containing FGDF motifs bind G3BP to block stress granule formation.

PLoS Pathog 2015 Feb 6;11(2):e1004659. Epub 2015 Feb 6.

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1371/journal.ppat.1004659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450067PMC
February 2015

PyTMs: a useful PyMOL plugin for modeling common post-translational modifications.

BMC Bioinformatics 2014 Nov 28;15:370. Epub 2014 Nov 28.

Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Applied Immunology & Immunotherapy, L8:04, Karolinska Hospital, SE-171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s12859-014-0370-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256751PMC
November 2014

Melanocortin 1 Receptor-derived peptides are efficiently recognized by cytotoxic T lymphocytes from melanoma patients.

Immunobiology 2014 Mar 12;219(3):189-97. Epub 2013 Oct 12.

Millennium Institute on Immunology and Immunotherapy, Faculty of Medicine, University of Chile, 8380453 Santiago, Chile. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01712985130017
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http://dx.doi.org/10.1016/j.imbio.2013.10.002DOI Listing
March 2014

The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold.

Open Biol 2014 Jan 15;4:130090. Epub 2014 Jan 15.

Science for Life Laboratory, Center for Infectious Medicine (CIM), Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet Science Park, Tomtebodavägen 23A Solna, Stockholm 17165, Sweden.

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http://dx.doi.org/10.1098/rsob.130090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909270PMC
January 2014

Proline substitution independently enhances H-2D(b) complex stabilization and TCR recognition of melanoma-associated peptides.

Eur J Immunol 2013 Nov 30;43(11):3051-60. Epub 2013 Aug 30.

Science for Life Laboratory, Center for Infectious Medicine (CIM), Department of Medicine, Karolinska Insitutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1002/eji.201343456DOI Listing
November 2013

Cis association of leukocyte Ig-like receptor 1 with MHC class I modulates accessibility to antibodies and HCMV UL18.

Eur J Immunol 2013 Apr 4;43(4):1042-52. Epub 2013 Mar 4.

Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1002/eji.201242607DOI Listing
April 2013

Unexpected T-cell recognition of an altered peptide ligand is driven by reversed thermodynamics.

Eur J Immunol 2012 Nov 20;42(11):2990-3000. Epub 2012 Sep 20.

Center for Infectious Medicine, Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/eji.201242588DOI Listing
November 2012

Inflammation-associated nitrotyrosination affects TCR recognition through reduced stability and alteration of the molecular surface of the MHC complex.

PLoS One 2012 14;7(3):e32805. Epub 2012 Mar 14.

Centre for Infectious Medicine, Department of Medicine Huddinge, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0032805PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303804PMC
July 2012

Crystal structure of the HIV-2 neutralizing Fab fragment 7C8 with high specificity to the V3 region of gp125.

PLoS One 2011 Apr 26;6(4):e18767. Epub 2011 Apr 26.

F59 Department of Medicine, Center for Infectious Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0018767PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082531PMC
April 2011

Crystal structure of the dog lipocalin allergen Can f 2: implications for cross-reactivity to the cat allergen Fel d 4.

J Mol Biol 2010 Aug 26;401(1):68-83. Epub 2010 May 26.

Centre for Infectious Medicine, F59, Department of Medicine Huddinge, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jmb.2010.05.043DOI Listing
August 2010

Two crystal structures of pneumococcal pilus sortase C provide novel insights into catalysis and substrate specificity.

J Mol Biol 2009 Oct 31;393(3):704-16. Epub 2009 Aug 31.

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden.

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http://dx.doi.org/10.1016/j.jmb.2009.08.058DOI Listing
October 2009

Design of agonistic altered peptides for the robust induction of CTL directed towards H-2Db in complex with the melanoma-associated epitope gp100.

Cancer Res 2009 Oct 29;69(19):7784-92. Epub 2009 Sep 29.

Departments of Immunohematology and Blood transfusion and Clinical Oncology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-1724DOI Listing
October 2009

Production, purification, crystallization and preliminary X-ray diffraction analysis of the HIV-2-neutralizing V3 loop-specific Fab fragment 7C8.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 Jul 27;65(Pt 7):705-8. Epub 2009 Jun 27.

Center for Infectious Medicine (CIM), F59 Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, SE-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1107/S1744309109020685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705640PMC
July 2009

Production, crystallization and preliminary X-ray diffraction analysis of the allergen Can f 2 from Canis familiaris.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 May 24;65(Pt 5):467-71. Epub 2009 Apr 24.

Centre for Infectious Medicine, Department of Medicine Huddinge, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1107/S1744309109010884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675586PMC
May 2009

Human cytomegalovirus-derived protein UL18 alters the phenotype and function of monocyte-derived dendritic cells.

J Leukoc Biol 2008 Jan 26;83(1):56-63. Epub 2007 Sep 26.

Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1189/jlb.0307181DOI Listing
January 2008

Immune modulation by the human cytomegalovirus-encoded molecule UL18, a mystery yet to be solved.

J Immunol 2008 Jan;180(1):19-24

Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.4049/jimmunol.180.1.19DOI Listing
January 2008

Structural elements underlying the high binding affinity of human cytomegalovirus UL18 to leukocyte immunoglobulin-like receptor-1.

J Mol Biol 2007 Oct 21;373(3):695-705. Epub 2007 Aug 21.

Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jmb.2007.08.020DOI Listing
October 2007

Malondialdehyde modification of myelin oligodendrocyte glycoprotein leads to increased immunogenicity and encephalitogenicity.

Eur J Immunol 2007 Jul;37(7):1986-95

Department of Clinical Neurosciences, Applied Immunology, Centre for Molecular Medicine, Karolinska University Hospital at Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1002/eji.200636912DOI Listing
July 2007

Structural characterization of the tetrameric form of the major cat allergen Fel d 1.

J Mol Biol 2007 Jul 10;370(4):714-27. Epub 2007 May 10.

Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jmb.2007.04.074DOI Listing
July 2007

Crystal structure of the major Malassezia sympodialis allergen Mala s 1 reveals a beta-propeller fold: a novel fold among allergens.

J Mol Biol 2007 Jun 12;369(4):1079-86. Epub 2007 Apr 12.

Department of Medicine, Clinical Allergy Research Unit, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jmb.2007.04.009DOI Listing
June 2007

Deletion of the V1/V2 region does not increase the accessibility of the V3 region of recombinant gp125.

Curr HIV Res 2006 Apr;4(2):229-37

Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden.

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April 2006

Dissection of the interaction of the human cytomegalovirus-derived US2 protein with major histocompatibility complex class I molecules: prominent role of a single arginine residue in human leukocyte antigen-A2.

J Biol Chem 2006 Mar 1;281(13):8950-7. Epub 2006 Feb 1.

Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1074/jbc.M507121200DOI Listing
March 2006

Structural basis of the differential stability and receptor specificity of H-2Db in complex with murine versus human beta2-microglobulin.

J Mol Biol 2006 Feb 7;356(2):382-96. Epub 2005 Dec 7.

Center for Infectious Medicine, F59, Department of Medicine, Karolinska Institutet, Karolinska University Hospital in Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jmb.2005.11.068DOI Listing
February 2006

Crystallization and preliminary crystallographic study of the yeast Malassezia sympodialis allergen Mala s 1.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 Feb 27;62(Pt 2):97-9. Epub 2006 Jan 27.

Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1107/S1744309105041011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150955PMC
February 2006

Expression, refolding and crystallization of murine MHC class I H-2Db in complex with human beta2-microglobulin.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 Dec 24;61(Pt 12):1090-3. Epub 2005 Nov 24.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1107/S1744309105037942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978157PMC
December 2005

A structural basis for CD8+ T cell-dependent recognition of non-homologous peptide ligands: implications for molecular mimicry in autoreactivity.

J Biol Chem 2005 Jul 21;280(29):27069-75. Epub 2005 Apr 21.

Department of Medical Biochemistry and Biophysics, Microbiology and Tumor Biology Center, and Strategic Research Center IRIS for Studies of Integrated Recognition in the Immune System, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1074/jbc.M500927200DOI Listing
July 2005

Cloning, expression, and purification of HIV-2 gp125: A target for HIV vaccination.

Mol Biotechnol 2005 Jun;30(2):155-62

Microbiology and Tumor Biology Center, Karolinska Institutet, S-171 77, Stockholm, Sweden.

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http://link.springer.com/10.1385/MB:30:2:155
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http://dx.doi.org/10.1385/MB:30:2:155DOI Listing
June 2005

Crystallization and preliminary crystallographic data of a Fel d 1 (1+2) construct corresponding to the major allergen from cat.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 Feb 1;61(Pt 2):232-4. Epub 2005 Feb 1.

Center for Infectious Medicine, F59, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.

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http://scripts.iucr.org/cgi-bin/paper?S1744309105001776
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http://dx.doi.org/10.1107/S1744309105001776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952269PMC
February 2005

Determination of structural principles underlying three different modes of lymphocytic choriomeningitis virus escape from CTL recognition.

J Immunol 2004 May;172(9):5504-11

Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.4049/jimmunol.172.9.5504DOI Listing
May 2004

The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family.

J Biol Chem 2003 Sep 8;278(39):37730-5. Epub 2003 Jul 8.

Department of Medicine, Unit of Clinical Immunology and Allergy, Karolinska Institutet and Hospital L2:04, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1074/jbc.M304740200DOI Listing
September 2003

Three-dimensional structure of Fel d 1, the major allergen in cat.

Int Arch Allergy Immunol 2003 Sep;132(1):25-6

Department of Medicine, Unit of Clinical Immunology and Allergy, Karolinska Institutet and Hospital L2:04, Stockholm, Sweden.

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https://www.karger.com/Article/FullText/73261
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http://dx.doi.org/10.1159/000073261DOI Listing
September 2003

Production, crystallization and preliminary crystallographic study of the major cat allergen Fel d 1.

Acta Crystallogr D Biol Crystallogr 2003 Jun 23;59(Pt 6):1103-5. Epub 2003 May 23.

Department of Medicine, Unit of Clinical Immunology and Allergy, Karolinska Institutet and Hospital, Stockholm, Sweden.

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http://journals.iucr.org/d/issues/2003/06/00/cy0123/cy0123.p
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http://dx.doi.org/10.1107/s0907444903007741DOI Listing
June 2003

A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition.

J Exp Med 2002 Dec;196(11):1403-14

Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194258PMC
http://dx.doi.org/10.1084/jem.20020797DOI Listing
December 2002

NK cell inhibitory receptor Ly-49C residues involved in MHC class I binding.

J Immunol 2002 Jan;168(2):793-800

Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.4049/jimmunol.168.2.793DOI Listing
January 2002