Adi Gazdar

Adi Gazdar

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Adi Gazdar

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Correction: LCE: an open web portal to explore gene expression and clinical associations in lung cancer.

Oncogene 2020 Jan;39(3):718-719

Quantitative Biomedical Research Center, Department of Clinical Sciences, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA.

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http://dx.doi.org/10.1038/s41388-019-1000-6DOI Listing
January 2020

A Bayesian hidden Potts mixture model for analyzing lung cancer pathology images.

Biostatistics 2019 10;20(4):565-581

Department of Clinical Sciences, UT Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1093/biostatistics/kxy019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797059PMC
October 2019

ClickGene: an open cloud-based platform for big pan-cancer data genome-wide association study, visualization and exploration.

BioData Min 2019 26;12:12. Epub 2019 Jun 26.

1School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072 China.

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http://dx.doi.org/10.1186/s13040-019-0202-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595587PMC
June 2019

Development and Validation of a Pathology Image Analysis-based Predictive Model for Lung Adenocarcinoma Prognosis - A Multi-cohort Study.

Sci Rep 2019 May 3;9(1):6886. Epub 2019 May 3.

Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.

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http://dx.doi.org/10.1038/s41598-019-42845-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499884PMC
May 2019

Comparison of four DLL3 antibodies performance in high grade neuroendocrine lung tumor samples and cell cultures.

Diagn Pathol 2019 May 20;14(1):47. Epub 2019 May 20.

Diagnostic and Research Center for Molecular BioMedicine, Diagnostic and Research Institute of Pathology, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010, Graz, Austria.

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https://diagnosticpathology.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13000-019-0827-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528329PMC
May 2019

LCE: an open web portal to explore gene expression and clinical associations in lung cancer.

Oncogene 2019 04 7;38(14):2551-2564. Epub 2018 Dec 7.

Quantitative Biomedical Research Center, Department of Clinical Sciences, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA.

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http://dx.doi.org/10.1038/s41388-018-0588-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477796PMC
April 2019

Small cell lung cancers made from scratch.

J Exp Med 2019 Mar 13;216(3):476-478. Epub 2019 Feb 13.

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX

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http://dx.doi.org/10.1084/jem.20182216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400528PMC
March 2019

Retraction notice to "Sun exposure related methylation in malignant and non-malignant skin lesions" [Cancer Letters 245/1-2 (2007) 112-120].

Cancer Lett 2018 Sep;432:272

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas75390-8593, USA; Departments of Pathology, University of Texas Southwestern Medical Center, Dallas, TX75390, USA.

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http://dx.doi.org/10.1016/j.canlet.2018.07.010DOI Listing
September 2018

Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers.

Cell Metab 2018 09 28;28(3):369-382.e5. Epub 2018 Jun 28.

Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pediatrics and Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125205PMC
September 2018

Preface: lung cancer in never smokers.

Authors:
Adi F Gazdar

Transl Lung Cancer Res 2018 Aug;7(4):437-438

UT Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.21037/tlcr.2018.06.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131179PMC
August 2018

A quantitative method for assessing smoke associated molecular damage in lung cancers.

Transl Lung Cancer Res 2018 Aug;7(4):439-449

Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.21037/tlcr.2018.07.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131178PMC
August 2018

Comprehensive analysis of lung cancer pathology images to discover tumor shape and boundary features that predict survival outcome.

Sci Rep 2018 Jul 10;8(1):10393. Epub 2018 Jul 10.

Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.

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http://dx.doi.org/10.1038/s41598-018-27707-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039531PMC
July 2018

Main bronchus location is a predictor for metastasis and prognosis in lung adenocarcinoma: A large cohort analysis.

Lung Cancer 2018 06 19;120:22-26. Epub 2018 Mar 19.

Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA; Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, 75390, USA; Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2018.03.011DOI Listing
June 2018

The Epithelial Sodium Channel (αENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors.

Transl Oncol 2018 Apr 2;11(2):292-299. Epub 2018 Feb 2.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2018.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884185PMC
April 2018

Dysregulation of fibulin-5 and matrix metalloproteases in epithelial ovarian cancer.

Oncotarget 2018 Mar 14;9(18):14251-14267. Epub 2018 Feb 14.

Department of Obstetrics and Gynecology, Green Center for Reproductive Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.18632/oncotarget.24484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865667PMC
March 2018

Meta-analysis approaches to combine multiple gene set enrichment studies.

Stat Med 2018 02 19;37(4):659-672. Epub 2017 Oct 19.

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.

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http://dx.doi.org/10.1002/sim.7540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771852PMC
February 2018

Morphologic and Other Forms of Heterogeneity in Small Cell Lung Cancer: What Can We Learn from Them?

Authors:
Adi F Gazdar

J Thorac Oncol 2018 02;13(2):148-150

Hamon Center for Therapeutic Oncology Research and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2017.11.004DOI Listing
February 2018

Small-cell lung cancer: what we know, what we need to know and the path forward.

Nat Rev Cancer 2017 12 27;17(12):725-737. Epub 2017 Oct 27.

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75230-8593, USA.

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http://dx.doi.org/10.1038/nrc.2017.87DOI Listing
December 2017

Small-cell lung cancer: what we know, what we need to know and the path forward.

Nat Rev Cancer 2017 Nov 10;17(12):765. Epub 2017 Nov 10.

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http://dx.doi.org/10.1038/nrc.2017.106DOI Listing
November 2017

Integrative gene set enrichment analysis utilizing isoform-specific expression.

Genet Epidemiol 2017 09 4;41(6):498-510. Epub 2017 Jun 4.

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

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http://dx.doi.org/10.1002/gepi.22052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598160PMC
September 2017

Evaluation of the 7 and 8 editions of the AJCC/UICC TNM staging systems for lung cancer in a large North American cohort.

Oncotarget 2017 Sep 24;8(40):66784-66795. Epub 2017 May 24.

Department of Clinical Sciences, Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://www.oncotarget.com/fulltext/18158
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http://dx.doi.org/10.18632/oncotarget.18158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620136PMC
September 2017

Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types.

Biochem Pharmacol 2017 08 2;137:1-9. Epub 2017 Apr 2.

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, United States.

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http://dx.doi.org/10.1016/j.bcp.2017.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555585PMC
August 2017

GLI1 Blockade Potentiates the Antitumor Activity of PI3K Antagonists in Lung Squamous Cell Carcinoma.

Cancer Res 2017 08 26;77(16):4448-4459. Epub 2017 Jun 26.

Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research and Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-3315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559311PMC
August 2017

Genome-wide copy number variation pattern analysis and a classification signature for non-small cell lung cancer.

Genes Chromosomes Cancer 2017 07 4;56(7):559-569. Epub 2017 May 4.

School of Chemical Engineering and Technology, Tianjin University, 300072 Tianjin, People's Republic of China.

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http://dx.doi.org/10.1002/gcc.22460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555588PMC
July 2017

Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors.

Cell Rep 2017 05;19(8):1669-1684

Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.04.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531293PMC
May 2017

A statistical method for detecting differentially expressed SNVs based on next-generation RNA-seq data.

Biometrics 2017 03 8;73(1):42-51. Epub 2016 Jun 8.

Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas, U.S.A.

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http://dx.doi.org/10.1111/biom.12548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5151178PMC
March 2017

Comprehensive Computational Pathological Image Analysis Predicts Lung Cancer Prognosis.

J Thorac Oncol 2017 03 4;12(3):501-509. Epub 2016 Nov 4.

Department of Bioinformatics, University of Texas Southwestern Medical Center at Dallas, Texas; Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center at Dallas, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2016.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462113PMC
March 2017

Characterization of Human Cancer Cell Lines by Reverse-phase Protein Arrays.

Cancer Cell 2017 02;31(2):225-239

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501076PMC
February 2017

Proportion of Never-Smoker Non-Small Cell Lung Cancer Patients at Three Diverse Institutions.

J Natl Cancer Inst 2017 01 28;109(7). Epub 2017 Jan 28.

Affiliations of authors: Department of Internal Medicine, Hematology/Oncology, Harold C. Simmons Comprehensive Cancer Center (LP, AM, JDM, JS), Department of Biostatistics (CA, AG), Hamon Center for Therapeutic Oncology Research (JDM, AFG), Department of Pharmacology (JDM), Department of Pathology (AFG), UT Southwestern, Dallas, TX; Department of Hematology/Oncology, Vanderbilt University, Vanderbilt-Ingram Cancer Center, Nashville, TN (LH, DM); Parkland Memorial Hospital, Dallas, TX (JC).

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http://dx.doi.org/10.1093/jnci/djw295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279285PMC
January 2017

SHOX2 is a Potent Independent Biomarker to Predict Survival of WHO Grade II-III Diffuse Gliomas.

EBioMedicine 2016 Nov 28;13:80-89. Epub 2016 Oct 28.

The Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.10.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264450PMC
November 2016

Developing New, Rational Therapies for Recalcitrant Small Cell Lung Cancer.

J Natl Cancer Inst 2016 10 31;108(10). Epub 2016 May 31.

Hamon Center of Therapeutic Oncology Research, Simmons Comprehensive Cancer Center (AFG, JDM) and Departments of Pathology (AFG), Internal Medicine, and Pharmacology (JDM), UT Southwestern Medical Center, Dallas, TX.

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http://dx.doi.org/10.1093/jnci/djw119DOI Listing
October 2016

An Expression Signature as an Aid to the Histologic Classification of Non-Small Cell Lung Cancer.

Clin Cancer Res 2016 Oct 28;22(19):4880-4889. Epub 2016 Jun 28.

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas. Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492382PMC
October 2016

ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers.

J Thorac Oncol 2016 09 24;11(9):1469-81. Epub 2016 May 24.

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Pathology and Harold Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2016.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555593PMC
September 2016

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs.

Cell Rep 2016 08 21;16(5):1259-1272. Epub 2016 Jul 21.

Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.06.081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972690PMC
August 2016

Correction: "From Mice to Men and Back: An Assessment of Preclinical Model Systems for the Study of Lung Cancers".

J Thorac Oncol 2016 07;11(7):e88-9

Hamon Center for Therapeutic Oncology Research, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas; Departments of Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1016/j.jtho.2016.04.003DOI Listing
July 2016

Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer.

Genes Dev 2016 06;30(11):1289-99

Division of human Biology, Fred Hutchinson Cancer Research Center,Seattle,Washington 98109, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA;

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http://dx.doi.org/10.1101/gad.279307.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911928PMC
June 2016

From Mice to Men and Back: An Assessment of Preclinical Model Systems for the Study of Lung Cancers.

J Thorac Oncol 2016 Mar 24;11(3):287-99. Epub 2015 Dec 24.

Hamon Center for Therapeutic Oncology Research, Simmons Comprehensive Cancer Center and Departments of Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1016/j.jtho.2015.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809191PMC
March 2016

Inhibiting the Jumonji family: a potential new clinical approach to targeting aberrant epigenetic mechanisms.

Epigenomics 2016 Mar 26;8(3):313-6. Epub 2016 Feb 26.

Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.2217/epi.15.115DOI Listing
March 2016

Ethnicity affects and gene alterations of lung adenocarcinoma.

Oncol Lett 2015 Sep 23;10(3):1775-1782. Epub 2015 Jun 23.

Department of Thoracic Surgery Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Okayama, Japan.

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http://dx.doi.org/10.3892/ol.2015.3414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533243PMC
September 2015

High Incidence of Somatic BAP1 alterations in sporadic malignant mesothelioma.

J Thorac Oncol 2015 Apr;10(4):565-76

*University of Hawai'i Cancer Center, University of Hawai'i, Honolulu, Hawaii; †Hamon Center for Therapeutic Oncology Research and Department of Pathology, UT Southwestern Medical Center, Dallas, Texas; ‡Department of Biomedical Sciences and Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California; §Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania; and ‖Department of Cardiothoracic Surgery, New York University Langone Medical Center, New York, New York.

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http://dx.doi.org/10.1097/JTO.0000000000000471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408084PMC
April 2015

The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung.

J Thorac Oncol 2015 Apr;10(4):553-64

*Hamon Center for Therapeutic Oncology Research and Department of Pathology, UT Southwestern Medical Center, Dallas, TX; †Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX; ‡Cancer Genomics Centre, The Netherlands Cancer Institute, Amsterdam, The Netherlands; §Departments of Pediatrics and Genetics, Stanford University, Stanford, CA; ‖Center for Cancer Research, National Cancer Institute, Bethesda, MD; ¶Division of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA; #David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142; **Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY; and ††Departementd'Anatomie et Cytologie Pathologiques, INSERM Unit 823, Centre Hospitalier Universitaire Albert Michallon, and Institut Albert Bonniot University, Grenoble, France.

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http://dx.doi.org/10.1097/JTO.0000000000000459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523224PMC
April 2015

Genetic mutation of p53 and suppression of the miR-17∼92 cluster are synthetic lethal in non-small cell lung cancer due to upregulation of vitamin D Signaling.

Cancer Res 2015 Feb 17;75(4):666-75. Epub 2014 Dec 17.

Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas. Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas. Department of Pediatrics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas.

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http://cancerres.aacrjournals.org/content/75/4/666.full.pdf
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http://cancerres.aacrjournals.org/content/early/2014/12/17/0
Web Search
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-14-1329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333022PMC
February 2015

Proteomic signatures associated with p53 mutational status in lung adenocarcinoma.

Proteomics 2014 Dec 20;14(23-24):2750-9. Epub 2014 Nov 20.

Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1002/pmic.201400378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403731PMC
December 2014

ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers.

Proc Natl Acad Sci U S A 2014 Oct 29;111(41):14788-93. Epub 2014 Sep 29.

Hamon Center for Therapeutic Oncology Research, Simmons Comprehensive Cancer Center, and Pharmacology, Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235;

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http://dx.doi.org/10.1073/pnas.1410419111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205603PMC
October 2014

Analysis of TP53 mutation status in human cancer cell lines: a reassessment.

Hum Mutat 2014 Jun 6;35(6):756-65. Epub 2014 May 6.

Université Pierre et Marie Curie-Paris 6, Paris, 75005, France.

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http://doi.wiley.com/10.1002/humu.22556
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http://dx.doi.org/10.1002/humu.22556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451114PMC
June 2014

Methylation analysis in spontaneous sputum for lung cancer diagnosis.

Lung Cancer 2014 May 31;84(2):127-33. Epub 2014 Jan 31.

Department of Pathology, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2014.01.019DOI Listing
May 2014

Hereditary lung cancer syndrome targets never smokers with germline EGFR gene T790M mutations.

J Thorac Oncol 2014 Apr;9(4):456-63

*Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX; †Department of Pathology, UT Southwestern Medical Center, Dallas, TX; ‡Cancer Genetics, Simmons Cancer Center, UT Southwestern Medical Center, Dallas, TX; §Department of Clinical Science and McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, TX; ‖Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY; ¶Department of Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan; #Department of Radiology, UT Southwestern Medical Center, Dallas, TX; **Department of Clinical Science and Simmons Cancer Center, UT Southwestern Medical Center, Dallas, TX; ††Department of Cardiovascular and Thoracic Surgery, UT Southwestern Medical Center, Dallas, TX; and ‡‡Department of Medicine and Simmons Cancer Center, UT Southwestern Medical Center, Dallas, TX.

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http://dx.doi.org/10.1097/JTO.0000000000000130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509739PMC
April 2014

Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer.

Clin Cancer Res 2014 Mar 31;20(6):1610-22. Epub 2014 Jan 31.

Authors' Affiliations: Departments of Cell Biology; Pathology; Molecular Biology; Plastic Surgery; and Clinical Sciences; Simmons Comprehensive Cancer Center; Hamon Center for Therapeutic Oncology; Departments of Internal Medicine; Pharmacology; and Radiation Oncology, UT Southwestern Medical Center, Dallas; Departments of Thoracic/Head and Neck Medical Oncology; and Translational Molecular Pathology; The University of Texas MD Anderson Cancer Center, Houston, Texas; and Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-13-2589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961755PMC
March 2014

EGFR mutations in lung cancer: different frequencies for different folks.

Authors:
Adi F Gazdar

J Thorac Oncol 2014 Feb;9(2):139-40

Hamon Center for Therapeutic Oncology Research and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1097/JTO.0000000000000063DOI Listing
February 2014

Identification of breast cancer DNA methylation markers optimized for fine-needle aspiration samples.

Cancer Epidemiol Biomarkers Prev 2013 Dec 2;22(12):2212-21. Epub 2013 Oct 2.

Authors' Affiliations: Departments of Surgery, Pathology, Clinical Sciences, and Pathology, Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center; and Department of Molecular and Cell Biology, Center for Systems Biology, The University of Texas, Dallas, Texas.

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http://dx.doi.org/10.1158/1055-9965.EPI-13-0208DOI Listing
December 2013

YEATS4 is a novel oncogene amplified in non-small cell lung cancer that regulates the p53 pathway.

Cancer Res 2013 Dec 29;73(24):7301-12. Epub 2013 Oct 29.

Authors' Affiliations: Integrative Oncology, BC Cancer Research Center, Vancouver, BC, Canada; National Institutes of Health, Bethesda, Maryland; Department of Genetics, Harvard Medical School, Boston, Massachusetts; and Hamon Center of Therapeutics, University of Texas South Western, Dallas, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959870PMC
December 2013

CDKN2A/p16 inactivation mechanisms and their relationship to smoke exposure and molecular features in non-small-cell lung cancer.

J Thorac Oncol 2013 Nov;8(11):1378-88

*Hamon Center for Therapeutic Oncology Research and †Division of Biostatistics, University of Texas Southwestern Medical Center, Dallas, Texas; ‡Department of Integrative Oncology, British Columbia Cancer Agency Research Centre, Vancouver, B.C., Canada; §Texas Scottish Rite Hospital for Children, Dallas, Texas; ‖Department of Surgery, Biochemistry, and Molecular Biology, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, Los Angeles, California; ¶Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; #Oncology Biomarker Development, Genentech Inc., South San Francisco, California; **Department of Molecular and Cell Biology, Center for Systems Biology, University of Texas at Dallas, Dallas, Texas; and ††Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1097/JTO.0b013e3182a46c0cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951422PMC
November 2013

The pivotal role of pathology in the management of lung cancer.

J Thorac Dis 2013 Oct;5 Suppl 5:S463-78

University of Queensland Thoracic Research Centre, The Prince Charles Hospital, QLD, Australia; ; Department of Anatomical Pathology, Royal Brisbane and Women's Hospital, QLD, Australia;

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http://www.jthoracdis.com/article/view/1518
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http://dx.doi.org/10.3978/j.issn.2072-1439.2013.08.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804871PMC
October 2013

Precision medicine for cancer patients: lessons learned and the path forward.

J Natl Cancer Inst 2013 Sep 20;105(17):1262-3. Epub 2013 Aug 20.

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http://dx.doi.org/10.1093/jnci/djt219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760782PMC
September 2013

Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations.

Mol Cancer Res 2013 Jun 28;11(6):638-50. Epub 2013 Feb 28.

Hamon Center for Therapeutic Oncology Research, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas 75390, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-12-0634-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687022PMC
June 2013

DNA methylation data analysis and its application to cancer research.

Epigenomics 2013 Jun;5(3):301-16

Department of Molecular & Cell Biology, Center for Systems Biology, The University of Texas at Dallas, Richardson, TX 75080, USA.

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http://dx.doi.org/10.2217/epi.13.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525706PMC
June 2013

SH3GL2 is frequently deleted in non-small cell lung cancer and downregulates tumor growth by modulating EGFR signaling.

J Mol Med (Berl) 2013 Mar 12;91(3):381-93. Epub 2012 Sep 12.

Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA, USA.

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http://dx.doi.org/10.1007/s00109-012-0955-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691869PMC
March 2013

Automated sputum cytometry for detection of intraepithelial neoplasias in the lung.

Anal Cell Pathol (Amst) 2012 ;35(3):187-201

Integrative Oncology Department, BC Cancer Research Centre, Vancouver, Canada.

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http://dx.doi.org/10.3233/ACP-2012-0053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412676PMC
January 2013

Preneoplasia of lung cancer.

Cancer Biomark 2010 ;9(1-6):385-96

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical School, Dallas, TX, USA.

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http://dx.doi.org/10.3233/CBM-2011-0166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428013PMC
July 2012

Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression.

Genome Res 2012 Jul 21;22(7):1197-211. Epub 2012 May 21.

Department of Surgery, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9176, USA.

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http://dx.doi.org/10.1101/gr.132662.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396362PMC
July 2012

Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis.

Biochem Biophys Res Commun 2012 Jul 16;423(3):613-9. Epub 2012 Jun 16.

Tianjin Lung Cancer Institute, Tianjin General Hospital, Tianjin Medical University, Tianjin 300070, China.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X1201138
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http://dx.doi.org/10.1016/j.bbrc.2012.06.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512951PMC
July 2012

The evolving role of the pathologist in the management of lung cancer.

Authors:
Adi F Gazdar

Lung Cancer Manag 2012;1(4):273-281

Hamon Center for Therapeutic Oncology Research & Department of Pathology, UT Southwestern Medical Center, Bld NB8-206, 6000 Harry Hines Blvd, TX 75390-8593, USA; Tel.: +1 214 648 4921; ;

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http://dx.doi.org/10.2217/lmt.12.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535720PMC
January 2012

SMAC mimetic (JP1201) sensitizes non-small cell lung cancers to multiple chemotherapy agents in an IAP-dependent but TNF-α-independent manner.

Cancer Res 2011 Dec 2;71(24):7640-8. Epub 2011 Nov 2.

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382117PMC
December 2011

Methylation profiling of lung cancer: a decade of progress.

Mol Cancer Ther 2011 Nov;10(11):2020

Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama City, Okayama, Japan.

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http://dx.doi.org/10.1158/1535-7163.MCT-11-0768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522280PMC
November 2011