Publications by authors named "Adelheid Cerwenka"

83Publications

Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity.

Immunity 2020 Jun 22;52(6):1075-1087.e8. Epub 2020 May 22.

Department of Immunobiochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany; Innate Immunity, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; European Center for Angioscience (ECAS), Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2020.05.001DOI Listing
June 2020

Type 1 T cells promote the generation of CD8 tissue-resident memory T cells.

Nat Immunol 2020 07 18;21(7):766-776. Epub 2020 May 18.

Instituto de Medicina Molecular, João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.

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http://dx.doi.org/10.1038/s41590-020-0674-9DOI Listing
July 2020

Memory-Like NK Cells: Remembering a Previous Activation by Cytokines and NK Cell Receptors.

Front Immunol 2018 28;9:2796. Epub 2018 Nov 28.

Department for Immunobiochemistry, Universitätsmedizin Mannheim, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Germany.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02796
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http://dx.doi.org/10.3389/fimmu.2018.02796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279934PMC
October 2019

NK-cell responses are biased towards CD16-mediated effector functions in chronic hepatitis B virus infection.

J Hepatol 2019 03 18;70(3):351-360. Epub 2018 Oct 18.

Department of Medicine II, University Hospital Freiburg - Faculty of Medicine, University of Freiburg, Hugstetter Straße 55, Freiburg 79106, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2018.10.006DOI Listing
March 2019

Checkpoint inhibition: NK cells enter the scene.

Nat Immunol 2018 07;19(7):650-652

Centre for Biomedicine and Medical Technology, Heidelberg University, Medical Faculty Mannheim, Mannheim, Germany.

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http://www.nature.com/articles/s41590-018-0142-y
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http://dx.doi.org/10.1038/s41590-018-0142-yDOI Listing
July 2018

Distinct human circulating NKp30FcεRIγCD8 T cell population exhibiting high natural killer-like antitumor potential.

Proc Natl Acad Sci U S A 2018 06 12;115(26):E5980-E5989. Epub 2018 Jun 12.

Group of Innate Immunity, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1073/pnas.1720564115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042091PMC
June 2018

NKp44-Derived Peptide Binds Proliferating Cell Nuclear Antigen and Mediates Tumor Cell Death.

Front Immunol 2018 23;9:1114. Epub 2018 May 23.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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http://dx.doi.org/10.3389/fimmu.2018.01114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974751PMC
July 2019

The NKG2D/NKG2DL Axis in the Crosstalk Between Lymphoid and Myeloid Cells in Health and Disease.

Front Immunol 2018 23;9:827. Epub 2018 Apr 23.

Innate Immunity (D080), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.3389/fimmu.2018.00827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924773PMC
June 2019

Natural killers join the fight against cancer.

Science 2018 03;359(6383):1460-1461

Department of Microbiology and Immunology and Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1126/science.aat2184DOI Listing
March 2018

CD16A Activation of NK Cells Promotes NK Cell Proliferation and Memory-Like Cytotoxicity against Cancer Cells.

Cancer Immunol Res 2018 05 7;6(5):517-527. Epub 2018 Mar 7.

Innate Immunity, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1158/2326-6066.CIR-17-0550DOI Listing
May 2018

Radiation effects on antitumor immune responses: current perspectives and challenges.

Ther Adv Med Oncol 2018 18;10:1758834017742575. Epub 2018 Jan 18.

Programme in Solid Tumours and Biomarkers, Division of Oncology, Centre for Applied Biomedical Research (CIMA), IdiSNA, Navarra Institute for Health Research, Department of Histology and Pathology, University of Navarra, School of Medicine, Pamplona, Spain. Centro de Investigación Biomédica en Red de Cáncer (CIBERONC).

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http://dx.doi.org/10.1177/1758834017742575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784573PMC
January 2018

KIR downregulation by IL-12/15/18 unleashes human NK cells from KIR/HLA-I inhibition and enhances killing of tumor cells.

Eur J Immunol 2018 02 29;48(2):355-365. Epub 2017 Nov 29.

Innate Immunity Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1002/eji.201747128DOI Listing
February 2018

Hepatitis C virus-induced natural killer cell proliferation involves monocyte-derived cells and the OX40/OX40L axis.

J Hepatol 2018 03 1;68(3):421-430. Epub 2017 Nov 1.

Innate Immunity Group, German Cancer Research Center, Heidelberg, Germany; Division of Immunbiochemistry, University Heidelberg, Medical Faculty Mannheim, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.10.021DOI Listing
March 2018

Early inflammatory players in cutanous fibrosis.

J Dermatol Sci 2017 Sep 15;87(3):228-235. Epub 2017 Jun 15.

Department of Dermatology, Division for Experimental and Translational Research, University Medical Center of the Johannes Gutenberg-University Mainz, Germany; Research Center for Immune Therapy, University Medical Center of the Johannes Gutenberg-University Mainz, Germany.

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http://dx.doi.org/10.1016/j.jdermsci.2017.06.009DOI Listing
September 2017

Hepatitis C Virus and Human Cytomegalovirus-Natural Killer Cell Subsets in Persistent Viral Infections.

Front Immunol 2017 17;8:566. Epub 2017 May 17.

Research Group Innate Immunity, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.3389/fimmu.2017.00566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434107PMC
May 2017

Shaping of Natural Killer Cell Antitumor Activity by Cultivation.

Front Immunol 2017 26;8:458. Epub 2017 Apr 26.

Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents Medicine, Hospital of the Goethe University, Frankfurt, Germany.

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.00
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http://dx.doi.org/10.3389/fimmu.2017.00458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405078PMC
April 2017

HMGB1: The metabolic weapon in the arsenal of NK cells.

Mol Cell Oncol 2016 Jul 15;3(4):e1175538. Epub 2016 Apr 15.

Institute of Pathology, University of Heidelberg, Heidelberg, Germany; German Cancer Research Center, Clinical Cooperation Unit Molecular Tumor Pathology, Heidelberg, Germany.

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http://dx.doi.org/10.1080/23723556.2016.1175538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972106PMC
July 2016

Active but not inactive granulomatosis with polyangiitis is associated with decreased and phenotypically and functionally altered CD56(dim) natural killer cells.

Arthritis Res Ther 2016 09 13;18(1):204. Epub 2016 Sep 13.

Leibniz Research Center for Working Environment and Human Factors at TU Dortmund (IfADo), Ardeystraße 67, Dortmund, 44139, Germany.

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http://dx.doi.org/10.1186/s13075-016-1098-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022237PMC
September 2016

CD2-CD58 interactions are pivotal for the activation and function of adaptive natural killer cells in human cytomegalovirus infection.

Eur J Immunol 2016 10 29;46(10):2420-2425. Epub 2016 Aug 29.

Clinical Cooperation Unit Applied Tumor Immunity, Antigen Presentation & T/NK Cell Activation Group, German Cancer Research Center (DKFZ/D121), Heidelberg, Germany.

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http://dx.doi.org/10.1002/eji.201646492DOI Listing
October 2016

STAT5 Loss Awakens the Dark Force in Natural Killer Cells.

Cancer Discov 2016 Apr;6(4):347-9

German Cancer Research Center (DKFZ), Research Group Innate Immunity, Heidelberg, Germany.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0247DOI Listing
April 2016

Natural killer cell memory in infection, inflammation and cancer.

Nat Rev Immunol 2016 Feb 25;16(2):112-23. Epub 2016 Jan 25.

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/nri.2015.9DOI Listing
February 2016

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease.

Blood 2016 Jan 16;127(4):473-86. Epub 2015 Dec 16.

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany; Molecular Medicine Partnership Unit, Heidelberg University & European Molecular Biology Laboratory, Heidelberg, Germany;

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http://dx.doi.org/10.1182/blood-2015-08-663245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850229PMC
January 2016

Tricking the balance: NK cells in anti-cancer immunity.

Immunobiology 2017 01 26;222(1):11-20. Epub 2015 Jul 26.

Innate Immunity Group, D080, German Cancer Research Center, DKFZ Im Neuenheimer Feld 280, 69221 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.imbio.2015.07.012DOI Listing
January 2017

Immunology. MULT1plying cancer immunity.

Science 2015 Apr;348(6230):45-6

Innate Immunity Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1126/science.aaa9842DOI Listing
April 2015

Targeting natural killer cell reactivity by employing antibody to NKp46: implications for type 1 diabetes.

PLoS One 2015 26;10(2):e0118936. Epub 2015 Feb 26.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel; The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118936PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342013PMC
January 2016

Exploiting natural killer cells for therapy of melanoma.

J Dtsch Dermatol Ges 2015 Jan;13(1):23-9

Innate Immunity Group (D080), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1111/ddg.12557DOI Listing
January 2015

Antigen dependently activated cluster of differentiation 8-positive T cells cause perforin-mediated neurotoxicity in experimental stroke.

J Neurosci 2014 Dec;34(50):16784-95

Department of Neurology, University of Heidelberg, D-69120 Heidelberg, Germany, Division of Brain Sciences, Imperial College London, SW7 2AZ London, United Kingdom

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http://dx.doi.org/10.1523/JNEUROSCI.1867-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608504PMC
December 2014

Chronic liver inflammation and hepatocellular carcinogenesis are independent of S100A9.

Int J Cancer 2015 May 13;136(10):2458-63. Epub 2014 Nov 13.

Division of Signal Transduction and Growth Control, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.29282DOI Listing
May 2015

CTLA-4 is expressed by activated mouse NK cells and inhibits NK Cell IFN-γ production in response to mature dendritic cells.

J Immunol 2014 May 31;192(9):4184-91. Epub 2014 Mar 31.

Innate Immunity Group, German Cancer Research Center, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.4049/jimmunol.1302091DOI Listing
May 2014

New prospects on the NKG2D/NKG2DL system for oncology.

Oncoimmunology 2013 Oct 25;2(10):e26097. Epub 2013 Oct 25.

Institute for Molecular Medicine; Goethe-University Frankfurt am Main; Frankfurt am Main, Germany.

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http://dx.doi.org/10.4161/onci.26097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862635PMC
October 2013

Memory of infections: an emerging role for natural killer cells.

PLoS Pathog 2013 26;9(9):e1003548. Epub 2013 Sep 26.

Innate Immunity Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1003548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784484PMC
April 2014

Toward the next generation of NK cell-based adoptive cancer immunotherapy.

Oncoimmunology 2013 Apr;2(4):e23811

German Cancer Research Center (DKFZ); Junior Research Group Innate Immunity; Heidelberg, Germany.

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http://dx.doi.org/10.4161/onci.23811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654599PMC
April 2013

Shaping of NK cell responses by the tumor microenvironment.

Cancer Microenviron 2013 Aug 16;6(2):135-46. Epub 2012 Dec 16.

Innate Immunity, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s12307-012-0125-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717064PMC
August 2013

Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors.

J Exp Med 2012 Dec 3;209(13):2351-65. Epub 2012 Dec 3.

Junior Research Group Innate Immunity, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

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http://www.jem.org/lookup/doi/10.1084/jem.20120944
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http://dx.doi.org/10.1084/jem.20120944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526364PMC
December 2012

Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth.

J Immunol 2012 Dec 14;189(12):5602-11. Epub 2012 Nov 14.

Innate Immunity, Research Program Tumor Immunology, German Cancer Research Center, Heidelberg D-69120, Germany.

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http://dx.doi.org/10.4049/jimmunol.1201018DOI Listing
December 2012

Human NK cells are alerted to induction of p53 in cancer cells by upregulation of the NKG2D ligands ULBP1 and ULBP2.

Cancer Res 2011 Sep 15;71(18):5998-6009. Epub 2011 Jul 15.

Innate Immunity Group, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3211DOI Listing
September 2011

Natural killer cells and solid tumors.

J Innate Immun 2011 18;3(4):355-64. Epub 2011 Apr 18.

Innate Immunity, German Cancer Research Center, Heidelberg, Germany.

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https://www.karger.com/Article/FullText/325465
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http://dx.doi.org/10.1159/000325465DOI Listing
October 2011

NF-κ B-dependent upregulation of ICAM-1 by HPV16-E6/E7 facilitates NK cell/target cell interaction.

Int J Cancer 2011 Mar;128(5):1104-13

German Cancer Research Center, Research Group Innate Immunity, Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.25442DOI Listing
March 2011

Regulatory T cells control macrophage accumulation and activation in lymphoma.

Int J Cancer 2010 Sep;127(5):1131-40

Boveri junior research group of Innate Immunity, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.25132DOI Listing
September 2010

Host-derived interleukin-1alpha is important in determining the immunogenicity of 3-methylcholantrene tumor cells.

J Immunol 2009 Apr;182(8):4874-81

The Shraga Segal Department of Microbiology and Immunology and Faculty of Health Sciences and The Cancer Research Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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http://dx.doi.org/10.4049/jimmunol.0803916DOI Listing
April 2009

New twist on the regulation of NKG2D ligand expression.

J Exp Med 2009 Feb 9;206(2):265-8. Epub 2009 Feb 9.

Group of Innate Immunity, German Cancer Research Center, 69120 Heidelberg, Germany.

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http://jem.rupress.org/content/206/2/265.full.pdf
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http://www.jem.org/lookup/doi/10.1084/jem.20090225
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http://dx.doi.org/10.1084/jem.20090225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646580PMC
February 2009

Natural killer cell accumulation in tumors is dependent on IFN-gamma and CXCR3 ligands.

Cancer Res 2008 Oct;68(20):8437-45

Divisions of Innate Immunity and Immunogenetics, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1440DOI Listing
October 2008

Mononuclear myeloid-derived "suppressor" cells express RAE-1 and activate natural killer cells.

Blood 2008 Nov 27;112(10):4080-9. Epub 2008 Aug 27.

Division of Innate Immunity, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1182/blood-2008-03-143776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582006PMC
November 2008

Activating NK cell receptor ligands are differentially expressed during progression to cervical cancer.

Int J Cancer 2008 Nov;123(10):2343-53

Division of Innate Immunity, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.23733DOI Listing
November 2008

The TREM-1/DAP12 pathway.

Immunol Lett 2008 Mar 26;116(2):111-6. Epub 2007 Dec 26.

German Cancer Research Center DKFZ, Division of Innate Immunity, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.imlet.2007.11.021DOI Listing
March 2008

Identification of CLEC12B, an inhibitory receptor on myeloid cells.

J Biol Chem 2007 Aug 11;282(31):22370-5. Epub 2007 Jun 11.

Institute for Immunology, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1074/jbc.M704250200DOI Listing
August 2007

NK cells--from basic research to cancer therapy.

Eur J Immunol 2007 May;37(5):1161-4

Institute for Immunology, INF 305, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1002/eji.200790017DOI Listing
May 2007

Non-T cell activation linker (NTAL) negatively regulates TREM-1/DAP12-induced inflammatory cytokine production in myeloid cells.

J Immunol 2007 Feb;178(4):1991-9

German Cancer Research Center (DKFZ), Division of Innate Immunity, Heidelberg, Germany, Europe.

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http://dx.doi.org/10.4049/jimmunol.178.4.1991DOI Listing
February 2007

Adenovirus serotype 5 E1A sensitizes tumor cells to NKG2D-dependent NK cell lysis and tumor rejection.

J Exp Med 2005 Dec 28;202(11):1477-82. Epub 2005 Nov 28.

Integrated Department of Immunology, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, CO 80262, USA.

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http://www.jem.org/lookup/doi/10.1084/jem.20050240
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http://dx.doi.org/10.1084/jem.20050240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213342PMC
December 2005

Cutting edge: the minor histocompatibility antigen H60 peptide interacts with both H-2Kb and NKG2D.

J Immunol 2002 Apr;168(7):3131-4

Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.4049/jimmunol.168.7.3131DOI Listing
April 2002