Publications by authors named "Adel ElTahan"

2 Publications

  • Page 1 of 1

Correction to: Prevalence of prolonged QT interval in patients with HCV-related chronic liver disease.

Egypt Heart J 2019 Oct 29;71(1):21. Epub 2019 Oct 29.

Department of Endemic Medicine, Faculty of Medicine, Helwan University, Cairo, Egypt.

Following publication of the original article [1], the authors reported that the family name of Mohamed El Kassas was incorrectly published as Mohamed ElKassas.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s43044-019-0020-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821435PMC
October 2019

Prevalence of prolonged QT interval in patients with HCV-related chronic liver disease.

Egypt Heart J 2019 Sep 7;71(1):15. Epub 2019 Sep 7.

Department of Endemic Medicine, Faculty of Medicine, Helwan University, Cairo, Egypt.

Background: Hepatitis C virus (HCV) is a common disease in Egypt with a high socioeconomic burden and extra-hepatic manifestations as QT prolongation, but previous studies included mainly patients with advanced liver disease, so in this study, we aimed to delineate the prevalence of QT prolongation in early-stage HCV patients.

Results: The study included 874 HCV patients with early cirrhosis; in Child's class A, 57 (6.5%) patients had prolonged QT interval corrected (QTc). There was significant higher proportion of cirrhotic patients in the prolonged QTc group (31.6%) vs. in the normal QTc group (11.5%). QTc was 424.39 ± 36.6 vs. 411.51 ± 32.89 ms in cirrhotic and non-cirrhotic patients, respectively (P, 0.001). There was significant higher proportion of Fibrosis 4 (FIB-4) ≥ 1.45 score in the prolonged QTc (77.2%) vs. in the normal QTc group (56.8%) (P, 0.003). QTc interval was 417.76 ± 34.12 ms in patients with FIB-4 score ≥ 1.45 vs. 406.78 ± 31.95 ms in those with FIB-4 < 1.45 (P, < 0.001). FIB-4 score value of 2.108 predicted prolonged QTc with a sensitivity of 63.2% and a specificity of 64.5% (P, < 0.001). Twenty-four patients of long QTc group sent ECGs after HCV eradication, and 19 patients (79%) showed QTc normalization.

Conclusions: HCV is associated with QTc prolongation even in patients with early chronic liver disease stages without significant fibrosis. Also, it is related to the degree of fibrosis and cirrhosis. At a cutoff value of 2.108, FIB-4 score can predict prolonged QTc. HCV eradication is associated with a high incidence of QTc normalization.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s43044-019-0016-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821436PMC
September 2019
-->