Adam M Goldsmith

Adam M Goldsmith

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Adam M Goldsmith

Adam M Goldsmith

Publications by authors named "Adam M Goldsmith"

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IL-1β prevents ILC2 expansion, type 2 cytokine secretion and mucus metaplasia in response to early-life rhinovirus infection in mice.

Allergy 2020 Feb 22. Epub 2020 Feb 22.

Departments of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, 48109, United States.

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http://dx.doi.org/10.1111/all.14241DOI Listing
February 2020

Myristoylated rhinovirus VP4 protein activates TLR2-dependent proinflammatory gene expression.

Am J Physiol Lung Cell Mol Physiol 2019 Jul 25;317(1):L57-L70. Epub 2019 Mar 25.

Departments of Pediatrics and Communicable Diseases, University of Michigan , Ann Arbor, Michigan.

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https://www.physiology.org/doi/10.1152/ajplung.00365.2018
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http://dx.doi.org/10.1152/ajplung.00365.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689742PMC
July 2019

Impact of community respiratory viral infections in urban children with asthma.

Ann Allergy Asthma Immunol 2019 02 29;122(2):175-183.e2. Epub 2018 Oct 29.

Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2018.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360098PMC
February 2019

Gene Expression Signatures Point to a Male Sex-Specific Lung Mesenchymal Cell PDGF Receptor Signaling Defect in Infants Developing Bronchopulmonary Dysplasia.

Sci Rep 2018 11 20;8(1):17070. Epub 2018 Nov 20.

Division of Pediatric Pulmonology, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1038/s41598-018-35256-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244280PMC
November 2018

Tracheal Aspirate Levels of the Matricellular Protein SPARC Predict Development of Bronchopulmonary Dysplasia.

PLoS One 2015 11;10(12):e0144122. Epub 2015 Dec 11.

Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144122PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676701PMC
June 2016

Hyperoxic Exposure of Immature Mice Increases the Inflammatory Response to Subsequent Rhinovirus Infection: Association with Danger Signals.

J Immunol 2016 06 29;196(11):4692-705. Epub 2016 Apr 29.

Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI 48109

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http://dx.doi.org/10.4049/jimmunol.1501116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875849PMC
June 2016

Reduced platelet-derived growth factor receptor expression is a primary feature of human bronchopulmonary dysplasia.

Am J Physiol Lung Cell Mol Physiol 2014 Aug 6;307(3):L231-9. Epub 2014 Jun 6.

Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan; and

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http://dx.doi.org/10.1152/ajplung.00342.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121643PMC
August 2014

Macrophage activation state determines the response to rhinovirus infection in a mouse model of allergic asthma.

Respir Res 2014 Jun 7;15:63. Epub 2014 Jun 7.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, 48109 Ann Arbor, MI, USA.

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http://dx.doi.org/10.1186/1465-9921-15-63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066837PMC
June 2014

Suppression of inflammatory cell trafficking and alveolar simplification by the heme oxygenase-1 product carbon monoxide.

Am J Physiol Lung Cell Mol Physiol 2014 Apr 14;306(8):L749-63. Epub 2014 Feb 14.

Univ. of Michigan, 7220 C, Medical Science Research Bldg. III, 1150 West Medical Center Dr., Ann Arbor, MI 48109-0644 (e-mail address:

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http://dx.doi.org/10.1152/ajplung.00236.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989725PMC
April 2014

Macrophage/epithelial cell CCL2 contributes to rhinovirus-induced hyperresponsiveness and inflammation in a mouse model of allergic airways disease.

Am J Physiol Lung Cell Mol Physiol 2013 Feb 30;304(3):L162-9. Epub 2012 Nov 30.

Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1152/ajplung.00182.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567365PMC
February 2013

Mesenchymal stromal cells from neonatal tracheal aspirates demonstrate a pattern of lung-specific gene expression.

Stem Cells Dev 2011 Nov 6;20(11):1995-2007. Epub 2011 Apr 6.

Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109-5688, USA.

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http://dx.doi.org/10.1089/scd.2010.0494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202893PMC
November 2011

MDA5 and TLR3 initiate pro-inflammatory signaling pathways leading to rhinovirus-induced airways inflammation and hyperresponsiveness.

PLoS Pathog 2011 May 26;7(5):e1002070. Epub 2011 May 26.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1002070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102730PMC
May 2011

Isolation of tracheal aspirate mesenchymal stromal cells predicts bronchopulmonary dysplasia.

Pediatrics 2010 Nov 11;126(5):e1127-33. Epub 2010 Oct 11.

Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, MSRBII, 1150 W Medical Center Dr, Ann Arbor, MI 48109-5688, USA.

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http://dx.doi.org/10.1542/peds.2009-3445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887445PMC
November 2010

Ovalbumin sensitization and challenge increases the number of lung cells possessing a mesenchymal stromal cell phenotype.

Respir Res 2010 Sep 21;11:127. Epub 2010 Sep 21.

Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1186/1465-9921-11-127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949728PMC
September 2010

Autocrine production of TGF-beta1 promotes myofibroblastic differentiation of neonatal lung mesenchymal stem cells.

Am J Physiol Lung Cell Mol Physiol 2010 Jun 26;298(6):L735-43. Epub 2010 Feb 26.

Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan 48109-5688, USA.

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http://dx.doi.org/10.1152/ajplung.00347.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886615PMC
June 2010

Elastase- and LPS-exposed mice display altered responses to rhinovirus infection.

Am J Physiol Lung Cell Mol Physiol 2009 Nov 11;297(5):L931-44. Epub 2009 Sep 11.

Department of Pediatrics and Communicable Diseases, University of Michigan, 1150 W. Medical Center Dr., Rm. 3570, MSRBII, Box 5688, Ann Arbor, MI 48109-5688, USA.

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http://www.physiology.org/doi/10.1152/ajplung.00150.2009
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http://dx.doi.org/10.1152/ajplung.00150.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777490PMC
November 2009

Inhibition of glycogen synthase kinase-3beta is sufficient for airway smooth muscle hypertrophy.

J Biol Chem 2008 Apr 5;283(15):10198-207. Epub 2008 Feb 5.

Department of Pediatrics and Communicable Diseases, University of Michigan, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1074/jbc.M800624200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442285PMC
April 2008

Cooperative effects of rhinovirus and TNF-{alpha} on airway epithelial cell chemokine expression.

Am J Physiol Lung Cell Mol Physiol 2007 Oct 13;293(4):L1021-8. Epub 2007 Jul 13.

Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan 48109-0688, USA.

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http://dx.doi.org/10.1152/ajplung.00060.2007DOI Listing
October 2007

Lung cells from neonates show a mesenchymal stem cell phenotype.

Am J Respir Crit Care Med 2007 Jun 1;175(11):1158-64. Epub 2007 Mar 1.

Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1164/rccm.200607-941OCDOI Listing
June 2007

Rhinovirus activates interleukin-8 expression via a Src/p110beta phosphatidylinositol 3-kinase/Akt pathway in human airway epithelial cells.

J Virol 2007 Feb 22;81(3):1186-94. Epub 2006 Nov 22.

Department of Pediatrics, University of Michigan, 1150 W. Medical Center Dr., Room 3570, MSRBII, Box 0688, Ann Arbor, MI 48109-0688, USA.

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http://jvi.asm.org/content/81/3/1186.full.pdf
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http://jvi.asm.org/cgi/doi/10.1128/JVI.02309-06
Publisher Site
http://dx.doi.org/10.1128/JVI.02309-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797503PMC
February 2007

Regulation of airway smooth muscle alpha-actin expression by glucocorticoids.

Am J Physiol Lung Cell Mol Physiol 2007 Jan 15;292(1):L99-L106. Epub 2006 Sep 15.

Department of Pediatrics, University of Michigan, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0688, USA.

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http://dx.doi.org/10.1152/ajplung.00269.2006DOI Listing
January 2007

Transforming growth factor-beta induces airway smooth muscle hypertrophy.

Am J Respir Cell Mol Biol 2006 Feb 20;34(2):247-54. Epub 2005 Oct 20.

Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1165/rcmb.2005-0166OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644185PMC
February 2006

Phosphatidylinositol 3-kinase is required for rhinovirus-induced airway epithelial cell interleukin-8 expression.

J Biol Chem 2005 Nov 24;280(44):36952-61. Epub 2005 Aug 24.

Department of Pediatrics, Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1074/jbc.M502449200DOI Listing
November 2005

4E-binding protein phosphorylation and eukaryotic initiation factor-4E release are required for airway smooth muscle hypertrophy.

Am J Respir Cell Mol Biol 2005 Aug 18;33(2):195-202. Epub 2005 May 18.

Department of Pediatrics and Communicable Diseases, University of Michigan, 1150 W. Medical Center Dr., Room 3570, MSRBII, Box 0688, Ann Arbor, MI 48109-0688, USA.

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http://www.atsjournals.org/doi/abs/10.1165/rcmb.2004-0411OC
Publisher Site
http://dx.doi.org/10.1165/rcmb.2004-0411OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1578595PMC
August 2005

Human bronchial smooth muscle cell lines show a hypertrophic phenotype typical of severe asthma.

Am J Respir Crit Care Med 2004 Mar 23;169(6):703-11. Epub 2003 Dec 23.

Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109-0688, USA.

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http://dx.doi.org/10.1164/rccm.200307-964OCDOI Listing
March 2004