Dr Adam Lesner, PhD, DSc - University of Gdańsk - associate professor

Dr Adam Lesner

PhD, DSc

University of Gdańsk

associate professor

Gdansk, Poland | Poland

Additional Specialties: bioorganic chemistry, biochemistry enzymology

ORCID logohttps://orcid.org/0000-0001-8335-3431

Dr Adam Lesner, PhD, DSc - University of Gdańsk - associate professor

Dr Adam Lesner

PhD, DSc

Introduction

Primary Affiliation: University of Gdańsk - Gdansk, Poland , Poland

Additional Specialties:

Publications

52Publications

1106Reads

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156PubMed Central Citations

Design, Synthesis, and Enzymatic Evaluation of Novel ZnO Quantum Dot-Based Assay for Detection of Proteinase 3 Activity.

Bioconjug Chem 2018 05 20;29(5):1576-1583. Epub 2018 Apr 20.

Department of Solid State Physics, Faculty of Applied Physics and Mathematics , Gdansk University of Technology , Gdansk 80-233 , Poland.

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http://dx.doi.org/10.1021/acs.bioconjchem.8b00100DOI Listing
May 2018
9 Reads
4.513 Impact Factor

A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA.

J Immunol 2018 04 23;200(7):2327-2340. Epub 2018 Feb 23.

Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Krakow, 30-387 Krakow, Poland;

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http://dx.doi.org/10.4049/jimmunol.1701391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860981PMC
April 2018
27 Reads
4.922 Impact Factor

Biochemical properties of the HtrA homolog from bacterium Stenotrophomonas maltophilia.

Int J Biol Macromol 2018 Apr 16;109:992-1005. Epub 2017 Nov 16.

Department of General and Medical Biochemistry, Faculty of Biology, University of Gdansk, Gdansk 80-308, Poland. Electronic address:

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http://dx.doi.org/10.1016/j.ijbiomac.2017.11.086DOI Listing
April 2018
11 Reads
2.860 Impact Factor

Inhibition of human and yeast 20S proteasome by analogues of trypsin inhibitor SFTI-1.

PLoS One 2014 25;9(2):e89465. Epub 2014 Feb 25.

Department of Bioorganic Chemistry, Faculty of Chemistry, University of Gdansk, Gdansk, Poland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089465PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934894PMC
December 2014
36 Reads
3.234 Impact Factor

Substrate profiling of Finegoldia magna SufA protease, inhibitor screening and application to prevent human fibrinogen degradation and bacteria growth in vitro.

Biochimie 2014 Aug 22;103:137-43. Epub 2014 May 22.

Division of Medicinal Chemistry and Microbiology, Faculty of Chemistry, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland.

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http://dx.doi.org/10.1016/j.biochi.2014.05.006DOI Listing
August 2014
12 Reads
2.963 Impact Factor

The LA loop as an important regulatory element of the HtrA (DegP) protease from Escherichia coli: structural and functional studies.

J Biol Chem 2014 May 15;289(22):15880-93. Epub 2014 Apr 15.

From the Department of Biochemistry, Faculty of Biology, University of Gdansk, Wita Stwosza 59, 80-308 Gdansk, Poland,

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http://dx.doi.org/10.1074/jbc.M113.532895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140941PMC
May 2014
18 Reads
4 Citations
4.573 Impact Factor

Inhibitors of cathepsin G: a patent review (2005 to present).

Expert Opin Ther Pat 2013 Dec 30;23(12):1611-24. Epub 2013 Sep 30.

University of Gdansk, Department of Bioorganic Chemistry , Wita Stwosza 63, 80-952 Gdansk , Poland +48585235095 ; +48585235472 ;

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http://dx.doi.org/10.1517/13543776.2013.835397DOI Listing
December 2013
7 Reads
6 Citations
4.300 Impact Factor

Future of protease activity assays.

Curr Pharm Des 2013 ;19(6):1062-7

Faculty of Chemistry, Gdansk University, Sobieskiego 18, 80-952 Gdansk, Poland.

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http://dx.doi.org/10.2174/1381612811319060008DOI Listing
July 2013
46 Reads
2 Citations
3.452 Impact Factor

Temperature-induced changes of HtrA2(Omi) protease activity and structure.

Cell Stress Chaperones 2013 Jan 1;18(1):35-51. Epub 2012 Aug 1.

Department of Biochemistry, University of Gdansk, Kladki 24, 80-952, Gdansk, Poland.

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http://dx.doi.org/10.1007/s12192-012-0355-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508124PMC
January 2013
17 Reads
9 Citations
3.163 Impact Factor

Pegylated fluorescent peptides as substrates of proteolytic enzymes.

Protein Pept Lett 2012 Dec;19(12):1237-44

Faculty of Chemistry, Gdańsk University, Gdańsk, Poland.

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http://dx.doi.org/10.2174/092986612803521684DOI Listing
December 2012
22 Reads
1.070 Impact Factor

Three wavelength substrate system of neutrophil serine proteinases.

Anal Chem 2012 Aug 8;84(16):7241-8. Epub 2012 Aug 8.

Faculty of Chemistry, University of Gdansk, Sobieskiego 18, 80-952 Gdansk, Poland.

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http://dx.doi.org/10.1021/ac301684wDOI Listing
August 2012
104 Reads
2 Citations
5.640 Impact Factor

Inhibitory and antimicrobial activities of OGTI and HV-BBI peptides, fragments and analogs derived from amphibian skin.

Peptides 2012 Jun 9;35(2):276-84. Epub 2012 Apr 9.

Department of Bioorganic Chemistry, University of Gdansk, Gdansk, Poland.

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http://dx.doi.org/10.1016/j.peptides.2012.04.001DOI Listing
June 2012
7 Reads
3 Citations
2.620 Impact Factor

Surface plasmon resonance imaging biosensor for cathepsin G based on a potent inhibitor: development and applications.

Anal Biochem 2012 Apr 7;423(2):218-23. Epub 2012 Feb 7.

Department of Electrochemistry, Institute of Chemistry, University of Bialystok, 15-443 Bialystok, Poland.

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http://dx.doi.org/10.1016/j.ab.2012.01.033DOI Listing
April 2012
5 Reads
5 Citations
2.220 Impact Factor

Substrate specificity of Staphylococcus aureus cysteine proteases--Staphopains A, B and C.

Biochimie 2012 Feb 23;94(2):318-27. Epub 2011 Jul 23.

Department of Microbiology, Faculty of Biochemistry Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.

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http://dx.doi.org/10.1016/j.biochi.2011.07.020DOI Listing
February 2012
19 Reads
3 Citations
2.963 Impact Factor

Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery.

Curr Pharm Des 2011 Dec;17(38):4308-17

University of Gdansk, Gdansk, Poland.

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http://dx.doi.org/10.2174/138161211798999393DOI Listing
December 2011
7 Reads
8 Citations
3.452 Impact Factor

Introduction of Pro and its analogues in the conserved P1' position of trypsin inhibitor SFTI-1 retains its inhibitory activity.

Protein Pept Lett 2011 Nov;18(11):1158-67

Faculty of Chemistry, University of Gdansk, Sobieskiego 18, 80-952 Gdansk, Poland.

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http://dx.doi.org/10.2174/092986611797201002DOI Listing
November 2011
9 Reads
1 Citation
1.070 Impact Factor

Analogues of trypsin inhibitor SFTI-1 modified in the conserved P₁' position by synthetic or non-proteinogenic amino acids retain their inhibitory activity.

J Pept Sci 2011 Apr 3;17(4):281-7. Epub 2011 Feb 3.

Faculty of Chemistry, University of Gdansk, 80-952 Gdansk, Poland.

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http://dx.doi.org/10.1002/psc.1330DOI Listing
April 2011
7 Reads
1 Citation
1.550 Impact Factor

Implication of the disulfide bridge in trypsin inhibitor SFTI-1 in its interaction with serine proteinases.

Bioorg Med Chem 2010 Dec 29;18(23):8188-93. Epub 2010 Oct 29.

University of Gdansk, Poland.

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http://dx.doi.org/10.1016/j.bmc.2010.10.014DOI Listing
December 2010
18 Reads
3 Citations
2.793 Impact Factor

Analogues of trypsin inhibitor SFTI-1 with disulfide bridge substituted by various length of carbonyl bridges.

Protein Pept Lett 2010 Oct;17(10):1223-7

Faculty of Chemistry, University of Gdansk, Sobieskiego 18, 80-952 Gdansk, Poland.

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http://dx.doi.org/10.2174/092986610792231483DOI Listing
October 2010
65 Reads
1 Citation
1.070 Impact Factor

Inhibitory activity of double-sequence analogues of trypsin inhibitor SFTI-1 from sunflower seeds: an example of peptide splicing.

FEBS J 2010 May 19;277(10):2351-9. Epub 2010 Apr 19.

Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland.

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http://dx.doi.org/10.1111/j.1742-4658.2010.07650.xDOI Listing
May 2010
8 Reads
1 Citation
4.001 Impact Factor

The new fluorogenic substrates of neutrophil proteinase 3 optimized in prime site region.

Anal Biochem 2010 Apr 13;399(2):196-201. Epub 2010 Jan 13.

Faculty of Chemistry, University of Gdańsk, 80-952 Gdańsk, Poland.

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http://dx.doi.org/10.1016/j.ab.2010.01.007DOI Listing
April 2010
77 Reads
4 Citations
2.220 Impact Factor

Selection of peptomeric inhibitors of bovine alpha-chymotrypsin and cathepsin G based on trypsin inhibitor SFTI-1 using a combinatorial chemistry approach.

Mol Divers 2010 Feb 9;14(1):51-8. Epub 2009 Apr 9.

Faculty of Chemistry, University of Gdańsk, Sobieskiego 18, Gdańsk, 80-952, Poland.

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http://dx.doi.org/10.1007/s11030-009-9142-zDOI Listing
February 2010
6 Reads
1.900 Impact Factor

Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4(+) T cells and has anti-viral activity.

Biochem Biophys Res Commun 2009 Nov 29;389(2):284-9. Epub 2009 Aug 29.

Protein Chemistry Laboratory, St. Luke's/Roosevelt Institute for Health Sciences, Columbia University, New York, NY 10019, USA.

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http://dx.doi.org/10.1016/j.bbrc.2009.08.140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957897PMC
November 2009
30 Reads
18 Citations
2.300 Impact Factor

Application of specific cell permeable cathepsin G inhibitors resulted in reduced antigen processing in primary dendritic cells.

Mol Immunol 2009 Sep 16;46(15):2994-9. Epub 2009 Jul 16.

Catheomics, Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Medical Center Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany.

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http://dx.doi.org/10.1016/j.molimm.2009.06.017DOI Listing
September 2009
22 Reads
7 Citations
2.973 Impact Factor

Low-molecular-weight aldehyde inhibitors of cathepsin G.

Protein Pept Lett 2009 ;16(4):408-10

Faculty of Chemistry, University of Gdansk, 80-952 Gdansk, Poland.

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http://dx.doi.org/10.2174/092986609787848144DOI Listing
June 2009
5 Reads
1.070 Impact Factor

Introduction of non-natural amino acid residues into the substrate-specific P1 position of trypsin inhibitor SFTI-1 yields potent chymotrypsin and cathepsin G inhibitors.

Bioorg Med Chem 2009 May 27;17(9):3302-7. Epub 2009 Mar 27.

Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland.

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http://dx.doi.org/10.1016/j.bmc.2009.03.045DOI Listing
May 2009
19 Reads
1 Citation
2.793 Impact Factor

New potent cathepsin G phosphonate inhibitors.

Bioorg Med Chem 2008 Oct 31;16(19):8863-7. Epub 2008 Aug 31.

Division of Medicinal Chemistry and Microbiology, Faculty of Chemistry, Wrocław University of Technology, Wybrzeze Wyspiańskiego 27, 50-370 Wrocław, Poland.

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http://dx.doi.org/10.1016/j.bmc.2008.08.069DOI Listing
October 2008
51 Reads
2 Citations
2.793 Impact Factor

The influence of substrate peptide length on human beta-tryptase specificity.

J Pept Sci 2008 Aug;14(8):917-23

Bioorganic Chemistry Department, Faculty of Chemistry, University of Gdańsk, Sobieskiego 18 80-952 Gdańsk, Poland.

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http://dx.doi.org/10.1002/psc.1026DOI Listing
August 2008
17 Reads
1.550 Impact Factor

Design of selective substrates of proteinase 3 using combinatorial chemistry methods.

Anal Biochem 2008 Jul 7;378(2):208-15. Epub 2008 Apr 7.

Faculty of Chemistry, University of Gdańsk, 80-952 Gdańsk, Poland.

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http://dx.doi.org/10.1016/j.ab.2008.04.003DOI Listing
July 2008
5 Reads
6 Citations
2.220 Impact Factor

Designing of substrates and inhibitors of bovine alpha-chymotrypsin with synthetic phenylalanine analogues in position P(1).

Protein Pept Lett 2008 ;15(3):260-4

Faculty of Chemistry, University of Gdańsk, 80-952 Gdańsk, Poland.

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http://dx.doi.org/10.2174/092986608783744180DOI Listing
July 2008
18 Reads
1 Citation
1.070 Impact Factor

Peptomeric analogues of trypsin inhibitor SFTI-1 isolated from sunflower seeds.

Bioorg Med Chem 2008 May 1;16(10):5644-52. Epub 2008 Apr 1.

Faculty of Chemistry, University of Gdańsk, Sobieskiego 18, 80-952 Gdańsk, Poland.

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http://dx.doi.org/10.1016/j.bmc.2008.03.075DOI Listing
May 2008
9 Reads
2.793 Impact Factor

Development of sensitive cathepsin G fluorogenic substrate using combinatorial chemistry methods.

Anal Biochem 2008 Apr 19;375(2):306-12. Epub 2008 Jan 19.

Faculty of Chemistry, University of Gdańsk, 80-952 Gdańsk, Poland.

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http://dx.doi.org/10.1016/j.ab.2008.01.020DOI Listing
April 2008
7 Reads
3 Citations
2.220 Impact Factor

Inhibition of HIV-1 or bacterial activation of macrophages by products of HIV-1-resistant human cells.

Immunol Cell Biol 2007 Nov-Dec;85(8):603-9. Epub 2007 Jul 17.

Molecular Virology Division, St Luke's-Roosevelt Hospital Center, Columbia University Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1038/sj.icb.7100092DOI Listing
February 2008
11 Reads
7 Citations
4.150 Impact Factor

Design of serine proteinase inhibitors by combinatorial chemistry using trypsin inhibitor SFTI-1 as a starting structure.

J Pept Sci 2007 Nov;13(11):749-55

Faculty of Chemistry, University of Gdańsk, Sobieskiego 18, 80-952 Gdańsk, Poland.

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http://dx.doi.org/10.1002/psc.887DOI Listing
November 2007
5 Reads
3 Citations
1.550 Impact Factor

New chromogenic substrates of human neutrophil cathepsin G containing non-natural aromatic amino acid residues in position P(1) selected by combinatorial chemistry methods.

Mol Divers 2007 May 25;11(2):93-9. Epub 2007 Jul 25.

Bioorganic Chemistry Department, Faculty of Chemistry, University of Gdańsk, Sobieskiego 18, 80-952 Gdańsk, Poland.

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http://dx.doi.org/10.1007/s11030-007-9063-7DOI Listing
May 2007
8 Reads
4 Citations
1.900 Impact Factor

Selection of new chromogenic substrates of serine proteinases using combinatorial chemistry methods.

Comb Chem High Throughput Screen 2007 Mar;10(3):171-80

Bioorganic Chemistry Department, Faculty of Chemistry, University of Gdańsk, ul. Sobieskiego 18, 80-952 Gdańsk, Poland.

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http://dx.doi.org/10.2174/138620707780126714DOI Listing
March 2007
35 Reads
2 Citations
1.222 Impact Factor

A soluble factor secreted by an HIV-1-resistant cell line blocks transcription through inactivating the DNA-binding capacity of the NF-kappa B p65/p50 dimer.

J Immunol 2005 Aug;175(4):2548-54

Molecular Virology Division, St. Luke's-Roosevelt Hospital Center, Columbia University Medical Center, New York, NY 10019, USA.

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http://dx.doi.org/10.4049/jimmunol.175.4.2548DOI Listing
August 2005
3 Reads
12 Citations
4.922 Impact Factor

Monoubiquitinated histone H1B is required for antiviral protection in CD4(+)T cells resistant to HIV-1.

Biochemistry 2004 Dec;43(51):16203-11

Molecular Virology Division, St. Luke's/Roosevelt Hospital Center, Columbia University, New York, New York 10019, USA.

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http://dx.doi.org/10.1021/bi0492758DOI Listing
December 2004
12 Reads
7 Citations
3.020 Impact Factor

A simple method for selection of trypsin chromogenic substrates using combinatorial chemistry approach.

Biochem Biophys Res Commun 2004 Jun;319(1):185-8

Faculty of Chemistry, University of Gdańsk, Sobieskiego 18, PL-80-952 Gdańsk, Poland.

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http://dx.doi.org/10.1016/j.bbrc.2004.04.170DOI Listing
June 2004
12 Reads
2.300 Impact Factor

Microarray analysis of differentially expressed genes in cells resistant to HIV-1.

Immunol Lett 2004 Apr;93(1):79-86

Molecular Virology Laboratory, Molecular Virology Division, Department of Medicine, St. Luke's/Roosevelt Hospital Center, Columbia University, 432 West 58th Street, Rm. 709, New York, NY 10019, USA.

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http://dx.doi.org/10.1016/j.imlet.2004.02.009DOI Listing
April 2004
6 Reads
6 Citations
2.512 Impact Factor

Induction of secreted human immunodeficiency virus type 1 (HIV-1) resistance factors in CD4-positive T lymphocytes by attenuated HIV-1 infection.

Virology 2002 Mar;294(1):1-12

Molecular Virology Division, St. Luke's-Roosevelt Hospital Center, Antenucci Researech Building, 432 West 58th Street, New York, NY 10019, USA.

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http://dx.doi.org/10.1006/viro.2001.1300DOI Listing
March 2002
56 Reads
9 Citations
3.321 Impact Factor

Top co-authors

Krzysztof Rolka
Krzysztof Rolka

University of Gda?sk

27
Magdalena Wysocka
Magdalena Wysocka

University of Gda?sk

27
Anna Legowska
Anna Legowska

University of Gdansk

10
Malgorzata Simm
Malgorzata Simm

Columbia University

6
Francis Gauthier
Francis Gauthier

University of Tours

5
Brice Korkmaz
Brice Korkmaz

Université François Rabelais

5