Adam J Engler

Adam J Engler

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Adam J Engler

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Substrate stiffness directs diverging vascular fates.

Acta Biomater 2019 Jul 19. Epub 2019 Jul 19.

Graduate Program in Biological Engineering and Small-scale Technologies, University of California, Merced, United States; Materials Science and Engineering Department, University of California, Merced, United States. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2019.07.030DOI Listing
July 2019

Mechanical influences on cardiovascular differentiation and disease modeling.

Exp Cell Res 2019 Apr 19;377(1-2):103-108. Epub 2019 Feb 19.

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, United States; Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037, United States. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2019.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408970PMC
April 2019

Matrix stiffness mechanically conditions EMT and migratory behavior of oral squamous cell carcinoma.

J Cell Sci 2019 Jan 9;132(1). Epub 2019 Jan 9.

Department of Oral Pathology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

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http://dx.doi.org/10.1242/jcs.224360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340137PMC
January 2019

Biomaterials to model and measure epithelial cancers.

Nat Rev Mater 2018 Nov 6;3(11):418-430. Epub 2018 Sep 6.

Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224155PMC
November 2018

Rationally engineered advances in cancer research.

APL Bioeng 2018 Sep 26;2(3):031601. Epub 2018 Sep 26.

Biophysical Engineering Labs, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1063/1.5056176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481711PMC
September 2018

Recent Advances in Extrusion-Based 3D Printing for Biomedical Applications.

Adv Healthc Mater 2018 04 28;7(8):e1701161. Epub 2017 Dec 28.

Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California, San Diego, 2880 Torrey Pines Scenic Drive, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1002/adhm.201701161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954828PMC
April 2018

The role of mechanobiology in progression of rotator cuff muscle atrophy and degeneration.

J Orthop Res 2018 02 11;36(2):546-556. Epub 2017 Aug 11.

Department of Orthopedic Surgery, University of California, 9500 Gilman Dr (0863), La Jolla, 92093, California.

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http://dx.doi.org/10.1002/jor.23662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788743PMC
February 2018

Heterogeneous muscle gene expression patterns in patients with massive rotator cuff tears.

PLoS One 2018 2;13(1):e0190439. Epub 2018 Jan 2.

Department of Orthopedic Surgery, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190439PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749784PMC
February 2018

Understanding the extracellular forces that determine cell fate and maintenance.

Development 2017 12;144(23):4261-4270

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA

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http://dx.doi.org/10.1242/dev.158469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769638PMC
December 2017

Extracellular matrix downregulation in the Drosophila heart preserves contractile function and improves lifespan.

Matrix Biol 2017 10 25;62:15-27. Epub 2016 Oct 25.

Biomedical Sciences Program, UC, San Diego; La Jolla, CA 92093, USA; Department of Bioengineering, UC, San Diego; La Jolla, CA 92093, USA; Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2016.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405015PMC
October 2017

Rotator cuff tear state modulates self-renewal and differentiation capacity of human skeletal muscle progenitor cells.

J Orthop Res 2017 08 16;35(8):1816-1823. Epub 2016 Oct 16.

Biomedical Sciences Program, UC San Diego, La Jolla, California, 92093.

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http://dx.doi.org/10.1002/jor.23453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438295PMC
August 2017

Mechanical regulation of cardiac fibroblast profibrotic phenotypes.

Mol Biol Cell 2017 Jul 3;28(14):1871-1882. Epub 2017 May 3.

Department of Bioengineering, University of California San Diego, La Jolla, CA 92093.

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http://dx.doi.org/10.1091/mbc.E17-01-0014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541838PMC
July 2017

Mechanically patterned neuromuscular junctions-in-a-dish have improved functional maturation.

Mol Biol Cell 2017 Jul 11;28(14):1950-1958. Epub 2017 May 11.

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093

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http://dx.doi.org/10.1091/mbc.E17-01-0046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541845PMC
July 2017

The provisional matrix: setting the stage for tissue repair outcomes.

Matrix Biol 2017 07;60-61:1-4

Department of Bioengineering, Jacob School of Engineering, University of California San Diego, La Jolla, CA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2017.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831186PMC
July 2017

Histological Evidence of Muscle Degeneration in Advanced Human Rotator Cuff Disease.

J Bone Joint Surg Am 2017 Feb;99(3):190-199

1Departments of Bioengineering (M.C.G. and A.J.E.), Orthopaedic Surgery (T.C., M.P., S.S., and S.R.W.), and Radiology (S.R.W.), University of California San Diego, San Diego, California 2Kaiser Permanente, San Diego, California.

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http://dx.doi.org/10.2106/JBJS.16.00335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395080PMC
February 2017

Metastatic State of Cancer Cells May Be Indicated by Adhesion Strength.

Biophys J 2017 Feb;112(4):736-745

Department of Bioengineering, University of California, San Diego, La Jolla, California; Biomedical Sciences Program, University of California, San Diego, La Jolla, California; Sanford Consortium for Regenerative Medicine, La Jolla, California. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2016.12.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340156PMC
February 2017

Muscle architectural changes after massive human rotator cuff tear.

J Orthop Res 2016 12 21;34(12):2089-2095. Epub 2016 Apr 21.

Department of Orthopedic Surgery, University of California, La Jolla, California.

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http://dx.doi.org/10.1002/jor.23256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423410PMC
December 2016

High content image analysis of focal adhesion-dependent mechanosensitive stem cell differentiation.

Integr Biol (Camb) 2016 10;8(10):1049-1058

Department of Bioengineering, University of California, 9500 Gilman Drive, MC 0695, La Jolla, San Diego, CA, USA. and Sanford Consortium for Regenerative Medicine, La Jolla, CA 92093, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079280PMC
http://dx.doi.org/10.1039/c6ib00076bDOI Listing
October 2016

Sixth International AFM BioMed Conference on AFM in life sciences and medicine, December 13 to 17, 2014, San Diego, California.

J Mol Recognit 2016 09;29(9):404-5

Institut de Biologie Structurale, Grenoble, France.

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http://dx.doi.org/10.1002/jmr.2556DOI Listing
September 2016

Mechanical Regulation of Cardiac Aging in Model Systems.

Circ Res 2016 05;118(10):1553-62

From the Biomedical Sciences Program (A.O.S., A.J.E.) and Department of Bioengineering, University of California, San Diego, La Jolla (A.J.E.); and Sanford Consortium for Regenerative Medicine, La Jolla, CA (A.J.E.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.307472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868502PMC
May 2016

Mechanical Forces Reshape Differentiation Cues That Guide Cardiomyogenesis.

Circ Res 2016 Jan;118(2):296-310

From the Department of Bioengineering, University of California, San Diego, La Jolla; and Sanford Consortium for Regenerative Medicine, La Jolla, CA.

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http://dx.doi.org/10.1161/CIRCRESAHA.115.305139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743530PMC
January 2016

Haptotaxis is cell type specific and limited by substrate adhesiveness.

Cell Mol Bioeng 2015 Dec 3;8(4):530-542. Epub 2015 Jun 3.

Department of Bioengineering, UC San Diego; La Jolla, CA, 92093, USA ; Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037, USA.

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http://link.springer.com/content/pdf/10.1007%2Fs12195-015-03
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http://link.springer.com/10.1007/s12195-015-0398-3
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http://dx.doi.org/10.1007/s12195-015-0398-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667988PMC
December 2015

Epimuscular Fat in the Human Rotator Cuff Is a Novel Beige Depot.

Stem Cells Transl Med 2015 Jul 21;4(7):764-74. Epub 2015 May 21.

Departments of Bioengineering, Orthopedic Surgery, and Radiology, University of California, San Diego, La Jolla, California, USA; Sanford Consortium for Regenerative Medicine, La Jolla, California, USA

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http://doi.wiley.com/10.5966/sctm.2014-0287
Publisher Site
http://dx.doi.org/10.5966/sctm.2014-0287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479624PMC
July 2015

Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy.

Cell Stem Cell 2015 Jul 18;17(1):89-100. Epub 2015 Jun 18.

Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546705PMC
July 2015

The cytoskeleton regulates cell attachment strength.

Biophys J 2015 Jul;109(1):57-65

Department of Bioengineering, University of California, San Diego, La Jolla, California; Sanford Consortium for Regenerative Medicine, La Jolla, California. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2015.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572469PMC
July 2015

3D surface topology guides stem cell adhesion and differentiation.

Biomaterials 2015 Jun 24;52:140-7. Epub 2015 Feb 24.

Department of Chemistry, University College London, London WC1H 0AJ, UK; The MRC/UCL Centre for Medical Molecular Virology, University College London, London WC1H 0AJ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2015.01.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379418PMC
June 2015

Transfer stamping of human mesenchymal stem cell patches using thermally expandable hydrogels with tunable cell-adhesive properties.

Biomaterials 2015 Jun 29;54:44-54. Epub 2015 Mar 29.

Department of Bioengineering, Hanyang University, 17 Haengdang-dong, Seongdong-gu, Seoul 133-791, Republic of Korea; BK21 Plus Future Biopharmaceutical Human Resources Training and Research Team, Hanyang University, 17 Haengdang-dong, Seongdong-gu, Seoul 133-791, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2015.03.016DOI Listing
June 2015

Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart.

Sci Transl Med 2015 Jun;7(292):292ra99

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA. Biomedical Sciences Program, University of California, San Diego, La Jolla, CA 92093, USA. Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa5843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507505PMC
June 2015

Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway.

Nat Cell Biol 2015 May 20;17(5):678-88. Epub 2015 Apr 20.

1] Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive La Jolla, California 92093-0819, USA [2] Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive La Jolla, California 92093-0819, USA.

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http://dx.doi.org/10.1038/ncb3157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452027PMC
May 2015

Traction forces mediated by integrin signaling are necessary for definitive endoderm specification.

J Cell Sci 2015 May 23;128(10):1961-8. Epub 2015 Apr 23.

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037, USA Biomedical Sciences Program, University of California, San Diego, La Jolla, CA 92093, USA

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http://dx.doi.org/10.1242/jcs.166157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457159PMC
May 2015

From stem cells to cardiomyocytes: the role of forces in cardiac maturation, aging, and disease.

Prog Mol Biol Transl Sci 2014 ;126:219-42

Department of Bioengineering, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1016/B978-0-12-394624-9.00009-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281561PMC
April 2015

Mechanotransduction. Preface.

Prog Mol Biol Transl Sci 2014 ;126:xiii-xiv

Department of Bioengineering, University of California, Berkeley, Berkeley, CA.

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http://dx.doi.org/10.1016/B978-0-12-394624-9.09985-1DOI Listing
April 2015

Cation type specific cell remodeling regulates attachment strength.

PLoS One 2014 11;9(7):e102424. Epub 2014 Jul 11.

Department of Bioengineering, Institute of Engineering in Medicine, University of California San Diego, La Jolla, California, United States of America; Sanford Consortium for Regenerative Medicine, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102424PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094514PMC
March 2015

Muscle progenitor cell regenerative capacity in the torn rotator cuff.

J Orthop Res 2015 Mar 6;33(3):421-9. Epub 2015 Jan 6.

Department of Bioengineering, University of California, San Diego, La Jolla, California, 92093.

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http://dx.doi.org/10.1002/jor.22786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346515PMC
March 2015

Extracellular matrix regulation in the muscle satellite cell niche.

Connect Tissue Res 2015 Feb 12;56(1):1-8. Epub 2014 Aug 12.

Department of Biomedical Sciences and.

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http://dx.doi.org/10.3109/03008207.2014.947369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464813PMC
February 2015

Acute shear stress direction dictates adherent cell remodeling and verifies shear profile of spinning disk assays.

Phys Biol 2015 Jan 26;12(1):016011. Epub 2015 Jan 26.

Departments of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA. Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1088/1478-3975/12/1/016011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323404PMC
January 2015

Interplay of matrix stiffness and protein tethering in stem cell differentiation.

Nat Mater 2014 Oct 10;13(10):979-87. Epub 2014 Aug 10.

1] Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA [2] Sanford Consortium for Regenerative Medicine, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nmat4051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172528PMC
October 2014

Mechanosensitive kinases regulate stiffness-induced cardiomyocyte maturation.

Sci Rep 2014 Sep 19;4:6425. Epub 2014 Sep 19.

1] Department of Bioengineering, University of California, San Diego, CA 92093 [2] Department of Material Science Program, University of California, San Diego, CA 92093 [3] Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037.

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http://dx.doi.org/10.1038/srep06425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168277PMC
September 2014

Digital Plasmonic Patterning for Localized Tuning of Hydrogel Stiffness.

Adv Funct Mater 2014 Aug;24(31):4922-4926

Department of NanoEngineering, University of California, San Diego, La Jolla, CA 92093-0448, USA.

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http://dx.doi.org/10.1002/adfm.201400274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479157PMC
August 2014

A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging.

Aging Cell 2014 Jun 9;13(3):431-40. Epub 2014 Jan 9.

Development, Aging and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA.

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http://doi.wiley.com/10.1111/acel.12193
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http://dx.doi.org/10.1111/acel.12193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032615PMC
June 2014

Materials as stem cell regulators.

Nat Mater 2014 Jun;13(6):547-57

1] Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA [2] Sanford Consortium for Regenerative Medicine, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nmat3937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163547PMC
June 2014

A Drosophila melanogaster model of diastolic dysfunction and cardiomyopathy based on impaired troponin-T function.

Circ Res 2014 Jan 12;114(2):e6-17. Epub 2013 Nov 12.

From the Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (M.C.V., A.C.); Department of Bioengineering, University of California, San Diego, La Jolla, CA (G.K., A.J.E.); and Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA (W.L.).

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http://dx.doi.org/10.1161/CIRCRESAHA.114.302028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526186PMC
January 2014

In situ mechanotransduction via vinculin regulates stem cell differentiation.

Stem Cells 2013 Nov;31(11):2467-77

Department of Bioengineering, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1002/stem.1490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833960PMC
November 2013

Stimulation of adipogenesis of adult adipose-derived stem cells using substrates that mimic the stiffness of adipose tissue.

Biomaterials 2013 Nov 15;34(34):8581-8. Epub 2013 Aug 15.

Department of Bioengineering, University of California, San Diego, Sanford Consortium for Regenerative Medicine, 2880 Torrey Pines Scenic Dr., La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2013.07.103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786695PMC
November 2013

A co-culture device with a tunable stiffness to understand combinatorial cell-cell and cell-matrix interactions.

Integr Biol (Camb) 2013 Nov 24;5(11):1344-54. Epub 2013 Sep 24.

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1039/c3ib40078fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848881PMC
November 2013

Defined extracellular matrix components are necessary for definitive endoderm induction.

Stem Cells 2013 Oct;31(10):2084-94

Department of Bioengineering, University of California, San Diego, La Jolla, California, USA; Sanford Consortium for Regenerative Medicine, La Jolla, California, USA.

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http://dx.doi.org/10.1002/stem.1453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812380PMC
October 2013

Dynamic and reversible surface topography influences cell morphology.

J Biomed Mater Res A 2013 Aug 27;101(8):2313-21. Epub 2013 Jan 27.

Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1002/jbm.a.34543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433743PMC
August 2013

In vivo response to dynamic hyaluronic acid hydrogels.

Acta Biomater 2013 Jul 21;9(7):7151-7. Epub 2013 Mar 21.

Department of Bioengineering, University of California, San Diego, CA 92093, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674107PMC
http://dx.doi.org/10.1016/j.actbio.2013.03.019DOI Listing
July 2013

Stem cell differentiation: Post-degradation forces kick in.

Nat Mater 2013 May;12(5):384-6

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http://dx.doi.org/10.1038/nmat3636DOI Listing
May 2013

Mesenchymal stem cell durotaxis depends on substrate stiffness gradient strength.

Biotechnol J 2013 Apr 28;8(4):472-84. Epub 2013 Feb 28.

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1002/biot.201200205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749305PMC
April 2013

Density gradient multilayered polymerization (DGMP): a novel technique for creating multi-compartment, customizable scaffolds for tissue engineering.

J Vis Exp 2013 Feb 12(72). Epub 2013 Feb 12.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California-San Diego, CA, USA.

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http://dx.doi.org/10.3791/50018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601043PMC
February 2013

Cell instructive microporous scaffolds through interface engineering.

J Am Chem Soc 2012 Dec 30;134(49):20103-9. Epub 2012 Nov 30.

The Krebs Institute, The University of Sheffield, Sheffield S10 2TN, United Kingdom.

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http://dx.doi.org/10.1021/ja308523fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556732PMC
December 2012

The alignment and fusion assembly of adipose-derived stem cells on mechanically patterned matrices.

Biomaterials 2012 Oct 15;33(29):6943-51. Epub 2012 Jul 15.

Departments of Bioengineering, University of California, San Diego, CA 92093, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2012.06.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408879PMC
October 2012

Control of stem cell fate and function by engineering physical microenvironments.

Integr Biol (Camb) 2012 Sep;4(9):1008-18

Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476065PMC
September 2012

Mechanical derivation of functional myotubes from adipose-derived stem cells.

Biomaterials 2012 Mar 23;33(8):2482-91. Epub 2011 Dec 23.

Department of Bioengineering, University of California, San Diego, CA, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2011.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261363PMC
March 2012

In situ mechanical analysis of myofibrillar perturbation and aging on soft, bilayered Drosophila myocardium.

Biophys J 2011 Dec;101(11):2629-37

Department of Bioengineering, University of California at San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1016/j.bpj.2011.10.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297788PMC
December 2011

More than a feeling: discovering, understanding, and influencing mechanosensing pathways.

Curr Opin Biotechnol 2011 Oct 30;22(5):648-54. Epub 2011 Apr 30.

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.copbio.2011.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150613PMC
October 2011

Wet nanoscale imaging and testing of polymersomes.

Small 2011 Jul 22;7(14):2010-5. Epub 2011 Jun 22.

The Krebs Institute, Department of Biomedical Science, The University of Sheffield, Sheffield, S10 2TN, UK.

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http://dx.doi.org/10.1002/smll.201100511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325755PMC
July 2011

Hydrogels with time-dependent material properties enhance cardiomyocyte differentiation in vitro.

Biomaterials 2011 Feb 10;32(4):1002-9. Epub 2010 Nov 10.

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2010.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000555PMC
February 2011

Stiffness gradients mimicking in vivo tissue variation regulate mesenchymal stem cell fate.

PLoS One 2011 Jan 5;6(1):e15978. Epub 2011 Jan 5.

Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016411PMC
January 2011

Preparation of hydrogel substrates with tunable mechanical properties.

Curr Protoc Cell Biol 2010 Jun;Chapter 10:Unit 10.16

Department of Bioengineering, University of California, San Diego, La Jolla, California, USA.

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http://doi.wiley.com/10.1002/0471143030.cb1016s47
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June 2010

Detecting cell-adhesive sites in extracellular matrix using force spectroscopy mapping.

J Phys Condens Matter 2010 May;22(19):194102

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1088/0953-8984/22/19/194102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997741PMC
May 2010

Intrinsic extracellular matrix properties regulate stem cell differentiation.

J Biomech 2010 Jan 2;43(1):55-62. Epub 2009 Oct 2.

Department of Engineering Materials, The Kroto Research Institute, University of Sheffield, S3 7HQ, UK.

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http://dx.doi.org/10.1016/j.jbiomech.2009.09.009DOI Listing
January 2010

Innovations in cell mechanobiology.

J Biomech 2010 Jan 8;43(1). Epub 2009 Oct 8.

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January 2010

Cell rheology: Stressed-out stem cells.

Nat Mater 2010 Jan;9(1):4-6

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January 2010

Nanoscopic mechanical anisotropy in hydrogel surfaces.

Soft Matter 2010 Jan;6(18):4466-4470

Department of Biomedical Science, University of Sheffield, Addison Building, Western Bank, Sheffield, S10 2TN, United Kingdom.

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http://dx.doi.org/10.1039/C0SM00339EDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954611PMC
January 2010

A novel mode of cell detachment from fibrillar fibronectin matrix under shear.

J Cell Sci 2009 May 28;122(Pt 10):1647-53. Epub 2009 Apr 28.

Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

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http://dx.doi.org/10.1242/jcs.040824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680103PMC
May 2009

Multiscale modeling of form and function.

Science 2009 Apr;324(5924):208-12

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1126/science.1170107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527531PMC
April 2009

Matrix strains induced by cells: Computing how far cells can feel.

Cell Mol Bioeng 2009 Mar;2(1):39-48

Biophysical Engineering Lab, University of Pennsylvania, Philadelphia, PA 19104.

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http://dx.doi.org/10.1007/s12195-009-0052-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891090PMC
March 2009

Stem cell fate dictated solely by altered nanotube dimension.

Proc Natl Acad Sci U S A 2009 Feb 28;106(7):2130-5. Epub 2009 Jan 28.

Department of Materials Science and Engineering, University California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.0813200106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650120PMC
February 2009

Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating.

J Cell Sci 2008 Nov 28;121(Pt 22):3794-802. Epub 2008 Oct 28.

Molecular and Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1242/jcs.029678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740334PMC
November 2008

Fibronectin expression modulates mammary epithelial cell proliferation during acinar differentiation.

Cancer Res 2008 May;68(9):3185-92

Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544-1014, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-2673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748963PMC
May 2008

Cell responses to the mechanochemical microenvironment--implications for regenerative medicine and drug delivery.

Adv Drug Deliv Rev 2007 Nov 14;59(13):1329-39. Epub 2007 Aug 14.

Department of Physics and Astronomy, University of Pennsylvania, Philadelphia PA 19104, USA.

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http://dx.doi.org/10.1016/j.addr.2007.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124491PMC
November 2007

Microtissue elasticity: measurements by atomic force microscopy and its influence on cell differentiation.

Methods Cell Biol 2007 ;83:521-45

Biophysical Engineering and Polymers Laboratory, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1016/S0091-679X(07)83022-6DOI Listing
August 2007

Matrix elasticity directs stem cell lineage specification.

Cell 2006 Aug;126(4):677-89

Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, 19104, USA.

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http://dx.doi.org/10.1016/j.cell.2006.06.044DOI Listing
August 2006

A hemoglobin fragment found in cervicovaginal fluid from women in labor potentiates the action of agents that promote contraction of smooth muscle cells.

Peptides 2006 Jul 18;27(7):1794-800. Epub 2006 Apr 18.

Center for Research on Reproduction and Women's Health, University of Pennsylvania Medical School, Biomedical Research Building II/III, 421 Curie Blvd., Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.peptides.2006.03.015DOI Listing
July 2006

Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance.

Am J Physiol Heart Circ Physiol 2006 Jun 10;290(6):H2196-203. Epub 2006 Feb 10.

Division of Cardiothoracic Surgery, Department of Physiology, University of Pennsylvania School of Medicine, A700 Richards Bldg., 3700 Hamilton Walk, Philadelphia, PA 19104-6085, USA.

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http://dx.doi.org/10.1152/ajpheart.01017.2005DOI Listing
June 2006

Power-law rheology of isolated nuclei with deformation mapping of nuclear substructures.

Biophys J 2005 Oct 29;89(4):2855-64. Epub 2005 Jul 29.

Johns Hopkins University, Baltimore, MD 21202, USA.

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http://dx.doi.org/10.1529/biophysj.105.062554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366783PMC
October 2005

Targeted worm micelles.

Biomacromolecules 2004 Sep-Oct;5(5):1714-9

Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia 19104-6391, USA.

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http://dx.doi.org/10.1021/bm049884vDOI Listing
February 2005

Elasticity of native and cross-linked polyelectrolyte multilayer films.

Biomacromolecules 2004 Sep-Oct;5(5):1908-16

Institut National de la Santé et de la Recherche Médicale, Unité 595, Université Louis Pasteur, 11 rue Humann, 67085 Strasbourg Cedex, France.

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http://dx.doi.org/10.1021/bm0498023DOI Listing
February 2005

Patterning, prestress, and peeling dynamics of myocytes.

Biophys J 2004 Feb;86(2):1209-22

Department of Chemical and Biomolecular Engineering, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1303913PMC
http://dx.doi.org/10.1016/S0006-3495(04)74195-8DOI Listing
February 2004