Adam Ewing

Adam Ewing

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Adam Ewing

Adam Ewing

Publications by authors named "Adam Ewing"

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LINE-1 Evasion of Epigenetic Repression in Humans.

Mol Cell 2019 Aug 20;75(3):590-604.e12. Epub 2019 Jun 20.

Mater Research Institute, University of Queensland, TRI Building, Woolloongabba, QLD 4102, Australia; Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765193039
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http://dx.doi.org/10.1016/j.molcel.2019.05.024DOI Listing
August 2019

Germline contamination and leakage in whole genome somatic single nucleotide variant detection.

BMC Bioinformatics 2018 01 31;19(1):28. Epub 2018 Jan 31.

Informatics & Biocomputing Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, Ontario, M5G 0A3, Canada.

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https://bmcbioinformatics.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12859-018-2046-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793408PMC
January 2018

Analysis of LINE-1 Elements in DNA from Postmortem Brains of Individuals with Schizophrenia.

Neuropsychopharmacology 2017 Dec 6;42(13):2602-2611. Epub 2017 Jun 6.

Translational Research Laboratories, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/npp.2017.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686486PMC
December 2017

On the role of H3.3 in retroviral silencing.

Nature 2017 08;548(7665):E1-E3

The Eunice Kennedy Shriver National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/nature23277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258051PMC
August 2017

Reading LINEs within the cocaine addicted brain.

Brain Behav 2017 05 6;7(5):e00678. Epub 2017 Apr 6.

Department of Psychiatry Center for Neurobiology and Behavior University of Pennsylvania Perelman School of Medicine Philadelphia PA USA.

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http://dx.doi.org/10.1002/brb3.678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434184PMC
May 2017

Transposable element detection from whole genome sequence data.

Authors:
Adam D Ewing

Mob DNA 2015 29;6:24. Epub 2015 Dec 29.

Mater Research Institute - University of Queensland, 37 Kent St Level 4, Woolloongabba, QLD 4102 Australia.

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http://dx.doi.org/10.1186/s13100-015-0055-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696183PMC
December 2015

RADIA: RNA and DNA integrated analysis for somatic mutation detection.

PLoS One 2014 18;9(11):e111516. Epub 2014 Nov 18.

University of California Santa Cruz Genomics Institute, Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America; Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111516PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236012PMC
July 2015

Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection.

Nat Methods 2015 Jul 18;12(7):623-30. Epub 2015 May 18.

1] Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada. [2] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. [3] Department of Pharmacology &Toxicology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nmeth.3407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856034PMC
July 2015

Ubiquitous L1 mosaicism in hippocampal neurons.

Cell 2015 Apr;161(2):228-39

Mater Research Institute - University of Queensland, TRI Building, Woolloongabba QLD 4102, Australia; Queensland Brain Institute, University of Queensland, Brisbane QLD 4072, Australia. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(15)00313-X.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S009286741500313
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http://dx.doi.org/10.1016/j.cell.2015.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398972PMC
April 2015

An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons.

Nature 2014 Dec 28;516(7530):242-5. Epub 2014 Sep 28.

1] Center for Biomolecular Science and Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA [2] Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, California 95064, USA.

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http://dx.doi.org/10.1038/nature13760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268317PMC
December 2014

Enrichment of processed pseudogene transcripts in L1-ribonucleoprotein particles.

Hum Mol Genet 2013 Sep 21;22(18):3730-48. Epub 2013 May 21.

McKusick-Nathans Institute of Genetic Medicine and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1093/hmg/ddt225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749862PMC
September 2013

Extensive somatic L1 retrotransposition in colorectal tumors.

Genome Res 2012 Dec 11;22(12):2328-38. Epub 2012 Sep 11.

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1101/gr.145235.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514663PMC
December 2012

Pathogenic orphan transduction created by a nonreference LINE-1 retrotransposon.

Hum Mutat 2012 Feb 8;33(2):369-71. Epub 2011 Dec 8.

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/humu.21663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258325PMC
February 2012

Whole-genome resequencing allows detection of many rare LINE-1 insertion alleles in humans.

Genome Res 2011 Jun 27;21(6):985-90. Epub 2010 Oct 27.

The McKusick-Nathans Institute for Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1101/gr.114777.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106331PMC
June 2011

High-throughput sequencing reveals extensive variation in human-specific L1 content in individual human genomes.

Genome Res 2010 Sep 20;20(9):1262-70. Epub 2010 May 20.

University of Pennsylvania Department of Genetics, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gr.106419.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928504PMC
September 2010

Exon-trapping mediated by the human retrotransposon SVA.

Genome Res 2009 Nov 27;19(11):1983-91. Epub 2009 Jul 27.

Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://genome.cshlp.org/cgi/doi/10.1101/gr.093153.109
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http://dx.doi.org/10.1101/gr.093153.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775590PMC
November 2009