Adam E Snook

Adam E Snook

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Adam E Snook

Adam E Snook

Publications by authors named "Adam E Snook"

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APC-β-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis.

Cancer Biol Ther 2020 May 9;21(5):441-451. Epub 2020 Feb 9.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1080/15384047.2020.1721262DOI Listing
May 2020

Talkin' Toxins: From Coley's to Modern Cancer Immunotherapy.

Toxins (Basel) 2020 Apr 9;12(4). Epub 2020 Apr 9.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.3390/toxins12040241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232517PMC
April 2020

Non-Thermal Plasma-Induced Immunogenic Cell Death in Cancer: A Topical Review.

J Phys D Appl Phys 2019 Oct 6;52(42). Epub 2019 Aug 6.

Division of Surgery Oncology, Department of Surgery, Drexel University College of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1088/1361-6463/ab31c1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726388PMC
October 2019

Biomarker targeting of colorectal cancer stem cells.

Biomark Med 2019 08 6;13(11):891-894. Epub 2019 Aug 6.

Department of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.2217/bmm-2019-0227DOI Listing
August 2019

Adenovirus-Mediated ABCC6 Gene Therapy for Heritable Ectopic Mineralization Disorders.

J Invest Dermatol 2019 06 11;139(6):1254-1263. Epub 2019 Jan 11.

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, and PXE International Center of Excellence in Research and Clinical Care, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535136PMC
June 2019

Silencing the GUCA2A-GUCY2C tumor suppressor axis in CIN, serrated, and MSI colorectal neoplasia.

Hum Pathol 2019 05 2;87:103-114. Epub 2019 Feb 2.

Department of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, United States. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2018.11.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988773PMC
May 2019

Therapeutic targeting of gastrointestinal cancer stem cells.

Regen Med 2019 05 26;14(4):331-343. Epub 2019 Apr 26.

Pharmacology & Experimental Therapeutics, Sidney, 1020 Locust St, JAH368, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.2217/rme-2018-0146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886570PMC
May 2019

Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients.

J Immunother Cancer 2019 04 23;7(1):104. Epub 2019 Apr 23.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 1020 Locust Street, JAH 368, Philadelphia, PA, 19107, USA.

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http://dx.doi.org/10.1186/s40425-019-0576-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477737PMC
April 2019

TCR Retrogenic Mice as a Model To Map Self-Tolerance Mechanisms to the Cancer Mucosa Antigen GUCY2C.

J Immunol 2019 02 14;202(4):1301-1310. Epub 2019 Jan 14.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107

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http://dx.doi.org/10.4049/jimmunol.1801206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363846PMC
February 2019

Advances in Chimeric Antigen Receptor T-Cell Therapies for Solid Tumors.

Clin Pharmacol Ther 2019 01;105(1):71-78

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://doi.wiley.com/10.1002/cpt.1280
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http://dx.doi.org/10.1002/cpt.1280DOI Listing
January 2019

as a Vector for Cancer Immunotherapy: Current Understanding and Progress.

Vaccines (Basel) 2018 Jul 25;6(3). Epub 2018 Jul 25.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA.

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http://www.mdpi.com/2076-393X/6/3/48
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http://dx.doi.org/10.3390/vaccines6030048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160973PMC
July 2018

Non-thermal plasma induces immunogenic cell death in murine CT26 colorectal tumors.

Oncoimmunology 2018 26;7(9):e1484978. Epub 2018 Jul 26.

C. & J. Nyheim Plasma Institute, Drexel University, Camden, NJ, USA.

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http://dx.doi.org/10.1080/2162402X.2018.1484978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140551PMC
July 2018

Immunotherapy regimens for metastatic colorectal carcinomas.

Hum Vaccin Immunother 2018 02 6;14(2):250-254. Epub 2017 Dec 6.

a Departments of Pharmacology and Experimental Therapeutics , Thomas Jefferson University , Philadelphia , PA , USA.

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http://dx.doi.org/10.1080/21645515.2017.1397244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806658PMC
February 2018

GUCY2C maintains intestinal LGR5 stem cells by opposing ER stress.

Oncotarget 2017 Nov 26;8(61):102923-102933. Epub 2017 Oct 26.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, United States of America, PA, USA.

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http://dx.doi.org/10.18632/oncotarget.22084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732700PMC
November 2017

ST-Producing E. coli Oppose Carcinogen-Induced Colorectal Tumorigenesis in Mice.

Toxins (Basel) 2017 09 12;9(9). Epub 2017 Sep 12.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.3390/toxins9090279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618212PMC
September 2017

The Heat-Stable Enterotoxin Receptor, Guanylyl Cyclase C, as a Pharmacological Target in Colorectal Cancer Immunotherapy: A Bench-to-Bedside Current Report.

Toxins (Basel) 2017 09 15;9(9). Epub 2017 Sep 15.

Department of Pharmacology and Experimental Therapeutics, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.3390/toxins9090282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618215PMC
September 2017

GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome.

Cancer Res 2017 09;77(18):5095-5106

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678756PMC
September 2017

Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer.

Expert Rev Clin Pharmacol 2017 May 10;10(5):549-557. Epub 2017 Apr 10.

a Department of Pharmacology and Experimental Therapeutics , Sidney Kimmel Medical College at Thomas Jefferson University , Philadelphia , PA , USA.

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http://dx.doi.org/10.1080/17512433.2017.1292124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742255PMC
May 2017

Prime-Boost Immunization Eliminates Metastatic Colorectal Cancer by Producing High-Avidity Effector CD8 T Cells.

J Immunol 2017 05 24;198(9):3507-3514. Epub 2017 Mar 24.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107;

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http://dx.doi.org/10.4049/jimmunol.1502672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435941PMC
May 2017

The swinging pendulum of cancer immunotherapy personalization.

Per Med 2017 05 5;14(3):259-270. Epub 2017 May 5.

Department of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, 1020 Locust Street Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.2217/pme-2016-0108DOI Listing
May 2017

siRNA-Encapsulated Hybrid Nanoparticles Target Mutant K-ras and Inhibit Metastatic Tumor Burden in a Mouse Model of Lung Cancer.

Mol Ther Nucleic Acids 2017 Mar 31;6:259-268. Epub 2016 Dec 31.

Department of Pharmaceutical Science, College of Pharmacy, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2016.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363504PMC
March 2017

Preclinical Evaluation of a Replication-Deficient Recombinant Adenovirus Serotype 5 Vaccine Expressing Guanylate Cyclase C and the PADRE T-helper Epitope.

Hum Gene Ther Methods 2016 12;27(6):238-250

1 Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/hgtb.2016.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175423PMC
December 2016

Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins.

Infect Immun 2016 10 19;84(10):3083-91. Epub 2016 Sep 19.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/IAI.00639-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038068PMC
October 2016

Guanylyl Cyclase C Hormone Axis at the Intersection of Obesity and Colorectal Cancer.

Mol Pharmacol 2016 Sep 1;90(3):199-204. Epub 2016 Jun 1.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania

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http://dx.doi.org/10.1124/mol.115.103192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998665PMC
September 2016

GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity.

Oncoimmunology 2016 2;5(10):e1227897. Epub 2016 Sep 2.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University , Philadelphia, PA, USA.

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https://www.tandfonline.com/doi/full/10.1080/2162402X.2016.1
Publisher Site
http://dx.doi.org/10.1080/2162402X.2016.1227897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087292PMC
September 2016

Biodistribution and Pharmacokinetics Study of siRNA-loaded Anti-NTSR1-mAb-functionalized Novel Hybrid Nanoparticles in a Metastatic Orthotopic Murine Lung Cancer Model.

Mol Ther Nucleic Acids 2016 Jan 26;5:e282. Epub 2016 Jan 26.

Department of Pharmaceutical Science, College of Pharmacy, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/mtna.2015.56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012553PMC
January 2016

A novel CDX2 isoform regulates alternative splicing.

PLoS One 2014 7;9(8):e104293. Epub 2014 Aug 7.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104293PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125279PMC
November 2015

Could targeting T-helper cells aid the development of effective cancer vaccines?

Authors:
Adam E Snook

Immunotherapy 2014 ;6(9):959-61

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http://dx.doi.org/10.2217/imt.14.79DOI Listing
July 2015

DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis.

Cancer Cell 2015 Jul;28(1):97-113

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Department of Urology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531387PMC
July 2015

The paracrine hormone for the GUCY2C tumor suppressor, guanylin, is universally lost in colorectal cancer.

Cancer Epidemiol Biomarkers Prev 2014 Nov 10;23(11):2328-37. Epub 2014 Oct 10.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1055-9965.EPI-14-0440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221461PMC
November 2014

Challenges to chimeric antigen receptor (CAR)-T cell therapy for cancer.

Discov Med 2014 Nov;18(100):265-71

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 1020 Locust Street, JAH 368, Philadelphia, PA 19107, USA.

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November 2014

GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer.

Oncotarget 2014 Oct;5(19):9460-71

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253446PMC
http://dx.doi.org/10.18632/oncotarget.2455DOI Listing
October 2014

Epithelial immunization induces polyfunctional CD8+ T cells and optimal mousepox protection.

J Virol 2014 Aug 4;88(16):9472-5. Epub 2014 Jun 4.

Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/JVI.01464-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136261PMC
August 2014

Selective antigen-specific CD4(+) T-cell, but not CD8(+) T- or B-cell, tolerance corrupts cancer immunotherapy.

Eur J Immunol 2014 Jul 21;44(7):1956-66. Epub 2014 May 21.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/eji.201444539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107120PMC
July 2014

Tumor radiation therapy creates therapeutic vaccine responses to the colorectal cancer antigen GUCY2C.

Int J Radiat Oncol Biol Phys 2014 Apr;88(5):1188-95

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2013.12.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967134PMC
April 2014

Polyamine-blocking therapy reverses immunosuppression in the tumor microenvironment.

Cancer Immunol Res 2014 Mar 7;2(3):274-85. Epub 2013 Oct 7.

Authors' Affiliations: Aminex Therapeutics, Inc., Kenmore, Washington.

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http://dx.doi.org/10.1158/2326-6066.CIR-13-0120-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101915PMC
March 2014

Intestinal GUCY2C prevents TGF-β secretion coordinating desmoplasia and hyperproliferation in colorectal cancer.

Cancer Res 2013 Nov 1;73(22):6654-66. Epub 2013 Oct 1.

Authors' Affiliations: Departments of Pharmacology and Experimental Therapeutics, and Medicine, Thomas Jefferson University; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania; and Department of Pathology, University of Utah, University Hospital, Salt Lake City, Utah.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838632PMC
November 2013

Translating colorectal cancer prevention through the guanylyl cyclase C signaling axis.

Expert Rev Clin Pharmacol 2013 Sep 24;6(5):557-64. Epub 2013 Aug 24.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 132 S. 10th St. 1170 Main Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1586/17512433.2013.827406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048542PMC
September 2013

Colorectal cancer immunotherapy.

Discov Med 2013 May;15(84):301-8

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042089PMC
May 2013

Immunotherapeutic strategies to target prognostic and predictive markers of cancer.

Biomark Med 2013 Feb;7(1):23-35

Department of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, Philadelphia, 132 South 10th Street, 1170 Main, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.2217/bmm.12.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755011PMC
February 2013

Advances in cancer immunotherapy.

Discov Med 2013 Feb;15(81):120-5

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066887PMC
February 2013

Epitope-targeted cytotoxic T cells mediate lineage-specific antitumor efficacy induced by the cancer mucosa antigen GUCY2C.

Cancer Immunol Immunother 2012 May 6;61(5):713-23. Epub 2011 Nov 6.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1007/s00262-011-1133-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880860PMC
May 2012

GUCY2C-targeted cancer immunotherapy: past, present and future.

Immunol Res 2011 Dec;51(2-3):161-9

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 1020 Locust Street, JAH 348A, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1007/s12026-011-8253-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892460PMC
December 2011

A uroguanylin-GUCY2C endocrine axis regulates feeding in mice.

J Clin Invest 2011 Sep 25;121(9):3578-88. Epub 2011 Aug 25.

Department of Pharmacology and Experimental Therapeutics, Division of Clinical Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/JCI57925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223926PMC
September 2011

Bacterial heat-stable enterotoxins: translation of pathogenic peptides into novel targeted diagnostics and therapeutics.

Toxins (Basel) 2010 08 5;2(8):2028-54. Epub 2010 Aug 5.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 132 South 10th Street, 1170 Main, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.3390/toxins2082028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153287PMC
August 2010

Guanylyl cyclase C as a biomarker for targeted imaging and therapy of metastatic colorectal cancer.

Biomark Med 2009 Feb;3(1):33-45

School of Biomedical Engineering, Science & Health Systems, Drexel University, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.2217/17520363.3.1.33DOI Listing
February 2009

CANCER MUCOSA ANTIGENS A NOVEL PARADIGM IN CANCER IMMUNOTHERAPEUTICS.

Bioforum Eur 2009;3:14-16

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia PA 19107.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742354PMC
January 2009

Cytokine adjuvanation of therapeutic anti-tumor immunity targeted to cancer mucosa antigens.

Clin Transl Sci 2008 Dec;1(3):263-4

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1111/j.1752-8062.2008.00054.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718574PMC
December 2008

Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunity.

J Natl Cancer Inst 2008 Jul 24;100(13):950-61. Epub 2008 Jun 24.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 132 South Tenth St, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1093/jnci/djn178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749952PMC
July 2008

Derivation and fluidity of acutely induced dysfunctional CD8+ T cells.

J Immunol 2008 Apr;180(8):5300-8

Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.4049/jimmunol.180.8.5300DOI Listing
April 2008

Mucosally restricted antigens as novel immunological targets for antitumor therapy.

Biomark Med 2007 Jun;1(1):187-202

Thomas Jefferson University, Department of Pharmacology and Experimental Therapeutics, Philadelphia, PA, USA.

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http://dx.doi.org/10.2217/17520363.1.1.187DOI Listing
June 2007