Publications by authors named "Adam Atoot"

12 Publications

  • Page 1 of 1

New-onset depression after colorectal cancer diagnosis: a population-based longitudinal study.

Int J Colorectal Dis 2021 Jul 17. Epub 2021 Jul 17.

Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Introduction: To date, no large studies examining the temporal relationship between colorectal cancer (CRC) and the subsequent development of depressive disorders exist. We aimed to assess the incidence of depression post-colorectal cancer (CRC) diagnosis.

Methods: To conduct this longitudinal study, we searched the large US population-based database, Explorys (IBM), from January 1, 1999, to January 1, 2021. We investigated new-onset depression and its associated mortality as well as the role of the mental health provider post-CRC diagnosis. Confidence intervals were calculated for all outcomes and multivariate regression analysis was performed.

Results: Incident depression post-CRC diagnosis was 20.8 vs 8.9 per 100 person-years [OR 3.46, p < 0.0001] in the general population and conferred a 123% increased risk of all-cause mortality [P < 0.0001]. Male patients (OR: 1.89) were more likely to become depressed post-CRC diagnosis as compared to females. Moreover, the absolute number of male patients with post-CRC depression was significantly higher than that of females (68% vs 32%; P < 0.0001). In addition, depression after CRC was more common among Whites (OR: 1.68) and patients aged > 65 years (OR: 5.17). Referral to a mental health provider resulted in significantly lower all-cause mortality (3.6% vs 26.9%; p < 0.0001).

Discussion: Our findings advocate for initiating depression screening for high-risk patients post-CRC diagnosis and prompt mental health provider referral.
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http://dx.doi.org/10.1007/s00384-021-03994-8DOI Listing
July 2021

A rare cause of acute compartment syndrome after gluteal cyst rupture.

J Community Hosp Intern Med Perspect 2021 Mar 23;11(2):266-268. Epub 2021 Mar 23.

Department of Internal Medicine and Department of Family Medicine Hackensack Meridian Health Palisades Medical CenterNorth Bergen NJ USA.

Acute Compartment Syndrome (ACS) is a serious medical condition that often results in high morbidity. ACS more commonly presents after substantial trauma in the extremities where compartment pressures can be measured. Here, we present an unusual case of a healthy man who presented with ACS of the thigh secondary to rupture of the gluteal cyst which was formed after multiple unsupervised testosterone injections. Our goal is to encourage a broad differential diagnosis while keeping limb threatening conditions and emergencies on top in patients complaining of leg pain and also to educate the patient population on safety concerns of unsupervised intramuscular injections.
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http://dx.doi.org/10.1080/20009666.2021.1877401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043523PMC
March 2021

IgG4-Related Disease Retroperitoneal Fibrosis: An Unusual Cause of Low Back Pain.

Cureus 2021 Feb 28;13(2):e13608. Epub 2021 Feb 28.

Internal Medicine, Hackensack University Medical Center - Palisades Medical Center, North Bergen, USA.

IgG4-related disease (IgG4-RD) is a cluster of rare fibroinflammatory diseases that more commonly affect organs such as major salivary glands, biliary tree, periorbital tissues, kidneys, lungs, lymph nodes, retroperitoneum, and less frequently, meninges, aorta, prostate, thyroid gland, pericardium, and the skin. The clinical picture mainly depends on the affected organ and the effects on the surrounding organs, however, the histopathologic findings are very similar regardless of the organ affected. Most patients have a subclinical presentation of the disease and the only clinical manifestation is related to the anatomic location of the disease, whereas some patients may have constitutional symptoms such as weight loss and are often misdiagnosed as having other pathologies (i.e., malignancies, other inflammatory conditions, etc.). Up to 40 percent of patients can have symptoms of allergy or asthma. Patients often have diseases confined to one organ but multiorgan involvement is not uncommon. Patients with multiple organs involvement can have an elevation of up to 30-40 upper limit of normal serum IgG4 concentration; patients with fewer organ involvement can have normal serum IgG4 concentration despite histopathologic findings of the disease.  Idiopathic retroperitoneal fibrosis (RPF) is a commonly encountered subtype of IgG4-RD. Idiopathic retroperitoneal fibrosis accounts for approximately 70 percent of cases and can be divided into IgG4-RD and non-IgG4-RD. Most cases of RPF are incidental findings on radiology studies but should be suspected in any patients complaining of back pain and flank pain, with new-onset kidney dysfunction.
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http://dx.doi.org/10.7759/cureus.13608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009451PMC
February 2021

Impact of inflammatory bowel disease on hospital outcomes in acute ischemic stroke: a nationwide cohort study.

Int J Colorectal Dis 2021 Aug 17;36(8):1759-1764. Epub 2021 Mar 17.

Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Purpose: Patients with inflammatory bowel disease (IBD) have an increased risk of venous thrombotic events. The impact IBD has on arterial thrombosis is not well characterized. We aimed to identify the impact of IBD on hospital outcomes in patients admitted for acute ischemic stroke (AIS).

Methods: This is a retrospective cohort study utilizing the 2017 National Inpatient Sample. We identified all adult patients with a principal diagnosis of AIS and compared those with a concurrent diagnosis of IBD to those without-subgrouped by ulcerative colitis (UC) and Crohn's disease (CD). Outcomes were mortality and healthcare usage among IBD patients with AIS. Multivariate analysis was used to control for confounders. Analyses were performed using STATA.

Results: Five hundred twenty-four thousand and forty-five patients were admitted for AIS in 2017; of them 2200 (0.41%) had a concurrent diagnosis of IBD. The presence of IBD did not significantly affect in-hospital mortality (4.09% vs. 4.01%) among patients admitted for AIS [OR 1.07 95% CI: 0.65-1.76], with similar findings upon subgroup analysis of UC [OR 0.91, 95% CI: 0.39-2.09] and CD [OR 1.17, 95% CI: 0.62-2.19]. Mean hospital length of stay and charges/costs in AIS were similar irrespective of IBD.

Conclusions: UC and CD do not appear to be associated with a higher risk of mortality or increased healthcare usage in AIS. AIS risk assessment in patients with IBD is important but should be done in a similar fashion to the general population.
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http://dx.doi.org/10.1007/s00384-021-03912-yDOI Listing
August 2021

Calcium-Alkali Syndrome: Historical Review, Pathophysiology and Post-Modern Update.

Cureus 2021 Feb 11;13(2):e13291. Epub 2021 Feb 11.

Internal Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, USA.

Milk-alkali syndrome or calcium-alkali syndrome (CAS) is the triad of hypercalcemia, metabolic alkalosis and renal impairment. It is often related to ingestion of high amounts of calcium carbonate, which was used historically for the treatment of peptic ulcer disease. The incidence of the syndrome decreased dramatically after the introduction of newer peptic ulcer medications such as proton pump inhibitors and histamine blocking agents. However, a resurgence was seen in the late 1980s with the wide use of over-the-counter calcium supplements, mainly by females for osteoporosis prophylaxis. The modern version of the syndrome continues to evolve along with medical management. This review focuses on the historical context of CAS, pathogenesis, resurgence of the condition with variable presentations, and contemporary management.
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http://dx.doi.org/10.7759/cureus.13291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955894PMC
February 2021

Management of West Nile Encephalitis: An Uncommon Complication of West Nile Virus.

Cureus 2021 Feb 6;13(2):e13183. Epub 2021 Feb 6.

General Practice, Drexel University College of Medicine, Philadelphia, USA.

West Nile virus disease (WNVD) is a mosquito-borne disease that affects the meninges and central nervous system, causing West Nile virus (WNV) encephalitis, a debilitating, life-threatening condition, especially in the elderly. While there is a lot of research discussing different aspects of the disease, the treatment is mainly unknown. We conducted a literature review to explore the wide variety of treatment options that consolidate the knowledge about the most recent management of WNV encephalitis. We did a combined advanced search and Medical Subject Headings (MeSH) search on PubMed. Inclusion criteria included papers written in the English language and human subjects research for the past 25 years. We initially gather 110 papers, and after applying the inclusion/exclusion criteria, we end up with 30 articles for the paper's discussion. This review aims to provide clinicians with an overview of the latest approach in treating and managing hospitalized WNVD patients. It discusses case reports and the outcome of different treatment regimens done in vitro and in vivo. The study discusses all the advancements in treatment and prophylaxis and compares their effectiveness. However, more research is warranted to gain further insight to develop a single guideline for the management of this disease. This review discusses the following treatment modalities: ribavirin, interferon-alpha, intravenous immunoglobulin (IVIG), and other less-used drugs. More studies about ribavirin are needed to know if the drug is useful for WNV encephalitis. Interferon-alpha has been shown to have both protective and disease limiting properties. At the moment, there are no guidelines for the treatment of WNV encephalitis, nor is there a single Food and Drug Administration (FDA)-approved drug. For the time being, IVIG offers the best results in treating WNV encephalitis.
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http://dx.doi.org/10.7759/cureus.13183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939534PMC
February 2021

Mimicking COVID-19 Chronic Follicular Conjunctivitis.

Case Rep Ophthalmol Med 2021 30;2021:6654347. Epub 2021 Jan 30.

Department of Ophthalmology, New York Eye and Ear infirmary of Mount Sinai School of Medicine, Hackensack University Medical Center, Riverside Medical Group, USA.

Purpose: To characterize the clinical presentation and report lab findings of follicular conjunctivitis in two patients with a positive history of active COVID-19 infection. . Two patients with follicular conjunctivitis with a recent history of COVID-19 infection.

Design: Retrospective, noncomparative, case report.

Methods: Demographic data including age, gender, and place of residence were recorded. A full exam with an emphasis on inflammatory characteristics and systematic workup. Sample follicles were surgically excised in selected cases, and molecular and histopathological analyses were performed.

Results: Both patients were initially treated for viral conjunctivitis. After symptoms failed to resolve, biopsy results indicated that both patients were positive for chlamydia conjunctivitis and treated accordingly.

Conclusions: These cases illustrate the role of biopsy as an investigative tool in chronic conjunctivitis and the importance of having a broad differential when treating patients with acute conjunctivitis.
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http://dx.doi.org/10.1155/2021/6654347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868163PMC
January 2021

Babesiosis: Appreciating the Pathophysiology and Diverse Sequela of the Infection.

Cureus 2020 Oct 21;12(10):e11085. Epub 2020 Oct 21.

Internal Medicine, Palisades Medical Center, North Bergen, USA.

Babesiosis is a blood-borne disease found mainly in the United States caused by a parasitic piroplasm. While most infections are mild to moderate in immunocompetent hosts, life-threatening complications can occur in those with significant comorbidities like congestive heart failure (CHF) or chronic obstructive pulmonary disease (COPD). There is sparse literature discussing the complications of infection or the pathophysiology and management thereof. A literature review was conducted to consolidate the current knowledge about the disease, pathophysiology, and proposed management of all potential complications based on risk factors and other clinical information. A MeSH cross-references strategy was employed in PubMed using the search terms "babesia" and "babesiosis" and the established associated conditions, and the search expanded to increase capture. Only papers written in the English language and discussing human subjects in the North American patient population were included. The initial search yielded 315 papers and, after applying the inclusion/exclusion criteria, a final number of 18 was reviewed. The various complications and pathophysiology thereof are then discussed according to organ system. is a subversive parasite associated with a variety of conditions. We hope a better appreciation of all potential presentations and complications will help clinicians manage this increasingly common zoonosis and reduce adverse effects. More research is recommended into the pathophysiology and prevention of complications following this and other tick-borne illnesses.
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http://dx.doi.org/10.7759/cureus.11085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678756PMC
October 2020

Atherosclerotic cardiovascular disease in inflammatory bowel disease: The role of chronic inflammation.

World J Gastrointest Pathophysiol 2020 Aug;11(5):104-113

Division of Gastroenterology, Department of Medicine, Olive View-UCLA Medical Center, Sylmar, CA 91342, United States.

Inflammatory bowel disease (IBD) causes systemic vascular inflammation. The increased risk of venous as well as arterial thromboembolic phenomena in IBD is well established. More recently, a relationship between IBD and atherosclerotic cardiovascular disease (ASCVD) has been postulated. Systemic inflammatory diseases, such as rheumatoid arthritis and systemic lupus erythematosus, have well characterized cardiac pathologies and treatments that focus on prevention of disease associated ASCVD. The impact of chronic inflammation on ASCVD in IBD remains poorly characterized. This manuscript aims to review and summarize the current literature pertaining to IBD and ASCVD with respect to its pathophysiology and impact of medications in order to encourage further research that can improve understanding and help develop clinical recommendations for prevention and management of ASCVD in patients with IBD.
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http://dx.doi.org/10.4291/wjgp.v11.i5.104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403753PMC
August 2020

An Unusual Culprit of Drug-Induced Pancreatitis.

Dig Dis Sci 2020 05 30;65(5):1549-1552. Epub 2019 Sep 30.

Division of Gastroenterology, Department of Medicine, Olive View-UCLA Medical Center, Sylmar, CA, USA.

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http://dx.doi.org/10.1007/s10620-019-05864-4DOI Listing
May 2020

A Rare Presentation of Epstein-Barr Virus-induced Hepatitis With an Interesting Twist: A Case Report Involving a Clinical Pearl.

Cureus 2018 Jun 14;10(6):e2808. Epub 2018 Jun 14.

Internal Medicine, Palisades Medical Center, New Jersey, USA.

An Epstein-Barr Virus (EBV) infection generally presents with the classic infectious mononucleosis symptomatology-sore throat, lymph node enlargement, and fatigue. However, there are cases in which induced hepatitis does occur. The liver enzymes leaked during the acute damage would be apparent in the serum as an elevation of transaminases and alkaline phosphatase. These elevations are almost always mild in nature. In addition, the associated presenting symptomatology is a generalized weakness, lethargy, and fatigue. Aside from the marked elevation of liver enzymes, what makes our case a rarity is the fact that the chief complaint was polydipsia and polyuria. Furthermore, an initial negative hepatitis A panel was found to be positive weeks later. The insight offered by this case is a true clinical pearl-namely, that the seroconversion of hepatitis A takes several weeks to occur.
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http://dx.doi.org/10.7759/cureus.2808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093274PMC
June 2018

Takotsubo Cardiomyopathy Precipitated by Tapering of Anxiolytic Medication: A Case Report.

Clin Med Insights Cardiol 2017 10;11:1179546817746643. Epub 2017 Dec 10.

Department of Cardiology, Staten Island University Hospital, Northwell Health, Staten Island, NY, USA.

Takotsubo cardiomyopathy is a transient apical ballooning of the left ventricle typically with electrocardiographic changes and enzyme release without evidence of obstructive coronary artery disease. It typically occurs in postmenopausal women and may have a predilection for patients with anxiety disorders. The following is a case in which we believe takotsubo cardiomyopathy was induced by the tapering of antianxiety medications. We feel that health care professionals should be aware of this possibility in such a patient population especially when they have demonstrated cardiovascular symptomatology.
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http://dx.doi.org/10.1177/1179546817746643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731616PMC
December 2017
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