Achla Gupta

Achla Gupta

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Achla Gupta

Achla Gupta

Publications by authors named "Achla Gupta"

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33Publications

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Targeting Cannabinoid 1 and Delta Opioid Receptor Heteromers Alleviates Chemotherapy-Induced Neuropathic Pain.

ACS Pharmacol Transl Sci 2019 Aug 5;2(4):219-229. Epub 2019 Jun 5.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.

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http://dx.doi.org/10.1021/acsptsci.9b00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764458PMC
August 2019

Regulation of an Opioid Receptor Chaperone Protein, RTP4, by Morphine.

Mol Pharmacol 2019 01 22;95(1):11-19. Epub 2018 Oct 22.

Departments of Frontier Life Science (W.F.) and Therapeutic Innovation and Pharmacology (M.Y., H.U.), Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; and Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York (I.G., A.G., L.A.D.)

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http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.118
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http://dx.doi.org/10.1124/mol.118.112987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277927PMC
January 2019

Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states.

PLoS One 2017 1;12(11):e0187306. Epub 2017 Nov 1.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187306PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665533PMC
December 2017

Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity.

Proc Natl Acad Sci U S A 2016 May 9;113(21):6041-6. Epub 2016 May 9.

Department of Pharmacology & Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029;

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http://dx.doi.org/10.1073/pnas.1521825113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889365PMC
May 2016

Identification of GPR83 as the receptor for the neuroendocrine peptide PEN.

Sci Signal 2016 04 26;9(425):ra43. Epub 2016 Apr 26.

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/scisignal.aad0694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147544PMC
April 2016

Antibodies to probe endogenous G protein-coupled receptor heteromer expression, regulation, and function.

Front Pharmacol 2014 3;5:268. Epub 2014 Dec 3.

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai New York, NY, USA ; The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai New York, NY, USA.

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http://dx.doi.org/10.3389/fphar.2014.00268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253664PMC
December 2014

Opioid receptor function is regulated by post-endocytic peptide processing.

J Biol Chem 2014 Jul 20;289(28):19613-26. Epub 2014 May 20.

From the Department of Pharmacology and Systems Therapeutics and the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029

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http://dx.doi.org/10.1074/jbc.M113.537704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094072PMC
July 2014

GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding.

Proc Natl Acad Sci U S A 2013 Oct 16;110(40):16211-6. Epub 2013 Sep 16.

Department of Pharmacology and Systems Therapeutics, Ichan School of Medicine at Mount Sinai, New York, NY 10029.

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http://dx.doi.org/10.1073/pnas.1312938110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791715PMC
October 2013

G-protein-coupled heteromers: regulation in disease.

Methods Enzymol 2013 ;521:219-38

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1016/B978-0-12-391862-8.00012-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976561PMC
July 2013

Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity.

Proc Natl Acad Sci U S A 2013 Jul 1;110(29):12072-7. Epub 2013 Jul 1.

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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http://dx.doi.org/10.1073/pnas.1222044110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718106PMC
July 2013

Dimerization with cannabinoid receptors allosterically modulates delta opioid receptor activity during neuropathic pain.

PLoS One 2012 14;7(12):e49789. Epub 2012 Dec 14.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0049789PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522681PMC
June 2013

Cannabinoid receptor 2-mediated attenuation of CXCR4-tropic HIV infection in primary CD4+ T cells.

PLoS One 2012 20;7(3):e33961. Epub 2012 Mar 20.

Department of Infectious Diseases, Department of Medicine, Immunology Institute, Mount Sinai School of Medicine, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033961PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309010PMC
August 2012

Potentiation of μ-opioid receptor-mediated signaling by ketamine.

J Neurochem 2011 Oct 20;119(2):294-302. Epub 2011 Sep 20.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07361.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856727PMC
October 2011

Role of antibodies in developing drugs that target G-protein-coupled receptor dimers.

Mt Sinai J Med 2010 Jul-Aug;77(4):374-80

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1002/msj.20199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917817PMC
June 2011

AT1R-CB₁R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II.

EMBO J 2011 May 3;30(12):2350-63. Epub 2011 May 3.

Department of Pharmacology and Systems Therapeutics, New York Mount Sinai School of Medicine, New York, NY, USA.

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http://emboj.embopress.org/cgi/doi/10.1038/emboj.2011.139
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http://dx.doi.org/10.1038/emboj.2011.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116274PMC
May 2011

Increased abundance of opioid receptor heteromers after chronic morphine administration.

Sci Signal 2010 Jul 20;3(131):ra54. Epub 2010 Jul 20.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/scisignal.2000807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125674PMC
July 2010

Modulation of opiate-related signaling molecules in morphine-dependent conditioned behavior: conditioned place preference to morphine induces CREB phosphorylation.

Neuropsychopharmacology 2010 Mar 2;35(4):955-66. Epub 2009 Dec 2.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://www.nature.com/articles/npp2009199
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http://dx.doi.org/10.1038/npp.2009.199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820136PMC
March 2010

Novel endogenous peptide agonists of cannabinoid receptors.

FASEB J 2009 Sep 20;23(9):3020-9. Epub 2009 Apr 20.

Department of Pharmacology and Systems Therapeutics, Mt. Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1096/fj.09-132142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735371PMC
September 2009

Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4.

Proc Natl Acad Sci U S A 2008 Oct 3;105(41):16045-50. Epub 2008 Oct 3.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1073/pnas.0804106105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572960PMC
October 2008

Antibodies against G-protein coupled receptors: novel uses in screening and drug development.

Comb Chem High Throughput Screen 2008 Jul;11(6):463-7

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125642PMC
http://dx.doi.org/10.2174/138620708784911465DOI Listing
July 2008

Post-activation-mediated changes in opioid receptors detected by N-terminal antibodies.

J Biol Chem 2008 Apr 6;283(16):10735-44. Epub 2008 Feb 6.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1074/jbc.M709454200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447646PMC
April 2008

Conformation state-sensitive antibodies to G-protein-coupled receptors.

J Biol Chem 2007 Feb 4;282(8):5116-24. Epub 2006 Dec 4.

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1074/jbc.M609254200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856726PMC
February 2007

The use of receptor-specific antibodies to study G-protein-coupled receptors.

Mt Sinai J Med 2006 Jul;73(4):673-81

Department of Pharmacology and Biological Chemistry, Box 1603, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

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July 2006

Targeting opioid receptor heterodimers: strategies for screening and drug development.

AAPS J 2006 Mar 10;8(1):E153-9. Epub 2006 Mar 10.

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1208/aapsj080118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751434PMC
March 2006

A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia.

Proc Natl Acad Sci U S A 2004 Apr 24;101(14):5135-9. Epub 2004 Mar 24.

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

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http://dx.doi.org/10.1073/pnas.0307601101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC387386PMC
April 2004