Publications by authors named "Abraham Lo"

7 Publications

  • Page 1 of 1

Multisystem thromboembolism in a COVID-19 patient: a case report.

J Community Hosp Intern Med Perspect 2021 Jun 21;11(4):489-495. Epub 2021 Jun 21.

Internal Medicine Department, Hackensack Meridian Health Palisades Medical Center.

Hypercoagulability has been found in patients diagnosed with the novel coronavirus 19 (COVID-19) and has been identified as a major cause of morbidity and mortality. Herein, we report the challenge in managing a patient presenting with a 5 day history of COVID-19 diagnosis, complicated by deep venous thrombosis, pulmonary embolism and ischemic stroke in the setting of atrial septal aneurysm, presumed patent foramen ovale and paradoxical embolism, identified to have clots in transit on echocardiogram. The application of anticoagulation was felt to be high risk. The patient was transferred to a tertiary facility where the patient underwent thrombus aspiration and was eventually complicated by hemorrhagic conversion of the stroke.
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http://dx.doi.org/10.1080/20009666.2021.1933715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221132PMC
June 2021

Life-Threatening Diffuse Alveolar Hemorrhage as an Initial Presentation of Microscopic Polyangiitis: COVID-19 as a Likely Culprit.

Cureus 2021 Apr 10;13(4):e14403. Epub 2021 Apr 10.

Internal Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, USA.

Microscopic polyangiitis (MPA) is a systemic small vessel vasculitis but it is rare to see life-threatening diffuse alveolar hemorrhage (DAH) in MPA as an initial presentation. MPA more commonly presents with renal involvement and develops pulmonary manifestations later in the disease course. Our patient is a 77-year-old female with a recent history of recovered COVID-19 infection who presented with sudden onset fever, dyspnea, and hemoptysis for three days. She was diagnosed with MPA because of the new-onset DAH, a strongly positive myeloperoxidase (MPO) antibody, and the low likelihood of another etiology. The patient was treated with pulse-dose steroids and plasmapheresis while being on mechanical ventilation. This case highlights the importance of the prompt recognition of DAH as an initial presentation of MPA and illustrates the possible role of COVID-19 in inciting autoimmune conditions.
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http://dx.doi.org/10.7759/cureus.14403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109046PMC
April 2021

A rare cause of acute compartment syndrome after gluteal cyst rupture.

J Community Hosp Intern Med Perspect 2021 Mar 23;11(2):266-268. Epub 2021 Mar 23.

Department of Internal Medicine and Department of Family Medicine Hackensack Meridian Health Palisades Medical CenterNorth Bergen NJ USA.

Acute Compartment Syndrome (ACS) is a serious medical condition that often results in high morbidity. ACS more commonly presents after substantial trauma in the extremities where compartment pressures can be measured. Here, we present an unusual case of a healthy man who presented with ACS of the thigh secondary to rupture of the gluteal cyst which was formed after multiple unsupervised testosterone injections. Our goal is to encourage a broad differential diagnosis while keeping limb threatening conditions and emergencies on top in patients complaining of leg pain and also to educate the patient population on safety concerns of unsupervised intramuscular injections.
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http://dx.doi.org/10.1080/20009666.2021.1877401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043523PMC
March 2021

How low can you go? Severe hyponatremia with a sodium of 94 mg/dL corrected with proactive strategy.

J Community Hosp Intern Med Perspect 2020 Sep 3;10(5):460-461. Epub 2020 Sep 3.

Department of Internal Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ, USA.

We present a case of severe symptomatic hyponatremia (94 mEq/L) in a male patient who presented with nausea, vomiting, and multiple falls. The patient was found with symptomatic hypo-osmolar hypovolemic hyponatremia secondary to volume loss from vomiting, diuretic use, and consumption of solute-free water. To manage such a severely hyponatremic patient, concomitant 3% hypertonic saline and DDAVP were initiated with successful slow and sustained correction of sodium without complications of osmotic demyelination syndrome.
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http://dx.doi.org/10.1080/20009666.2020.1809928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671735PMC
September 2020

Herbal supplement-induced acute pancreatitis: An unfamiliar culprit.

Pancreatology 2020 03 13;20(2):297-299. Epub 2019 Dec 13.

Division of Gastroenterology, Department of Medicine, Olive View-UCLA Medical Center, Sylmar, CA, USA.

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http://dx.doi.org/10.1016/j.pan.2019.12.009DOI Listing
March 2020

An Unusual Culprit of Drug-Induced Pancreatitis.

Dig Dis Sci 2020 05 30;65(5):1549-1552. Epub 2019 Sep 30.

Division of Gastroenterology, Department of Medicine, Olive View-UCLA Medical Center, Sylmar, CA, USA.

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http://dx.doi.org/10.1007/s10620-019-05864-4DOI Listing
May 2020

The metal- and DNA-binding activities of Helicobacter pylori NikR.

J Inorg Biochem 2006 May 15;100(5-6):1005-14. Epub 2005 Dec 15.

Department of Chemistry, University of Toronto, 80 St. George St., Toronto, Ont., Canada M5S 3H6.

The pathogenic bacteria Helicobacter pylori require nickel as a cofactor of the enzymes urease and hydrogenase. One of the proteins that controls nickel homeostasis in this organism is Helicobacter pylori NikR (HpNikR), a homologue of nickel-dependent transcription factors from other organisms, which regulates the expression of multiple proteins such as the urease structural subunits and itself. To examine the properties of this protein, metal analysis was used to demonstrate that HpNikR can bind stoichiometric nickel or copper, and electronic absorption spectroscopy revealed that HpNikR binds nickel with picomolar affinity in what is likely a conserved square-planar site. In vitro DNA-binding assays revealed that HpNikR can bind directly to the promoter region of the ureA operon in response to nickel, and the location of the binding site was defined. Nickel also induces DNA binding to the nikR promoter sequence but the complex is much weaker. These experiments suggest that HpNikR directly controls the expression of multiple genes by binding to separate DNA sequences, and the possible mechanisms for differential regulation are discussed.
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http://dx.doi.org/10.1016/j.jinorgbio.2005.10.014DOI Listing
May 2006