Publications by authors named "Abolghasem Daneshvar Kakhaki"

10 Publications

  • Page 1 of 1

Expression of miR-9 and miR-200c, ZEB1, ZEB2 and E-cadherin in Non-Small Cell Lung Cancers in Iran.

Asian Pac J Cancer Prev 2019 06 1;20(6):1633-1639. Epub 2019 Jun 1.

Department of Molecular Medicine, Biotechnology Research center, Pasteur Institute of Iran, Tehran, Iran. Email:

MicroRNAs (miRNAs) exert a critical influence on physiological and pathological processes through posttranscriptional modification of their mRNA targets. They play important roles in tumorigenesis and are considered to be potential diagnostic and prognostic biomarkers with various cancers. MiR-200c and miR-9 are regulatory elements that can have dual impacts as oncogenes and/or tumor suppressor genes. MiR-200c regulates two transcription factors, ZEB1 and ZEB2, while miR-9 is a regulatory factor for the E-cadherin protein which has a critical function in cell-cell junctions and is inhibited by two transcription factors ZEB1 and ZEB2. In this study, expression levels of miR-200c and miR-9, ZEB-1, ZEB-2 and E-cadherin were assessed in 30 non-small cell lung cancers (NSCLCs) by real-time qPCR. MiR-9 was down-regulated significantly in tumor tissues compared to normal adjacent tissues, while there was no significant change in expression level of miR-200c. On the other hand, ZEB1 demonstrated significant increase and ZEB2a decrease at the mRNA level. These results indicate roles for miR-9 and ZEB1 in genesis of lung cancer, although clinico-pathological associations were not evident. Further studies are necessary to assess implications for treatment of lung cancer.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.31557/APJCP.2019.20.6.1633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021597PMC
June 2019

ECMO-assisted resection of huge thoracic mass.

J Cardiovasc Thorac Res 2018 21;10(3):174-176. Epub 2018 May 21.

Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Some advanced thoracic malignancy cannot be resected safely by using of conventional ventilation, so some sort of cardiopulmonary support is needed for hemodynamic and ventilation management of the patient. Using extracorporeal membrane oxygenation (ECMO) in comparing with cardiopulmonary bypass has some advantages. Three patients with huge thoracic tumors with different ages experienced major surgery in our center by using ECMO in order to face major complications mainly due to the size of mass to achieve better hemostatic stabilities, lower bleeding, and injuries to main airways and secure oxygenation. This is the first case series in Iran, as our best knowledge that explains cases of huge chest mass which were operated perfectly by using ECMO and short ICU stay and interestingly no major complications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.15171/jcvtr.2018.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203866PMC
May 2018

Thoracoscopic Thymectomy for Myasthenia Gravis: Seven Years of Clinical Experience.

Tanaffos 2016 ;15(3):175-179

Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Myasthenia gravis (MG) is an autoimmune disease affecting patients' quality of life and necessitating long-term medical therapy. The efficacy of thymectomy for treatment of MG has been well established. Although several techniques have been used for thymectomy, there has been controversy over the best method with highest rate of improvement. Herein, we discuss our seven years of clinical experience with thoracoscopic thymectomy for MG.

Materials And Methods: We evaluated all patients who were operated on with preoperative diagnosis of non-thymomatous MG from 2007 to 2013 in Masih Daneshvari Hospital (Tehran, Iran). All patients underwent thoracoscopic thymectomy, and rates of remission and cumulative improvement were compared to those reported by other studies.

Results: Thoracoscopic thymectomy was performed in 34 patients with MG. The rate of complete remission and cumulative improvement at the end of the third year was 44.1% and 85.3%, respectively. Patients who were operated early after the diagnosis showed higher improvement rate, although it was not statistically significant (P=0.065).

Conclusion: Thoracoscopic thymectomy is a safe procedure for treatment of MG with comparable results to other techniques. Thymectomy soon after the diagnosis may be associated with higher improvement rate.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304962PMC
January 2016

Right Ventricular Perforation with the Body of Swan-Ganz Catheter during Lung Transplantation by ECMO Support: A Case Report.

Tanaffos 2017 ;16(3):240-244

Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

A 46-year-old woman with a 12-year history of lymphangiomyomatosis (LAM) was admitted for lung transplantation in January 2017. We decided to apply veno-arterial extracorporeal membrane oxygenation (ECMO) to manage arrhythmia and hypotension during lung transplantation, since it was not controllable with inotropic drugs. After transplanting the right (first) lung and at the time of left pneumonectomy, the body of the Swan-Ganz catheter was suddenly observed to be protruding from the right ventricular (RV) wall. The catheter was found folded at part of its body and ran out 0.5 cm from the RV. The protruding part of the catheter was inserted before the perforated part of the cardiac muscle was repaired in order to control the bleeding. ECMO was used throughout the rest of the procedure and the patient was transferred to the intensive care unit (ICU) in good condition before being weaned from the ventilator after 16 hours. It seems that gentle manipulation, concurrent use of transesophageal echocardiography (TEE), insertion of the appropriate length of the catheter into the heart chambers, and a softer material in the structure of the catheters would be helpful to prevent these kinds of potentially fatal complications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960229PMC
January 2017

Paracetamol Instead of Ketorolac in Post-Video-Assisted Thoracic Surgery Pain Management: A Randomized Trial.

Anesth Pain Med 2016 Dec 21;6(6):e39175. Epub 2016 Aug 21.

Chronic Respiratory Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Video-assisted thoracic surgery (VATS) is a minimally invasive procedure that is growing more common around the world. Despite causing less pain compared open thoracic surgery, postoperative pain management is still important.

Objectives: The aim of the present study was to compare the analgesic effects of paracetamol and ketorolac in VATS patients.

Methods: This was a double-blinded randomized clinical trial conducted on 70 patients undergoing lobectomy or segmentectomy due to lung masses, using video-assisted methods. The patients were randomly divided into two groups (each n = 35): the ketorolac (K) group and the paracetamol (P) group. The K group received ketorolac 30 mg IV stat at the end of surgery and then a 90 mg/24 h infusion. The P group received paracetamol 1 g IV stat at the end of surgery and then a 3 g/24 h infusion. Pain scores were recorded during recovery and 2, 4, 8, 12, and 24 hours after drug administration. Pain scores, total doses of rescue analgesics, and patient satisfaction levels were compared between the groups.

Results: There was no significant difference between the K and P groups in pain scores in any of the evaluations. Seventeen (48.6 %) and 9 (25.7 %) patients in the K and P groups, respectively, did not require any rescue analgesia (P = 0.047). The mean doses of rescue analgesia in the K and P groups were 3.129 ± 4.27 mg and 4.38 ± 3.69 mg, respectively, which were similar (P = 0.144). There was no significant difference between the groups in satisfaction scores (P = 0.175).

Conclusions: Paracetamol 1 g stat + 3 g/24 h infusion is as effective as ketorolac 30 mg stat + 90 mg/24 h infusion in post-VATS pain management, with good tolerability and a low incidence of adverse effects.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5812/aapm.39175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560568PMC
December 2016

The Role of Systemic Steroids in Postintubation Tracheal Stenosis: A Randomized Clinical Trial.

Ann Thorac Surg 2017 Jan 29;103(1):246-253. Epub 2016 Jul 29.

Tracheal Diseases Research Center (TDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Most patients with postintubation tracheal stenosis are not ideal candidates for airway resection at presentation and their airways must be temporarily kept open by repeated bronchoscopic dilation (RBD). Meanwhile, some sufficiently recover by RBD without further airway resection requirement. We hypothesized whether systemic corticosteroids could lengthen RBD intervals, decrease the number of patients who eventually need airway resection, and shorten the required length of airway resection.

Methods: Between February 2009 and November 2012, a randomized double-blind clinical trial with a 1:1 ratio (corticosteroids group [group C], prednisolone 15 mg/day; placebo group [group P]) was conducted on 120 patients without tracheostomy or T tube and in no ideal situation for airway resection at presentation, whose precipitating injury had occurred recently. All underwent RBD until they became asymptomatic or prepared for airway resection. Asymptomatic patients received the capsules (prednisolone or placebo) for 6 months; others discontinued them before surgery. Those requiring RBD at short intervals underwent tracheostomy or T tube placement and were then excluded. Follow-up terminated 6 months after airway resection or capsule discontinuation.

Results: There were 105 patients (72 male; 50 in group C), aged 15 to 64 years, who completed their follow-up. There was no significant difference between the two groups in age, sex, history of tracheostomy, intubation cause and duration, time interval between intubation and initial bronchoscopy, length of stenosis, and subglottic involvement. Our study showed a trend for RBD with longer intervals (22 days), and fewer operations, 17% (28 of 50 versus 40 of 55) in group C, although statistically insignificant. Furthermore, the required airway resection length became significantly shorter (5.3 mm) in group C.

Conclusions: Early low-dose systemic corticosteroids can be beneficial in postintubation tracheal stenosis management.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.athoracsur.2016.05.063DOI Listing
January 2017

Outpatient pleuroscopy: Report of an experience in a referral hospital.

Pneumologia 2016 Jul-Sep;65(3):142-5

Pleuroscopy is a safe diagnostic procedure for evaluation of pleural diseases, with minimum complications. This procedure has been recently conducted on outpatient basis. Results support its safety, especially in busy referral hospitals. We aimed to report our experience on performing outpatient pleuroscopy at Masih Daneshvari hospital; Tehran, Iran. All eligible patients referred to Masih Daneshvari Hospital for pleuroscopy between May 2015 and May 2016 were enrolled. Air evacuation was conducted in operating room though a thin Nelaton catheter attached to low pressure suction. Compression dressing using Vaseline gauze was done after air leak terminated. Patients were discharged if first chest x-ray was negative for pneumothorax and were advised to stay in touch and return 12 hours later for second chest radiograph. Baseline characteristics, radiographic and pathologic reports were reviewed. Outpatient pleuroscopy was conducted on 10 patients. Average procedure time was 22±9 minutes. All patients were discharged after 4 hours. Eight of the patients remained free of complications after 12 hours, and 2 patients presented with pneumothorax (both who had massive pleural effusion) and were successfully managed by our team. Considering pathologic diagnosis, pleural tuberculosis was as common diagnosis as malignancy in our patients (4 patients), adenocarcinoma was the most malignancy reported (3 out of 4 patients). Chronic nonspecific inflammation was reported by our pathologist in 2 cases. Outpatient pleuroscopy can be conducted safely and effectively, reducing the number of unnecessary hospitalizations in a referral center. Closed follow up, patient education and proper patient selection are necessary for minimizing complications.
View Article and Find Full Text PDF

Download full-text PDF

Source
April 2018

Different and Unpredictable Clinical Outcome of Ruptured Pulmonary Hydatid Cysts.

Tanaffos 2015 ;14(3):217-21

Zabol University of Medical Sciences. Zabol, Iran.

Most authors believe that the best treatment for pulmonary hydatid disease is surgical evacuation. Although albendazole has been used prophylactically before surgery, there are many reports about increased incidence of the rupture of cyst after albendazole therapy, which can cause some complications. In this case report we present a patient with bilateral pulmonary hydatid cyst that was ruptured after using albendazole and different strategies were used for management of each cyst.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745192PMC
February 2016

Gorham's Disease With Chest Wall Involvement: A Case Report and a Review of the Literature.

Iran Red Crescent Med J 2014 Nov 17;16(11):e12180. Epub 2014 Nov 17.

Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.

Introduction: Gorham's disease is a rare disorder characterized by osteolysis and abnormal vascular growth within bones. Diagnosis of Gorham's disease is often delayed and for accurate and early diagnosis high clinical suspicion is crucial. No specific treatment is available. Management options include surgery, radiation therapy and medical therapy. We aimed to present the first case of Gorham's disease with chest wall involvement in Iran. By review of the literature we discussed important issues of this rare disease including clinical findings, diagnosis and treatment options.

Case Presentation: We present a 48-year-old man with a history of dyspnea following a blunt chest trauma who was admitted to our clinic several times due to reaccumulation of pleural fluid and chylothorax. Gorham's disease was finally established according to clinical manifestations and radiological findings including massive osteolysis in his left ribs and also histological examination.

Discussion: According to review of the literature and considering all treatment modalities the patients was successfully treated with a combination of radiotherapy, pamidronate and thalidomide. We suggest that this disease should be considered among differential diagnoses of patients with chest pain, pleural effusion and/or chylothorax with an unknown reason and more importantly history of chest trauma. In suspected cases, it is essential to examine biopsy specimens of the bone adjacent to the inflammated tissues in order to confirm diagnosis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5812/ircmj.12180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329932PMC
November 2014

Huge hilar carcinoid tumor resected by transsternal pneumonectomy: a case presentation.

Tanaffos 2014 ;13(4):55-7

Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Carcinoid tumors comprise an uncommon group of pulmonary neoplasms with neuroendocrine origin. In comparison with typical carcinoid tumors, atypical tumors are less common and more aggressive. We present a 35-year old female with atypical carcinoid tumor. The mass was located centrally and transsternal pneumonectomy was performed to resect the tumor.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386017PMC
April 2015