Publications by authors named "Abir Aouam"

7 Publications

  • Page 1 of 1

A case of interstitial granulomatous dermatitis associated with human immunodeficiency virus infection.

Australas J Dermatol 2021 Aug 23. Epub 2021 Aug 23.

Dermatology Department, Research Laboratory LR20SP03A, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, Tunisia.

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http://dx.doi.org/10.1111/ajd.13696DOI Listing
August 2021

Cerebral nocardiosis with osteomyelitis of skull vault complicating a primary neck lesion in an immunocompetent patient: a case report.

Pan Afr Med J 2021 12;38:349. Epub 2021 Apr 12.

Infectious Diseases Department, Fattouma Bourguiba Hospital, Monastir, Tunisia.

Nocardia infection is an uncommon and rare condition in immunocompetent patient. A case of cutaneous nocardiosis complicated with osteomyelitis of the vault scalp in a 64-year-old man, with no remarkable past medical history, is reported. Treatment with trimethoprime-sulfamethoxazole than doxycycline for 12 months led to complete resolution and no evidence of recurrence was noted. Nocardia infection should be considered even in immunocomptent patients and doxycycline is a good alternative for treatment.
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http://dx.doi.org/10.11604/pamj.2021.38.349.26635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308935PMC
August 2021

Isoniazid Therapeutic Drug Monitoring in Tunisian Patients With Tuberculosis.

J Clin Pharmacol 2021 07 19;61(7):972-978. Epub 2021 Jan 19.

Laboratory of Pharmacology, Faculty of Medicine of Monastir, Monastir, Tunisia.

A regular therapeutic drug monitoring (TDM) of isoniazid could be useful to predict the acetylation profile and to prescribe doses associated with optimal efficacy and safety. We aimed to assess the usefulness of isoniazid TDM in the Tunisian population, to describe the acetylation profile distribution in this population, and to investigate the influence of certain parameters on acetylation phenotype. We performed a retrospective study including Tunisian patients with tuberculosis underwent an isoniazid TDM. Isoniazid concentrations were measured 3 hours after drug intake (C ). Subsequent isoniazid doses were adjusted to maintain the C within the recommended target (1-2 µg/mL). Patients were qualified as slow acetylators (SAs) or rapid acetylators (RAs) according to their acetylation index. Among the 255 patients, 58% were SAs and 42% were RAs. Of all patients, only 30.6% had a C value within the target range. A dose adjustment has been performed for patients with C outside the target range. C was controlled in 77 patients. It became within the target range in 39 patients (50.6%). The median recommended isoniazid weight doses for SAs and RAs were 2.1 ± 0.7 mg/kg and 4.2 ± 1.4 mg/kg, respectively. The multivariate analysis showed that body weight, C and C /isoniazid dose were found to be significantly different between the 2 acetylation groups. In the pediatric group, only 9 had a C value within the target range, and all of them were RAs. The irrevocable interest of isoniazid TDM has been shown in Tunisian patients with tuberculosis, in both adult and pediatric patients, as isoniazid demonstrates an unpredictable pharmacokinetic profile.
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http://dx.doi.org/10.1002/jcph.1813DOI Listing
July 2021

The use of benzathine penicillin in streptococcal erythema nodosum: May it reduce recurrence?

Presse Med 2019 Oct 11;48(10):1180-1182. Epub 2019 Nov 11.

Fattouma Bourguiba Hospital, Infectious Disease Department, 5000 Monastir, Tunisia.

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http://dx.doi.org/10.1016/j.lpm.2018.10.022DOI Listing
October 2019

Successful treatment of postoperative multidrug-resistant Acinetobacter baumannii meningitis by tigecycline.

J Glob Antimicrob Resist 2016 Jun 21;5:62-3. Epub 2015 Dec 21.

Department of Infectious Diseases, Fattouma Bourguiba Hospital, Farhat Hached Street 5000, Monastir, Tunisia.

Tigecycline is a broad-spectrum antibiotic with activity against multidrug-resistant (MDR) bacteria. It has limited indications. Studies are necessary to elaborate new guidelines. Here we report a case of postoperative MDR Acinetobacter baumannii meningitis treated by tigecycline combined with colimycin for 21 days. The treatment was well tolerated with a favourable outcome. In conclusion, tigecycline was shown to be effective in a case of MDR A. baumannii meningitis.
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http://dx.doi.org/10.1016/j.jgar.2015.12.003DOI Listing
June 2016

[Diagnostic and therapeutic management of lymph node tuberculosis in Tunisia].

Pan Afr Med J 2014 27;19:211. Epub 2014 Oct 27.

Service de Maladies Infectieuses, CHU Fattouma Bourguiba, 5000 Monastir, Tunisie.

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http://dx.doi.org/10.11604/pamj.2014.19.211.5213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372307PMC
November 2015
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