Abigail S Hackam

Abigail S Hackam

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Abigail S Hackam

Abigail S Hackam

Publications by authors named "Abigail S Hackam"

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Multi-Omic Analyses of Growth Cones at Different Developmental Stages Provides Insight into Pathways in Adult Neuroregeneration.

iScience 2020 Feb 14;23(2):100836. Epub 2020 Jan 14.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Miami Integrative Metabolomics Research Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Program in Biomedical Sciences & Neuroscience Graduate Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2020.100836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997871PMC
February 2020

Increased Neuroprotective Microglia and Photoreceptor Survival in the Retina from a Peptide Inhibitor of Myeloid Differentiation Factor 88 (MyD88).

J Mol Neurosci 2020 Feb 18. Epub 2020 Feb 18.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.

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http://dx.doi.org/10.1007/s12031-020-01503-0DOI Listing
February 2020

Lipid profiling dataset of the Wnt3a-induced optic nerve regeneration.

Data Brief 2019 Aug 24;25:103966. Epub 2019 May 24.

Bascom Palmer Eye Institute, Miller School of Medicine at University of Miami, Miami, FL, 33136, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S23523409193031
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http://dx.doi.org/10.1016/j.dib.2019.103966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723204PMC
August 2019

Wnt signaling induces neurite outgrowth in mouse retinal ganglion cells.

Exp Eye Res 2019 05 14;182:39-43. Epub 2019 Mar 14.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2019.03.004DOI Listing
May 2019

Impact of seasonal variation in meteorological conditions on dry eye severity.

Clin Ophthalmol 2018 29;12:2471-2481. Epub 2018 Nov 29.

Public Health Sciences, Environmental Health Division, University of Miami, Miami, FL, USA,

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http://dx.doi.org/10.2147/OPTH.S181637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278710PMC
November 2018

A growing field: The regulation of axonal regeneration by Wnt signaling.

Neural Regen Res 2018 Jan;13(1):43-52

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.4103/1673-5374.224359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840987PMC
January 2018

Application of Scanning Electron Microscopy With Energy-Dispersive X-Ray Spectroscopy for Analyzing Ocular Surface Particles on Schirmer Strips.

Cornea 2017 Jun;36(6):752-756

*Department of Public Health Sciences, University of Miami, Miami, FL; †Miami Veterans Administration Medical Center, Miami, FL; ‡Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, FL; §Center for Advanced Microscopy, College of Arts and Sciences, University of Miami, Miami, FL; ¶Miami Project Imaging and Histology Cores, Miami Project to Cure Paralysis, University of Miami, Miami, FL; and ‖Department of Ophthalmology, School of Medicine, University of Maryland, Baltimore, MD.

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http://dx.doi.org/10.1097/ICO.0000000000001173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419879PMC
June 2017

Wnt signaling promotes axonal regeneration following optic nerve injury in the mouse.

Neuroscience 2017 02 21;343:372-383. Epub 2016 Dec 21.

Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2016.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5263026PMC
February 2017

Defining the Relationships Among Retinal Function, Layer Thickness and Visual Behavior During Oxidative Stress-Induced Retinal Degeneration.

Curr Eye Res 2016 07 10;41(7):977-86. Epub 2015 Nov 10.

a Bascom Palmer Eye Institute , University of Miami Miller School of Medicine , Miami , FL , USA.

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http://dx.doi.org/10.3109/02713683.2015.1083588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994529PMC
July 2016

Protective effects of a grape-supplemented diet in a mouse model of retinal degeneration.

Nutrition 2016 Mar 28;32(3):384-90. Epub 2015 Oct 28.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nut.2015.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744109PMC
March 2016

Human Tear Serotonin Levels Correlate with Symptoms and Signs of Dry Eye.

Ophthalmology 2015 Aug 14;122(8):1675-80. Epub 2015 May 14.

University of Miami Miller School of Medicine, Bascom Palmer Eye Institute, Miami, Florida; Miami Veterans Administration Medical Center, Miami, Florida. Electronic address:

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http://dx.doi.org/10.1016/j.ophtha.2015.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516582PMC
August 2015

Reduced photoreceptor death and improved retinal function during retinal degeneration in mice lacking innate immunity adaptor protein MyD88.

Exp Neurol 2015 May 25;267:1-12. Epub 2015 Feb 25.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, McKnight Bldg., Rm. 407, 1638 NW 10th Ave., Miami, FL 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2015.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417011PMC
May 2015

Activation of Wnt/β-catenin signaling in Muller glia protects photoreceptors in a mouse model of inherited retinal degeneration.

Neuropharmacology 2015 Apr 6;91:1-12. Epub 2014 Dec 6.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2014.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312718PMC
April 2015

A novel protective role for the innate immunity Toll-Like Receptor 3 (TLR3) in the retina via Stat3.

Mol Cell Neurosci 2014 Nov 28;63:38-48. Epub 2014 Sep 28.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2014.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250317PMC
November 2014

Signal transducer and activator of transcription 3 (STAT3) signaling in retinal pigment epithelium cells.

JAKSTAT 2013 Oct 17;2(4):e25434. Epub 2013 Jun 17.

Bascom Palmer Eye Institute; University of Miami Miller School of Medicine; Miami, FL USA.

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http://dx.doi.org/10.4161/jkst.25434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876436PMC
October 2013

Toll-like receptor 3 (TLR3) protects retinal pigmented epithelium (RPE) cells from oxidative stress through a STAT3-dependent mechanism.

Mol Immunol 2013 Jun 23;54(2):122-31. Epub 2012 Dec 23.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01615890120046
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http://dx.doi.org/10.1016/j.molimm.2012.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640317PMC
June 2013

The Wnt/β-catenin pathway cross-talks with STAT3 signaling to regulate survival of retinal pigment epithelium cells.

PLoS One 2012 4;7(10):e46892. Epub 2012 Oct 4.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046892PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464242PMC
May 2013

Novel role for the innate immune receptor Toll-like receptor 4 (TLR4) in the regulation of the Wnt signaling pathway and photoreceptor apoptosis.

PLoS One 2012 17;7(5):e36560. Epub 2012 May 17.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036560PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355158PMC
September 2012

Expression of brain-derived neurotrophic factor is regulated by the Wnt signaling pathway.

Neuroreport 2012 Feb;23(3):189-94

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 NW 10th Ave., Miami, FL 33136, USA.

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http://dx.doi.org/10.1097/WNR.0b013e32834fab06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265333PMC
February 2012

The Wnt signaling pathway protects retinal ganglion cell 5 (RGC-5) cells from elevated pressure.

Cell Mol Neurobiol 2011 Jan;31(1):163-73

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, FL 33136, USA.

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http://dx.doi.org/10.1007/s10571-010-9603-zDOI Listing
January 2011

Analysis of Dickkopf3 interactions with Wnt signaling receptors.

Growth Factors 2010 Aug;28(4):232-42

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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http://dx.doi.org/10.3109/08977191003738832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950226PMC
August 2010

Lithium chloride regulates the proliferation of stem-like cells in retinoblastoma cell lines: a potential role for the canonical Wnt signaling pathway.

Mol Vis 2010 Jan 13;16:36-45. Epub 2010 Jan 13.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805422PMC
January 2010

Basic fibroblast growth factor impact on retinoblastoma progression and survival.

Invest Ophthalmol Vis Sci 2008 Dec 9;49(12):5215-21. Epub 2008 Jul 9.

Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida, USA.

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http://dx.doi.org/10.1167/iovs.07-1668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139118PMC
December 2008

Regulation of neurotrophin expression and activity in the retina.

Authors:
Abigail S Hackam

Adv Exp Med Biol 2008 ;613:343-9

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 NW10th Ave., Miami, FL 33136, USA.

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http://dx.doi.org/10.1007/978-0-387-74904-4_40DOI Listing
February 2008

Translation of genetic discoveries into clinical therapies.

Ann Intern Med 2008 Feb;148(3):246-7

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http://dx.doi.org/10.7326/0003-4819-148-3-200802050-00019DOI Listing
February 2008

Characterization of Wnt signaling during photoreceptor degeneration.

Invest Ophthalmol Vis Sci 2007 Dec;48(12):5733-41

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, FL 33136, USA.

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.0
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http://dx.doi.org/10.1167/iovs.07-0097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2330018PMC
December 2007

Identification of two novel activities of the Wnt signaling regulator Dickkopf 3 and characterization of its expression in the mouse retina.

BMC Cell Biol 2007 Dec 19;8:52. Epub 2007 Dec 19.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1186/1471-2121-8-52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233618PMC
December 2007

Human embryonic and neuronal stem cell markers in retinoblastoma.

Mol Vis 2007 Jun 8;13:823-32. Epub 2007 Jun 8.

Ross Eye Institute, University of Buffalo, Buffalo, NY 14214, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768758PMC
June 2007

The Wnt signaling pathway has tumor suppressor properties in retinoblastoma.

Biochem Biophys Res Commun 2006 Oct 15;349(1):261-9. Epub 2006 Aug 15.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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http://dx.doi.org/10.1016/j.bbrc.2006.08.044DOI Listing
October 2006

The Wnt signaling pathway in retinal degenerations.

Authors:
Abigail S Hackam

IUBMB Life 2005 Jun;57(6):381-8

Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33136, USA.

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http://dx.doi.org/10.1080/15216540500137586DOI Listing
June 2005

Identification of gene expression changes associated with the progression of retinal degeneration in the rd1 mouse.

Invest Ophthalmol Vis Sci 2004 Sep;45(9):2929-42

Guerrieri Center for Genetic Engineering and Molecular Ophthalmology at the Wilmer Eye Institute, John Hopkins University School of medicine, Baltimore MD 21287, USA.

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http://dx.doi.org/10.1167/iovs.03-1184DOI Listing
September 2004

Comparative gene expression analysis of murine retina and brain.

Mol Vis 2004 Aug 31;10:637-49. Epub 2004 Aug 31.

Guerrieri Center for Genetic Engineering and Molecular Ophthalmology at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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August 2004

Changes in retinal pigment epithelial gene expression induced by rod outer segment uptake.

Invest Ophthalmol Vis Sci 2004 Jul;45(7):2098-106

Guerrieri Center for Genetic Engineering and Molecular Ophthalmology, Wilmer Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1167/iovs.03-0863DOI Listing
July 2004

Increased expression of iron-regulating genes in monkey and human glaucoma.

Invest Ophthalmol Vis Sci 2004 May;45(5):1410-7

Guerrieri Center for Genetic Engineering and Molecular Ophthalmology, Wilmer Ophthalmological Institute, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1167/iovs.03-0872DOI Listing
May 2004

Gene expression variation in the adult human retina.

Hum Mol Genet 2003 Nov 30;12(22):2881-93. Epub 2003 Sep 30.

Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddg326DOI Listing
November 2003

Identification of novel genes preferentially expressed in the retina using a custom human retina cDNA microarray.

Invest Ophthalmol Vis Sci 2003 Sep;44(9):3732-41

Guerrieri Center at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1167/iovs.02-1080DOI Listing
September 2003

Gene discovery in the embryonic chick retina.

Mol Vis 2003 Jun 20;9:262-76. Epub 2003 Jun 20.

Guerrieri Center for Genetic Engineering and Molecular Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287-9257, USA.

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June 2003

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.

Nat Cell Biol 2002 Feb;4(2):95-105

Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Pointe-Claire-Dorval, Quebec, Canada H9R 4P8.

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http://dx.doi.org/10.1038/ncb735DOI Listing
February 2002