Publications by authors named "Abida-Islam Pranty"

2 Publications

  • Page 1 of 1

Neurotropic Effects of SARS-CoV-2 Modeled by the Human Brain Organoids.

Stem Cell Reports 2021 03 12;16(3):373-384. Epub 2021 Feb 12.

Institute of Human Genetics, Universitätsklinikum Heinrich-Heine-Universität Düsseldorf, Universität Street 1, 40225 Düsseldorf, Germany. Electronic address:

COVID-19, caused by SARS-CoV-2, is a socioeconomic burden, which exhibits respiratory illness along with unexpected neurological complications. Concerns have been raised about whether the observed neurological symptoms are due to direct effects on CNS or associated with the virus's systemic effect. Recent SARS-CoV-2 infection studies using human brain organoids revealed that SARS-CoV-2 targets human neurons. Human brain organoids are stem cell-derived reductionist experimental systems that have highlighted the neurotropic effects of SARS-CoV-2. Here, we summarize the neurotoxic effects of SARS-CoV-2 using brain organoids and comprehensively discuss how brain organoids could further improve our understanding when they are fine-tuned.
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http://dx.doi.org/10.1016/j.stemcr.2021.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879157PMC
March 2021

SARS-CoV-2 targets neurons of 3D human brain organoids.

EMBO J 2020 10 23;39(20):e106230. Epub 2020 Sep 23.

Institute of Human Genetics, University Hospital Düsseldorf, Heinrich-Heine-Universität, Düsseldorf, Germany.

COVID-19 pandemic caused by SARS-CoV-2 infection is a public health emergency. COVID-19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports indicate that neurological symptoms continue to rise, suggesting detrimental effects of SARS-CoV-2 on the central nervous system (CNS). Here, we show that a Düsseldorf isolate of SARS-CoV-2 enters 3D human brain organoids within 2 days of exposure. We identified that SARS-CoV-2 preferably targets neurons of brain organoids. Imaging neurons of organoids reveal that SARS-CoV-2 exposure is associated with altered distribution of Tau from axons to soma, hyperphosphorylation, and apparent neuronal death. Our studies, therefore, provide initial insights into the potential neurotoxic effect of SARS-CoV-2 and emphasize that brain organoids could model CNS pathologies of COVID-19.
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http://dx.doi.org/10.15252/embj.2020106230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560208PMC
October 2020