Publications

Impaired Protein Quality Control During Left Ventricular Remodeling in Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor.
Circ Heart Fail 2017 Dec;10(12)
From the Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO (J.H., X.M., A.D., D.L.M.); John Cochran VA Medical Center, St. Louis, MO (A.D.); and Winters Center for Heart Failure Research, Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (G.D.S., W.W.).

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis.
Nat Commun 2017 Jun 7;8:15750. Epub 2017 Jun 7.
Department of Medicine, Cardiovascular Division, Washington University School of Medicine, Campus Box 8086, 660 S Euclid Avenue, St Louis, Missouri 63110, USA.

Comparison of Antibacterial Efficacy of Turmeric Extract, Morinda Citrifolia and 3% Sodium Hypochlorite on Enterococcus faecalis: An In-vitro Study.
J Clin Diagn Res 2016 Oct 1;10(10):ZC55-ZC57. Epub 2016 Oct 1.
Former Professor, Department of Endodontics, Sri Rajiv Gandhi College of Dental Sciences and Hospital , Bengaluru, Karnataka, India .

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation.
Cell Metab 2016 Jul 30;24(1):158-66. Epub 2016 Jun 30.
Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Human Immunology and Immunotherapy Programs, Washington University at St. Louis, St. Louis, MO 63110, USA. Electronic address:

IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions.
Sci Signal 2015 Jun 23;8(382):ra62. Epub 2015 Jun 23.
Division of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Regulation of the transcription factor EB-PGC1α axis by beclin-1 controls mitochondrial quality and cardiomyocyte death under stress.
Mol Cell Biol 2015 Mar 5;35(6):956-76. Epub 2015 Jan 5.
Division of Cardiology and Center for Cardiovascular Research, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, USA John Cochran VA Medical Center, St. Louis, Missouri, USA

Tumor necrosis factor receptor-associated factor 2 mediates mitochondrial autophagy.
Circ Heart Fail 2015 Jan 22;8(1):175-87. Epub 2014 Oct 22.
From the Division of Cardiology and Center for Cardiovascular Research, Department of Internal Medicine (K.-C.Y., X.M., H.L., J.M., P.M.B., D.L.M., A.D.), Department of Cell Biology and Physiology (D.L.M., A.D.), Washington University School of Medicine, St. Louis, MO; and Department of Medicine, John Cochran VA Medical Center, St. Louis, MO (X.M., H.L., A.D.).

Induction of lysosomal biogenesis in atherosclerotic macrophages can rescue lipid-induced lysosomal dysfunction and downstream sequelae.
Arterioscler Thromb Vasc Biol 2014 Sep 24;34(9):1942-1952. Epub 2014 Jul 24.
Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO (R.E., I.S., S.B., S.E., A.D., B.R.) and Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO (J.T., B.R.); John Cochran VA Medical Center, St. Louis, MO (A.D.); Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy (C.S., A.B.); and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX (C.S., A.B.).

Tumor necrosis factor receptor-associated factor 2 signaling provokes adverse cardiac remodeling in the adult mammalian heart.
Circ Heart Fail 2013 May 14;6(3):535-43. Epub 2013 Mar 14.
Winters Center for Heart Failure Research Section of Cardiology, Baylor College of Medicine, Houston, TX, USA.

Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy 2012 Apr;8(4):445-544
Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy.
Proc Natl Acad Sci U S A 2010 May 23;107(20):9035-42. Epub 2010 Apr 23.
Department of Medicine, Center for Pharmacogenomics, and Departments of Medicine and Pathology and Immunology, Division of Molecular Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.

MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts.
Circ Res 2010 Jan 5;106(1):166-75. Epub 2009 Nov 5.
Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.




Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis.
Proc Natl Acad Sci U S A 2007 Apr 9;104(16):6794-9. Epub 2007 Apr 9.
Center for Molecular Cardiovascular Research and Department of Pediatrics, Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45267, USA.


Targeted overexpression of noncleavable and secreted forms of tumor necrosis factor provokes disparate cardiac phenotypes.
Circulation 2004 Jan 29;109(2):262-8. Epub 2003 Dec 29.
Winters Center for Heart Failure Research, Houston VAMC, Baylor College of Medicine and the Methodist Hospital, Houston, Tex 77030, USA.

Activation and functional significance of the renin-angiotensin system in mice with cardiac restricted overexpression of tumor necrosis factor.
Circulation 2003 Aug 21;108(5):598-604. Epub 2003 Jul 21.
Winters Center for Heart Failure Research, Cardiology Section of Department of Medicine, Houston VAMC and Baylor College of Medicine, Houston, Tex 77030, USA.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy 2016 ;12(1):1-222
kb Emory University, School of Medicine , Department of Microbiology and Immunology , Atlanta , GA , USA.

Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway.
Autophagy 2017 25;13(11):1952-1968. Epub 2017 Nov 25.
a Center for Cardiovascular Research and Division of Cardiology , Washington University School of Medicine , St. Louis , MO , USA.

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