Publications by authors named "Abeer Almutairi"

9 Publications

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Impact of work environment perceptions and communication satisfaction on the intention to quit: an empirical analysis of nurses in Saudi Arabia.

PeerJ 2021 17;9:e10949. Epub 2021 Mar 17.

College of Nursing, King Saud University, Riyadh, Saudi Arabia.

Objective: In consideration of the current nursing shortage in Saudi Arabia, we aimed to investigate the association among perceptions of work environment, communication satisfaction, and intentions to quit nursing profession among nurses. In addition, we aimed to investigate the mediating effect of communication satisfaction on the association between nurses' perception of work environment and their intentions to quit nursing profession.

Methods: This predictive correlational study was conducted at one of the major hospitals in Saudi Arabia from January 2020 to March 2020. It included a convenience sample of 367 full-time registered nurses who completed three types of close-ended questionnaires. We used IBM SPSS version 24.0 to analyze the collected data. Regression analyses were used to test the study's hypotheses. All regression assumptions were assessed and confirmed. Significance for all tests was set at ≤ .05.

Results: The findings indicated an affirmative association between work environment perception and communication satisfaction ( = .764, < .05) among nurses. In addition, findings showed that work environment perception ( = -.187, < .05) and communication satisfaction ( = -.226, < .05) have negative impacts on the nurses' intentions to quit; indicating that as work environment perception or communication satisfaction increases, the intention to quit decreases among nurses. Further, a mediation effect of communication satisfaction on the relationship between work environment perception and intention to quit was confirmed.

Conclusion: This study presents a novel conceptual framework developed based on the literature about the predisposing factors for nurses' intentions to quit nursing profession. Our results suggest that work environment perception and communication satisfaction among the most contributing factors for nurses resignation. Effective communication was established as a crucial factor for establishing attractive and healthy working environment. Nursing managers can benefit by applying these findings to develop appropriate strategies to inhibit the shortage of nurses in Saudi Arabia.
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http://dx.doi.org/10.7717/peerj.10949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980699PMC
March 2021

Prevalence of dry eye syndrome in association with the use of contact lenses in Saudi Arabia.

BMC Ophthalmol 2021 Mar 23;21(1):147. Epub 2021 Mar 23.

Department of Pharmacology and Toxicology, College of Pharmacy, Taibah university, Madinah, Kingdom of Saudi Arabia.

Background: Dry eye disease is a tear film disorder which can cause discomfort to patients and negatively affect vision acuity. A number of risk factors has been reported to affect the incidence and severity of dry eye syndrome (DES). The aim is to study the prevalence of DES in Saudi Arabia and the factors affecting the severity of DES in relation to the use of contact lenses.

Methods: A cross-sectional questionnaire-based study was conducted on 310 participants using the ocular surface disease index (OSDI) questionnaire and the eye dryness part from contact lens questionnaire-8 (CLDEQ-8). Dry eye OSDI scores were compared across different epidemiological and risk factors with focus on the use of contact lenses. Pearson and Spearman's correlation coefficients were used to analyze the frequency of contact lenses usage in relation to OSDI scores. Student's t-test and one-way analysis of variance (ANOVA) tests were used to compare means of two or more than two groups, respectively.

Results: Forty eight (15.5%) of participants did not have any degree of DES, achieving an OSDI score between 0 and 12. Forty participants (12.9%) scored from 13 to 22, (mild DES), 44 (14.2%) were moderate, scoring 23-32 on the OSDI, while those who scored above 33 were 178 (57.4%) had severe DES. The mean score for all participants was 37.8. A high percentage of participants (84.5%) had some degree of DES. There was a strong positive correlation between OSDI score and the frequency of the feeling of dry eye and a moderate positive correlation between OSDI score and the intensity of dryness feeling. Out of 310 participants, 136 (43.9%) indicated using contact lenses. There was no significant association between the use of contact lenses per se and DES, however, those who used contact lenses more frequently had significantly higher OSDI scores.

Conclusions: Dry eye syndrome is a widespread, underdiagnosed condition in Saudi Arabia. The frequency of contact lenses use may contribute to the incidence of DES.
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http://dx.doi.org/10.1186/s12886-021-01912-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986502PMC
March 2021

Educational and Behavioral Models for Promoting Health in Saudi Arabia: A Theoretical Overview.

Cureus 2020 Jul 30;12(7):e9471. Epub 2020 Jul 30.

Primary Health Care Center, Ministry of Health Holdings, Taif, SAU.

In recent years, the field of environmental health promotion gained new prominence as awareness of physical environmental stressors and exposures escalated in Saudi Arabia. Although, several theories and conceptual models are routinely used for guiding health education and promotion interventions, they are rarely applied to environmental health issues in Saudi Arabia. This study theoretically reviews the educational and behavioral models for promoting health in Saudi Arabia. This study examines how education and behavioral models can reduce exposure to environmental health risks. In particular, this article describes the application of ecological theory with regard to its theoretical, analytical, and methodological challenges to future research in educational and behavioral studies. The implications of ecological theory are discussed for environmental health promotion. Ecological theory can further demonstrate the dimensions of health behaviors such as procedures for changing them. Health behaviors are also affected by many forces such as physical and social environments. This theory can assist planners in identifying the most appropriate target audiences, methods to improve change, and consequences for assessment. This theory is also important in including social, cultural, and physical factors that affect health consequences, which include factors such as social cohesion, behavioral patterns, emotional wellbeing, genetic heritage, and developmental maturation.
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http://dx.doi.org/10.7759/cureus.9471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455385PMC
July 2020

Effect of Air Pollution on Glutathione S-Transferase Activity and Total Antioxidant Capacity: Cross Sectional Study in Kuwait.

J Health Pollut 2020 Sep 25;10(27):200906. Epub 2020 Aug 25.

Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan.

Background: Air pollution poses a significant threat to human health worldwide. Investigating potential health impacts is essential to the development of regulations and legislation to minimize health risks.

Objectives: The aim of the present study was to investigate the potentially hazardous effect of air pollution on the Ali Sabah Al Salem residential area in Kuwait by comparing the pollution level to a control area (Al-Qirawan) by assessing two biomarkers: erythrocyte glutathione S-transferases (e-GST) and total blood antioxidant, and then correlating the activity to pollution-related oxidative stress.

Methods: The average concentrations of several airborne gases were measured at Ali Sabah Al Salem and Al-Qirawan, including ozone, carbon monoxide, nitrogen dioxide, nitrogen oxides, particulate matter less than 10 μm (PM), sulfur dioxide, ammonia, carbon dioxide, hydrogen sulfide, methane, and non-methane hydrocarbon. A total of fifty-eight participants were sampled from two different areas and divided into two groups. The study group was composed of 40 residents exposed to polluted ambient air in the Ali Sabah Al Salem residential area. A reference group composed of 18 residents in the Al-Qairawan area living far from major pollution sources was also tested.

Results: All measured gases were higher in concentration at Ali Sabah Al Salem compared to the Al-Qirawan area. Furthermore, PM and sulfur dioxide were higher than World Health Organization (WHO) guidelines. The e-GST activity was lower among participants of the Ali Sabah Al Salem residential area compared to participants living in the Al-Qairawan area. The total antioxidant capacity in whole blood of Ali Sabah Al Salem residents was significantly (p<0.0001) higher than in control subjects.

Conclusions: Residents in Ali Sabah Al Salem are exposed to a high level of air pollution that has a serious impact on glutathione S-transferases levels. Subsequently, regulations on pollution sources are needed to lower current health risks. Furthermore, the present study provides evidence that finger-prick blood sampling is a quick, non-invasive method suitable for screening e-GST activity and total antioxidants which may be applied for surveillance purposes.

Participant Consent: Obtained.

Ethics Approval: The study was approved by the Scientific Research Committee of the Public Authority for Applied Education and Training, Kuwait.

Competing Interests: The authors declare no competing financial interests.
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http://dx.doi.org/10.5696/2156-9614-10.27.200906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453819PMC
September 2020

Illness Perception and Medication Adherence Among Patients with Primary Hypothyroidism in Al Qassim, Saudi Arabia.

Patient Prefer Adherence 2020 6;14:1111-1117. Epub 2020 Jul 6.

Department of Family and Community Medicine, King Saud Hospital, Al Qassim, Saudi Arabia.

Purpose: Poor adherence to levothyroxine is a potential risk factor for treatment failure that ultimately leads to increased healthcare costs and serious health outcomes. This study aimed to investigate the correlation between illness perception and medication adherence among primary hypothyroidism patients.

Patients And Methods: We conducted a cross-sectional survey among primary hypothyroidism patients who met the inclusion criteria in the Qassim region of Saudi Arabia using a questionnaire with demographic characteristics, clinical factors, the 12-Item Medication Adherence Scale, and the Brief Illness Perception Questionnaire (BIPQ). We included 400 patients in the analysis.

Results: We found a significant positive correlation between BIPQ subscales - personal control, treatment control, and understanding - with all domains of the 12-Item Medication Adherence Scale. The other dimensions of BIPQ subscales did not significantly correlate with medication adherence. However, a high BIPQ overall score was significantly correlated with poor medication adherence.

Conclusion: This study found a significant correlation between a high BIPQ overall score and poor medication adherence. This finding suggests the need to consider the emotional and cognitive representation of hypothyroidism in hypothyroid patients to improve their treatment adherence.
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http://dx.doi.org/10.2147/PPA.S257703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352375PMC
July 2020

Correlation of Blood Oxidative Stress Parameters to Indoor Radiofrequency Radiation: A Cross Sectional Study in Jordan.

Int J Environ Res Public Health 2020 06 29;17(13). Epub 2020 Jun 29.

Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Yarmouk University, Shafiq Irshidat st Irbid 21163, Jordan.

: Electromagnetic pollution is a general health concern worldwide, as cell phone towers are ubiquitous and are located adjacent to or on the roof of schools, and hospitals. However, the health risks are still inconclusive. This cross-sectional study evaluated the potential effect of electromagnetic radiation generated from various resources including cell phone towers on blood glutathione S transferase activity (e-GST) and total antioxidant activity of the Jordanian population. : The power density of three districts in the city of Irbid, Jordan was mapped to generate "outside the houses" and "inside the houses" maps. The effect of categorical variables (gender, using a cell phone, presence of Wi-Fi modem, previous exposure to medical imaging) and continuous variables (distance from the base station, the elevation of the house, the duration of stay in the house, power density outside houses, power density inside houses) on e-GST and total antioxidant activity were investigated. : The EMR generated outside the houses-including cell phone towers-did not reach inside the houses at the same power and had no significant influence on e-GST activity. The EMR inside the house, which primarily came from internal resources, has a significant effect on e-GST activity. The duration of stay inside the house, the use of cell phones, and the presence of a Wi-Fi modem had a proportional effect on e-GST activity. The total antioxidant activity was statistically equal between the tested and control groups. : Several factors such as building materials restricted the penetration of EMR reaching inside the houses. EMR generated inside rather than outside the houses had a proportional effect on e-GST. The differences in e-GST were compensated successfully by other antioxidant mechanisms. Further research is needed to identify other possible sources of antioxidants, and to evaluate long-term effects and genetic polymorphism.
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http://dx.doi.org/10.3390/ijerph17134673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369753PMC
June 2020

Brainstem hemorrhage is uncommon and is associated with high morbidity, mortality, and prolonged hospitalization.

Neurosciences (Riyadh) 2020 Apr;25(2):91-96

Division of Neurology, Department of Medicine, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia.

Objective: To determine the frequency, risk factors, and outcomes of patients with brainstem hemorrhage in stroke center at King Abdulaziz Medical City, Riyadh.

Methods: A retrospective, observational cohort study including all patients with brainstem hemorrhage from January 2014 to December 2017. The clinical presentation, location of hemorrhage, complications and clinical outcomes were analyzed.

Results: Of 1921 stroke patients, 219 had hemorrhagic stroke (11.4%), of whom only 10 (4.6%) had brainstem hemorrhage, comprising 0.5% of all stroke patients. All patients were men; mean age was 58.5 years. Most frequent presenting symptoms were headache (70%), unilateral weakness (60%), and loss of consciousness (50%). All patients had hemorrhage in pons, 5 had concomitant cerebellar hemorrhage (50%), one had medullary hemorrhage, and one midbrain hemorrhage (10% each). Mean ICU stay was 17 days; mean hospital stay was 58 days. At the time of discharge, three (30%) had mRS of 0-2, 5 (50%) had mRS of 3-5, whereas 2 (20%) had died. Glasgow coma scale (GCS) of >8 at presentation was associated with a good outcome at three months (p=0.03). Presentation within six hours of symptom onset (p=0.233), hypertension on presentation (p=0.233), and age less than 60 years (p=0.065) did not affect discharge outcomes.

Conclusion: Brainstem hemorrhage occurred in 0.5% of all stroke patients. It was associated with high morbidity and mortality. Low Glasgow Coma Scale at presentation was associated with poor outcomes.
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http://dx.doi.org/10.17712/nsj.2020.2.20190102DOI Listing
April 2020

Suppressor analysis of a histone defect identifies a new function for the hda1 complex in chromosome segregation.

Genetics 2006 May 16;173(1):435-50. Epub 2006 Jan 16.

Department of Biological Sciences, University of Arkansas, Fayetteville 72701, USA.

Histones are essential for the compaction of DNA into chromatin and therefore participate in all chromosomal functions. Specific mutations in HTA1, one of the two Saccharomyces cerevisiae genes encoding histone H2A, have been previously shown to cause chromosome segregation defects, including an increase in ploidy associated with altered pericentromeric chromatin structure, suggesting a role for histone H2A in kinetochore function. To identify proteins that may interact with histone H2A in the control of ploidy and chromosome segregation, we performed a genetic screen for suppressors of the increase-in-ploidy phenotype associated with one of the H2A mutations. We identified five genes, HHT1, MKS1, HDA1, HDA2, and HDA3, four of which encode proteins directly connected to chromatin function: histone H3 and each of the three subunits of the Hda1 histone deacetylase complex. Our results show that Hda3 has functions distinct from Hda2 and Hda1 and that it is required for normal chromosome segregation and cell cycle progression. In addition, HDA3 shows genetic interactions with kinetochore components, emphasizing a role in centromere function, and all three Hda proteins show association with centromeric DNA. These findings suggest that the Hda1 deacetylase complex affects histone function at the centromere and that Hda3 has a distinctive participation in chromosome segregation. Moreover, these suppressors provide the basis for future studies regarding histone function in chromosome segregation.
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http://dx.doi.org/10.1534/genetics.105.050559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1461434PMC
May 2006

The OsLti6 genes encoding low-molecular-weight membrane proteins are differentially expressed in rice cultivars with contrasting sensitivity to low temperature.

Gene 2005 Jan;344:171-80

Department of Crop, Soil and Environmental Sciences, University of Arkansas, Fayetteville, AR 72701, USA.

Rice (Oryza sativa L.) is sensitive to chilling particularly at early stages of seedling establishment. Two closely related genes (OsLti6a, OsLti6b), which are induced by low temperature during seedling emergence were isolated from a cold tolerant temperate japonica rice cultivar. These genes are closely related to the Arabidopsis rare cold-inducible (RCI2) and barley low-temperature-inducible (BLT101) genes. Based on direct biochemical and indirect physiological evidence and similarity with a conserved protein domain in the Cluster of Orthologous Groups (COG) database (e.g., yeast PMP3), the rice genes belong to a class of low-molecular-weight hydrophobic proteins involved in maintaining the integrity of the plasma membrane during cold, dehydration and salt stress conditions. Both genes exhibit a genotype-specific expression signature characterized by early and late stress-inducible expression in tolerant and intolerant genotypes, respectively. The differences in temporal expression profiles are consistent with cultivar differences in cold-induced membrane leakiness and seedling vigor. The presence of CRT/DRE promoter cis-elements is consistent with the synchronized expression of OsLti6 genes with the C-repeat binding factor/drought responsive element-binding protein (CBF/DREB) transcriptional activator. The present results indicate that the Oslti6 genes are part of a battery of cold stress defense-related genes regulated by a common switch.
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http://dx.doi.org/10.1016/j.gene.2004.09.033DOI Listing
January 2005