Publications by authors named "Abdullah H Baqui"

346 Publications

Maternal serum lipidomics identifies lysophosphatidic acid as a predictor of small for gestational age neonates.

Mol Omics 2021 Sep 14. Epub 2021 Sep 14.

International Center for Maternal and Newborn Health, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

To discover lipidomic alterations during pregnancy in mothers who subsequently delivered small for gestational age (SGA) neonates and identify predictive lipid markers that can help recognize and manage these mothers, we carried out untargeted lipidomics on maternal serum samples collected between 24-28 weeks of gestation. We used a nested case-control study design and serum from mothers who delivered SGA and appropriate for gestational age babies. We applied untargeted lipidomics using mass spectrometry to characterize lipids and discover changes associated with SGA births during pregnancy. Multivariate pattern recognition software Collaborative Laboratory Integrated Reports (CLIR) was used for the post-analytical recognition of range differences in lipid ratios that could differentiate between SGA and control mothers and their integration for complete separation between the two groups. Here, we report changes in lipids from serum collected during pregnancy in mothers who delivered SGA neonates. In contrast to normal pregnancies where lysophosphatidic acid increased over the course of the pregnancy owing to increased activity of lysophospholipase D, we observed a decrease (32%; = 0.05) of 20:4-lysophosphatidic acid in SGA mothers, which could potentially compromise fetal growth and development. Integration of lipid ratios in an interpretive tool (CLIR) could completely separate SGA mothers from controls demonstrating the power of untargeted lipidomic analyses for identifying novel predictive biomarkers. Additional studies are required for further assessment of the lipid biomarkers identified in this report.
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http://dx.doi.org/10.1039/d1mo00131kDOI Listing
September 2021

Appel urgent à l’action pour limiter la hausse de la température mondiale, restaurer la biodiversité et protéger la santé: les pays riches doivent en faire beaucoup plus, et plus rapidement.

CMAJ 2021 Sep;193(35):E1410-E1412

Rédacteur en chef, East African Medical Journal (Atwoli); rédacteur en chef, Journal of Health, Population and Nutrition (Baqui); rédacteur en chef, Danish Medical Journal (Benfield); rédactrice en chef, PLOS Medicine (Bosurgi); rédactrice en chef, The BMJ (Godlee); rédacteur en chef, British Dental Journal (Hancocks); rédacteur en chef, The Lancet (Horton); conseiller principal, UK Health Alliance on Climate Change (Laybourn-Langton); rédacteur en chef, Revista de Saúde Pública (Monteiro); rédacteur en chef, International Journal of Nursing Studies (Norman); rédactrice en chef par intérim, CMAJ (Patrick); directeur général, Pharmaceutical Journal (Praities); rédacteur en chef, Dutch Journal of Medicine (Olde Rikkert); rédacteur en chef, NEJM (Rubin); rédacteur en chef, National Medical Journal of India (Sahni); président, UK Health Alliance on Climate Change (Smith); rédacteur en chef, Medical Journal of Australia (Talley); rédactrice en chef, International Nursing Review (Sue Turale); rédacteur en chef, Pan American Journal of Public Health (Vázquez).

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http://dx.doi.org/10.1503/cmaj.211338-fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443296PMC
September 2021

Call for emergency action to limit global temperature increases, restore biodiversity, and protect health: wealthy nations must do much more, much faster.

CMAJ 2021 Sep;193(35):E1395-E1397

Editor-in-chief, East African Medical Journal (Atwoli); editor-in-chief, Journal of Health, Population and Nutrition (Baqui); editor-in-chief, Danish Medical Journal (Benfield); editor-in-chief, PLOS Medicine (Bosurgi); editor-in-chief, The BMJ (Godlee); editor-in-chief, British Dental Journal (Hancocks); editor-in-chief, The Lancet (Horton); senior adviser, UK Health Alliance on Climate Change (Laybourn-Langton); editor-in-chief, Revista de Saúde Pública (Monteiro); editor-in-chief, International Journal of Nursing Studies (Norman); interim-editor-in-chief, CMAJ (Patrick); executive editor, Pharmaceutical Journal (Praities); editor-in-chief, Dutch Journal of Medicine (Olde Rikkert); editor-in-chief, NEJM (Rubin); editor-in-chief, National Medical Journal of India (Sahni); chair, UK Health Alliance on Climate Change (Smith); editor-in-chief, Medical Journal of Australia (Talley); editor-in-chief, International Nursing Review (Turale); editor-in-chief, Pan American Journal of Public Health (Vázquez).

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http://dx.doi.org/10.1503/cmaj.211338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443294PMC
September 2021
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