Publications by authors named "Abdulhadi Jfri"

27 Publications

  • Page 1 of 1

The Efficacy and Effectiveness of Non-ablative Light-Based Devices in Hidradenitis Suppurativa: A Systematic Review and Meta-Analysis.

Front Med (Lausanne) 2020 3;7:591580. Epub 2020 Nov 3.

Division of Dermatology, McGill University Health Centre, Montreal, QC, Canada.

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder that may be treated with non-ablative light-based devices; however, no systematic reviews on the topic exist to date. We conducted a systematic review and meta-analysis to determine efficacy of non-ablative light-based devices in treating HS. Specifically, a systematic review was conducted using MEDLINE, EMBASE, Web of Science and CINAHL. We analyzed the use of non-ablative light-based devices in the treatment of HS. At least two investigators performed title/abstract review and data extraction. Meta-analysis was conducted using comprehensive meta-analysis software. 5 RCTs and 11 case reports/series were included ( = 211 unique patients). No observational studies were found. For Nd:YAG laser, meta-analysis of 3 RCTs reported improvement in modified HS Lesion Area and Severity Index (HS-LASI) when compared to control subjects. In addition, three case reports/series reported HS-LASI, Physician Global Assessment (PGA) scores and number-of-lesion improvements in treated patients. For intense pulsed light (IPL), two RCTs reported HS-LASI and Dermatology Life Quality Index (DLQI) score improvements. For Alexandrite laser, one case report showed lesion improvement. In conclusion, meta-analysis of Nd:YAG laser in HS patients suggests significant improvement in HS-LASI scores. For IPL, evidence is limited, but suggests improvement in HS-LASI and DLQI scores. For Alexandrite laser, evidence precludes conclusions. Given small sample sizes and inconsistent reporting scales, larger RCTs are required to better determine the efficacy of these modalities in treating HS.
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http://dx.doi.org/10.3389/fmed.2020.591580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670045PMC
November 2020

Novel variants of and genes in familial hidradenitis suppurativa: A case report.

SAGE Open Med Case Rep 2020 25;8:2050313X20953113. Epub 2020 Sep 25.

Division of Dermatology, McGill University Health Centre, Montreal General Hospital, Montreal, QC, Canada.

We report a two-generation Canadian family of Armenian ancestry with hidradenitis suppurativa where novel mutations in and genes were identified. The father and both children shared a mild-to-moderate hidradenitis suppurativa phenotype together with the features of follicular occlusion (e.g. acne and scalp folliculitis). Based on our findings and previous literature, we recommend considering genetic testing with a periodic fever/autoinflammatory disorder panel in patients with a strong family history of hidradenitis suppurativa and lack of common triggers such as smoking and being overweight.
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http://dx.doi.org/10.1177/2050313X20953113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522817PMC
September 2020

Sonography of Encapsulated Fat Necrosis with Histologic Correlation.

Med Ultrason 2020 Sep;22(3):397-380

Dermatology Department, Hospital Universitario Puerta de Hierro Majadahonda, C/ manuel de Falla 2 29022 Majadahonda, Madrid, Spain.

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http://dx.doi.org/10.11152/mu-2650DOI Listing
September 2020

Apremilast in dermatology: A review of literature.

Dermatol Ther 2020 11 27;33(6):e14261. Epub 2020 Sep 27.

Division of Dermatology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada.

Apremilast is an orally administered small molecule that specifically inhibits the phosphodiesterase-4 enzyme and modulates the immune system by increasing the levels of intracellular cyclic adenosine monophosphate (cAMP) and inhibiting IL-2 & 8, interferon-γ and tumor necrosis factor (TNF) production. It is FDA approved for the treatment of psoriasis, psoriatic arthritis, and oral ulcers of Behcet's disease. More recently, apremilast has been used off-label to treat varied dermatological diseases where systemic corticosteroids or immunosuppressive agents were not effective. We review the efficacy and safety of apremilast in the treatment of aphthous stomatitis, Behçet's disease, chronic actinic dermatitis, atopic dermatitis, cutaneous sarcoidosis, hidradenitis suppurativa, lichen planus, and discoid lupus erythematosus in cases where standard treatment has failed.
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http://dx.doi.org/10.1111/dth.14261DOI Listing
November 2020

Association of Clinical Severity Scores with Psychosocial Impact in Patients with Hidradenitis Suppurativa.

J Am Acad Dermatol 2020 Aug 8. Epub 2020 Aug 8.

Division of Dermatology, McGill University Health Centre, Montreal General Hospital, Rm. L8-201, 1650 Cedar Avenue, Montreal, QC H3G 1A4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.08.022DOI Listing
August 2020

Sonography of solitary fibrofolliculoma with histologic correlation.

J Ultrasound 2020 Jul 21. Epub 2020 Jul 21.

Dermatology Department, Hospital Universitario Puerta de Hierro Majadahonda, C/Manuel de Falla 2, Majadahonda, 29022, Madrid, Spain.

We present a case of 15-year old male with solitary fibrofolliculoma on the ear and we demonstrate the use of ultrasound in outlining the features of this rare benign skin tumor with histological correlation. Fibrofolliculoma can be associated with a rare syndrome known as Birt-Hogg-Dubé which affects the skin, lungs and kidneys.
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http://dx.doi.org/10.1007/s40477-020-00510-6DOI Listing
July 2020

A pediatric case of Stevens-Johnson syndrome/toxic epidermal necrolysis with rapid response to intravenous cyclosporine.

JAAD Case Rep 2020 Jun 7;6(6):555-557. Epub 2020 May 7.

Division of Dermatology, McGill University Health Center-Glen site, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.jdcr.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265061PMC
June 2020

Preliminary Data Suggests That Biologics in Dermatology Are Not Associated With Adverse COVID-19 Outcomes.

J Cutan Med Surg 2020 Jul/Aug;24(4):420-421. Epub 2020 May 25.

54473507266 Division of Dermatology, McGill University Health Centre, Montreal General Hospital, QC, Canada.

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http://dx.doi.org/10.1177/1203475420929250DOI Listing
August 2020

Newer and Safer Kappa-Opioid Agonist for Your Patients With Uremic Pruritus.

J Cutan Med Surg 2020 Sep/Oct;24(5):525-526. Epub 2020 May 19.

54473 Division of Dermatology, McGill University Health Centre, Montreal General Hospital, Quebec, Canada.

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http://dx.doi.org/10.1177/1203475420926989DOI Listing
May 2020

Cutaneous Manifestations of Coronavirus Disease 2019 (COVID-19) Infection-What Do We Know So Far?

J Cutan Med Surg 2020 Jul/Aug;24(4):416-417. Epub 2020 May 11.

507266 Division of Dermatology, McGill University Health Center, Montreal, QC, Canada.

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http://dx.doi.org/10.1177/1203475420928375DOI Listing
August 2020

Spesolimab: A Novel Treatment for Pustular Psoriasis.

J Cutan Med Surg 2020 Mar/Apr;24(2):199-200

54473 507266 Division of Dermatology, McGill University Health Centre, Montreal General Hospital, QC, Canada.

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http://dx.doi.org/10.1177/1203475419888862DOI Listing
February 2021

Treatment Modalities for Varicose Veins of Lower Extremities.

J Cutan Med Surg 2020 Mar/Apr;24(2):203-204

54473 507266 Division of Dermatology, McGill University Health Centre, Montreal, QC, Canada.

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http://dx.doi.org/10.1177/1203475419891082DOI Listing
February 2021

Pityriasis Rosea: Risk and Treatment During Pregnancy.

J Cutan Med Surg 2020 Mar/Apr;24(2):207-208

5620 Division of Dermatology, Jewish General Hospital, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1177/1203475420902049DOI Listing
February 2021

Herpes Zoster Ophthalmicus with Unilateral Sixth Nerve Palsy.

Can J Neurol Sci 2020 03;47(2):273-274

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1017/cjn.2019.340DOI Listing
March 2020

Ultrasound use to diagnose septal panniculitis.

Med Ultrason 2019 Nov;21(4):499-500

Hospital de manises.

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http://dx.doi.org/10.11152/mu-2203DOI Listing
November 2019

Congenital sideroblastic anemia associated with B cell immunodeficiency, periodic fevers, and developmental delay: A case report and review of mucocutaneous features.

SAGE Open Med Case Rep 2019 16;7:2050313X19876710. Epub 2019 Sep 16.

Division of Dermatology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada.

This is a 40-year-old woman with sideroblastic anemia with B cell immunodeficiency, periodic fevers, and developmental delay syndrome, who has genital and extragenital lichen sclerosus on the abdomen and the upper back that have become erythematous and painful during febrile episodes. This report summarizes the published cases of sideroblastic anemia with B cell immunodeficiency, periodic fevers, and developmental delay and highlights associated mucocutaneous features.
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http://dx.doi.org/10.1177/2050313X19876710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747858PMC
September 2019

Hailey-Hailey disease treated successfully with naltrexone and magnesium.

JAAD Case Rep 2019 Sep 29;5(9):760-762. Epub 2019 Aug 29.

Division of Dermatology, McGill University Health Centre, Montreal General Hospital, Montreal, Canada.

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http://dx.doi.org/10.1016/j.jdcr.2019.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728728PMC
September 2019

Paraneoplastic pyoderma gangrenosum in solid organ malignancy: a literature review.

Int J Dermatol 2020 Feb 12;59(2):154-158. Epub 2019 Sep 12.

Division of Dermatology, McGill University Health Centre, Montreal, QC, Canada.

Pyoderma gangrenosum (PG) is a rare destructive, ulcerative, and inflammatory cutaneous disease. PG can be associated with inflammatory bowel disease (IBD), arthritis, autoinflammatory syndromes, and hematological malignancies. Multiple reports in the literature have found an association between PG and solid organ tumors. This article provides a summary and review of PG in patients with solid organ malignancies. We performed a PubMed search using the terms pyoderma gangrenosum, paraneoplastic pyoderma gangrenosum, cancer, malignancy, tumor, and solid organ malignancy. Out of 529 papers screened, 19 relevant cases were included that reported patients above the age of 12 years old with antecedent, coincident, or subsequent occurrence of PG in association with a solid organ malignancy. The most common malignancies associated with PG were found in the breast (n = 6, 31.6%). In a majority of the cases, the site of PG was found to be the lower extremities (n = 12, 63.2%). Almost all cases were presented with ulcerative PG subtype (n = 18, 94.7%). Moreover, 78.9% of cases (n = 15) were reported to have PG prior to tumor diagnosis. PG lesions resolved in 100% of patients after either tumor or PG-specific treatment. We identified a strong temporal relationship between ulcerative PG and its associated solid organ malignancy. Other associations with breast cancer and lower extremity location exist but are not as strong.
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http://dx.doi.org/10.1111/ijd.14637DOI Listing
February 2020

Association of hidradenitis suppurativa and keloid formation: A therapeutic challenge.

JAAD Case Rep 2019 Aug 2;5(8):675-678. Epub 2019 Aug 2.

Division of Dermatology, University of Toronto, Women's College Hospital, Toronto, Canada.

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http://dx.doi.org/10.1016/j.jdcr.2019.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698290PMC
August 2019

Naltrexone for the Treatment of Darier and Hailey-Hailey Diseases.

J Cutan Med Surg 2019 Jul/Aug;23(4):453-454

1 Division of Dermatology, McGill University Health Centre, Montreal General Hospital, QC, Canada.

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http://dx.doi.org/10.1177/1203475419843122DOI Listing
May 2020

Hidradenitis Suppurativa: Comprehensive Review of Predisposing Genetic Mutations and Changes.

J Cutan Med Surg 2019 Sep/Oct;23(5):519-527. Epub 2019 Jun 6.

1 Division of Dermatology, McGill University Health Centre, Montreal, QC, Canada.

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder. A genetic component in the pathogenesis is highly likely considering that ~30% to 40% of patients with HS report a family history of the disease. The genetic mutations related to HS that have been reported to date suggest HS can be inherited as a monogenic trait because of a defect in either the signaling pathway or inflammasome function, or as a polygenic disorder resulting from defects in genes regulating epidermal proliferation, ceramide production, or in immune system function. This review provides a summary of genetic mutations reported in patients diagnosed with HS and discusses the mechanisms by which these genes are involved in its pathogenesis.
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http://dx.doi.org/10.1177/1203475419852049DOI Listing
February 2020

Incidence trends of conjunctival malignant melanoma in Canada.

Br J Ophthalmol 2020 01 11;104(1):23-25. Epub 2019 May 11.

Division of Dermatology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada

Background: Melanoma is the most common primary malignancy of the eye in adults. While the epidemiology of uveal melanoma has recently been described in Canada, little is known about the epidemiology and geographic distribution of patients with conjunctival melanoma (CM) in Canada.

Methods: We conducted a population-based study of CM incidence across all Canadian provinces and territories during 1992-2010 using two independent population-based registries.

Results: 190 patients were diagnosed with CM in Canada from 1992 to 2010. 55.3 % of these patients were men. The mean annual incidence rate of CM in Canada was 0.32 cases per million individuals (0.35 and 0.29 cases per million individuals for men and women, respectively). The incidence rates for Canadian provinces demonstrated that the eastern provinces of Nova Scotia and New Brunswick had higher age-adjusted incidence rates than the national average, with rates of 0.52 and 0.47 cases per million individuals per year, respectively.

Conclusions: This analysis demonstrates novel variations in CM incidence rates between different Canadian provinces. These results taken together with the data reported from the USA confirm the North-to-South geographic gradient of increasing CM incidence. This research highlights that the epidemiology of CM in North America is comparable to that of cutaneous malignant melanoma in contrast to the trends for uveal melanoma distribution.
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http://dx.doi.org/10.1136/bjophthalmol-2019-313977DOI Listing
January 2020

Idiopathic Atrophoderma of Pasini and Pierini: Case report and literature review.

Clin Case Rep 2019 Feb 18;7(2):258-263. Epub 2018 Dec 18.

Division of Dermatology McGill University Health Centre Montreal Québec Canada.

Idiopathic Atrophoderma of Pasini and Pierini should be considered on the differential in a patient presenting with an asymptomatic atrophic plaque on the skin. Differentiation from Linear Atrophoderma of Moulin and morphea remains a challenge; however, features of the presentation and tissue biopsy can help establish the diagnosis.
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http://dx.doi.org/10.1002/ccr3.1958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389486PMC
February 2019

Spontaneous Keloids: A Literature Review.

Dermatology 2018 16;234(3-4):127-130. Epub 2018 Aug 16.

Background: Keloids are benign fibroproliferative tumors that extend beyond the original wound. Spontaneous keloids are those that result without a significant history of trauma. There are multiple reported cases in the literature.

Objective: This article provides a summary and review of the cases that have been reported with spontaneous keloids and organizes them according to their associated medical conditions.

Methods: A literature review was conducted using PubMed and MEDLINE that included all English published cases and case series from May 1955 to February 2018.

Results: Spontaneous keloids have been reported mainly in association with syndromes such as Rubinstein-Taybi syndrome, Dubowitz syndrome, Noonan syndrome, Goeminne syndrome, Bethlem myopathy, conjunctivocorneal dystrophy, X-linked recessive polyfibromatosis and a novel X-linked syndrome with flamin A mutation. Furthermore, spontaneous keloids were reported in atopic patients and a couple of patients who are medically healthy.

Conclusion: Spontaneous keloids are diagnosed clinically based on the patient's history, and it is challenging to confirm since they might be triggered by minimal injury or inflammation especially if it is a single lesion. Reported syndromes indicate a genetic possibility in the pathogenesis of spontaneous keloids.
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http://dx.doi.org/10.1159/000491924DOI Listing
December 2018

Porokeratotic eccrine ostial and dermal duct nevus: a unique case treated with CO laser.

Clin Case Rep 2017 05 31;5(5):675-678. Epub 2017 Mar 31.

Department of Dermatology Mount Sinai School of Medicine New York City New York USA.

Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is a rare eccrine hamartoma, with treatment generally being unsatisfactory. The unique features of PEODDN presented include bilateral and facial lesions, and extensive body involvement. Management with CO laser was successful, and follow-up will be necessary to monitor for recurrent lesions.
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http://dx.doi.org/10.1002/ccr3.846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412763PMC
May 2017

Retrospective Study of Punch Scoring Versus Freehand Approach for First Stage Mohs Micrographic Surgery.

J Clin Aesthet Dermatol 2016 Sep 1;9(9):55-56. Epub 2016 Sep 1.

Division of Dermatologic Surgery, Department of Dermatology, Mount Sinai School of Medicine, New York, New York.

The objective was to observe whether there is a difference in the number of subjects requiring more than one stage of Mohs micrographic surgery for small lesion nonmelanoma skin cancers using the punch scoring method versus freehand approach. Retrospective review. Outpatient Mohs Clinic. Thirty patients with small lesion (<5mm) basal cell and squamous cell carcinoma who had Mohs micrographic surgery using either the punch scoring method (15) for scoring the first layer or the freehand method (15). Differences between the two groups were evaluated by the number of subjects requiring more than one stage and the reason for any additional stages. There was no observed difference in the number of subjects requiring more than one Mohs stage between the punch scoring group and the freehand group. Dermatologic surgeons can use the punch scoring method or the freehand approach for scoring small lesion Mohs based on provider preference.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110330PMC
September 2016

A Case of Multiple Spontaneous Keloid Scars.

Case Rep Dermatol 2015 May-Aug;7(2):156-60. Epub 2015 Jul 24.

King Fahad General Hospital, Jeddah, Saudi Arabia.

Keloid scars result from an abnormal healing response to cutaneous injury or inflammation that extends beyond the borders of the original wound. Spontaneous keloid scars forming in the absence of any previous trauma or surgical procedure are rare. Certain syndromes have been associated with this phenomenon, and few reports have discussed the evidence of single spontaneous keloid scar, which raises the question whether they are really spontaneous. Here, we present a 27-year-old mentally retarded single female with orbital hypertelorism, broad nasal bridge, repaired cleft lip and high-arched palate who presented with progressive multiple spontaneous keloid scars in different parts of her body which were confirmed histologically by the presence of typical keloidal collagen. This report supports the fact that keloid scars can appear spontaneously and are possibly linked to a genetic factor. Furthermore, it describes a new presentation of spontaneous keloid scars in the form of multiple large lesions in different sites of the body.
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http://dx.doi.org/10.1159/000437249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560309PMC
September 2015