Publications by authors named "Abdulhadi Jfri"

33 Publications

Plerixafor on a WHIM - Promise or Fantasy of a New CXCR4 Inhibitor for This Rare, but Important Syndrome?

Skin Therapy Lett 2022 Mar;27(2):1-5

Division of Dermatology, McGill University Health Centre, Montréal, QC, Canada.

Warts, Hypogammaglobulinemia, Infections and Myelokathexis (WHIM) is a primary immunodeficiency syndrome. Patients with WHIM syndrome are more susceptible to human papillomavirus (HPV) infections and commonly present to a dermatologist with recalcitrant to treatment warts. Other cardinal features of WHIM syndrome include recurrent sinopulmonary bacterial infections, neutropenia/lymphopenia, low levels of immunoglobulins (IgG, IgA, IgM) and myelokathexis. Research demonstrated that truncating gain-of-function mutations of the C-X-C chemokine receptor type 4 gene (CXCR4) are responsible for this disease. Plerixafor, a specific small molecule antagonist of CXCR4, is currently used for peripheral blood hematopoietic stem cell (HSC) mobilization in stem cell transplant recipients. It has recently shown promise for the treatment of WHIM syndrome in phase I/II clinical trials. In this paper we review the emerging patient clinical data for this medication and highlight the role of CXCR4 in other important skin diseases including keratinocyte carcinomas, psoriasis and cutaneous T-cell lymphoma.
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March 2022

Performance of Ultrasound for Identifying Morphological Characteristics and Thickness of Cutaneous Basal Cell Carcinoma: A Systematic Review.

Dermatology 2022 Jan 13:1-19. Epub 2022 Jan 13.

Institute for Diagnostic Imaging and Research of the Skin and Soft Tissues, Santiago, Chile.

Advances in ultrasound technology and non-surgical treatments of basal cell carcinomas (BCCs) have raised the need to study the performance of high-frequency ultrasound (HFUS) in BCCs. We aimed to assess the performance of HFUS in the evaluation of BCCs to formulate recommendations for its uses and conducted a systematic review of the literature to do so. A search of Central, Medline, Embase, CINHAL, and Web of Science was performed using key/MESH terms "ultrasonography" and "basal cell carcinoma" (January 2005-December 2020). We included primary studies reporting biopsy-confirmed BCCs for which the target intervention was ultrasound assessment at 15 MHz or higher frequency. Thirty articles were included, studying a total of 1,203 biopsy-confirmed BCCs. HFUS provides accurate depth measurements, especially for BCCs >1 mm. The definition of lateral margins in vivo needs further studies; however, ex vivo margin assessment seems convincing. There is a diagnostic role for HFUS in identifying higher recurrence risk BCC subtypes, which can help in risk stratification. Performance of HFUS is significant in BCC management. Pre-surgical scans may support case selection for Mohs. HFUS can improve safety when used to plan brachytherapy treatments, help with case selection and adjunct treatment choice pre-photodynamic therapy. Finally, HFUS can help follow lesions after intervention, particularly non-surgical management, and support the decision to observe or re-intervene. HFUS can enhance clinical practice by providing useful information that cannot be deducted from the clinical examination. It would be recommended to evaluate the extent, mainly depth, and detect the aggressiveness of the BCCs.
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http://dx.doi.org/10.1159/000520751DOI Listing
January 2022

Discriminative deep learning based benignity/malignancy diagnosis of dermatologic ultrasound skin lesions with pretrained artificial intelligence architecture.

Skin Res Technol 2022 Jan 22;28(1):35-39. Epub 2021 Aug 22.

Dermatology Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.

Background: Deep-learning algorithms (DLAs) have been used in artificial intelligence aided ultrasonography diagnosis of thyroid and breast lesions. However, its use has not been described in the case of dermatologic ultrasound lesions. Our purpose was to train a DLA to discriminate benign form malignant lesions in dermatologic ultrasound images.

Materials And Methods: We trained a prebuilt neural network architecture (EfficientNet B4) in a commercial artificial intelligence platform (Peltarion, Stockholm, Sweden) with 235 color Doppler images of both benign and malignant ultrasound images of 235 excised and histologically confirmed skin lesions (84.3% training, 15.7% validation). An additional 35 test images were used for testing the algorithm discrimination for correct benign/malignant diagnosis. One dermatologist with more than 5 years of experience in dermatologic ultrasound blindly evaluated the same 35 test images for malignancy or benignity.

Results: EfficientNet B4 trained dermatologic ultrasound algorithm sensitivity; specificity; predictive positive values, and predicted negative values for validation algorithm were 0.8, 0.86, 0.86, and 0.8, respectively for malignancy diagnosis. When tested with 35 previously unevaluated images sets, the algorithm´s accuracy for correct benign/malignant diagnosis was 77.1%, not statistically significantly different from the dermatologist's evaluation (74.1%).

Conclusion: An adequately trained algorithm, even with a limited number of images, is at least as accurate as a dermatologic-ultrasound experienced dermatologist in the evaluation of benignity/malignancy of ultrasound skin tumor images devoid of clinical data.
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http://dx.doi.org/10.1111/srt.13086DOI Listing
January 2022

Prevalence of Hidradenitis Suppurativa: A Systematic Review and Meta-regression Analysis.

JAMA Dermatol 2021 Aug;157(8):924-931

Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane and Faculty of Health Sciences Brandenburg, Dessau, Germany.

Importance: Hidradenitis suppurativa/acne inversa (HS) is a chronic inflammatory skin disease characterized by occlusion of hair follicles as a primary pathogenic factor. There are scarce data regarding the prevalence of HS.

Objective: To estimate overall HS prevalence.

Data Sources: This review and meta-regression analysis was conducted using the Meta-analysis of Observational Studies in Epidemiology (MOOSE) reporting guideline. The academic search included PubMed, Cochrane registry, ClinicalTrials.gov, and evidence by NHS UK and Trip databases from inception through May 2020. To analyze HS prevalence, only cross-sectional studies or baseline assessments of longitudinal cohorts using census-based surveys or probabilistic and nonprobabilistic epidemiologic methods were considered. The search terms were (prevalence OR incidence OR epidemiology) AND (hidradenitis suppurativa OR acne inversa OR Verneuil's disease). No language restriction was applied.

Study Selection: Original investigations that reported HS prevalence were included. After exclusion criteria were applied, 17 studies qualified for qualitative analysis, but only 16 studies were quantitatively assessed.

Data Extraction And Measures: Two reviewers extracted data by age, diagnostic criteria, presence of any comorbidity, sample sizes, continent/location, sex, and other characteristics. Assessment of bias risk used the Joanna Briggs Institute Critical Appraisal Instrument for Studies Reporting Prevalence Data using random-effects models to synthesize available evidence.

Main Outcomes And Measures: Hidradenitis suppurativa prevalence (with 95% CI) among the overall population and among subgroups. Between-study heterogeneity was assessed (Cochran Q statistic) and quantified (I2 statistic).

Results: In 16 quantitatively assessed studies included, prevalence estimates were reported only from Western European and Scandinavian countries, the US, and Australia. Meta-analysis with random effects, after adjusting for publication bias in the prevalence estimates, revealed a 0.40% prevalence (95% CI, 0.26%-0.63%) for HS. Studies based on clinical samples revealed a higher pooled prevalence of HS (1.7%) than population-based studies (0.3%).

Conclusions And Relevance: The findings of this systematic review and meta-regression analysis may help facilitate policy formulation, channeling funding and guiding principles for better disease diagnosis using universal valid tools and management.
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http://dx.doi.org/10.1001/jamadermatol.2021.1677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156162PMC
August 2021

Cutaneous Squamous Cell Carcinoma in Patients with Hidradenitis Suppurativa.

Cancers (Basel) 2021 Mar 8;13(5). Epub 2021 Mar 8.

Division of Dermatology, McGill University Health Centre, Montreal, QC H3G 1A4, Canada.

: Cutaneous squamous cell carcinoma (cSCC) is a rare complication of hidradenitis suppurativa (HS). : To conduct a systematic review and an individual patient data (IPD) meta-analysis to describe the clinical characteristics of HS patients developing cSCC and determine predictors of poor outcome. : Medline/PubMed, Embase, and Web of Science were searched for studies reporting cSCC arising in patients with HS from inception to December 2019. A routine descriptive analysis, statistical hypothesis testing, and Kaplan-Meier survival curves/Cox proportional hazards regression models were performed. : A total of 34 case reports and series including 138 patients were included in the study. The majority of patients were males (81.6%), White (83.3%), and smokers (n = 22/27 reported) with a mean age of 53.5 years. Most patients had gluteal (87.8%), Hurley stage 3 HS (88.6%). The mean time from the diagnosis of HS to the development of cSCC was 24.7 years. Human papillomavirus was identified in 12/38 patients tested. Almost 50% of individuals had nodal metastasis and 31.3% had distant metastases. Half of the patients succumbed to their disease. : cSCC is a rare but life-threatening complication seen in HS patients, mainly occurring in White males who are smokers with severe, long-standing gluteal HS. Regular clinical examination and biopsy of any suspicious lesions in high-risk patients should be considered. The use of HPV vaccination as a preventive and possibly curative method needs to be explored.
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http://dx.doi.org/10.3390/cancers13051153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962537PMC
March 2021

Clinical and psychosocial factors affecting work productivity among patients with hidradenitis suppurativa: A cluster analytical investigation.

J Am Acad Dermatol 2022 03 1;86(3):675-677. Epub 2021 Mar 1.

Division of Dermatology, McGill University Health Centre, Montreal General Hospital, Montreal, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2021.02.066DOI Listing
March 2022

The Efficacy and Effectiveness of Non-ablative Light-Based Devices in Hidradenitis Suppurativa: A Systematic Review and Meta-Analysis.

Front Med (Lausanne) 2020 3;7:591580. Epub 2020 Nov 3.

Division of Dermatology, McGill University Health Centre, Montreal, QC, Canada.

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder that may be treated with non-ablative light-based devices; however, no systematic reviews on the topic exist to date. We conducted a systematic review and meta-analysis to determine efficacy of non-ablative light-based devices in treating HS. Specifically, a systematic review was conducted using MEDLINE, EMBASE, Web of Science and CINAHL. We analyzed the use of non-ablative light-based devices in the treatment of HS. At least two investigators performed title/abstract review and data extraction. Meta-analysis was conducted using comprehensive meta-analysis software. 5 RCTs and 11 case reports/series were included ( = 211 unique patients). No observational studies were found. For Nd:YAG laser, meta-analysis of 3 RCTs reported improvement in modified HS Lesion Area and Severity Index (HS-LASI) when compared to control subjects. In addition, three case reports/series reported HS-LASI, Physician Global Assessment (PGA) scores and number-of-lesion improvements in treated patients. For intense pulsed light (IPL), two RCTs reported HS-LASI and Dermatology Life Quality Index (DLQI) score improvements. For Alexandrite laser, one case report showed lesion improvement. In conclusion, meta-analysis of Nd:YAG laser in HS patients suggests significant improvement in HS-LASI scores. For IPL, evidence is limited, but suggests improvement in HS-LASI and DLQI scores. For Alexandrite laser, evidence precludes conclusions. Given small sample sizes and inconsistent reporting scales, larger RCTs are required to better determine the efficacy of these modalities in treating HS.
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http://dx.doi.org/10.3389/fmed.2020.591580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670045PMC
November 2020

Novel variants of and genes in familial hidradenitis suppurativa: A case report.

SAGE Open Med Case Rep 2020 25;8:2050313X20953113. Epub 2020 Sep 25.

Division of Dermatology, McGill University Health Centre, Montreal General Hospital, Montreal, QC, Canada.

We report a two-generation Canadian family of Armenian ancestry with hidradenitis suppurativa where novel mutations in and genes were identified. The father and both children shared a mild-to-moderate hidradenitis suppurativa phenotype together with the features of follicular occlusion (e.g. acne and scalp folliculitis). Based on our findings and previous literature, we recommend considering genetic testing with a periodic fever/autoinflammatory disorder panel in patients with a strong family history of hidradenitis suppurativa and lack of common triggers such as smoking and being overweight.
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http://dx.doi.org/10.1177/2050313X20953113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522817PMC
September 2020

Sonography of Encapsulated Fat Necrosis with Histologic Correlation.

Med Ultrason 2020 Sep;22(3):397-380

Dermatology Department, Hospital Universitario Puerta de Hierro Majadahonda, C/ manuel de Falla 2 29022 Majadahonda, Madrid, Spain.

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http://dx.doi.org/10.11152/mu-2650DOI Listing
September 2020

Apremilast in dermatology: A review of literature.

Dermatol Ther 2020 11 27;33(6):e14261. Epub 2020 Sep 27.

Division of Dermatology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada.

Apremilast is an orally administered small molecule that specifically inhibits the phosphodiesterase-4 enzyme and modulates the immune system by increasing the levels of intracellular cyclic adenosine monophosphate (cAMP) and inhibiting IL-2 & 8, interferon-γ and tumor necrosis factor (TNF) production. It is FDA approved for the treatment of psoriasis, psoriatic arthritis, and oral ulcers of Behcet's disease. More recently, apremilast has been used off-label to treat varied dermatological diseases where systemic corticosteroids or immunosuppressive agents were not effective. We review the efficacy and safety of apremilast in the treatment of aphthous stomatitis, Behçet's disease, chronic actinic dermatitis, atopic dermatitis, cutaneous sarcoidosis, hidradenitis suppurativa, lichen planus, and discoid lupus erythematosus in cases where standard treatment has failed.
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http://dx.doi.org/10.1111/dth.14261DOI Listing
November 2020

Association of clinical severity scores with psychosocial impact in patients with hidradenitis suppurativa.

J Am Acad Dermatol 2021 Jun 8;84(6):1712-1715. Epub 2020 Aug 8.

Division of Dermatology, Department of Medicine, McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.08.022DOI Listing
June 2021

Sonography of solitary fibrofolliculoma with histologic correlation.

J Ultrasound 2021 Sep 21;24(3):359-360. Epub 2020 Jul 21.

Dermatology Department, Hospital Universitario Puerta de Hierro Majadahonda, C/Manuel de Falla 2, Majadahonda, 29022, Madrid, Spain.

We present a case of 15-year old male with solitary fibrofolliculoma on the ear and we demonstrate the use of ultrasound in outlining the features of this rare benign skin tumor with histological correlation. Fibrofolliculoma can be associated with a rare syndrome known as Birt-Hogg-Dubé which affects the skin, lungs and kidneys.
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http://dx.doi.org/10.1007/s40477-020-00510-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363690PMC
September 2021

A pediatric case of Stevens-Johnson syndrome/toxic epidermal necrolysis with rapid response to intravenous cyclosporine.

JAAD Case Rep 2020 Jun 7;6(6):555-557. Epub 2020 May 7.

Division of Dermatology, McGill University Health Center-Glen site, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.jdcr.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265061PMC
June 2020

Preliminary Data Suggests That Biologics in Dermatology Are Not Associated With Adverse COVID-19 Outcomes.

J Cutan Med Surg 2020 Jul/Aug;24(4):420-421. Epub 2020 May 25.

54473507266 Division of Dermatology, McGill University Health Centre, Montreal General Hospital, QC, Canada.

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http://dx.doi.org/10.1177/1203475420929250DOI Listing
August 2020

Newer and Safer Kappa-Opioid Agonist for Your Patients With Uremic Pruritus.

J Cutan Med Surg 2020 Sep/Oct;24(5):525-526. Epub 2020 May 19.

54473 Division of Dermatology, McGill University Health Centre, Montreal General Hospital, Quebec, Canada.

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http://dx.doi.org/10.1177/1203475420926989DOI Listing
August 2021

Cutaneous Manifestations of Coronavirus Disease 2019 (COVID-19) Infection-What Do We Know So Far?

J Cutan Med Surg 2020 Jul/Aug;24(4):416-417. Epub 2020 May 11.

507266 Division of Dermatology, McGill University Health Center, Montreal, QC, Canada.

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http://dx.doi.org/10.1177/1203475420928375DOI Listing
August 2020

Spesolimab: A Novel Treatment for Pustular Psoriasis.

J Cutan Med Surg 2020 Mar/Apr;24(2):199-200

54473 507266 Division of Dermatology, McGill University Health Centre, Montreal General Hospital, QC, Canada.

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http://dx.doi.org/10.1177/1203475419888862DOI Listing
February 2021

Treatment Modalities for Varicose Veins of Lower Extremities.

J Cutan Med Surg 2020 Mar/Apr;24(2):203-204

54473 507266 Division of Dermatology, McGill University Health Centre, Montreal, QC, Canada.

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http://dx.doi.org/10.1177/1203475419891082DOI Listing
February 2021

Pityriasis Rosea: Risk and Treatment During Pregnancy.

J Cutan Med Surg 2020 Mar/Apr;24(2):207-208

5620 Division of Dermatology, Jewish General Hospital, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1177/1203475420902049DOI Listing
February 2021

Herpes Zoster Ophthalmicus with Unilateral Sixth Nerve Palsy.

Can J Neurol Sci 2020 03;47(2):273-274

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1017/cjn.2019.340DOI Listing
March 2020

Ultrasound use to diagnose septal panniculitis.

Med Ultrason 2019 Nov;21(4):499-500

Hospital de manises.

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http://dx.doi.org/10.11152/mu-2203DOI Listing
November 2019

Congenital sideroblastic anemia associated with B cell immunodeficiency, periodic fevers, and developmental delay: A case report and review of mucocutaneous features.

SAGE Open Med Case Rep 2019 16;7:2050313X19876710. Epub 2019 Sep 16.

Division of Dermatology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada.

This is a 40-year-old woman with sideroblastic anemia with B cell immunodeficiency, periodic fevers, and developmental delay syndrome, who has genital and extragenital lichen sclerosus on the abdomen and the upper back that have become erythematous and painful during febrile episodes. This report summarizes the published cases of sideroblastic anemia with B cell immunodeficiency, periodic fevers, and developmental delay and highlights associated mucocutaneous features.
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http://dx.doi.org/10.1177/2050313X19876710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747858PMC
September 2019

Hailey-Hailey disease treated successfully with naltrexone and magnesium.

JAAD Case Rep 2019 Sep 29;5(9):760-762. Epub 2019 Aug 29.

Division of Dermatology, McGill University Health Centre, Montreal General Hospital, Montreal, Canada.

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http://dx.doi.org/10.1016/j.jdcr.2019.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728728PMC
September 2019

Paraneoplastic pyoderma gangrenosum in solid organ malignancy: a literature review.

Int J Dermatol 2020 Feb 12;59(2):154-158. Epub 2019 Sep 12.

Division of Dermatology, McGill University Health Centre, Montreal, QC, Canada.

Pyoderma gangrenosum (PG) is a rare destructive, ulcerative, and inflammatory cutaneous disease. PG can be associated with inflammatory bowel disease (IBD), arthritis, autoinflammatory syndromes, and hematological malignancies. Multiple reports in the literature have found an association between PG and solid organ tumors. This article provides a summary and review of PG in patients with solid organ malignancies. We performed a PubMed search using the terms pyoderma gangrenosum, paraneoplastic pyoderma gangrenosum, cancer, malignancy, tumor, and solid organ malignancy. Out of 529 papers screened, 19 relevant cases were included that reported patients above the age of 12 years old with antecedent, coincident, or subsequent occurrence of PG in association with a solid organ malignancy. The most common malignancies associated with PG were found in the breast (n = 6, 31.6%). In a majority of the cases, the site of PG was found to be the lower extremities (n = 12, 63.2%). Almost all cases were presented with ulcerative PG subtype (n = 18, 94.7%). Moreover, 78.9% of cases (n = 15) were reported to have PG prior to tumor diagnosis. PG lesions resolved in 100% of patients after either tumor or PG-specific treatment. We identified a strong temporal relationship between ulcerative PG and its associated solid organ malignancy. Other associations with breast cancer and lower extremity location exist but are not as strong.
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http://dx.doi.org/10.1111/ijd.14637DOI Listing
February 2020

Association of hidradenitis suppurativa and keloid formation: A therapeutic challenge.

JAAD Case Rep 2019 Aug 2;5(8):675-678. Epub 2019 Aug 2.

Division of Dermatology, University of Toronto, Women's College Hospital, Toronto, Canada.

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http://dx.doi.org/10.1016/j.jdcr.2019.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698290PMC
August 2019

Naltrexone for the Treatment of Darier and Hailey-Hailey Diseases.

J Cutan Med Surg 2019 Jul/Aug;23(4):453-454

1 Division of Dermatology, McGill University Health Centre, Montreal General Hospital, QC, Canada.

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http://dx.doi.org/10.1177/1203475419843122DOI Listing
May 2020

Hidradenitis Suppurativa: Comprehensive Review of Predisposing Genetic Mutations and Changes.

J Cutan Med Surg 2019 Sep/Oct;23(5):519-527. Epub 2019 Jun 6.

1 Division of Dermatology, McGill University Health Centre, Montreal, QC, Canada.

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder. A genetic component in the pathogenesis is highly likely considering that ~30% to 40% of patients with HS report a family history of the disease. The genetic mutations related to HS that have been reported to date suggest HS can be inherited as a monogenic trait because of a defect in either the signaling pathway or inflammasome function, or as a polygenic disorder resulting from defects in genes regulating epidermal proliferation, ceramide production, or in immune system function. This review provides a summary of genetic mutations reported in patients diagnosed with HS and discusses the mechanisms by which these genes are involved in its pathogenesis.
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http://dx.doi.org/10.1177/1203475419852049DOI Listing
February 2020

Incidence trends of conjunctival malignant melanoma in Canada.

Br J Ophthalmol 2020 01 11;104(1):23-25. Epub 2019 May 11.

Division of Dermatology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada

Background: Melanoma is the most common primary malignancy of the eye in adults. While the epidemiology of uveal melanoma has recently been described in Canada, little is known about the epidemiology and geographic distribution of patients with conjunctival melanoma (CM) in Canada.

Methods: We conducted a population-based study of CM incidence across all Canadian provinces and territories during 1992-2010 using two independent population-based registries.

Results: 190 patients were diagnosed with CM in Canada from 1992 to 2010. 55.3 % of these patients were men. The mean annual incidence rate of CM in Canada was 0.32 cases per million individuals (0.35 and 0.29 cases per million individuals for men and women, respectively). The incidence rates for Canadian provinces demonstrated that the eastern provinces of Nova Scotia and New Brunswick had higher age-adjusted incidence rates than the national average, with rates of 0.52 and 0.47 cases per million individuals per year, respectively.

Conclusions: This analysis demonstrates novel variations in CM incidence rates between different Canadian provinces. These results taken together with the data reported from the USA confirm the North-to-South geographic gradient of increasing CM incidence. This research highlights that the epidemiology of CM in North America is comparable to that of cutaneous malignant melanoma in contrast to the trends for uveal melanoma distribution.
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http://dx.doi.org/10.1136/bjophthalmol-2019-313977DOI Listing
January 2020

Idiopathic Atrophoderma of Pasini and Pierini: Case report and literature review.

Clin Case Rep 2019 Feb 18;7(2):258-263. Epub 2018 Dec 18.

Division of Dermatology McGill University Health Centre Montreal Québec Canada.

Idiopathic Atrophoderma of Pasini and Pierini should be considered on the differential in a patient presenting with an asymptomatic atrophic plaque on the skin. Differentiation from Linear Atrophoderma of Moulin and morphea remains a challenge; however, features of the presentation and tissue biopsy can help establish the diagnosis.
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http://dx.doi.org/10.1002/ccr3.1958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389486PMC
February 2019

Spontaneous Keloids: A Literature Review.

Dermatology 2018 16;234(3-4):127-130. Epub 2018 Aug 16.

Background: Keloids are benign fibroproliferative tumors that extend beyond the original wound. Spontaneous keloids are those that result without a significant history of trauma. There are multiple reported cases in the literature.

Objective: This article provides a summary and review of the cases that have been reported with spontaneous keloids and organizes them according to their associated medical conditions.

Methods: A literature review was conducted using PubMed and MEDLINE that included all English published cases and case series from May 1955 to February 2018.

Results: Spontaneous keloids have been reported mainly in association with syndromes such as Rubinstein-Taybi syndrome, Dubowitz syndrome, Noonan syndrome, Goeminne syndrome, Bethlem myopathy, conjunctivocorneal dystrophy, X-linked recessive polyfibromatosis and a novel X-linked syndrome with flamin A mutation. Furthermore, spontaneous keloids were reported in atopic patients and a couple of patients who are medically healthy.

Conclusion: Spontaneous keloids are diagnosed clinically based on the patient's history, and it is challenging to confirm since they might be triggered by minimal injury or inflammation especially if it is a single lesion. Reported syndromes indicate a genetic possibility in the pathogenesis of spontaneous keloids.
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http://dx.doi.org/10.1159/000491924DOI Listing
December 2018
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