Publications by authors named "Abdul S Khan"

14 Publications

  • Page 1 of 1

Screening for depression, anxiety, and obsessive-compulsive disorders among secondary school students in Al-Hasa Region, Saudi Arabia.

J Family Community Med 2021 Jan-Apr;28(1):28-34. Epub 2021 Jan 7.

Department of Emergency Services, Al-Jafer Hospital, Al-Ahsa, Saudi Arabia.

Background: The purpose of this study was to determine the prevalence of anxiety, depression, and obsessive-compulsive disorder (OCD) and assess their severity in both male and female secondary school students.

Materials And Methods: This cross-sectional study was conducted among secondary school students in Al Hasa region. A sample of student was selected using multi-stage sampling technique. Data were collected using valid self administered questionnaires (Patient Health Questionnaire 9, Anxiety Disorder 7, and Yale-Brown Obsessive-Compulsive scale). Study was approved by institutional ethical review committee, and informed consent was obtained from each participant. SPSS used for data entry and analysis. Chi-square test was used to test for statistical significance.

Results: A total of 1783 of students, 930 males and 853 females, were enrolled in the study. The prevalence of depression, anxiety, and OCD was 76.2%, 49.9%, and 61.6%, respectively. Most of the diagnosed students had mild forms of the diseases, fewer had moderate form, and very few had severe forms. The most significant risk factor was gender, but other risk factors were significant for some of the diseases.

Conclusion: The prevalence of the three diseases is high and significantly associated with gender. Further work is needed to evaluate this high prevalence and assess the severity of the diseases and other risk factors.
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http://dx.doi.org/10.4103/jfcm.JFCM_386_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927964PMC
January 2021

Production of hyperimmune anti-SARS-CoV-2 intravenous immunoglobulin from pooled COVID-19 convalescent plasma.

Immunotherapy 2021 04 9;13(5):397-407. Epub 2021 Feb 9.

Dow University of Health Sciences, Karachi, Pakistan.

This study assesses the feasibility of producing hyperimmune anti-COVID-19 intravenously administrable immunoglobulin (C-IVIG) from pooled convalescent plasma (PCP) to provide a safe and effective passive immunization treatment option for COVID-19. PCP was fractionated by modified caprylic acid precipitation followed by ultrafiltration/diafiltration to produce hyperimmune C-IVIG. In C-IVIG, the mean SARS-CoV-2 antibody level was found to be threefold (104 ± 30 cut-off index) that of the PCP (36 ± 8.5 cut-off index) and mean protein concentration was found to be 46 ± 3.7 g/l, comprised of 89.5% immunoglobulins.  The current method of producing C-IVIG is feasible as it uses locally available PCP and simpler technology and yields a high titer of SARS-CoV-2 antibody. The safety and efficacy of C-IVIG will be evaluated in a registered clinical trial (NCT04521309).
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http://dx.doi.org/10.2217/imt-2020-0263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871744PMC
April 2021

Psychological insulin resistance among type 2 diabetic patients attending primary healthcare centers, Al-Ahsa, Saudi Arabia.

J Family Community Med 2020 Sep-Dec;27(3):192-199. Epub 2020 Sep 25.

Department of Family and Community Medicine, College of Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.

Background: Patients' adherence to insulin therapy is crucial to achieve good glycemic control. The present study was conducted to determine psychological insulin resistance (PIR) and the effect of doctor-patient relationship on PIR among type 2 diabetes patients attending primary health-care centers of Al-Ahsa region in Saudi Arabia.

Materials And Methods: This was a cross-sectional survey of all type 2 diabetic patients attending the primary healthcare centers of Al-Ahsa. A multistage sampling technique was used. The calculated sample size was 396. Two validated structured questionnaires were used to collect information. The degree of agreement to insulin therapy was done on the Likert 5° scale. SPSS was used for data entry and analysis. Chi-square test was used to test for stistical significane at P=0.05.

Results: Out of 396 patients who were given the questionnaires, 366 filled the questionnaires yielding 92% response rate. Fifty-one percent were male and about 85% were older than 35 years. Willingness to use insulin was significantly associated with age ( = 0.013) and duration of diabetes (P=0.0001). The strongest negative attitudes toward insulin therapy arose from participants having heard about a bad experience with insulin (59.34%, < 0.05) and the fear of possible dependence (54.20%, < 0.05). Participants who responded of "mostly appropriate" and "very appropriate" to questions on patient-doctor relationship were significantly more willing to take insulin (64.9% vs 24.5%, and 70.3% vs 22.9%, = 0.0001).

Conclusion: The study showed that one-third of the patients with type 2 diabetes had PIR. Since the behavior of doctor plays an important role in reducing PIR, there is a need for greater emphasis on the importance of good doctor-patient relationship and the establishment of a therapeutic education program.
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http://dx.doi.org/10.4103/jfcm.JFCM_226_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745782PMC
September 2020

'Spoon-Fed' Versus Self-Directed Learning in an Arab Context.

Authors:
Abdul S Khan

Sultan Qaboos Univ Med J 2018 05 9;18(2):e247-e248. Epub 2018 Sep 9.

Department of Family & Community Medicine, King Faisal University, Hafuf, Saudi Arabia.

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http://dx.doi.org/10.18295/squmj.2018.18.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132514PMC
May 2018

Microwave-assisted synthesis and evaluation of type 1 collagen-apatite composites for dental tissue regeneration.

J Biomater Appl 2018 07 2;33(1):103-115. Epub 2018 May 2.

4 Imam Abdulrahman Bin Faisal University College of Dentistry, Dammam, Saudi Arabia.

The aim was to develop an economical and biocompatible collagen-based bioactive composite for tooth regeneration. Acid-soluble collagen was extracted and purified from fish scales. The design was innovated to molecularly tailor the surface charge sites of the nano-apatite providing chemical bonds with the collagen matrix via microwave irradiation technique. The obtained collagen was identified by sodium dodecyl sulfate polyacrylamide gel electrophoresis analysis. The composites were characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis/differential scanning calorimetry, and scanning electron microscopy. MC3T3-E1 cell lines were used to assess the biological effects of these materials by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetra zolium bromide (MTT) assay. Indirect contact test was performed by extracting representative elutes in cell culture media and sulforhodamine B analysis was performed. Chorioallantoic membrane assay was conducted to define the new vessels formation behavior. The purity of collagen extracts was determined and showed two α-chains, i.e. the characteristic of type I collagen. Fourier transform infrared spectroscopy showed the characteristic peaks for amide I, I, III, and phosphate for collagen and composites. Scanning electron microscopy images showed three-dimensional mesh of collagen/apatite nano-fibers. Nontoxic behavior of composites was observed and there were graded and dose-related effects on experimental compounds. The angiogenesis and vessels formation behavior were observed in bioactive collagen composite. The obtained composites have potential to be used for tooth structure regeneration.
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http://dx.doi.org/10.1177/0885328218773220DOI Listing
July 2018

Microwave assisted synthesis and characterization of magnesium substituted calcium phosphate bioceramics.

Mater Sci Eng C Mater Biol Appl 2015 Nov 9;56:286-93. Epub 2015 May 9.

Interdisciplinary Research Centre in Biomedical Materials, COMSATS Institute of Information Technology, M. A. Jinnah Campus, Defence Road, Off Raiwind Road, Lahore, Pakistan. Electronic address:

Hydroxyapatite is used extensively in hard tissue repair due to its biocompatibility and similarity to biological apatite, the mineral component of bone. It differs subtly in composition from biological apatite which contains other ions such as magnesium, zinc, carbonate and silicon (believed to play biological roles). Traditional methods of hydroxyapatite synthesis are time consuming and require strict reaction parameter control. This paper outlines synthesis of magnesium substituted hydroxyapatite using simple microwave irradiation of precipitated suspensions. Microwave irradiation resulted in a drastic decrease in ageing times of amorphous apatitic phases. Time taken to synthesize hydroxyapatite (which remained stable upon heat treatment at 900°C for 1h) reduced twelve folds (to 2h) as compared to traditionally required times. The effects of increasing magnesium concentration in the precursors on particle size, surface area, phase-purity, agglomeration and thermal stability, were observed using scanning electron microscopy, BET surface area analysis, X-ray diffraction and photo acoustic Fourier transform infra-red spectroscopy. Porous agglomerates were obtained after a brief heat-treatment (1h) at 900°C.
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http://dx.doi.org/10.1016/j.msec.2015.05.025DOI Listing
November 2015

Structural and in vitro adhesion analysis of a novel covalently coupled bioactive composite.

J Biomed Mater Res B Appl Biomater 2012 Jan 21;100(1):239-48. Epub 2011 Nov 21.

Interdisciplinary Research Centre in Biomedical Materials, COMSATS Institute of Information Technology, Lahore, Pakistan.

The interfacial adhesion between a restorative composite and tooth is one of the major factors that determine the ultimate performance of composite restoration. A novel polyurethane (PU) composite material was prepared by chemically binding the nano-hydroxyapatite (nHA) to the diisocyanate component in the PU backbone by utilizing solvent polymerization. The procedure involved stepwise addition of monomeric units of the PU and optimizing the reagent concentrations. The resultant materials were characterized structurally (Raman Spectroscopy) and in vitro bioactive analysis was conducted in modified-simulated body fluid for periodical time intervals. The in vitro study evaluated the push-out bond strength of existing obturating material and novel covalently linked PU/nHA composites to dentin after long-term storage in deionized water and artificial saliva. Human extracted molar roots were filled with experimental samples and analyzed at predetermined time intervals. The shear bond strength of samples was measured and surface morphologies were evaluated. Covalent bond formation was achieved between PU and nHA without intermediate coupling agent. With the increase in concentration of nHA, the composite showed more bioactivity and adhesion toward tooth structure. Bond strength of this new composite were in accordance with obutrating material, therefore, the material can be used as an obturating material because of its direct adhesion with tooth structure.
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http://dx.doi.org/10.1002/jbm.b.31945DOI Listing
January 2012

Sedation, analgesia, and monitoring.

Clin Colon Rectal Surg 2010 Feb;23(1):14-20

Department of Gastroenterology, Ochsner Clinic Foundation, New Orleans, Louisiana.

Endoscopic procedures are common and sedation is frequently used to minimize anxiety and discomfort, reduce the potential for physical injury during the procedure, and improve overall patient tolerability and satisfaction. In this article, the authors review the variety of options for sedation and analgesia available to the gastroenterologist or surgical endoscopist.
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http://dx.doi.org/10.1055/s-0030-1247852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850162PMC
February 2010

Predictors of outcome for non-traumatic intracerebral hemorrhage.

Neurosciences (Riyadh) 2008 Jul;13(3):263-7

Department of Neurosurgery, Arar Central Hospital, Northern Borders, Riyadh, Kingdom of Saudi Arabia.

Objective: To evaluate the prognosis, neurologic outcome, and predictors of survival in patients with non-traumatic intracerebral hemorrhage.

Methods: We evaluated prospectively a cohort of 96 Saudi adult males and females with stroke during the month of July 2005 at Arar Central Hospital, Riyadh, Kingdom of Saudi Arabia. Out of 103 patients, 96 patients, who were diagnosed as having intracerebral hemorrhage (ICH) presenting to the emergency department for initial evaluation, were included, except those with recurrent intracerebral hemorrhage, arteriovenous malformation, subarachnoid hemorrhage, traumatic brain injury, hemorrhagic infarctions, and patients receiving anticoagulant therapy. No patient underwent any neurosurgical procedure.

Results: The results of 96 patients were analyzed. The mean age at ICH was 67.2 (+/-14.7) years (range, 30-100 years), and mean Glasgow coma scale (GCS) score on admission was 8.42 (+/-1.73) and (range, 4-13). Mean ICH volume on initial CT scan was 10.61 (+/-14.01) ml3 (range, 1-63). Mean pulse pressure on hospital arrival was 81.9 (+/-22.8) mm Hg (range, 70-120 mm Hg). In uni-variate analysis, GCS score (p=0.0005), ICH volume (p=0.001), mass effect (p=0.001), and presence of intraventricular hemorrhage (p=0.0005) were all associated with 30-days mortality, while in multivariable analysis, the most significant independent predictors of 30-day mortality were, GCS score and the intraventricular extension of hemorrhage.

Conclusion: This model may aid in making decisions quickly and easily regarding the appropriate level of care for such patients with intracerebral hemorrhage.
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July 2008

Comparison of the visco-elastic behavior of a pre-impregnated reinforced glass fiber composite with resin-based composite.

Dent Mater 2008 Nov 28;24(11):1534-8. Epub 2008 Apr 28.

Department of Materials, Queen Mary University of London, London, United Kingdom.

Objectives: The visco-elastic behavior of a pre-impregnated reinforced glass fiber composite (everStick) was compared with a resin-based particulate composite (Filtek P60) by using dynamic mechanical analysis (DMA) to determine their storage modulus (E') and damping ratio (tandelta).

Methods: These materials were subjected to three-point bend tests using a PerkinElmer DMA7. In temperature mode, the temperature was increased from 26 to 140 degrees C at 1 Hz. In frequency mode, the range was 1-10 Hz at a constant temperature of 37 degrees C.

Results: In both temperature and frequency modes, E' for everStick was significantly higher and tandelta was significantly lower than those for Filtek P60, indicating that the stiffness of the pre-impregnated glass fiber composite was higher and its damping property was lower than those for resin-based particulate composite.

Significance: The glass fiber restorative composite appears to absorb less energy in repeated stress and is less likely to retain external energy as residual stress.
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http://dx.doi.org/10.1016/j.dental.2008.03.017DOI Listing
November 2008

Is there any effect of age, gender and body mass index on the electrocardiographic T-wave amplitude in Northern Saudi Arabia?

Saudi Med J 2006 Mar;27(3):418-21

Department of Cardiology, Arar Central Hospital, Arar North Zone, Kingdom of Saudi Arabia.

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March 2006

Intensive behavioral therapy for primary enuresis.

Saudi Med J 2004 Jul;25(7):934-40

Department of Pediatrics, King Fahad Medical City Pediatric Hospital, PO Box 103249, Riyadh 11695, Kingdom of Saudi Arabia.

Objective: To assess the effect of intensive behavioral therapy on Saudi children with primary enuresis.

Methods: Twenty-six children, aged 6-14-years, presented with complains of bed wetting during a 12-months period from January 2001 through to January 2002, ArAr Central Hospital, Kingdom of Saudi Arabia were studied in an interventional, non-randomized trial without control. After complete verbal autopsy, physical examination and laboratory investigation, they were offered intensive behavioral therapy. They were evaluated for response, regularity, esteem and recurrence of enuresis.

Results: Mean age of the study group was 9.6-years (SD = +/- 2.6) and boys were affected almost twice of girls (P<0.05). Family history, social history and school performance did not show any significant (P>0.05) association with enuresis. Sixty point five percent were regular and out of those 27.9% never missed any visits. 91.7% were completely dry out of regular patients. There was 75% success rate in those, who visited 4-8 times while 25% in those, who visited 1-3 times. Ninety-six percent of the parents and 80.7% of the children were fully satisfied with this therapy. Socio-economic status seems to play a significant (P<0.05) role in regularity of follow up and response to behavioral therapy.

Conclusion: This result shows an excellent response to intensive behavioral therapy in primary enuresis if the follow up is regular.
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July 2004

Impact of prognostic factors on outcome in patients with severe head trauma.

Neurosciences (Riyadh) 2003 Oct;8(4):248-9

Department of Neurosurgery, Arar Central Hospital, Ministry of Health, Arar North Zone, Kingdom of Saudi Arabia. Tel. +966 (4) 6624004. Fax. +966 (4) 6626416.

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October 2003