Abdul Basit, Ph.D. - University of Washington - Senior Fellow/Technical Director for Quantitative Metabolomics and Proteomics

Abdul Basit

Ph.D.

University of Washington

Senior Fellow/Technical Director for Quantitative Metabolomics and Proteomics

Seattle, WA | United States

ORCID logohttps://orcid.org/0000-0002-1164-5520

Abdul Basit, Ph.D. - University of Washington - Senior Fellow/Technical Director for Quantitative Metabolomics and Proteomics

Abdul Basit

Ph.D.

Introduction

Bioanalytical scientist with hands on experience in DMPK research and managing complex interdisciplinary team projects focused on LC-MS/MS based quantitative proteomics, metabolomic/lipidomics and its application for biomarker discovery for disease progress and pathology.

Research Interest:
Discovery of endogenous probe for drug metabolizing enzymes to predict the interindividual variability and drug-drug interaction.

Quantitative proteomic analysis of drug metabolizing enzyme (DMEs) and drug transporters to explore interindividual variability in DMEs and transporters expression in various tissue across preclinical species and human.

Primary Affiliation: University of Washington - Seattle, WA , United States

Research Interests:

Education

Jan 2013 - Dec 2015
Istituto Italiano di Tecnologia
PhD (Bioanalytical Chemistry)
Drug Discovery and Development
Jul 2006 - Jun 2008
National Institute of Pharmaceutical Education and Research
M. Tech (Pharm)
Pharmaceutical Tecchnology

Experience

Feb 2017 - Jul 2019
University of Washington
Senior Fellow
Pharmaceutics
Jan 2016 - Dec 2016
Istituto Italiano di Tecnologia
Research Fellow (Postdoctral)
Drug Discovery and Development
Jun 2012 - Dec 2012
Vanta Bioscience
Sr. Research Associate
Pharmacology
Aug 2008 - Jun 2012
Sai Advantium Pharma Ltd
Research Associate
Drug Metabolism and Pharmacokinetics

Publications

14Publications

350Reads

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Major glucuronide metabolites of testosterone are primarily transported by MRP2 and MRP3 in human liver, intestine and kidney.

J Steroid Biochem Mol Biol 2019 Jul 5;191:105350. Epub 2019 Apr 5.

Department of Pharmaceutics, University of Washington, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2019.03.027DOI Listing
July 2019
2 Reads
3.628 Impact Factor

Inhibition of Serine Palmitoyltransferase by a Small Organic Molecule Promotes Neuronal Survival after Astrocyte Amyloid Beta 1-42 Injury.

ACS Chem Neurosci 2019 Mar 11;10(3):1627-1635. Epub 2018 Dec 11.

Computational and Chemical Biology , Istituto Italiano di Tecnologia , Via Morego 30 , 16163 Genova , Italy.

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http://pubs.acs.org/doi/10.1021/acschemneuro.8b00556
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http://dx.doi.org/10.1021/acschemneuro.8b00556DOI Listing
March 2019
3 Reads
4.362 Impact Factor

Elevated plasma ceramide levels in post-menopausal women: a cross-sectional study.

Aging (Albany NY) 2019 Jan;11(1):73-88

Departments of Anatomy and Neurobiology, Biochemistry and Pharmacology, University of California Irvine, Irvine, CA 92697, USA.

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http://dx.doi.org/10.18632/aging.101719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339790PMC
January 2019
4 Reads
6.432 Impact Factor

Effect of Dose and 5α-Reductase Inhibition on the Circulating Testosterone Metabolite Profile of Men Administered Oral Testosterone.

Clin Transl Sci 2018 09 19;11(5):513-522. Epub 2018 Jun 19.

Department of Pharmaceutics, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1111/cts.12569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132360PMC
September 2018
157 Reads
2.110 Impact Factor

Author Correction: Patch clamp-assisted single neuron lipidomics.

Sci Rep 2018 Apr 25;8(1):6772. Epub 2018 Apr 25.

Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA, 92697, USA.

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http://dx.doi.org/10.1038/s41598-018-24605-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915401PMC
April 2018
2 Reads
5.078 Impact Factor

Age-dependent changes in nervonic acid-containing sphingolipids in mouse hippocampus.

Biochim Biophys Acta Mol Cell Biol Lipids 2017 Dec 30;1862(12):1502-1511. Epub 2017 Aug 30.

Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, United States; Department of Biological Chemistry, University of California, Irvine, CA 92697, United States; Department of Pharmacology, University of California, Irvine, CA 92697, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2017.08.008DOI Listing
December 2017
7 Reads
5.162 Impact Factor

Sphingomyelin as a myelin biomarker in CSF of acquired demyelinating neuropathies.

Sci Rep 2017 08 10;7(1):7831. Epub 2017 Aug 10.

Department of Neurosciences, Rehabilitation Ophthalmology, Genetics and Maternal-Infantile Sciences (DINOGMI) and CEBR, University of Genoa, Genoa, Italy.

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http://dx.doi.org/10.1038/s41598-017-08314-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552737PMC
August 2017
11 Reads
5.078 Impact Factor

Patch clamp-assisted single neuron lipidomics.

Sci Rep 2017 07 13;7(1):5318. Epub 2017 Jul 13.

Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA, 92697, USA.

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http://dx.doi.org/10.1038/s41598-017-05607-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509708PMC
July 2017
47 Reads
5.078 Impact Factor

Starch-based bio-elastomers functionalized with red beetroot natural antioxidant.

Food Chem 2017 Feb 20;216:324-33. Epub 2016 Aug 20.

Smart Materials, Istituto Italiano di Tecnologia, Via Morego, 30, Genova 16163, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.foodchem.2016.08.055DOI Listing
February 2017
25 Reads
3.391 Impact Factor

Top co-authors

Andrea Armirotti
Andrea Armirotti

University of Genoa

7
Daniele Piomelli
Daniele Piomelli

University of California

4
Bhagwat Prasad
Bhagwat Prasad

University of Washington

4
Anna F Digilio
Anna F Digilio

Institute of Biosciences and Bioresources (IBBR)

3
Giuseppe Pepe
Giuseppe Pepe

Azienda Ospedaliero-Universitaria Careggi

3
Salvatore Castaldo
Salvatore Castaldo

IRCCS Neuromed

3
Vittorio Maglione
Vittorio Maglione

Duke University Medical Center

3
Enrico Amico
Enrico Amico

IRCCS Neuromed

3
Piyush Joshi
Piyush Joshi

Command Hospital (SC)

2