Abdelmonem Hegazy

Dr. Abdelmonem Hegazy

MD

Zagazig University

Professor

Zagazig, Sharkia | Egypt

Specialties: Basic Medical Sciences (Anatomy and Embryology)

ORCID logohttps://orcid.org/0000-0002-5993-6618

Abdelmonem Hegazy

Dr. Abdelmonem Hegazy

MD
Metrics

67

Publications

857

Profile Views

13

Reads

1

PubMed Central Citations

Education
Apr 2018
Zagazig University
Diploma
Apr 1999
Zagazig University
MD
Jan 1999
Zagazig University Faculty of Medicine
M.D.
Apr 1994
Zagazig University
MSc
Jan 1994
Zagazig University Faculty of Medicine
MSc
Apr 1989
Zagazig University
Diploma
Jan 1989
Zagazig University Faculty of Medicine
Diploma
Jan 1986
Military Sciences
Faculty of Reserve Officers
Sep 1978 - Dec 1983
Faculty of Medicine, Zagazig University
MB, BCH
Dec 1983
Zagazig University
MB, BCh
Experience
Aug 2016
Anatomy and Embryology Department, Zagazig University, Egypt
Head of Deparment
Mar 2015
Anatomy and Embryology in Zagazig University, Egypt
Professor
Mar 2015
Anatomy and Embryology in Zagazig University, Egypt
Professor
Apr 2011
Anatomy and Embryology in Majmaah University, Saudia Arabia
Associate professor
Apr 2008
Anatomy and Embryology in King Saud University
Assistant professor
Apr 2006
Anatomy and Embryology, Faculty of Medicine, Zagazig University, Egypt
Associate professor
Apr 2000
Anatomy and Embryology in Misurata, Faculty of Medicine, Libya
Assistant professor
Apr 1999
Anatomy and Embryology
Lecturer
Apr 1994
Anatomy and Embryology
Assistant lecturer
Apr 1990
Anatomy Department, Faculty of Medicine, Zagazig University, Egypt
Demonstrator
Apr 1986
Physician in Armed Forces and Ministry of Health
Obstetrics and Gynecology health care
Apr 1985
General practitioner
Health care
Feb 1960
Zagazig University Faculty of Medicine
Professor Dr.

Publications

67Publications

13Reads

1PubMed Central Citations

Newborns’ Cranial Vault: Clinical Anatomy and Authors’ Perspective

INTERNATIONAL JOURNAL OF HUMAN ANATOMY

Cranial vault is the case surrounding the brain. Its structure differs in newborns than in adults in some aspects. Such differences should be clear for both health and family members. Moreover, the anatomy and embryology of fetal skull take a little attention in the previous literature and textbooks. Therefore, this short review aimed to clarify some aspects of anatomy and clinical importance of cranial vault features in newborns. The newborn vault is formed of multiple separate flat bones connected by fibrous tissues with wide soft gaps called fontanelles. Development of bones of skull vault is closely correlated with the expanding growth of the underlying brain. Such brain shouldn't be struggled by continuous tightening of the newborns' vault. Also, the newborn skull could be affected even by a fixed sleeping position.

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July 2018

Hysterosalpingography might disturb the functional anatomy of Fallopian tube

Academia Anatomica International

It is concluded that injection of dye or any contrast medium into the fallopian tube in a direction against that of the normal flow might disturb the function of the cilia as well as the internal environment of the tube. Future researches are recommended to find out a new method depending on aeration as a diagnostic and therapeutic method for simple Fallopian tube occlusion.

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May 2018
1 Read

STUDY OF TOXIC EFFECT OF METHIMAZOLE ON THE CORTICAL STRUCTURE OF ADULT MALE ALBINO RATS KIDNEYS AND THE AMELIORATED EFFECT OF THYROXIN

ZUMJ. 2018 May 24(3):2018-219

Zagazig University Medical Journal

Kidney and thyroid functions interact with each other. Drugs used in treatment of any of them could have side reactions on any other organ. The effects of antithyroid medications on extrathyroidal organs could be due to oxidative stress and to damage in the renal cells. Aim: This work is designed to demonstrate the role of T4 in protection against the increase in oxidative stress caused by methimazole, and to detect if antithyroid drug-induced hypothyroidism (methimazole) or removal of thyroid by surgery causes damage of kidney cells or not. Methods: Twenty-five healthy adult male albino rats were used in the study. The animals were randomly separated into groups. Each group contained five rats: Group I (control group): This group received no drugs or treatment. Group II included rats with false thyroidectomy. Group III included thyroidectomized albino rats. Group IV included methimazole-induced hypothyroidism albino rats through receiving 60 mg/kg/day of methimazole in drinking water. Group V were administered methimazole (60 mg/kg/day) and l-thyroxine (T4) subcutaneous injection (20 μg/kg/day).The animals were anasethized and their abdomens were opened and both kidneys were removed, and immediately processed for histological & immunohistochemical study. Also oxidative enzymes were estimated. Rresults: Light microscopic examination of H&E stained sections showed marked damage of the structure of renal cortex in methimazole induced hypothyroidism group. This damage was concomitant with a decrease in kidney antioxidant enzymes. This damage was less pronounced in group of rats administrated T4 in association with methimazole. The cortex of kidney in rats of thyroidectomized group did not show any alterations in its micro structure. Conclusion: Methimazole causes both of hypothyroidism and alteration of the kidney cortex. This alteration is not noticed in case of surgical thyroidectomy inducing hypothyroidism. L-Thyroxine (T4) could decrease the effect of methimazole on kidney cortex.

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May 2018
1 Read

Clinical Anatomy of Thorax for medical students and doctors

LAP "Lambert Academic Publishing"

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March 2018
5 Reads

Effect of Induced Hypoglycemia on Postnatal Development of the Adrenal Gland in Albino Rats

British Journal of Science

BACKGROUND: Hypoglycemia is a life threatening stressor that is usually encountered in the neonatal period due to congenital hyperinsulinism, inborn error of carbohydrate metabolism or intensive insulin therapy for juvenile onset diabetes mellitus. Recurrent hypoglycemia usually affects the function of the adrenal gland. This evoked a question in this study; does this disaster stressor also affect the postnatal development of this gland?. OBJECTIVES: This study was designated to elucidate the effect of experimentally-induced recurrent episodes of hypoglycemia on the postnatal development of the adrenal gland in the albino rat. MATERIAL AND METHODS: Offspring rats of two weeks age were randomly divided into three equal groups, of 24 each. Group 1 (Negative control group): the offspring were not given any medication. Group 2 (Positive control group) were injected with 0.3ml normal saline subcutaneously (SC) three times weekly. Group 3 (Hypoglycemic group) were exposed to hypoglycemic episodes via SC injection with 3 IU/kg of human regular insulin three times weekly. Each of the above-mentioned groups was further subdivided (according to the week of sacrification) into four equal subgroups. 3 weeks (Neonatal), 7 weeks (Pubertal), 11 weeks (Young adult) and 16 weeks (Adult) subgroups. Adrenal gland specimens were processed for light and electron microscopic studies and morphometric measurements including the thickness and cell count of each zone of the gland were performed. Also, body weight and serum cortisol level were measured. RESULTS: In both control groups, the adrenal gland of 3 weeks old rats revealed ill-demarcation between the cortex and medulla. With a stepwise age progress, at the 7th week there was an apparent differentiation of the cortex into three zones; zona glomerulosa (ZG), zona fasiculata (ZF) and zona reticularis (ZR). At the 11th week, differentiation of ZG into outer small and inner large cells was noticed. Ultrastructurally, at 3,7 and 11 weeks, the cortical cells exhibited the normal steroid synthesis criteria of euchromatic nuclei, many mitochondria, smooth endoplasmic reticulum (sER) and many lipid droplets. Also, the chromaffin cells of the medulla displayed their characteristic secretory granules with nerve fibers inbetween. Interestingly, at the 16th week; nearly similar histological features like those of the previous age subgroup were encountered together with further differentiation of ZF into outer large and inner small cells. On the other hand, hypoglycemia led to detrimental effects on the normal histological architecture of the adrenal gland, where at the 3 rd week, focal hyperplastic areas in the cortex and mild congestion in the medulla were noticed, while at the 7th week, the cortical zones exhibited more hyperplasia with foci of lipid depletion. Moreover, at 11th week, partial degenerative changes were displayed, especially in the ZG in the form of irregular small pyknotic nuclei and distorted mitochondria. At 16th week, the sings of degeneration became prominent in all zones together with marked congestion, cellular infiltration and decrease in the secretory granules of the medulla. Compared to the both control groups, the hypoglycemic rats exhibited a mild change in the thickness and the cell count of the cortical zones and the medulla. Also, hypoglycemia led to a relative decrease in the body weight and the serum cortisol level, particularly at 16th week subgroup. CONCLUSION: It could be concluded that hypoglycemia had age-dependent detrimental drawbacks on the postnatal development of the adrenal gland in a zone-specific manner.

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October 2017

Vaginal Tightening Surgery: A New Technique

Ann. Int. Med. Den. Res. 2017;3(S1):32-36.

Annals of International Medical and Dental Research

Background: There are many surgical and non-surgical procedures designed for tightening the lax or redundant vagina. However, these methods are still experimental with no satisfactory results. This study aimed to report a new simple technique through a traction of bulbocavernosus muscle (BCM) in a trial to satisfy both partners regarding the female cosmetic and sexual purposes. Methods: The procedure was conducted for ten women aged 25-35 years. After a good preoperative preparation, a small perneovaginal wall flap was done. Then, traction of BCM of both sides and their approximation using delicate stitches were performed without excision neither mucosa nor muscle neither skin. Results: The post-operative appearance of the perineum was good. Muscles' tone at the vaginal introitus had been improved. There was no detected fibrosis nor reported dyspareunia. The sexual pleasure for both partners was greatly increased by time starting after the first three months postoperatively for all cases. Conclusions: Simple plication of BCMs at the vaginal introitus could be suggested as a simple surgical method for tightening the redundant vagina. Future studies regarding large numbers of volunteers are recommended to accurately evaluate the results of such new technique.

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October 2017
2 Reads

Effect of Gestational Exposure to Monosodium Glutamate on the Structure of Fetal Rat Lung.

Anatomy Physiol Biochem Int 2017; J 3(2): APBIJ.MS.ID.555609 (2017)

Anatomy Physiol Biochem Int

https://juniperpublishers.com/apbij/pdf/APBIJ.MS.ID.555609.pdf

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September 2017
1 Read

EFFECT OF BISPHENOL A ON CORPUS EPIDIDYMIS AND CHROMOSOMAL PATTERN OF ADULT RATS

ZUMJ;23(3) May; 2017: 171-181

Zagazig University Medical Journal

http://www.zumed.zu.edu.eg/index.php/zumed/article/view/691/438

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September 2017
1 Read

Effect of Formaldehyde on Rat Testis Structure

Acad. Anat. Int. 2017;3(2):15-23

Acad. Anat. Int.

https://mail.zu.edu.eg/owa/#path=/mail

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September 2017
2 Reads

Anatomy is a misnomer to aims of its study

Academia Anatomica International

The word "anatomy" originates from the Greek words "ana" meaning "up" and "tome" meaning "cutting". The dissection or cutting is a misnomer to the meaning of the science. Anatomy means the science dealing with the structure of the human body not its cutting. Dissection is not an aim but a mean of anatomy study. In the past, studies of anatomy have mainly depended on dissection, but nowadays, with imaging technology, it is easily to see the structure of the body without such dissection. Other means of study of anatomy include synthetic models simulating the structure of the human body. Imaging such as X-rays, CAT scans and MRIs is another mean of anatomical study. Human body photographs and moves films are another method for anatomy learning. Moreover, attendance of surgical operations even through a screen could approximate the study to the mind of medical students. When the surgeon operates in the theatre in an anatomical manner, this means in the correct position.

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July 2017
14 Reads

A Rare Case of Splenic Benign Mucinous Cystadenoma

Academia Anatomica International

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December 2016
6 Reads

Anatomy and embryology of umbilicus in newborns: a review and clinical correlations.

Front Med 2016 Sep 7;10(3):271-7. Epub 2016 Sep 7.

Department of Anatomy and Embryology, Faculty of Medicine, Zagazig University, Zagazig, 44519, Egypt.

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September 2016
4 Reads

EVALUATION OF FASCIN AND MMP-9 EXPRESSION AS MARKERS OF INVASION IN UROTHELIAL CARCINOMA OF THE URINARY BLADDER

Int. J. of Adv. Res. 2016:4 (8). 401-408

Int. J. of Adv. Res.

Background:Fascin and matrix metalloproteinase-9 (MMP-9) have been implicated in regulation of cell invasion and metastasis in many types of cancers. Aim: To evaluate the expression of fascin and MMP-9 in urothelial carcinoma (UC) of the urinary bladder and correlate their expression with the clinicopathological variables and to assess the relationship between them. Materials and methods: Fascin and MMP-9 immunoexpression was evaluated semiquantitatively in 60 cases of UCs according to the percentage of the positive cells. Results:Fascin and MMP-9 expression was observed in 66.7% and 60% of the studied cases of UCs respectively. The expression was significantly different from the normal urothelium. Fascin and MMP-9 expression was significantly higher with advanced tumor stage (P =0.02 and =0.01 respectively) and lymph-vascular space invasion (LVSI) (P<0.001 and =0.03 respectively). MMP-9 overexpression was significantly associated with the tumor grade (P =0.03). There was a positive correlation between fascin and MMP-9 expression (r =0.5, P =0.03). More intense immunostaining was detected at the invasive fronts compared with other areas of the tumor in 50% and 40% of UCs with positive fascin and MMP-9 expression respectively. Conclusion: Our results point to an association between increased fascin and MMP-9 expression and UC invasiveness and suggest that both markers may act in concert to mediate a more aggressive behavior through promoting tumor cell invasion.

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September 2016
7 Reads

Diagnostic Discrimination of Fine Needle Aspiration Specimens of Hepatic Nodules using Immunohistochemical Expression of GPC3 and EZH2

J Tumor Res. 2016

Journal of Tumor Research

The goal of the present study was to examine the immunohistochemical expression of Glypican-3 (GPC3) and Enhancer of zeste homologue 2 (EZH2) in various histological types of hepatic nodules in order to clarify their discriminatory diagnostic value. We correlated biomarkers’ expressions with the clinicopathological variables of primary liver malignancy. Biomarkers’ expression was investigated in 64 liver needle biopsies. The specimens included primary liver malignancy (57.81%), metastatic carcinomas (15.62%) and non-malignant nodules 26.56%. The expression of GPC3 was detected in 83.33% and 15.38% of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) respectively, but not expressed in any of metastatic nodules. In HCC, GPC3 was more expressed in cases with cirrhosis, large masses of tumor and high HCCs grades with statistically significant differences with P value of 0.01, 0.035 and 0.03 respectively. The EZH2 expression was detected in 91.66% of HCC, in all cases of CC and metastatic nodules and in 5.88% of non-malignant nodules. The sensitivity, specificity and diagnostic accuracy of differentiating HCCs from non-malignant nodules were 80.95%, 100% and 90.24% respectively for GPC3; and 85.71%, 95.65% and 91.89% respectively for EZH2. The sensitivity, specificity and diagnostic accuracy for differentiating HCCs from CCs were 73.33%, 90.91% and 83.78% respectively for GPC3; and 0.0%, 62.86% and 59.46% respectively for EZH2. The sensitivity, specificity and diagnostic accuracy for differentiating HCCs from metastatic nodules were 71.43%, 100% and 88.24% respectively for GPC3; and 0.0%, 68.75% and 64.71% respectively for EZH2. In conclusion, GPC3 might be used as a good biomarker for differential diagnosis of HCC from non-malignant nodules, CC and metastasis. Its overexpression might be an indication of poor HCC prognosis. On the other hand, EZH2 is not specific for HCC, but could be a reliable biomarker for discrimination of hepatic cancers compared to non-malignant nodules.

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July 2016
8 Reads

Anatomy and embryology of umbilicus in newborns: a review and clinical correlations

Front. Med. 2016

Frontiers of Medicine

Umbilicus is considered a mirror of the abdomen in newborns. Despite its importance, the umbilicus has been stated in literature and textbooks as discrete subjects with many body systems, such as the urinary, digestive, and cardiovascular ones. This article aimed to address the basic knowledge of the umbilicus in relation to clinical disorders under one integrated topic to aid physicians and surgeons in assessing newborns and infants. The umbilicus appears as early as the fourth week of fetal life when the folding of the embryonic plate occurs. The umbilicus appears initially as a primitive umbilical ring on the ventral aspect of the body. The primitive umbilicus contains the connecting stalk, umbilical vessels, vitelline duct and vessels, allantois, and loop of the intestine. Changes occur to form the definitive cord, which contains three umbilical vessels, namely, “one vein and two arteries,” embedded in Wharton’s jelly. After birth, the umbilical vessels inside the body obliterate and gradually form ligaments. Congenital disorders at the umbilicus include herniation, bleeding, and discharge of mucous, urine, or feces. Some of these disorders necessitate emergent surgical interference, whereas others may be managed conservatively. The umbilicus has many embryological remnants. Thus, the umbilicus is prone to various clinical disorders. Detecting these disorders as early as possible is essential to prevent or minimize possible complications.

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July 2016
9 Reads

Prognostic Value of Immunohistochemical Expressions of the Stem Cell Biomarker "LGR5" and the Proliferation Biomarker "TPX2" in Colorectal Carcinoma

J Tumor 2016

Journal of Tumor

AIM: Colorectal carcinoma (CRC) is the commonest and most deathly malignant gastrointestinal tumors. Carcinogenic process starts in a group of cancer cells, called cancer stem cells (CSCs) having the ability to start and maintain tumor growth and invasion. In order to detect and remove colon CSCs, a selective biomarker “LGR5 (leucine-rich-repeat-containing G-protein-coupled receptor 5)” might be required. At the same time, an abnormal expression of TPX2 (targeting protein for xenopus kinesin-like protein 2) has been found to be related to the development and progression of tumors. We aimed to evaluate the immunohistochemical expressions of LGR5 and TPX2 in CRC in a trial to clarify their relations to proliferation and metastasis of CRC, and hence its prognosis. MATERIALS AND METHODS: Immunohistochemical staining of both LGR5 and TPX2 was assessed in sections from sixty paraffin blocks of CRC. The relationships between their levels of expressions with the clinicopathological parameters and patient outcome were statistically analyzed. RESULTS: The immunoexpression of LGR5 in CRC was significantly positively correlated with location of the tumor, grade, stage, local recurrence, lymph node and distant metastasis (P <0.001). The expression of TPX2 in CRC was also found to be significantly correlated with the previous parameters (P < 0.001). Both biomarkers were up-regulated in CRC than in the adjacent non tumorous tissues. High LGR5 and TPX2 immunohistochemical expressions were strongly correlated with worse 3-year overall survival (OS), local recurrence free survival (LRFS) and distant metastases free survival (DMFS) (P < 0.001). CONCLUSIONS: High immunohistochemical expressions of both LGR5 and TPX2 and the positive correlation between both of them represent signs of poor prognosis of CRC.

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June 2016
10 Reads

Immunohistochemical Study of Prognostic Relevance of Nestin and Survivin Expression in Astrocytic glioma

J Interdiscipl Histopathol; 2016;4(2)

J Interdiscipl Histopathol

Background: Identification of the cellular origin of astrocytic gliomas is a step for improving the treatment strategies. Tumor stem cells have been detected in different neoplasms and have a major role in tumor initiation, progression, and therapy resistance. Objective: The study aimed to investigate the expression of nestin and survivin in different grades of astrocytic glioma as well as evaluation of their prognostic role in relation to other prognostic parameters. Materials and Methods: Immunohistochemical expressions of nestin and survivin were evaluated in 40 paraffin blocks of different grades of astrocytic glioma and correlated with other prognostic parameters. The obtained data were statistically analyzed. Results: The cases included 10 low grade, 12 anaplastic, and 18 glioblastoma multiforme. There was a significant correlation between each of nestin and survivin with the histological grade of astrocytoma and tumor size (P < 0.001). Nestin was strongly correlated to survivin index (P < 0.001). The univariate analysis showed that high histological grade, high nestin score, and high survivin index were significantly correlated with overall survival (OS). Multivariate analysis for all investigated cases proved the independent prognostic significance of the nestin expression (P = 0.011).Conclusion: Nestin and survivin are adverse prognostic markers for astrocytic glioma that increase significantly with tumor progression and associated with poor OS. Therefore, nestin and survivin could be used to predict high-risk group of astrocytoma with unfavorable outcome.

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May 2016
9 Reads

Prognostic implication of MYb-like, swirm and Mpn domain-containing protein-1 and Twist-1 in renal cell carcinoma

J Interdiscipl Histopathol 2016; 4(1): 1-8

Journal of Interdisciplinary Histopathology

Objective: The data available regarding the epithelial-mesenchymal transition (EMT) markers are little. This study aimed to evaluate the immunohistochemical expression of EMT markers; MYb-like, Swirm and Mpn domain-containing protein-1 (MYSM-1) and Twist-1 in renal cell carcinoma (RCC), in a trial to find their role in the prognosis of such type of cancer. Methods: Immunoexpressions of MYb-like, Swirm and Mpn domaincontaining protein-1 (MYSM-1) and Twist-1 were assessed in tissue specimens of 50 patients with RCC, and correlated with other clinicopathological features. The findings and their correlations were statistically determined. Results: Low expression of MYSM-1 was negatively correlated with size of the tumor, primary tumor (pT) stage, Fuhrman grade (P < 0.001), age (P = 0.002), and lymph node metastases (P = 0.010). Immunoexpression of MYSM-1 was significantly correlated with distant metastases (P = 0.004), overall survival (OS) (P < 0.001), and local recurrence (P = 0.001). High expression of Twist-1 was positively correlated with pT stage, Fuhrman grade, lymph node, distant metastases, age (P < 0.001), clinical stage (P = 0.002), the presence of sarcomatous change (P = 0.004), and tumor size (P = 0.008). Immunoexpression of Twist-1 was significantly correlated with distant metastases (P = 0.009), OS (P < 0.001), and local recurrence (P = 0.003). Conclusion: Overexpression of Twist-1 is an indication of poor prognosis in patients with RCC, whereas that of MYSM-1 is a marker of good prognosis.

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February 2016
7 Reads

Immunohistochemical Distinction of Hepatocellular Carcinoma Using Arginase-1, Hepatocyte Paraffin Antigen -1 and Glypican-3

Journal of Tumor 2016 February 18 4(1): 359-366

Journal of Tumor

AIM: The distinction of hepatocellular carcinoma (HCC) from the metastatic carcinoma (MC) and intrahepatic cholangiocarcinoma (CC) often presents a diagnostic challenge that carries a significant impact on its subsequent management. In this study we aimed to evaluate the immunohistochemical expressions of arginase-1, hepatocyte paraffin antigen-1 (HepPar-1), and glypican-3 (GPC-3) in a trial to distinguish HCC from non-HCC involving the liver. MATERIALS AND METHODS: The study included 64 cases (32 HCC, 28 MC and 4 CC) and 5 specimens of normal liver tissues. These cases were investigated retrospectively from the archive of the Pathology Department, Zagazig University Hospitals. The predictive capacity of arginase-1, HepPar-1 and GPC-3 staining was determined using sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) calculations. RESULTS: Both arginase-1 and HepPar-1 expressions were present in all cases of non-neoplastic hepatocellular tissues, whereas GPC-3 expression was absent in all cases. Only two of 28 (7.1%) cases of MC and one of 4 (25%) cases of CC showed positive immunoreactivity for arginase-1. HepPar-1 immunoreactivity was detected in 3 of 28 (10.7%) cases of MC and in one of 4 (25%) cases of CC. GPC-3 immunoreactivity was detected in 2 of 28 (7.1%) cases of MC and negative in all cases of CC. Arginase-1 was more sensitive (87.5%) than HepPar-1 (71.9%) or GPC-3 (65.6%) for HCC. GPC-3 was more specific (93.8%) than HepPar-1 (87.5%) and arginase-1 (90.6%). However, the combination of the three biomarkers for the diagnosis of HCC raised the specificity to 100%. CONCLUSION: Arginase-1 and HepPar-1 are effective biomarkers for HCC differentiation. Also, arginase-1 demonstrates a superior sensitivity in comparison with GPC-3 and HepPar-1 in the diagnosis of HCC, whereas GPC-3 demonstrates superior specificity. Hence, the use of combination of arginase-1 with HepPar-1 and GPC-3 could be useful in the precise diagnosis of HCC and distinguishing it from non-HCC.

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February 2016
12 Reads

Prognostic Value of ALDH1, EZH2 and Ki-67 in Astrocytic Gliomas

Turkish Journal of Pathology

Objective: Tumor stem cells have been found in a variety of neoplasms and stated to have a role in tumor progression. This study aimed to evaluate the prognostic significance of biomarkers which are said to be related to these cells, i.e., EZH2, ALDH1 and Ki-67, and their correlation with each other in astrocytic gliomas. Material and Method: Formalin-fixed, paraffin-embedded tissue specimens of 40 patients with astrocytic glioma who underwent initial surgery during the period from December 2011 to May 2014 at Zagazig University Hospitals were enrolled in the study. Consecutive 4-μm thick sections from formalin-fixed, paraffin-embedded tissue blocks were prepared and stained with hematoxylin and eosin for histopathological evaluation. Immunohistochemical analysis using ALDH1, EZH2 and Ki-67 antibodies were performed to examine the cases. Results: A total of forty patients; 22 males and 18 females were studied. The lesions were classified as follows: 14 cases of low-grade astrocytoma (WHO grade I or II), 11 cases of anaplastic astrocytoma (WHO grade III), and 15 glioblastomas (WHO grade IV). There was a significant increase in ALDH1 immunoreactivity with increasing the grade of astrocytoma (mean ±SD = 0.2 ±0.4, 0.5 ±0.6, 1.1 ±1.3 and 2.95 ±2.97 in grade I to IV astrocytic gliomas, respectively). This expression was significantly correlated with overall survival (OS) and progression-free survival (PFS) (P=0.004). EZH2 expression was also significantly associated with advanced grades (mean ±SD =1.35 ±0.4, 3.1 ±2.6, 7.2 ±3.5 and 9.9 ±4.1, in grade I to IV astrocytic gliomas, respectively). EZH2 and Ki-67 expressions were found to be correlated with OS and PFS (P < 0.001). Conclusion: Increased expression of ALDH1, EZH2 and KI67 are found to be associated with unfavourable prognosis in patients with astrocytic gliomas and may predict therapeutic modalities.

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January 2016
16 Reads

Female Circumcision in Egypt

Ann Int Med Dent Res. 2016;2:(1)1-2

Annals of International Medical and Dental Research

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January 2016
7 Reads

Immunohistochemical measurement and expression of Mcl-1 in infertile testes.

Front Med 2015 Sep 17;9(3):361-7. Epub 2015 Jun 17.

Pathology of Department, Faculty of Medicine, Zagazig University, Zagazig, 44159, Egypt.

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September 2015
1 Read

Hegazy’ Simplified Method of Tissue Processing (Consuming Less Time and Chemicals)

Ann Int Med Den Res. 2015;1(2):57-61

Annals of International Medical and Dental Research

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August 2015
49 Reads

MINIMAL ADENOCARCINOMA IN PROSTATE NEEDLE BIOPSY TISSUE: IMMUNOHISTOCHEMICAL STUDY

Int J Cur Res Rev 2015; 7(6)

Int J Cur Res Rev

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March 2015
8 Reads

DMPA- Induced Changes in Estrogen and Progesterone Receptors of Ampulla of Rat-oviducts: An Immunohistochemical Study

Univ J Med Sc.2015;3(2): 33-40

Universal Journal of Medical Science

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March 2015
5 Reads

Role of ERG, PTEN and KI67 Proteins Expression in Prognosis of Metastatic Prostate Cancer

Int J Adv Res. 2015;3(1)296-306

International Journal of Advanced Research

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February 2015
6 Reads

ANTHROPOMETRIC STUDY OF NASAL INDEX OF EGYPTIANS

Int J Anat Res 2014;2(4)761-67

International Journal of Anatomy and Research

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December 2014
6 Reads

EFFECT OF CYCLOSPORINE A ON THE KIDNEY OF RABBIT: A LIGHT AND ULTRASTRUCTURAL STUDY

Int J Anat Res 2014;2(4)768-76

International Journal of Anatomy and Research

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December 2014
7 Reads

CLINICOPATHOLOGICAL SIGNIFICANCE AND CORRELATION OF SURVIVIN, HER2 AND BCL2 EXPRESSION IN BREAST CARCINOMA

ZUMJ. 2014 Dec 20;20(6):883-898

Zagazig University Medical Journal

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December 2014
1 Read

Midsagittal anatomy of lumbar lordosis in adult egyptians: MRI study.

Anat Res Int 2014 18;2014:370852. Epub 2014 Aug 18.

Pathology Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.

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September 2014
4 Reads
1 PubMed Central Citation(source)

Immunohistochemical Expression of Aldehyde Dehydrogenase-1 and Hypoxia- Inducible Factor-1 alpha in Breast Cancer

Int. J. Adv. Res. 2 (7): 822-830, 2014

International Journal of Advanced Research

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July 2014
9 Reads

Expression and Significance of Ezrin and E-cadherin in Colorectal Carcinoma

Int. J. Adv. Res. 2014;2 (7): 936-944, .

International Journal of Advanced Research

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July 2014
7 Reads

Fine needle aspiration cytology and cell-block study of various breast lumps

Am J Biomed Life Sc. 2014;2(1) 8-17

American Journal of Biomedical and Life Sciences

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May 2014
6 Reads

Radiographic morphometric study of the normal distal humerus in adult Egyptians

Intl J Adv Res. 2013, 1(9):155-161

International Journal of Advanced Research

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November 2013
6 Reads

Age-Related Changes in Rabbit Optic Nerve: A Morphological Study

J Am Sc. 2013;9(10);86-77

Journal of American Science

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September 2013
7 Reads

Sex Assessment of the First Sacral Vertebra, MRI Study

J Am Sc 2013;9(10)

Journal of American Science

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September 2013
7 Reads

Expression of β-Catenin and Cyclooxygenase 2 in Colorectal Carcinoma: An Immunohistochemical Study

Univ J Med Sc 2013, 1(3):72-77

Universal Journal of Medical Science

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September 2013
9 Reads

FNAC and Cell-block Study of Thyroid Lesions

Univ J Med Sc. 2013 1(1): 1-8,

Universal Journal of Medical Science

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March 2013
6 Reads

Radiographic Height Variations and Sexual Dimorphism in the Two Bony Processes of the Proximal End of Ulna

New Egy J Med. 2012;46(6)585-92

The New Egyptian Journal of Medicine

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June 2012
6 Reads

Male circumcision: review and authors perspective

theHealth 2012; 3(1): 24-30

theHealth

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March 2012
7 Reads

Hymen: facts and conceptions

EuGeStA 2013, 3:67-12;

theHealth

Background: In conservative cultures, the presence of hymen without rupture in a virgin girl represents an indication of female pride and honor. Accordingly, there are many crimes, committed due to wrong views and conceptions among young people in such societies. The current review aimed to highlight the anatomy of the hymen, in a trial to create a better understanding and to eliminate misconceptions about virginity. Methods: Databases of PubMed, ScienceDirect, SpringerLink, Wiley Interscience and others were searched. The research papers are studied and discussed. Results: The hymen is a thin mucous membrane, partially closing the vaginal orifice. It represents an embryological remnant, originating from the urogenital sinus. It varies greatly in shape. Its elasticity increases after puberty so that it may allow penile penetration without rupture and bleeding. Conclusions: Hymen is not an accurate indication of virginity. Knowledge of the hymen anatomy and its abnormalities is essential to eliminate the misconceptions about it.

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