Dr. Abbas Smiley, MD, MSc, PhD - Indiana University in Bloomington

Dr. Abbas Smiley

MD, MSc, PhD

Indiana University in Bloomington

Bloomington, IN | United States

Main Specialties: Epidemiology, Family Practice, Preventive Medicine, Public Health, Sleep Medicine, Statistics

ORCID logohttps://orcid.org/0000-0003-0590-0553

Dr. Abbas Smiley, MD, MSc, PhD - Indiana University in Bloomington

Dr. Abbas Smiley

MD, MSc, PhD

Introduction

Primary Affiliation: Indiana University in Bloomington - Bloomington, IN , United States

Specialties:

Publications

25Publications

306Reads

443Profile Views

58PubMed Central Citations

Letter to the editor: snoring and incident cardiovascular disease in the Jackson heart study.

Sleep Breath 2020 Mar 19. Epub 2020 Mar 19.

Department of Epidemiology and Biostatistics, School of Public Health - Bloomington, Indiana University, Bloomington, IN, USA.

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http://dx.doi.org/10.1007/s11325-020-02043-yDOI Listing
March 2020
2.869 Impact Factor

Letter to Editor: Is Low-Volume Disease in the Sentinel Node After Neoadjuvant Chemotherapy an Indication for Axillary Dissection? Miscalculation of Sensitivity and False-Negative Rate.

Ann Surg Oncol 2020 Feb 28. Epub 2020 Feb 28.

Department of Surgery, Westchester Medical Center, Valhalla, NY, USA.

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http://dx.doi.org/10.1245/s10434-020-08262-7DOI Listing
February 2020
3.930 Impact Factor

Association between trail use and self-rated wellness and health.

BMC Public Health 2020 Jan 30;20(1):128. Epub 2020 Jan 30.

Eppley Institute for Parks and Public Lands, Indiana University School of Public Health- Bloomington, Bloomington, Indiana, USA.

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http://dx.doi.org/10.1186/s12889-020-8273-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990545PMC
January 2020
2.264 Impact Factor

The association between sleep duration and lipid profiles: the NHANES 2013-2014.

J Diabetes Metab Disord 2019 Dec 22;18(2):315-322. Epub 2019 Jun 22.

Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, 1025 E 7th St., Bloomington, IN 47405 USA.

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http://dx.doi.org/10.1007/s40200-019-00415-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914752PMC
December 2019

Nailfold microvascular changes in patients with systemic lupus erythematosus and their associative factors.

Microvasc Res 2019 11 10;126:103910. Epub 2019 Aug 10.

School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.mvr.2019.103910DOI Listing
November 2019
1 Read
2.126 Impact Factor

The Association between Sleep Duration and Metabolic Syndrome: The NHANES 2013/2014.

Nutrients 2019 Oct 26;11(11). Epub 2019 Oct 26.

Department of Epidemiology, School of Public Health, Indiana University, Bloomington, IN 47404, USA.

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http://dx.doi.org/10.3390/nu11112582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893635PMC
October 2019
3.148 Impact Factor

Mechanisms of Association of Sleep and Metabolic Syndrome

J. Med. Clin. Res. Rev. 2019 Jun;3:1-9

J. Med. Clin. Res. Rev

There is a U-shaped association between sleep duration and risk of metabolic syndrome. The related mechanisms can be grouped into two categories: I. Too little slow-wave sleep; II. Too much REM sleep. Too little slow-wave sleep. 1) Stage 3 is the most crucial sleep stage because growth hormone (GH) and GH releasing hormone (GHRH) are released during this stage. They induce fat burning, bone building, and general repair and regeneration. The greater the volume of GH and GHRH released, the more restorative the sleep. The longest part of stage 3 in sleep takes place before midnight. Delayed sleep onset until midnight or later, would suppress the largest GH pulse. 2) Sleep restriction induces high levels of ghrelin and low levels of leptin. Ghrelin stimulates appetite whereas leptin does the reverse. 3) Advanced glycation end products (AGEs) are significantly increased in chronic sleep insufficiency and are also associated with insulin resistance in males with chronic sleep insufficiency. 4) Sleep insufficiency increases sympathetic activity and pro-inflammatory cytokines, both of which increase insulin resistance. 5) Accumulations of extracellular β amyloid protein plaques and intracellular tau neurofibrillary tangles in brain tissues start immediately after one night of sleep insufficiency. These plaques and tangles are neurotoxins that potentiate each other’s destructive effects on the structures and functions of brain cells and cause neuronal death. The consequence is a global decrease in cognition and decision making, manifested in increased consumption of fatty foods and unhealthy snacks in late sleepers. 6) High levels of β amyloid and proteins might lead to sleep fragmentation, worsening of sleep quality and daytime somnolence. Concentration will be more difficult, and performance will be reduced. 7) Astrocytes are special giant cells in brain interstitial fluids that play a major role in β amyloid and tau cleanup. Their activity is increased by growth hormone. As a result, slow-wave sleep insufficiency may lead to impaired peripheral clearance of β amyloid and tau proteins predisposing the brain to Alzheimer’s disease. Too much REM sleep. 1) The REM stage is the dreaming stage. The level of cortisol starts to rise in the middle of night based on circadian rhythm, and peaks in the morning. Cortisol is the fight or flight hormone, equipping the individual both to meet the demands of daily life and to handle stressful situations. It stimulates the release of epinephrine and norepinephrine. These hormones increase heart rate and blood pressure as they prepare the body to initiate activity quickly. These reactions occur on top of heart rate variability and a rise in blood pressure induced by REM sleep. If the individual wakes up early in the morning, he will use the cortisol properly to prepare for the new day. If instead he or she remains asleep, there will be no physical activity, and the cortisol levels that are normal for a person who is awake will be high levels for the one who is asleep. Then, the sleeper may experience higher blood sugar, heart rate, and blood pressure. 2) A simulation of fight or flight reactions may be reflected in dreams. The prevalence of bizarre dreams in the morning is double of that at the beginning of the night. Moreover, emotionally charged dreams are significantly more frequent in the morning than early in the night. Bad dreams bring negative physical effects such as accelerated heartbeat, blood vessel spasms, increased blood pressure, and so on. Acute exacerbations of many chronic disorders occur in early morning sleep. 3) Waking up during the REM stage can make an individual feel more sleepy or tired during the day than waking up during stages 1-2.

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June 2019
6 Reads

Metabolic syndrome in Iranian patients with systemic lupus erythematosus and its determinants.

Clin Rheumatol 2018 Jun 5;37(6):1521-1528. Epub 2018 Jan 5.

Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, IN, USA.

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http://dx.doi.org/10.1007/s10067-017-3970-5DOI Listing
June 2018
8 Reads
1.774 Impact Factor

Sensitivity analyses of four systemic lupus erythematosus disease activity indices in predicting the treatment changes in consecutive visits: a longitudinal study.

Clin Rheumatol 2018 Apr 18;37(4):955-962. Epub 2017 Dec 18.

Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, IN, USA.

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http://dx.doi.org/10.1007/s10067-017-3949-2DOI Listing
April 2018
16 Reads
1.774 Impact Factor

Prognostic factors of mortality in Iranian patients with systemic lupus erythematosus admitted to intensive care unit.

Clin Rheumatol 2017 Nov 6;36(11):2471-2477. Epub 2017 Sep 6.

Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, IN, USA.

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http://dx.doi.org/10.1007/s10067-017-3808-1DOI Listing
November 2017
20 Reads
1.774 Impact Factor

Comment on "Ultraprocessed food consumption and risk of overweight and obesity: the University of Navarra Follow-Up (SUN) cohort study".

Am J Clin Nutr 2017 04;105(4):1012

From the Departments of Applied Health Science (EK; TB, e-mail: and Epidemiology and Biostatistics (AS and KH), Indiana University School of Public Health, Bloomington, IN.

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http://dx.doi.org/10.3945/ajcn.116.149302DOI Listing
April 2017
37 Reads
6.770 Impact Factor

Childhood versus adult-onset systemic lupus erythematosus: long-term outcome and predictors of mortality.

Clin Rheumatol 2017 Feb 23;36(2):343-350. Epub 2016 Dec 23.

Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, IN, USA.

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http://dx.doi.org/10.1007/s10067-016-3509-1DOI Listing
February 2017
8 Reads
2 Citations
1.774 Impact Factor

Prospective study of articular manifestations in Behçet's disease: five-year report.

Int J Rheum Dis 2017 Jan 25;20(1):97-102. Epub 2015 Jun 25.

Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1111/1756-185X.12633DOI Listing
January 2017
11 Reads
2 Citations
1.771 Impact Factor

The association between initial manifestations of childhood-onset systemic lupus erythematosus and the survival.

Int J Rheum Dis 2016 Oct 3;19(10):974-980. Epub 2015 Dec 3.

Department of Epidemiology, School of Public Health, Indiana University, Bloomington, Indiana, USA.

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http://dx.doi.org/10.1111/1756-185X.12807DOI Listing
October 2016
22 Reads
2 Citations
1.771 Impact Factor

Anti-C1q antibody in patients with lupus nephritic flare: 18-month follow-up and a nested case-control study.

Mod Rheumatol 2016 10;26(2):233-9. Epub 2015 Sep 10.

c Department of Clinical Epidemiology , Alzahra Hospital, Isfahan University of Medical Sciences , Isfahan , Iran.

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http://dx.doi.org/10.3109/14397595.2015.1074649DOI Listing
October 2016
28 Reads
2.210 Impact Factor

Relationship between articular and nonarticular manifestations in inflammatory bowel diseases.

J Res Med Sci 2016 14;21:48. Epub 2016 Jun 14.

Department of Epidemiology, Indiana University School of Public Health, Bloomington, IN, USA.

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http://dx.doi.org/10.4103/1735-1995.183989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122034PMC
June 2016
15 Reads
1 Citation
0.610 Impact Factor

Musculoskeletal manifestations in diabetic versus prediabetic patients.

Int J Rheum Dis 2015 Sep 14;18(7):791-9. Epub 2015 Jul 14.

Department of Biostatistics & Epidemiology, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://dx.doi.org/10.1111/1756-185X.12712DOI Listing
September 2015
14 Reads
1 Citation
1.771 Impact Factor

Outcome of adult onset systemic lupus erythematosus in Iran.

Lupus 2014 Oct 15;23(11):1211-6. Epub 2014 May 15.

Isfahan, Iran.

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http://dx.doi.org/10.1177/0961203314534304DOI Listing
October 2014
9 Reads
2.200 Impact Factor

Atorvastatin effect on systemic lupus erythematosus disease activity: a double-blind randomized clinical trial.

Clin Rheumatol 2014 Sep 13;33(9):1273-8. Epub 2014 May 13.

Department of Rheumatology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, 8174675731, Iran,

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http://dx.doi.org/10.1007/s10067-014-2654-7DOI Listing
September 2014
33 Reads
1.774 Impact Factor

Weight loss and proteinuria: systematic review of clinical trials and comparative cohorts.

Nephrol Dial Transplant 2010 Apr 27;25(4):1173-83. Epub 2009 Nov 27.

St. Joseph's Hospital, HealthEast Care System, University of Minnesota School of Public Health, Minneapolis, MN, USA.

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http://dx.doi.org/10.1093/ndt/gfp640DOI Listing
April 2010
26 Reads
35 Citations
3.580 Impact Factor

Therapeutic approach to "downhill" esophageal varices bleeding due to superior vena cava syndrome in Behcet's disease: a case report.

BMC Gastroenterol 2006 Dec 27;6:43. Epub 2006 Dec 27.

Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://dx.doi.org/10.1186/1471-230X-6-43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769384PMC
December 2006
13 Reads
6 Citations
2.370 Impact Factor

Effectiveness of hepatitis B vaccination in children of chronic hepatitis B mothers.

Saudi Med J 2004 Oct;25(10):1414-8

Research Center for Gastroenterology and Liver Diseases, Isfahan University of Medical Sciences, Isfahan, Iran.

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October 2004
10 Reads
8 Citations
0.554 Impact Factor

Top co-authors

Alimohammad Fatemi
Alimohammad Fatemi

KTH Royal Institute of Technology

11
Zahra Sayedbonakdar
Zahra Sayedbonakdar

a Department of Rheumatology and

5
Abbas Esmaeili
Abbas Esmaeili

Isfahan University of Medical Sciences

4
Aurelian Bidulescu
Aurelian Bidulescu

Morehouse School of Medicine

3
Elizabeth Kaschalk
Elizabeth Kaschalk

School of Public Health

2
Hamid Tavakkoli
Hamid Tavakkoli

Isfahan University of Medical Sciences

2
Ahmad Raeisi
Ahmad Raeisi

Tehran University of Medical Sciences

2
Mehdi Kazemi
Mehdi Kazemi

Carilion Clinic

2
Ka He
Ka He

University of North Carolina at Chapel Hill

2
David King
David King

Massachusetts General Hospital and Harvard Medical School

2