Publications by authors named "Abbas Aghaei"

20 Publications

  • Page 1 of 1

Gelatin Electrospun Mat as a Potential Co-culture System for Production of Sperm Cells from Embryonic Stem Cells.

ACS Biomater Sci Eng 2020 Oct 18;6(10):5823-5832. Epub 2020 Sep 18.

Cellular and Molecular Research Centre, Iran University of Medical Sciences, 14496-14535 Tehran, Iran.

Engineering of 3D substrates with maximum similarity to seminiferous tubules would help to produce functional sperm cells from stem cells. Here, we present a 3D electrospun gelatin (EG) substrate seeded with Sertoli cells and determine its potential for guided differentiation of embryonic stem cells (ESCs) toward germline cells. The EG was fabricated by electrospinning, and its morphology under SEM, as well as cytobiocompatibility for Sertoli cells and ESCs, was confirmed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide and cell attachment assay. Embryoid bodies (EBs) were formed from ESCs and co-cultured with Sertoli cells, induced with BMP4 for 3 and 7 consecutive days to induce the differentiation of EBs toward germline cells. The differentiation was investigated by immunocytochemistry (ICC), flow cytometry, and RT-PCR in four experimental groups of EBs (EBs cultured in gelatin-coated cell culture plates); Scaffold/EB (EBs cultured on EG); ESCs/Ser (EBs and Sertoli cells co-cultured on gelatin-coated cell culture plates without EG); and Scaffold/EB/Ser (EBs and Sertoli cells co-cultured on EG). All experimental groups exhibited a significantly increased MVH (germline-specific marker) and decreased c-KIT (stemness marker) expression when compared with the EB group. ICC and flow cytometry revealed that Scaffold/EB/Ser had the highest level of MVH and the lowest c-KIT expression at both 3 and 7 days postdifferentiation compared with other groups. RT-PCR results showed a significant increase in the germline marker () and a significant decrease in the ESC stemness marker () in Scaffold/EB compared to the EB group. The germline markers , , , , , and were significantly increased in Scaffold/EB/Ser compared to the Scaffold/EB group. Our findings revealed that the EG scaffold can provide an excellent substrate biomimicking the micro/nanostructure of native seminiferous tubules and a platform for Sertoli cell-EB communication required for growth and differentiation of ESCs into germline cells.
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http://dx.doi.org/10.1021/acsbiomaterials.0c00893DOI Listing
October 2020

Corticosteroids on the Management of Coronavirus Disease 2019 (COVID-19): A Systemic Review and Meta-Analysis.

Iran J Public Health 2020 Aug;49(8):1411-1421

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: We aimed to examine the available evidence regarding the efficacy and safety of corticosteroids on the management of coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome (SARS-CoV) and Middle East respiratory syndrome (MERS-CoV).

Method: An extensive search was conducted in Medline, Embase, and Central databases until the end of March 2020, using keywords related to corticosteroids, COVID-19, SARS-CoV and MERS-CoV. The main outcome was considered to be the mortality rate, length of stay, virus clearance time, symptom improvement, and lung function improvement. The findings are presented as odds ratio (OR) with 95% confidence interval (95% CI).

Results: Fifteen paper compromising 5 studies on COVID-19, 8 studies on SARS-CoV and 2 studies on MERS-CoV were included. One study was clinical trial and the rest were cohort. The analyses showed that corticosteroids were not reduce the mortality rate of COVID-19 (OR=1.08; 95% CI: 0.34 to 3.50) and SARS-CoV (OR=0.77; 95% CI: 0.34 to 1.3) patients, while they were associated with higher mortality rate of patients with MERS-CoV (OR = 2.52; 95% CI: 1.41 to 4.50). Moreover, it appears that corticosteroids administration would not be effective in shortening viral clearance time, length of hospitalization, and duration of relief symptoms following viral severe acute respiratory infections.

Conclusion: There is no evidences that corticosteroids are safe and effective on the treatment of severe acute respiratory infection when COVID-19 disease is suspected. Therefore, corticosteroids prescription in COVID-19 patients should be avoided.
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http://dx.doi.org/10.18502/ijph.v49i8.3863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554375PMC
August 2020

Higher Odds of Type 2 Diabetes for Some Blood Groups.

Public Health Genomics 2020 6;23(1-2):37-41. Epub 2020 Apr 6.

Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran,

Background: Diabetes is one of the most common metabolic diseases in humans that cause disruption in glucose and fat metabolism. The determination of the ABO blood group system is hereditary and both diabetes and blood groups have a genetic basis.

Objectives: The aim of this study was to investigate the odds of type 2 diabetes for some blood groups.

Methods: This case-control study was conducted in hospitals of Kermanshah in 2018. The case group consisted of patients with diabetes admitted to hospital and the control group of nondiabetic patients hospitalized in the surgical ward. Information such as age, sex, BMI, family history of diabetes and blood group is collected and analyzed by the univariate and multivariate logistic regression method.

Results: A total of 750 patients were enrolled in this study. The number of participants in both groups was 375. The average ages of the participants were 50.51 and 51.62 years, respectively. 67.5% of the patients in the case group were female in comparison with 73.6% of those in the control group. The value of Rh+ in the case and control groups was 94.4 and 93.6%, respectively (p = 0.645). The chance of having diabetes for patients with blood group A was 76% higher than for those with blood group O (p = 0.006).

Conclusion: According to the results of this study, the odds of type 2 diabetes for people in blood group A was higher than for those in other blood groups. It is recommended that blood group A be considered as a risk factor in the screening of type 2 diabetes.
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http://dx.doi.org/10.1159/000506294DOI Listing
December 2020

Comparison of the effect of manual compression and closure pad on postangiography complications: A randomized controlled trial.

J Vasc Nurs 2020 Mar 19;38(1):2-8. Epub 2020 Feb 19.

Health Institute, Social Development and Health Promotion Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:

Background: Different methods are available for the closure of the femoral artery after catheterization. The present study aimed at comparing the effect of manual compression (MC) and closure pad (CP) on vascular complications (hematoma and bleeding) of coronary angiography.

Methods: In the current clinical trial, a total of 238 patients who were candidates for angiography were randomly assigned to the MC and CP groups. In the MC group, after removal of the arterial sheath, the arterial puncture site was manually compressed for 5-10 minutes and hemostasis was achieved. In the CP group, after removal of the arterial sheath, the arterial puncture site was first manually compressed for 5-10 minutes and initial coagulation was achieved. Then, to continue the coagulation process, a CP was attached to the artery puncture site. Postangiography complications including bleeding and hematoma were monitored in both groups immediately and up to 24 hours after hemostasis. Data were analyzed by SPSS-18 software.

Results: After angiography, 7 (9.5%) and 5 (2.4%) patients had hematoma in the MC and CP groups, respectively; however, no significant difference was found between the groups. Rebleeding after hemostasis was observed in 2 (7.1%) patients in the MC group, but none of the subjects in the CP group had rebleeding. There was no significant difference in bleeding volume between the groups.

Conclusion: The results indicated the same efficacy of MC and CP methods in the prevention of postangiography vascular complications. Given the advantages of CP such as the possibility of changing the position in bed and increased physical comfort in the patient, this method is recommended for angiography and catheterization.
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http://dx.doi.org/10.1016/j.jvn.2020.01.001DOI Listing
March 2020

Application of data mining techniques and logistic regression to model drug use transition to injection: a case study in drug use treatment centers in Kermanshah Province, Iran.

Subst Abuse Treat Prev Policy 2019 12 12;14(1):55. Epub 2019 Dec 12.

PhD in Epidemiology, Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Background: Drug injection has been increasing over the past decades all over the world. Hepatitis B and C viruses (HBV and HCV) are two common infections among people who inject drugs (PWID) and more than 60% of new human immunodeficiency virus (HIV) cases are PWID. Thus, investigating risk factors associated with drug use transition to injection is essential and was the aim of this research.

Methods: We used a database from drug use treatment centers in Kermanshah Province (Iran) in 2013 that included 2098 records of people who use drugs (PWUD). The information of 29 potential risk factors that are commonly used in the literature on drug use was selected. We employed four classification methods (decision tree, neural network, support vector machine, and logistic regression) to determine factors affecting the decision of PWUD to transition to injection.

Results: The average specificity of all models was over 84%. Support vector machine produced the highest specificity (0.9). Also, this model showed the highest total accuracy (0.91), sensitivity (0.94), positive likelihood ratio [1] and Kappa (0.94) and the smallest negative likelihood ratio (0). Therefore, important factors according to the support vector machine model were used for further interpretation.

Conclusions: Based on the support vector machine model, the use of heroin, cocaine, and hallucinogens were identified as the three most important factors associated with drug use transition injection. The results further indicated that PWUD with the history of prison or using drug due to curiosity and unemployment are at higher risks. Unemployment and unreliable sources of income were other suggested factors of transition in this research.
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http://dx.doi.org/10.1186/s13011-019-0242-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909482PMC
December 2019

Relationship between study habits and academic achievement in students of medical sciences in Kermanshah-Iran.

Adv Med Educ Pract 2019 15;10:637-643. Epub 2019 Aug 15.

Health Institute, Social Development and Health Promotion Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Purpose: Study habits have been the most important predictor of academic performance and play a special role in the academic achievement of students. The aim of this study was to investigate the status of study habits and its relationship with academic achievement in medical sciences students in Kermanshah-Iran.

Materials And Methods: This cross-sectional study was carried out on 380 medical sciences students at Kermanshah University of Medical Sciences. The samples were randomly assigned to the study. The Palsane and Sharma study Habit Inventory was the tool used for data collection. Data were analyzed by descriptive and inferential statistics.

Results: The mean of students' grade point average was 15.73±1.5 out of 20 and the mean of total status of study habits was 45.70±11.36 out of 90. The status of study habits in 81.3% of the students was at moderate level. There was a direct and significant relationship between study habits and academic achievement.

Conclusion: The status of study habits was at moderate level for most students. Therefore, it is recommended to consider and assess students' study habits at the time of entry into university, in addition, specific training should be offered to students in order to help them learn or modify study habits to increase their academic achievements.
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http://dx.doi.org/10.2147/AMEP.S208874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699491PMC
August 2019

Stage of Breast Cancer Screening Adoption; The Role of Cognitive Predictors.

Asian Pac J Cancer Prev 2019 08 1;20(8):2373-2378. Epub 2019 Aug 1.

Infectious Disease and Tropical Medicine Center, Health Research Institute, Babol University of Medical Science, Babol, Iran. Email:

Breast cancer is the most common cancer among women. The present study investigated the stage of breast cancer screening adoption and the role of some of the cognitive predictors in a sample of Iranian married women. There were a total of 334 married women clients of eight health centers in Kermanshah city, the west of Iran, were randomly selected to participate voluntarily. Women filled out a self-report questionnaire. Data were analyzed by SPSS version 20 using One-way ANOVA, χ2-test, Fisher’s exact test, and bivariate correlations statistical tests at 95% significant level. The mean age was 39.75 years [SD: 7.73]. Nearly 58.4%, 26.9%, 3%, 9.6%, and 2.1% of the respondents were reported pre-contemplation, contemplation, preparation, action, and maintenance of breast cancer screening adoption, respectively. There was a significant association between age (P=0.005), and positive family history of breast cancer (P=0.037), perceived susceptibility (P=0.005), perceived severity (P=0.001) and knowledge of symptoms (P=0.018) with breast cancer stage of screening adoption. Our findings can provide better knowledge for the development and implementing of stage-targeted breast cancer screening adoption promotion programs. We conclude that it seems that the focus of health planner should be to rise to perceived severity; perceived susceptibility and knowledge of symptoms of breast cancer about the promotion of breast cancer screening adoption an Iranian woman.
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http://dx.doi.org/10.31557/APJCP.2019.20.8.2373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852829PMC
August 2019

Factors Related to Pediatric Unintentional Burns: The Comparison of Logistic Regression and Data Mining Algorithms.

J Burn Care Res 2019 08;40(5):606-612

Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Burn injuries are one of the traumas seen in all parts of the world and children are usually one of the vulnerable groups. The aim of this study was to determine the factors related to unintentional burns in children, using data mining algorithms. In this hospital-based case-control study conducted in Kermanshah province, Iran, data were collected over a period of 15 months. Children under the age of 15 years old who were referred to the burn ward of Imam Khomeini Hospital, the only burn referral in Kermanshah province, were included as cases. For the control group, children who were admitted to Dr. Mohammad Kermanshahi Hospital, the only specialist and subspecialist pediatric center in this province, were included. Frequency matching was performed for age and sex. Support vector machine, artificial neural network (ANN), random forest, and logistic regression were employed to determine the factors related to burns in children. The mean age of children with burn injuries was 4.29 ± 3.51 years and 58% of them were boys. The ANN algorithm had better performance than other algorithms. Body mass index (BMI), socioeconomic status, hours without a watchful, mother's age, mother's education, household size, father's job, father's age, having more than one watchful, and petroleum storage were the most important factors related to pediatric burns. The majority of the burn-related variables were related to individuals' social welfare status and their environments. Lessening the effects of these factors could reduce the incidence of pediatric burns.
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http://dx.doi.org/10.1093/jbcr/irz066DOI Listing
August 2019

The effects of position on gastric residual volume of premature infants in NICU.

Ital J Pediatr 2019 Jan 8;45(1). Epub 2019 Jan 8.

Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Nutrition cares are of the main measures to save premature infants. In this regard, proper positioning is one of the key measures that is done by nurses; still there is a paucity of studies in this field and the results of these few studies are an area of ongoing debates. In light of this, the present paper is an attempt to determine the effects of different positioning on gastric residual volume in premature infants in NICU.

Methods: A clinical trial cross-over study was carried out on premature infants in NICU. The subjects, who had inclusion criteria, were selected through convenience sampling based on inclusion criteria and randomly allocated into three groups. Gastric residual volume before and one hours after feeding was measured and recorded for three positions including right-lateral, left-lateral, and prone. The data was analyzed via SPSS-21 using descriptive statistics such as mean, standard deviation, and frequency; and inferential statistics such as Chi Squared, Kruskal Wallis test, and Friedman test.

Results: Totally, 135 infants in three groups were studied and the results showed that minimum and maximum gastric residual volumes were in prone (6.49 ± 8.25 ML) and supine (12.59 ± 11.9 ML) positions, respectively. However, Kruskal Wallis test did not show a significant relationship between the three positions under study and the mean gastric residual volume.

Conclusion: Prone position was featured with the lowest gastric residual volume and highest possibility of absorbing nutrient. Still, given the fact that no significant difference was found in the three groups, further and deeper studies are needed.

Trial Registration: The project is approved by Iranian Registry of Clinical Trial with no. IRCT. 201404134736 N6 .
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http://dx.doi.org/10.1186/s13052-018-0591-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323801PMC
January 2019

The relationship between care burden and quality of life in caregivers of hemodialysis patients.

BMC Nephrol 2018 11 12;19(1):321. Epub 2018 Nov 12.

Social Development and Health Promotion Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Caregivers of hemodialysis patients endure a significant caring pressure as a result of caring for patients with chronic illness, which can affect their quality of life. Disruptions in the quality of life of these caregivers impose double pressure on them and disrupt the care process. Therefore, the present study aimed to determine the level of care burden and its relationship with quality of life of caregivers of hemodialysis patients.

Methods: In this descriptive-analytical study, 246 caregivers of hemodialysis patients were enrolled by census method, so that, all patients and caregivers who attended the study environment at morning, evening and night participated in the study. The study tool was a three-part questionnaire, which included personal information, Novak & Guest Care burden Questionnaire, and WHOQOL-BREF Quality of Life Questionnaire. Data were analyzed by descriptive, statistical and inferential tests.

Results: In total, 37.4% of caregivers were experiencing high and very high levels of care burden and 42.7% of them were experiencing a moderate level of care burden. The mean and standard deviation of the quality of life of caregivers was 76.27 ± 13.67 out of 130. There was a significant and negative correlation between the total scores of care burden and quality of life (r = - 0. 436, P < 0.001). The factors influencing care burden included variables such as; level of patient's caring capability, the patient's incidence of other chronic diseases, and the age of the caregiver. So that, in case of reduced patient's capability in self-care, the patient's incidence of other chronic diseases, and the increased age of the caregiver, the level of care burden on the caregivers would be increased.

Conclusions: The caregivers of hemodialysis patients endure high level of care burden and this pressure has a negative effect on their quality of life. Therefore, it is recommended to pay more attention to the needs of caregivers and provide adequate social, economic, physical and psychological support for them.
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http://dx.doi.org/10.1186/s12882-018-1120-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233261PMC
November 2018

Mortality from aluminum phosphide poisoning in Kermanshah Province, Iran: characteristics and predictive factors.

Epidemiol Health 2018 27;40:e2018022. Epub 2018 May 27.

School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Objectives: Aluminum phosphide (ALP), also known in Iran as rice tablets, is one of the most effective rodenticides used to protect stored grain. However, ALP poisoning regularly causes mortality in humans. The aim of this study was to evaluate the characteristics and predictive factors of mortality from ALP poisoning.

Methods: This study evaluated all patients with ALP poisoning referred to Imam Khomeini Hospital in Kermanshah Province, Iran from 2014 to 2015. For each patient, the following information was recorded: age, sex, the number of tablets consumed, the number of suicide attempts, the time elapsed from consumption to treatment, blood pressure, blood pH, HCO levels, and PCO . Differences between the survivors and non-survivors of ALP poisoning were analyzed using univariate logistic regression and multivariate analysis.

Results: In this study, 48 patients were male and 29 patients were female (total: 77 patients). The average age of the survivors and non-survivors was 28.7 and 31.3 years, respectively. All cases (100%) of ALP poisoning were intentional, with the goal of committing suicide. The main predictive variables of mortality from ALP poisoning were blood pressure, blood pH, and time elapsed from consumption to treatment.

Conclusions: The likelihood of mortality in patients with ALP poisoning can be predicted using blood pressure, blood pH, and time elapsed from consumption to treatment. These findings may help healthcare providers take more effective measures to treat patients with ALP poisoning.
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http://dx.doi.org/10.4178/epih.e2018022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060335PMC
July 2018

A Systematic Review on the Epidemiology of Pediatric Burn in Iran.

J Burn Care Res 2017 Nov/Dec;38(6):e944-e951

From the *Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran; and †Clinical Research Development Center, Imam Khomeini and Mohammad Kermanshahi Hospitals, Kermanshah University of Medical Sciences, Iran.

Burn is the most common pediatric injuries all over the world. The aim of this study was to study the epidemiology of burn in under 15-year-old Iranian children by applying a systematic review. The related articles published before 2016 have been gathered from international databases by using the keywords in term of pediatric burns such as ScienceDirect, PubMed, Iranmedex, Google Scholar, Embase, Magiran, and SID. The checklists of STROBE have been applied to evaluate the quality of the reviewed data. A total of 35 relevant studies were extracted and evaluated. In most studies, the incidence of pediatric burns in male patients was more than female patients by 9.5 to 50 cases in 100,000 per children. Mortality rate of pediatric burn was between 1.7 and 18.5%. The most common cause of pediatric burn was hot water or other hot liquids. Pediatric burn in urban areas was higher and the highest number of pediatric burns occurred at home. Burn is considered as one of the major incidents related to children's health that required planning to reduce its incidence, especially in the lower age groups as well as male patients who are more active and susceptible to burn.
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http://dx.doi.org/10.1097/BCR.0000000000000524DOI Listing
July 2018

Evaluating Effect of Albendazole on Infection: A Systematic Review Article.

Iran J Parasitol 2016 Oct-Dec;11(4):441-447

Clinical Research Development Center, Imam Khomeini Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: The aim of the study was assessment of defaults and conducted meta-analysis of the efficacy of single-dose oral albendazole against infection.

Methods: We searched PubMed, ISI Web of Science, Science Direct, the Cochrane Central Register of Controlled Trials, and WHO library databases between 1983 and 2014. Data from 13 clinical trial articles were used. Each article was included the effect of single oral dose (400 mg) albendazole and placebo in treating two groups of patients with infection. For both groups in each article, sample size, the number of those with infection, and the number of those recovered following the intake of albendazole were identified and recorded. The relative risk and variance were computed. Funnel plot, Beggs and Eggers tests were used for assessment of publication bias. The random effect variance shift outlier model and likelihood ratio test were applied for detecting outliers. In order to detect influence, DFFITS values, Cook's distances and COVRATIO were used. Data were analyzed using STATA and R software.

Results: The article number 13 and 9 were outlier and influence, respectively. Outlier is diagnosed by variance shift of target study in inferential method and by RR value in graphical method. Funnel plot and Beggs test did not show the publication bias (=0.272). However, the Eggers test confirmed it (=0.034). Meta-analysis after removal of article 13 showed that relative risk was 1.99 (CI 95% 1.71 - 2.31).

Conclusion: The estimated RR and our meta-analyses show that treatment of with single oral doses of albendazole is unsatisfactory. New anthelminthics are urgently needed.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5251172PMC
January 2017

Intention and willingness in understanding Ritalin misuse among Iranian medical college students: a cross-sectional study.

Glob J Health Sci 2014 Jun 30;6(6):43-53. Epub 2014 Jun 30.

MSc of Health Education, Department of Public Health, School of Health, Hamadan University of Medical Sciences, Hamadan, Iran. E-mail:

Ritalin misuse can create powerful stimulant effects and serious health risks. The main aim of present study was compared that two cognitive construct (behavioral intention or behavioral willingness) for predicting Ritalin misuse. This cross-sectional study was conducted among 264 Iranian medical college students; participants selected in random sampling, and data were collected by using self-report questionnaire. Data were analyzed by SPSS version 21 at 95% significant level. Our findings showed, the three predictor variables of (1) attitude, (2) subjective norms, and (3) prototype accounted for 29% of the variation in intention and 25% of the variation in willingness to Ritalin misuse. In addition, behavioral intention was a stronger prediction factor compared to willingness for Ritalin misuse, with odds ratio estimate of 1.607 [95% CI: 1.167, 2.213]. There is some support to use the prototype willingness model to design interventions to improve individuals' beliefs that academic goals are achievable without the misuse of Ritalin.
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http://dx.doi.org/10.5539/gjhs.v6n6p43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825534PMC
June 2014

Randomized controlled trial of aripiprazole versus risperidone for the treatment of amphetamine-induced psychosis.

Am J Drug Alcohol Abuse 2014 Jan;40(1):10-5

Psychiatry Department, Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences , Kermanshah, Iran .

Background: Lifetime prevalence of amphetamine-induced psychotic disorder is reported as being up to 23% for methamphetamine (MA) abusers. Approximately 25% of those with a baseline DSM-IV diagnosis of substance-induced psychosis are diagnosed with primary psychosis at one-year follow-up. Evidence on the treatment of amphetamine psychosis is very limited.

Objectives: To investigate the efficacy of risperidone versus aripiprazole in treatment of amphetamine-induced psychotic symptoms.

Methods: In a double-blind study, 45 participants were randomly allocated to either aripiprazole 15 mg or risperidone 4 mg daily over a six-week trial. Positive and negative symptoms of psychosis were assessed using the Scale for Assessment of Negative Symptoms (SANS) and the Scale for Assessment of Positive Symptoms (SAPS) at baseline and completion of the trial.

Results: SANS and SAPS scores decreased significantly in both groups. Mean SAPS score reduction in risperidone and aripiprazole group was 16.20 and 10.80, respectively, after trial course (p < 0.001). Mean SANS score reduction in risperidone and aripiprazole group was 9.35 and 11.25, respectively (p = 0.08).

Conclusions: Both aripiprazole and risperidone were effective for patients diagnosed with amphetamine-induced psychotic disorder. However, risperidone had the greater effect on positive psychotic symptoms while patients with negative symptoms may respond better to aripiprazole. There is a case for further studies evaluating the efficacy of atypical antipsychotics in this disorder.
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http://dx.doi.org/10.3109/00952990.2013.861843DOI Listing
January 2014

Studies of the interaction between isoimperatorin and human serum albumin by multispectroscopic method: identification of possible binding site of the compound using esterase activity of the protein.

ScientificWorldJournal 2013 10;2013:305081. Epub 2013 Nov 10.

Nano Drug Delivery Research Center, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran.

Isoimperatorin is one of the main components of Prangos ferulacea as a linear furanocoumarin and used as anti-inflammatory, analgesic, antispasmodic, and anticancer drug. Human serum albumin (HSA) is a principal extracellular protein with a high concentration in blood plasma and carrier for many drugs to different molecular targets. Since the carrying of drug by HSA may affect on its structure and action, we decided to investigate the interaction between HSA and isoimperatorin using fluorescence and UV spectroscopy. Fluorescence data indicated that isoimperatorin quenches the intrinsic fluorescence of the HSA via a static mechanism and hydrophobic interaction play the major role in the drug binding. The binding average distance between isoimperatorin and Trp 214 of HSA was estimated on the basis of the theory of Förster energy transfer. Decrease of protein surface hydrophobicity (PSH) was also documented upon isoimperatorin binding. Furthermore, the synchronous fluorescence spectra show that the microenvironment of the tryptophan residues does not have obvious changes. Site marker compettive and fluorescence experiments revealed that the binding of isoimperatorin to HSA occurred at or near site I. Finally, the binding details between isoimperatorin and HSA were further confirmed by molecular docking and esterase activity inhibition studies which revealed that drug was bound at subdomain IIA.
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http://dx.doi.org/10.1155/2013/305081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844181PMC
June 2014

Estimation of esophageal cancer incidence in Tehran by log- linear method using population-based cancer registry data.

Asian Pac J Cancer Prev 2013 ;14(9):5367-70

Department of Epidemiology, School of Public Health, Shaheed Beheshti University of Medical Sciences, Tehran, Iran E-mail :

Background: Having knowledge or estimation of cancer incidence is necessary for planning and implementation of any cancer prevention and control programs. Population-based registries provide valuable information to achieve these objectives but require extra techniques to estimate the incidence rate. The present study aimed to estimate the esophageal cancer incidence using a log-linear method based on Tehran population-based cancer registry data.

Materials And Methods: New cases of esophageal cancer reported by three sources of pathology reports, medical records, and death certificates to Tehran Metropolitan Area Cancer Registry Center during 2002-2006 were entered into the study and the incidence rate was estimated based on log-linear models. We used Akaike statistics to select the best-fit model.

Results: During 2002-2006, 1,458 new cases of esophageal cancer were reported by the mentioned sources to the population-based cancer registry. Based on the reported cases, cancer incidence was 4.5 per 100,000 population and this was estimated to be 10.5 per 100,000 by the log-linear method.

Conclusions: Based on the obtained results, it can be concluded that an estimated incidence for 2004 of 8.3 per 100,000 population could be a good benchmark for the incidence of esophageal cancer in the population of Tehran metropolis.
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http://dx.doi.org/10.7314/apjcp.2013.14.9.5367DOI Listing
June 2014

Estimation of the gastric cancer incidence in Tehran by two- source capture-recapture.

Asian Pac J Cancer Prev 2013 ;14(2):673-7

Clinical Research Development Center, Imam Khomeini Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Introduction: Capture-recapture methods have been suggested for reducing costs of disease registration as well as reducing bias in incidence estimations. This study aimed to estimate the gastric cancer incidence in theTehran metropolis population during 2002-2006.

Materials And Methods: We investigated new cases of gastric cancer reported by three sources; death certificates, pathology reports, and medical records to Tehran population-based cancer registry during 2002-2006. G2 statistics and the two-source capture-recapture method were used to select the best-fitted log-linear model and to estimate incidence, respectively. EXCEL software version 2007 and SPSS software version 16 were used for this research.

Results: The number of reported cases was 4,463, with an average age of 68.5 (±12.9) years. We found the model that combined two sources of data including pathology reports and medical records and furthermore complemented by death certificates as the best model. The reported and the estimated incidences were 11.0 and 27.1 per 100,000 respectively.

Conclusions: The incidence estimated by two- source capture-recapture method is about three times higher than the incidence reported by the sources under investigation. It is recommended to move towards the implementation of population-based cancer registration using various sources of data collection to achieve more accurate data.
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http://dx.doi.org/10.7314/apjcp.2013.14.2.673DOI Listing
July 2014

Predicting Aggression among Male Adolescents: an Application of the Theory of Planned Behavior.

Health Promot Perspect 2013 31;3(2):269-75. Epub 2013 Dec 31.

Department of Public Health, Yasuj University of Medical Sciences, Yasuj, Iran.

Background: Aggressive behaviorin adolescencecan be expressed asa predictorfor crime, substanceabuse, depression and academic failure. The purpose of this study was to determine the prediction of aggression among Iranian adolescent based on theory of planned behavior (TPB) as a theoretical framework.

Methods: In this cross-sectional study, conducted in Yasuj County, south of Iran, during 2011, a total of 256 male adolescents, were randomly enrolled. Participants filled out a self-administered questionnaire. Data were analyzed by SPSS version 21 using bivariate correlations, and linear regression statistical tests at 95% signifi-cant level.

Result: The three predictor variables of 1) attitude, 2) subjective norms, and 3) perceived behavioral control, accounted for 40% of the variation in the outcome measure of the aggression intention. Besides, intention accounted for 15% of the variation in the outcome measure of the aggression behavior. There was a sig-nificant correlation between drug abuse and alcohol consumption, have friend drug user, unprotect sex and parents divorced with aggression (P< 0.05).

Conclusions: Designing intervention to reduction positive attitude and subjective norms toward aggressive behavior among adolescents could be usefulness result to aggression prevention.
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http://dx.doi.org/10.5681/hpp.2013.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963670PMC
April 2014

Coverage, density and completeness of sources used in Tehran Metropolitan Area Cancer Registry: according to the data of esophageal cancer, 2003-2007.

Asian Pac J Cancer Prev 2012 ;13(8):3617-9

Department of Epidemiology, Kermanshah University of Medical Science, Kermanshah, Iran.

Background: The completeness of cancer registration is a major validity index of any reported cancer incidence. The present study aimed to evaluate the esophageal cancer incidence registered in the Tehran Metropolitan Area Cancer Registry.

Materials And Methods: The data on esophageal cancer abstracted from three sources of 1) pathology departments, 2) medical records, and 3) death certificates during 2003 till 2007 were utilized. The completeness of the data sources were evaluated using coverage (defined as the proportion of a community population with esophageal cancer identified by the source) and density (defined as the proportion of non-empty fields of the data by source).

Results: A total 1,404 cases of esophageal cancer were reported for the duration of the study. Pathology provided 771, medical records 432, and death certificates 609. The coverage was 0.55 for pathology, 0.31 for medical records, and 0.43 for death certificates. The respective density values were 0.82, 0.96 and 0.98, respectively. Pathology (0.45) was the most complete source followed by medical records (0.42), and death certificates (0.29).

Discussion: A low degree of completeness dictates putting more effort into case finding plus abstracting data more thoroughly.
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http://dx.doi.org/10.7314/apjcp.2012.13.8.3617DOI Listing
April 2013