Publications by authors named "Abbas Abdollahi"

74 Publications

Psychometric Assessment of the Persian Version of Compassion Scale for Adolescents.

Eval Health Prof 2021 Dec 7:1632787211053855. Epub 2021 Dec 7.

School of Accounting, RinggoldID:71220Jiujiang University, Jiujiang, Jiangxi, China.

The compassion scale for adolescents is a 20-item self-report measure consisting of three dimensions, namely, compassion toward other people, compassion toward oneself, and compassion toward other living things. This scale evaluates compassion in adolescents aged between 12 and 18 years old. The purpose of the current study is to assess the psychometric properties of the compassion scale among Iranian adolescents in junior high school and senior high school students. The number of students who voluntarily took part in this research was 302. The relationships between the compassion scale, mindfulness, emotion regulation, and well-being were explored to assess the convergent validity. Furthermore, the relationship between the compassion scale and anxiety was investigated to assess the divergent validity. The results of confirmatory factor analysis supported the three factors of the compassion scale among Iranian junior and senior high school students same as the original version. The results show that the compassion scale appears to be a reliable and valid measure for Iranian adolescents.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/01632787211053855DOI Listing
December 2021

The Persian version of the centrality of event scale (CES): Assessment of validity and reliability among Iranian university students.

Brain Behav 2022 Jan 25;12(1):e32448. Epub 2021 Nov 25.

Department of Counseling, Faculty of Education and Psychology, Alzahra University, Tehran, Iran.

Background: Event centrality, the extent to which an experience is perceived as a central event in one's life, has been found to be a strong correlate of posttraumatic stress disorder (PTSD). The centrality of event scale (CES) is commonly used in different conditions and cultures to measure trauma-related effects. However, the psychometric properties of this scale have not been investigated in the Iranian context.

Methods: The present study examined the psychometric properties of the Persian translation of the 7-item CES in a sample of 525 university students with a history of a romantic breakup.

Results: Confirmatory factor analysis confirmed a one-factor structure. The CES score was positively correlated with psychological inflexibility and PTSD symptoms. The measurement invariance analyses showed that the 7-item CES is gender invariant and can be used for both men and women.

Findings: Findings supported the good psychometric properties of the 7-item CES for measuring event centrality in Iranian university students.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/brb3.2448DOI Listing
January 2022

The Comparison of the IFN-ɤ, TNF-α and IL-10 Cytokines in Healing and Non-healing Cutaneous Leishmaniasis.

Iran J Parasitol 2021 Jul-Sep;16(3):490-498

Nursing Department, Basic Sciences Faculty, Hamedan Branch, Islamic Azad University, Hamedan, Iran.

Background: Leishmaniasis is one of the main vectors borne and neglected tropical parasitic diseases. T cell cytokine responses are highly important in the presentations of disease such as control or progression, and understanding of the host immunological response is valuable in diagnosis, follow-up, and vaccine designs. In the current study, the profile of IFN-ɤ, TNF-α, and IL-10 cytokines was investigated through the ELISA technique in PBMCs isolated from antimony resistance and susceptible patients.

Methods: In this experimental study, 54 patients with healing (n=27) or non-healing (n=27) CL were recruited. Lesion samples were collected to determine the genotype of spp. and peripheral blood mononuclear cells (PBMCs) were obtained to evaluate the cytokines profiles using soluble antigen (SLA) and phytohaemagglutinin (PHA) mitogen. Cytokines were assessed by the ELISA technique.

Results: The IFN-ɤ and TNF-α cytokines were significantly increased in the healing group treated with both SLA antigen and PHA mitogen (<0.001). The level of IL-10 was significantly increased in non-healing and significantly declined in healing groups (<0.001).

Conclusion: The profile of IFN-ɤ, TNF-α, and IL-10 cytokines are crucially associated with the response of treatment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.18502/ijpa.v16i3.7103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476719PMC
January 2021

Correction to: Religious Perfectionism Scale: Assessment of Validity and Reliability Among Undergraduate Students in Iran.

J Relig Health 2021 Oct;60(5):3620

Educational Psychology and Inclusive Education, Faculty of Education, Monash University, Clayton, Australia.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10943-021-01383-7DOI Listing
October 2021

Psychometric Assessment of the Persian Translated Version of the Romantic Perfectionism Scale Among Couples.

Psychol Rep 2021 Aug 1:332941211036026. Epub 2021 Aug 1.

Educational Psychology and Inclusive Education, Faculty of Education, Monash University, Australia.

Romantic perfectionismi can be disruptive to relationships, yet no validated measure for assessing romantic perfectionism in Iranian couples has been developed. Therefore, the purpose of this study was to translate and validate the Romantic Perfectionism Scale (RPS) among Iranian couples. Participants in the study were 200 married men and 320 married women from Tehran, Iran, who completed the translated RPS, the Almost Perfect Scale-Revised, and the Depression Anxiety Stress Scale-21 online. Item impact scores were used to calculate face validity. Impact score values for all items were greater than 1.5, signaling appropriate face validity.. The Content Validity Index (CVI) and the Content Validity Ratio (CVR) were used to measure content validity. Values of the CVI were above the cut-off score of 0.7, implying satisfactory content validity of the items. The CVR values were greater than the Lawshe table (0.78) cut-off score, demonstrating that all items were essential. Confirmatory Factor Analysis (CFA) using AMOS software was used to evaluate the construct validity. The results of the goodness of fit indices confirmed the RPS with two subscales (i.e., self-oriented romantic perfectionism and other-oriented romantic perfectionism) as per the original scale. All items remained in the scale as all factor loading values were greater than 0.45. The findings showed that the two subscales, and the scale as a whole, had acceptable internal consistency, as the construct reliability values for self-oriented romantic perfectionism (0.81), other-oriented romantic perfectionism (0.72), and the whole scale (0.74) were greater than 0.7. The results support the psychometric properties of the Iranian version of the RPS, which could be used by future researchers and clinicians to assess romantic perfectionism in Iranian couples.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/00332941211036026DOI Listing
August 2021

Religious Perfectionism Scale: Assessment of Validity and Reliability Among Undergraduate Students in Iran.

J Relig Health 2021 Oct 27;60(5):3606-3619. Epub 2021 Jul 27.

Educational Psychology and Inclusive Education, Faculty of Education, Monash University, Clayton, Australia.

Religious perfectionism is a construct that may help to either improve mental health or cause mental health difficulties. The Religious Perfectionism Scale (RPS; Wang in J Relig Health 59: 318-333, 2020) is a useful tool for assessing religious perfectionism around the world, but its psychometric properties have yet to be tested in Iran. The sample in the present study consisted of 300 Iranian undergraduate students (180 females) from Azad University who completed the RPS, the Depression Anxiety Stress Scale-2, and the Moral Perfectionism Scale. The impact score was used to determine face validity, and the values of the impact score for all translated items were greater than 1.5, meaning that the items had satisfactory face validity. The Content Validity Index (CVI) values were above the acceptable cutoff score of 0.7, indicating the acceptable content validity of items. The Content Validity Ratio (CVR) scores were greater than the cutoff score of the Lawshe table (.78), indicating the satisfactory essentiality of the items. To measure construct validity, the results of a confirmatory factor analysis (CFA) using AMOS software confirmed the scale with two subscales (zealous religious dedication and religious self-criticism). No item was removed from the scale as all factor loading values were greater than 0.49. The findings support the psychometric properties of the scale for measuring religious perfectionism among undergraduate students in Iran.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10943-021-01362-yDOI Listing
October 2021

Surveying the chemical composition and antibacterial activity of essential oils from selected medicinal plants against human pathogens.

Iran J Microbiol 2020 Dec;12(6):577-583

Department of Microbiology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.

Background And Objectives: Essential oils (EOs) with different biological activities, such as antibacterial properties, are a valuable resource for developing new drugs.

Materials And Methods: Ingredients of six medicinally important EOs, including and , were identified using GC-MS analysis. Moreover, their five major compounds were also listed. Furthermore, the half-maximal inhibitory concentration (IC) against four important human bacteria was also investigated using the 96-well plate microdilution.

Results: EO with IC of 1.0 and 4.7 mg.mL have the most effect on the growth of and Moreover, EOs of (IC: 1.0 mg. Ml) and (IC: 1.3 mg.mL) significantly showed better inhibitory effect on and

Conclusion: These EOs could be used for developing inexpensive, potent, and green antibacterial agents.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.18502/ijm.v12i6.5032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884278PMC
December 2020

Sentinel lymph node mapping in colorectal cancers with radioactive tracer; is it an efficient method?

J Cancer Res Ther 2020 Dec;16(Supplement):S160-S164

Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Context: The sentinel lymph nodes (SLNs), as most other regions, are prone to tumoral invasion. In colorectal cancers, they can help the higher levels of pathological examination techniques.

Aims: We attempted to investigate the efficiency of the use of radioactive tracer in identifying SLNs in colorectal cancers using the same pathological technique.

Settings And Design: This cross-sectional, single-center study was carried out from 2014 to august 2016 at Mashhad University of Medical Sciences.

Subjects And Methods: The study population included 100 patients with colorectal cancers. We used a radioactive tracer to detect SLNs and to compare the number and involvement of SLNs and non-SLNs generally and in terms of the tumor site. For pathological study, we used the same conventional method in both the groups.

Statistical Analysis Used: Statistical analysis was performed using SPSS 22.0 software (IBM Corp., Armonk, NY, USA) with Chi-square and Fisher's exact test, Student's t-test, ANOVA test, Mann-Whitney U-test, and Kruskal-Wallis test.

Results: SLNs were detected in 89 of 100 patients. All the remaining 11 patients had T4 lower rectal cancer and the injection was performed ex vivo. We noted ten cases of upstaging due to SLN mapping and nine cases of false negative. Thus, the sensitivity was found to be 43.75%at and the accuracy was 78.65%.

Conclusions: We used the same traditional method in both the groups, and our sensitivity, accuracy and upstaging rate were fewer than similar studies. Our recommendation for further studies is to use intensive SLN biopsy method in both groups of SLNs and non-SLNs.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4103/jcrt.JCRT_272_17DOI Listing
December 2020

Moral Disengagement: Mediator Between Moral Perfectionism and Machiavellian Behavior Among Undergraduates?

Psychol Rep 2021 Dec 4;124(6):2761-2773. Epub 2020 Oct 4.

Educational Psychology and Inclusive Education, Faculty of Education, Monash University, Clayton, Australia.

To better understand Machiavellian behavior among undergraduate students, the current study examines moral disengagement as a mediator in the relationship between Machiavellian behavior and two dimensions of moral perfectionism (concern over moral mistakes perfectionism and personal moral standards perfectionism). Participants were 210 undergraduate students (64% female) from three universities in Tehran, Iran, aged between 18 and 27 years old. Structural equation modeling revealed that Machiavellian behavior was negatively associated with personal moral standards perfectionism and positively associated with moral disengagement. The results of the structural model showed a non-significant relationship between concern over moral mistakes perfectionism and Machiavellian behavior. However, multi-model analysis provided evidence that moral disengagement partially mediated the relationship between personal moral standards perfectionism and Machiavellian behavior. The findings also showed that there was a relationship between concern over moral mistakes perfectionism and Machiavellian behavior through moral disengagement. The results suggest that while moral perfectionism is often accompanied with moral disengagement, Machiavellian behavior may be an explanation for individuals with these traits.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/0033294120964067DOI Listing
December 2021

The effect of intra-striatal administration of GPR55 agonist (LPI) and antagonist (ML193) on sensorimotor and motor functions in a Parkinson's disease rat model.

Acta Neuropsychiatr 2021 Feb 24;33(1):15-21. Epub 2020 Sep 24.

Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: G protein-coupled receptor 55 (GPR55) is an orphan G protein-coupled receptor with various physiological functions. Recent evidence suggests that this receptor may be involved in the control of motor functions. Therefore, in the present study, we evaluated the effects of intra-striatal administration of GPR55 selective ligands in a rat model of Parkinson's disease.

Methods: Experimental Parkinson was induced by unilateral intra-striatal administration of 6-hydroxydopamine (6-OHDA, 10 µg/rat). L-α-lysophosphatidylinositol (LPI, 1 and 5 µg/rat), an endogenous GPR55 agonist, and ML193 (1 and 5 µg/rat), a selective GPR55 antagonist, were injected into the striatum of 6-OHDA-lesioned rats. Motor performance and balance skills were evaluated using the accelerating rotating rod and the ledged beam tests. The sensorimotor function of the forelimbs and locomotor activity were assessed by the adhesive removal and open field tests, respectively.

Results: 6-OHDA-lesioned rats had impaired behaviours in all tests. Intra-striatal administration of LPI in 6-OHDA-lesioned rats increased time on the rotarod, decreased latency to remove the label, with no significant effect on slip steps, and locomotor activity. Intra-striatal administration of ML193 also increased time on the rotarod, decreased latency to remove the label and slip steps in 6-OHDA-lesioned rats mostly at the dose of 1 µg/rat.

Conclusions: This study suggests that the striatal GPR55 is involved in the control of motor functions. However, considering the similar effects of GPR55 agonist and antagonist, it may be concluded that this receptor has a modulatory role in the control of motor deficits in an experimental model of Parkinson.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1017/neu.2020.30DOI Listing
February 2021

Development and Initial Validation of the Children's Hardiness Scale.

Psychol Rep 2021 Aug 30;124(4):1932-1949. Epub 2020 Jul 30.

Department of Counseling, Faculty of Education and Psychology, 48408Alzahra University, Tehran, Iran.

Several measures have been developed in the past decades to assess the dimensions of hardiness in adult populations, whereas the same for children has remained relatively understudied. The present research has sought to develop and validate children's hardiness scale (CHS) to assess hardiness attitudes in the respondents with age categories ranging between 10 and 12. Relying on a mixed-method approach, the research has been conducted in two studies. In the first, using both deductive and inductive methods, items were generated. The Content and face validity of the items was explored. To determine factor structure afterward, the exploratory factor analysis was conducted. In the course of the second study, confirmatory factor analysis confirmed the scale's dimensionality and factor structure. The significant correlation between CHS, academic hardiness, and perceived stress, demonstrated the construct validity of the scale. Using the convenience sampling method, a total sample of 641 children participated in both studies. The results demonstrated that the final scale in line with the hardiness theory comprised three subscales: "commitment", "control", and "challenge". The scale revealed acceptable internal consistency, reliability, and construct validity. Overall, the results of the current research indicated that a 20-item CHS can be applied in evaluating children's hardiness attitudes. Further studies are required, however, to assess the applicability of the scale in different cultural populations.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/0033294120945175DOI Listing
August 2021

Academic Hardiness as a Moderator between Evaluative Concerns Perfectionism and Academic Procrastination in Students.

J Genet Psychol 2020 Sep-Oct;181(5):365-374. Epub 2020 Jun 24.

Educational Psychology and Inclusive Education, Faculty of Education, Monash University, Clayton, Australia.

Academic procrastination is a common phenomenon in students that can have a negative impact on effective learning, academic achievement, self-esteem, and quality of life. This study examined the associations among the two dimensions of perfectionism (personal standards perfectionism and evaluative concerns perfectionism), academic hardiness, and academic procrastination, as well as the moderating role of academic hardiness in the relationship between the two dimensions of perfectionism and academic procrastination. Participants of this study included 410 high school students in grades 9 to 12 from six schools in Tehran, Iran who completed the Almost Perfect Scale-Revised, the Academic Hardiness Scale, and the Procrastination Assessment Scale. The results indicated that personal standards perfectionism and academic hardiness had negative relationships with academic procrastination, whereas evaluative concerns perfectionism had a positive relationship with academic procrastination. Interaction-moderation analysis demonstrated that academic hardiness only played a buffering role in the relationship between evaluative concerns perfectionism and academic procrastination. The results of this study elucidate the experience of academic procrastination in students and highlight the role of academic hardiness and personal standards perfectionism. Implications for educators and psychologists are discussed.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/00221325.2020.1783194DOI Listing
June 2021

Exploring membrane proteins of Leishmania major to design a new multi-epitope vaccine using immunoinformatics approach.

Eur J Pharm Sci 2020 Sep 10;152:105423. Epub 2020 Jun 10.

Department of Medical Biotechnology, Fasa University of Medical Sciences, Fasa, Iran. Electronic address:

Leishmaniasis is one of the major global endemic diseases. Among all the different forms of the disease, cutaneous Leishmaniasis has the highest prevalence worldwide. Treatment with current drugs has not had a significant effect on the improvement of the disease. An attempt to replace an appropriate vaccine that can stimulate host cellular immunity and induce the response of Major histocompatibility complex I (MHCI) and Major histocompatibility complex II (MHCII) against Leishmania is essential. Vaccine production remains a challenge despite the use of different antigens for vaccination against Leishmania major. Hence, we were used the immunoinformatics approach to design a new multi-epitope vaccine against L. major using immunogenic outer membrane proteins. Helper T-lymphocyte (HTL) and Cytotoxic T lymphocyte (CTL) epitopes were predicted and for final confirmation of the selected epitopes, docking analysis, and molecular dynamics simulation was performed. Then, GDGDG linker and profilin adjuvant were added to enhance the immunity of vaccines. The designed vaccine was evaluated in terms of molecular weight, PI, immunogenicity, and allergenicity. Moreover, the secondary and three-dimensional structure of the final construct was identified. In silico cloning approach was carried out to improve expression of the vaccine construct. Finally, molecular docking, followed by molecular dynamic was performed to determine the interaction between multi-epitope vaccine and TLR11. We hope that the designed vaccine can be a good candidate for the development of cutaneous leishmaniasis vaccine. but its effectiveness should be assessed in vivo.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejps.2020.105423DOI Listing
September 2020

Antibacterial potential of essential oils of and , micro- and nano-formulated forms.

Iran J Microbiol 2020 Feb;12(1):43-51

Department of Medicine, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.

Background And Objectives: Plant-derived essential oils (EOs) shave many usages in health and medicine, such as antibacterial agents. The aim of this study was the improvement of antibacterial activities of two EOs using nanotechnology.

Materials And Methods: Antibacterial activity was investigated on four important human pathogenic bacteria using the 96-well plate microdilution method, a quantitative approach. Eleven formulations were prepared using each of the EOs. Eventually, the best nanoformulation with the smallest particle size and polydispersive indices (PDI and SPAN) was selected using each EO for further investigations. Moreover, two microemulsions with similar ingredients and the same portion in comparison with two selected nanoemulsions were also prepared. Antibacterial activity of each EO was compared with its micro- and nano-emulsions.

Results: The antibacterial efficacy of Zataria multiflora EO (ZMEO) was significantly better than Mentha piperita EO (MPEO). Besides, the antibacterial activity of nanoemulsion of ZMEO with a particle size of 129 ± 12 nm was significantly better than no- and micro-formulated forms of ZMEO. Interestingly, the efficiency of MPEO nanoemulsion (160 ± 25 nm) was also significantly better than MPEO and its micro-formulated form.

Conclusion: Regardless of the intrinsic antibacterial property of two examined EOs, by formulating to nanoemulsion, their efficiencies were improved. Nanoemulsion of ZMEO introduced as an inexpensive, potent and green antibacterial agent.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163042PMC
February 2020

Self-compassion moderates the perceived stress and self-care behaviors link in women with breast cancer.

Psychooncology 2020 05 10;29(5):927-933. Epub 2020 Mar 10.

Educational Psychology and Inclusive Education, Faculty of Education, Monash University, Clayton, Victoria, Australia.

Objective: Women with breast cancer are exposed to various stressors, and self-care behaviors play an important role in their recovery. However, very few studies have investigated self-care behaviors specifically for women with breast cancer. The current study examined the relationship between perceived stress and self-care behaviors, and explored whether self-compassion moderated this relationship.

Methods: A sample of 210 women with breast cancer aged 27 to 60 years old from three hospitals in Tehran, Iran completed online self-report questionnaires of self-care behaviors, self-compassion, and perceived stress.

Results: Data analyses with structural equation modeling showed that perceived stress (β = -.37, P < .01) and self-compassion (β = .38, P < .01) were significant predictors of self-care behaviors. The interaction-moderation analysis showed that self-compassion acted as a moderator between perceived stress and self-care behaviors.

Conclusions: The findings enhance our understanding about the protective role of self-compassion in the relationship between perceived stress and self-care behaviors in women with breast cancer.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/pon.5369DOI Listing
May 2020

Effects of Death Anxiety on Perceived Stress in Individuals With Multiple Sclerosis and the Role of Self-Transcendence.

Omega (Westport) 2021 Nov 4;84(1):91-102. Epub 2019 Oct 4.

Department of Counseling, Faculty of Education and Psychology, Alzahra University, Tehran, Iran.

Stress is a commonly reported concern of individuals with chronical diseases, including multiple sclerosis (MS). This study sought to investigate the relationships between self-transcendence, death anxiety, and perceived stress among individuals with MS from Iran. A second aim of the study was to assess the buffering effect of self-transcendence in the relationship between death anxiety and perceived stress. Two hundred and fifteen participants with MS from four hospitals completed measures assessing self-transcendence, death anxiety, and perceived stress. Using structural equation modeling, death anxiety was found to be positively related to perceived stress. In addition, there was a negative relationship between self-transcendence and perceived stress. Results of the study suggest that self-transcendence is a buffer in the link between death anxiety and perceived stress for individuals with MS. The findings demonstrate the importance of self-transcendence in decreasing the effects of death anxiety on perceived stress and have clinical implications for health professionals.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/0030222819880714DOI Listing
November 2021

Effect of Using a Simulation Device for Ostomy Self-care Teaching in Iran: A Pilot, Randomized Clinical Trial.

Wound Manag Prev 2019 06;65(6):30-39

Mashhad University of the Sciences, Mashhad, Iran.

The appearance of a stoma and the potential for contact with stool may negatively affect postoperative teaching effectiveness, especially for patients with cultural and religious backgrounds that consider stool untouchable. Instruction that involves the use of a physical stoma simulator for practice may help address this problem.

Purpose: The aim of this pilot study was to determine the effects of simulation in ostomy self-care training on self-efficacy and adjustment.

Methods: A randomized clinical trial was conducted among patients at 2 public medical center surgical units in eastern Iran from April 2015 to December 2015 using consecutive sampling. Patients who spoke Persian, were 18 to 65 years of age, had a temporary or permanent intestinal stoma, and did not have comorbidities that might interfere with self-care teaching were invited to participate and randomly allocated to the simulation (SG) or the control group (CG). Both groups were provided 4 training sessions; the first and fourth session was the same for each group, but in sessions 2 and 3, the SG group used a wearable stoma simulator, whereas the CG group used the demonstration-return method. Demographic and stoma variables were collected, and the Stoma Self-Efficacy Scale (SSES) and Ostomy Adjustment Inventory-23 (OAI-23) were administered at baseline (following surgery), after 4 instructional sessions, and 45 days following the last education session. Descriptive statistics and chi-squared, Fisher's exact, Mann-Whitney , repeated measure, and least significant difference tests were used to analyze the data.

Results: Of the 53 patients enrolled, 46 (23 in each group) completed the study. Mean age for SG and CG patients was 45.91 ± 10.40 and 53.78 ± 9.15, respectively ( = .009). The majority of patients were female (SG: 11 [47.8%]; CG: 14 [60.9%]), married (SG: 20 [87.0%]; CG: 19 [82.6%]), and had a diagnosis of cancer (SG: 20 [87.0%]; CG: 21 [91.3%]). The mean SSES score for stoma self-efficacy was 103.82 ± 15.81 in the SG and 89.91 ± 13.41 in the CG after the fourth session. Results indicated an improvement in self-efficacy in both groups from baseline to final follow-up visit ( <.0001). SSES in the SG was significantly different from baseline to final follow-up visit during the study (F = 3.183, = .008). Mean OAI-23 scores were 51.04 ± 13.37 in the SG and 50.82 ± 13.84 in the CG at baseline and after the intervention (fourth session) were 60.56 ± 16.41 in the SG and 53.95 ± 13.22 in the CG group. The repeated measure test results indicated significant increases in adjustment scores from baseline to final follow-up visit in both groups ( = .000).

Conclusion: The results of this pilot study suggest that using simulation to teach ostomy self-care improves self-efficacy after 3 and 9 weeks. Further randomized controlled trials that expand the sample size and demographic should be conducted.
View Article and Find Full Text PDF

Download full-text PDF

Source
June 2019

Correction to: Variation in Blood and Colorectal Epithelia's Key Trace Elements along with Expression of Mismatch Repair Proteins from Localized and Metastatic Colorectal Cancer Patients.

Biol Trace Elem Res 2020 04;194(2):629

Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.

The original version of this article unfortunately contained a mistake. The name of "Ali Ghorbani Ranjbary" is now corrected in the author group of this article. The original article has been corrected.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12011-019-01787-3DOI Listing
April 2020

Variation in Blood and Colorectal Epithelia's Key Trace Elements Along with Expression of Mismatch Repair Proteins from Localized and Metastatic Colorectal Cancer Patients.

Biol Trace Elem Res 2020 Mar 6;194(1):66-75. Epub 2019 Jun 6.

Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.

Colorectal cancer (CRC) is an increasingly common medical issue affecting millions worldwide, and contribution of the body's trace elements to CRC is arguable. The concentrations and buffered status of selenium, iron, copper, zinc, and phosphorus in blood and large intestinal tissues of CRC patients are, respectively, variable and vital for cell physiology. The aim of this study was to assess selenium, iron, copper, zinc, and phosphorus variations in blood and colorectal epithelia along with examining the expression of mismatch repair proteins in CRC patients with/without metastasis for potential diagnosis/therapy. Concentrations of selenium, iron, copper, zinc, and phosphorus in blood of healthy versus CRC patients and colorectal epithelia (adenocarcinomatous versus non-adenocarcinomatous/control) were measured in 40 CRC patients (55.87 ± 11.9 years old) with/without metastasis before surgery using ICP-OES. Mismatch repair (MMR) protein expression was analyzed through histopathological/immunohistochemistry assays, which was sparse in 5 CRC patient's colorectal tissues (12%). Compared with healthy individuals, blood and colorectal tissue's levels of phosphorus, copper, and iron were significantly higher in the CRC patients, and more pronounced in metastatic CRC patients; conversely, blood and colorectal tissue's selenium levels were significantly lower in metastatic patients. Unlike blood zinc, cancerous colorectal tissue's zinc concentration was significantly lower in CRC patients compared to healthy control cohorts. There was no significant difference on the measured elements in samples from CRC patients with MMR compared to CRC patients with MMR. Receiver operating characteristic analysis revealed a correlation of blood iron, zinc, copper, and phosphorus to CRC, and inappropriately low levels of blood and colorectal selenium correlated with exacerbated metastasis. Altered levels of selenium, iron, copper, zinc, and phosphorus in vivo may impact the pathogenesis and detection of CRC, and their diagnostic/therapeutic potential in CRC would be revealing.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12011-019-01749-9DOI Listing
March 2020

The Association of Rumination and Perfectionism to Social Anxiety.

Authors:
Abbas Abdollahi

Psychiatry 2019 21;82(4):345-353. Epub 2019 May 21.

: Evaluative concerns perfectionism is related to both rumination and social anxiety. However, the mediating role of rumination between two types of perfectionism-namely, evaluative concerns perfectionism and personal standards perfectionism-and social anxiety has yet to be studied. Therefore, the objective of this study was to examine the mediating role of rumination on the association between perfectionism and social anxiety. : A cross-sectional study was conducted among 450 Malaysian undergraduate students using self-report questionnaires. : Structural equation modeling (SEM) revealed that evaluative concerns perfectionism and rumination were significant positive predictors of social anxiety. Multimodel analysis revealed that rumination partially mediated the association between evaluative concerns perfectionism and social anxiety. : The results suggested that evaluative concerns perfectionists were more likely to engage in rumination and were consequently more likely to experience social anxiety.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/00332747.2019.1608783DOI Listing
July 2020

The effects of perceived stress on hope in women with breast cancer and the role of psychological hardiness.

Psychooncology 2019 07 6;28(7):1477-1482. Epub 2019 Jun 6.

Educational Psychology and Inclusive Education, Faculty of Education, Monash University, Clayton, Australia.

Objective: Diagnosis and treatment of breast cancer are psychologically stressful events, and hope and hardiness have been found to be important constructs for women with breast cancer. Therefore, this research sought to examine the relationships of perceived stress and hardiness with hope, and the buffering role of hardiness in the link between perceived stress and hope among Iranian women with breast cancer.

Methods: Two hundred and twenty Iranian women with breast cancer from three hospitals completed online measures evaluating perceived stress, hardiness, and hope.

Results: Using structural equation modelling, perceived stress was found to be negatively related to hope. Additionally, there was a positive relationship between hardiness and hope. The findings indicate that hardiness is a buffer in the link between perceived stress and hope for women with breast cancer.

Conclusions: These findings demonstrate the importance of hardiness in reducing the effects of perceived stress on hope and have clinical implications for health professionals.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/pon.5102DOI Listing
July 2019

Evaluation of antibiotic prophylaxis for gastrointestinal surgeries in a teaching hospital: An interventional pre-post study.

J Perioper Pract 2019 Mar 19:1750458919825583. Epub 2019 Mar 19.

Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Mashhad, Iran.

Surgical site infections are related to a high morbidity, mortality and healthcare costs. Despite ample evidence demonstrating the effectiveness of antimicrobials to prevent surgical site infections, inappropriate timing, antibiotic selection and excessive continuation of antibiotics are common in practice. In this study, we compare the appropriateness of antibiotic prophylaxis in gastrointestinal surgery, before and after an evidence-based guideline implementation. One hundred patients were evaluated in each group. The implementation of the guideline resulted in significant reduction of incorrect use of antibiotics from 55% to 18% (P = 0.002). It also reduced duration of prophylactic antibiotics (43% vs. 23%, P = 0.025). Inappropriate doses diminished but not significantly (8% vs. 5%, P = 0.321). Based on our results, in more than half of of these cases patients received incorrect antibiotic prophylaxis regimens for gastrointestinal surgery in this hospital. Local guideline implementation can result in reduction of antibiotic use, dose and duration errors.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/1750458919825583DOI Listing
March 2019

Evaluation of antibiotic prophylaxis for gastrointestinal surgeries in a teaching hospital: An interventional pre-post study.

J Perioper Pract 2019 Mar 19:1750458919825583. Epub 2019 Mar 19.

Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Mashhad, Iran.

Surgical site infections are related to a high morbidity, mortality and healthcare costs. Despite ample evidence demonstrating the effectiveness of antimicrobials to prevent surgical site infections, inappropriate timing, antibiotic selection and excessive continuation of antibiotics are common in practice. In this study, we compare the appropriateness of antibiotic prophylaxis in gastrointestinal surgery, before and after an evidence-based guideline implementation. One hundred patients were evaluated in each group. The implementation of the guideline resulted in significant reduction of incorrect use of antibiotics from 55% to 18% (P = 0.002). It also reduced duration of prophylactic antibiotics (43% vs. 23%, P = 0.025). Inappropriate doses diminished but not significantly (8% vs. 5%, P = 0.321). Based on our results, in more than half of of these cases patients received incorrect antibiotic prophylaxis regimens for gastrointestinal surgery in this hospital. Local guideline implementation can result in reduction of antibiotic use, dose and duration errors.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/1750458919825583DOI Listing
March 2019

ErbB1 and ErbB3 co-over expression as a prognostic factor in gastric cancer.

Biol Res 2019 Jan 8;52(1). Epub 2019 Jan 8.

Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Epidermal growth factor receptor family members such as ErbB1 and ErbB3 are involved in tumor progression and metastasis. Although, there are various reports about the prognostic value of EGFR members separately in gastric cancer, there is not any report about the probable correlation between ErbB1 and ErbB3 co-expression and gastric cancer prognosis. In present study, we assessed the correlation between ErbB1 and ErbB3 co-overexpression (in the level of mRNA and protein expression) and gastric cancer prognosis for the first time.

Methods: ErbB1 and ErbB3 expressions were analyzed by immunohistochemistry and real-time PCR in 50 patients with gastric cancer. Parametric correlations were done between the ErbB1 and ErbB3 expression and clinicopathological features. Multivariate and logistic regression analyses were also done to assess the roles of ErbB1 and ErbB3 in tumor prognosis and survival.

Results: There were significant correlations between ErbB1/ErbB3 co-overexpression and tumor size (p = 0.026), macroscopic features (p < 0.05), tumor differentiation (p < 0.05), stage of tumor (p < 0.05), and recurrence (p < 0.05). Moreover, ErbB1/ErbB3 co-overexpression may predict the survival status of patients (p < 0.05).

Conclusion: ErbB1 and ErbB3 co-overexpression is accompanied with the poor prognosis and can be used efficiently in targeted therapy of gastric cancer patients.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-018-0208-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323733PMC
January 2019

A lentiviral vaccine expressing KMP11-HASPB fusion protein increases immune response to Leishmania major in BALB/C.

Parasitol Res 2018 Jul 29;117(7):2265-2273. Epub 2018 May 29.

Skin Diseases and Leishmaniasis Research Center, Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Hydrophilic acylated surface protein B (HASPB) is an immunogenic Leishmania-specific protein that antibodies are produced against it in the sera of Leishmania-infected individuals. Kinetoplastid membrane protein 11 (KMP11) is another Leishmania antigen and considered as the suitable candidate for vaccine development Leishmaniasis. It is a highly conserved surface protein expressed in both promastigotes and amastigotes. In this study, KMP11 and HASPB coding sequences were cloned into a pCDH-cGFP lentiviral vector as a fusion protein to be used as a DNA vaccine against L. major. The KMP11-HASPB fusion protein was successfully expressed as evidenced by RT-PCR and Western blot assays. The effect of the vaccine was determined by evaluating the level of IFN-γ, IL-10, IgG1, and IgG2a performed using ELISA as well as determining the parasite load after challenge with L. major in vaccinated mice. The results revealed that IFN-γ, IL-10, IgG1, and IgG2a significantly increased after vaccination using KMP11-HASPB-expressing lentiviruses in BALB/c mice. It is noteworthy that the level of IFN-γ and IgG2a was higher than that of IL-10 and IgG1, respectively, which indicates the activation Th1 cells, macrophages, and cellular immunity. Moreover, the parasite load in the spleen and lymph node of vaccinated mice after challenge was significantly lower than that of controls.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00436-018-5915-6DOI Listing
July 2018

Analysis of Th22, Th17 and CD4cells co-producing IL-17/IL-22 at different stages of human colon cancer.

Biomed Pharmacother 2018 Jul 26;103:1101-1106. Epub 2018 Apr 26.

Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Immunology and Allergy, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

T-helper (Th) 22 cells are involved in the immunopathogenesis of inflammatory diseases, but their specific role in the immunopathogenesis of cancer is unknown. In this study, we examined the profile of circulating and intratumoral Th17, Th22 and CD4 cells co-producing IL-17/IL-22 in colon cancer (CC) patients in relation to tumor staging. Thirty newly diagnosed colon cancer (CC) patients participated in this study. The percentage of Th1 (CD4IFN-γIL-17IL-22), Th17 (CD4IFN-γIL-17IL-22), Th22 (CD4IFN-γIL-17IL-22) and CD4 cells co-producing IL-17/IL-22 (CD4IFN-γIL-17IL-22) in the peripheral blood, tumor and paratumor tissues was assessed by multicolor flow cytometry. The percentage of circulating Th17 and Th22 cells was significantly increased in CC patients compared to that in healthy controls (HCs). In addition, the percentage of infiltrating Th1, Th17, Th22 and CD4 cells co-producing IL-17/IL-22 was significantly increased in the tumor tissues compared to that in the parartumor tissues. Furthermore, we also found that the percentage of circulating and intratumoral Th17, Th22 and CD4 cells co-producing IL-17/IL-22 was higher in advanced stages than in early stages. Our findings revealed that Th17, Th22 and CD4 cells co-producing IL-17/IL-22 were accumulated in colon cancer tissues and may be involved in the tumor development and progression. A better comprehension of the immunopathogenesis of Th17, Th22 and CD4 cells co-producing IL-17/IL-22 in colon cancer patients would help in the development of novel therapies.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biopha.2018.04.147DOI Listing
July 2018

Coping Styles Mediate Perfectionism Associations with Depression Among Undergraduate Students.

J Gen Psychol 2018 Jan-Mar;145(1):93-105. Epub 2018 Jan 18.

b University of Regina.

To better understand depression among adolescent university students, this study was designed to examine coping style as a potential mediator between perfectionism and depression. Participants comprised 510 undergraduate students from Malaysia. Structural Equation Modelling demonstrated that personal standards perfectionism and task-focused coping style were negatively associated with depression, while emotion-focused coping style, avoidant coping style, and evaluative concerns perfectionism were positively associated with depression. Multiple mediator modelling provided evidence that coping styles partially mediated the relationship between perfectionism and depression. These findings advance current knowledge by suggesting how perfectionism may contribute to depression and may inform the development of more effective prevention and intervention programs for depression.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/00221309.2017.1421137DOI Listing
August 2018

Three Anastomotic Techniques Following Laparoscopic Rectal Cancer Resection: Our Experience in 155 Patients.

Surg Innov 2018 Feb 9;25(1):57-61. Epub 2017 Dec 9.

4 Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Purpose: This study aimed to assess the impact of 3 anastomotic techniques after laparoscopic rectal cancer resection.

Methods: In a cross-sectional study, the data of 155 patients who underwent surgery for rectal cancer were retrieved. An anastomosis was created between the left colon and anal canal with 3 different methods: coloanal anastomosis with protective ileostomy (group A), coloanal anastomosis without ostomy (group B), and delayed coloanal anastomosis (group C). The rates of anastomotic problems (leakage, peritonitis, and collection) were calculated for each treatment method. Multivariate analysis was used to verify the effect of anastomosis techniques.

Results: In 5 (3.2%) patients, peritonitis was observed in which 3 (9.7%) of them belonged to group B and 2 (4.1%) belonged to group C. In 9 (5.8%) patients, presacral collection and anastomotic leakage were observed; 4 (8.2%) patients belonged to group C, 4 (12.9%) patients to group B, and 1 (1.3%) patient to group A. Postoperative obstructions occurred in 5 (10.2%) patients of group C, 2 (6.5%) patients of group B, and 2 (2.7%) patients of group A. Rectovaginal fistula was detected in 2 patients from group B.

Conclusions: Laparoscopic surgery of rectal cancer with transanal method is reliable and acceptable in terms of oncologic and surgical results. This study showed the best results in patients who had protective ostomy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/1553350617745976DOI Listing
February 2018

Iatrogenic injuries of the extrahepatic biliary system.

J Surg Res 2017 06 25;213:215-221. Epub 2015 Nov 25.

Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: Iatrogenic traumatic extrahepatic biliary tract injuries though rarely occur; they can lead to exceedingly morbid complications. The aim of this study was to evaluate the management strategies and outcomes of patients presented with iatrogenic bile duct injuries.

Methods: This is a retrospective study. Over 19 y, 124 patients were managed for iatrogenic biliary injuries at our institution. The data related to the etiology of biliary tract injury, symptoms of injury, laboratory and radiologic studies, injury-to-diagnosis time, type of biliary tract injury, injury management, hospitalization time, and postoperative complications were reviewed.

Results: The main clinical presentations were jaundice or recurrent cholangitis in 64 (51.61%) patients, followed by bile peritonitis in 34 (56.67%) and biliary fistula in 26 (43.33%) patients. Only in 23 (18.54%) cases, the injury was recognized intraoperatively. The most frequent surgical procedure was open cholecystectomy in 81 (65.32%) of 124 patients. The remaining patients were operated on laparoscopically. Good results were achieved in 99 of 101 patients with direct suture repair including hepaticojejunostomy, choledocoduodenostomy, and choledochocholedochostomy (98.02% success rate) at the first attempt. Three cases (2.97%) of biliary strictures after direct suture technique and four (3.96%) cases of postoperative mortalities were detected. The mortality rate was mostly affected by male gender, advanced age, and existence of bile peritonitis. Totally, 111 (89.52%) patients are still alive with a mean follow-up time of 78 ± 38 (2-230) mo.

Conclusions: Biliary injuries can be sometimes life-threatening complications. A successful repair may provide patients with a lifelong relief from symptoms, whereas a failed repair may result in recurrent biliary obstruction, reoperation, and even death.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jss.2015.11.032DOI Listing
June 2017
-->