Aaron Leong

Aaron Leong

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Aaron Leong

Publications by authors named "Aaron Leong"

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Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control.

Diabetes 2019 02 28;68(2):441-456. Epub 2018 Nov 28.

Massachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA

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http://dx.doi.org/10.2337/db18-0567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341299PMC
February 2019

Type 2 Diabetes Prevention: Implications of Hemoglobin A1c Genetics.

Rev Diabet Stud 2015 Fall-Winter;12(3-4):351-62. Epub 2016 Feb 10.

Massachusetts General Hospital, General Medicine Division, Boston, MA, USA.

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http://dx.doi.org/10.1900/RDS.2015.12.351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5275759PMC
July 2018

Genetics of HbA1c: a case study in clinical translation.

Curr Opin Genet Dev 2018 06 6;50:79-85. Epub 2018 Mar 6.

Department of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2018.02.008DOI Listing
June 2018

Prediction of Type 2 Diabetes by Hemoglobin A in Two Community-Based Cohorts.

Diabetes Care 2018 01 26;41(1):60-68. Epub 2017 Oct 26.

Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA

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http://dx.doi.org/10.2337/dc17-0607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741154PMC
January 2018

A Decade of Genetic and Metabolomic Contributions to Type 2 Diabetes Risk Prediction.

Curr Diab Rep 2017 Nov 4;17(12):135. Epub 2017 Nov 4.

Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02141, USA.

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http://dx.doi.org/10.1007/s11892-017-0958-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817914PMC
November 2017

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

Authors:
Eleanor Wheeler Aaron Leong Ching-Ti Liu Marie-France Hivert Rona J Strawbridge Clara Podmore Man Li Jie Yao Xueling Sim Jaeyoung Hong Audrey Y Chu Weihua Zhang Xu Wang Peng Chen Nisa M Maruthur Bianca C Porneala Stephen J Sharp Yucheng Jia Edmond K Kabagambe Li-Ching Chang Wei-Min Chen Cathy E Elks Daniel S Evans Qiao Fan Franco Giulianini Min Jin Go Jouke-Jan Hottenga Yao Hu Anne U Jackson Stavroula Kanoni Young Jin Kim Marcus E Kleber Claes Ladenvall Cecile Lecoeur Sing-Hui Lim Yingchang Lu Anubha Mahajan Carola Marzi Mike A Nalls Pau Navarro Ilja M Nolte Lynda M Rose Denis V Rybin Serena Sanna Yuan Shi Daniel O Stram Fumihiko Takeuchi Shu Pei Tan Peter J van der Most Jana V Van Vliet-Ostaptchouk Andrew Wong Loic Yengo Wanting Zhao Anuj Goel Maria Teresa Martinez Larrad Dörte Radke Perttu Salo Toshiko Tanaka Erik P A van Iperen Goncalo Abecasis Saima Afaq Behrooz Z Alizadeh Alain G Bertoni Amelie Bonnefond Yvonne Böttcher Erwin P Bottinger Harry Campbell Olga D Carlson Chien-Hsiun Chen Yoon Shin Cho W Timothy Garvey Christian Gieger Mark O Goodarzi Harald Grallert Anders Hamsten Catharina A Hartman Christian Herder Chao Agnes Hsiung Jie Huang Michiya Igase Masato Isono Tomohiro Katsuya Chiea-Chuen Khor Wieland Kiess Katsuhiko Kohara Peter Kovacs Juyoung Lee Wen-Jane Lee Benjamin Lehne Huaixing Li Jianjun Liu Stephane Lobbens Jian'an Luan Valeriya Lyssenko Thomas Meitinger Tetsuro Miki Iva Miljkovic Sanghoon Moon Antonella Mulas Gabriele Müller Martina Müller-Nurasyid Ramaiah Nagaraja Matthias Nauck James S Pankow Ozren Polasek Inga Prokopenko Paula S Ramos Laura Rasmussen-Torvik Wolfgang Rathmann Stephen S Rich Neil R Robertson Michael Roden Ronan Roussel Igor Rudan Robert A Scott William R Scott Bengt Sennblad David S Siscovick Konstantin Strauch Liang Sun Morris Swertz Salman M Tajuddin Kent D Taylor Yik-Ying Teo Yih Chung Tham Anke Tönjes Nicholas J Wareham Gonneke Willemsen Tom Wilsgaard Aroon D Hingorani Josephine Egan Luigi Ferrucci G Kees Hovingh Antti Jula Mika Kivimaki Meena Kumari Inger Njølstad Colin N A Palmer Manuel Serrano Ríos Michael Stumvoll Hugh Watkins Tin Aung Matthias Blüher Michael Boehnke Dorret I Boomsma Stefan R Bornstein John C Chambers Daniel I Chasman Yii-Der Ida Chen Yduan-Tsong Chen Ching-Yu Cheng Francesco Cucca Eco J C de Geus Panos Deloukas Michele K Evans Myriam Fornage Yechiel Friedlander Philippe Froguel Leif Groop Myron D Gross Tamara B Harris Caroline Hayward Chew-Kiat Heng Erik Ingelsson Norihiro Kato Bong-Jo Kim Woon-Puay Koh Jaspal S Kooner Antje Körner Diana Kuh Johanna Kuusisto Markku Laakso Xu Lin Yongmei Liu Ruth J F Loos Patrik K E Magnusson Winfried März Mark I McCarthy Albertine J Oldehinkel Ken K Ong Nancy L Pedersen Mark A Pereira Annette Peters Paul M Ridker Charumathi Sabanayagam Michele Sale Danish Saleheen Juha Saltevo Peter Eh Schwarz Wayne H H Sheu Harold Snieder Timothy D Spector Yasuharu Tabara Jaakko Tuomilehto Rob M van Dam James G Wilson James F Wilson Bruce H R Wolffenbuttel Tien Yin Wong Jer-Yuarn Wu Jian-Min Yuan Alan B Zonderman Nicole Soranzo Xiuqing Guo David J Roberts Jose C Florez Robert Sladek Josée Dupuis Andrew P Morris E-Shyong Tai Elizabeth Selvin Jerome I Rotter Claudia Langenberg Inês Barroso James B Meigs

PLoS Med 2017 Sep 12;14(9):e1002383. Epub 2017 Sep 12.

Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1002383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595282PMC
September 2017

Correcting hazard ratio estimates for outcome misclassification using multiple imputation with internal validation data.

Pharmacoepidemiol Drug Saf 2017 Aug 15;26(8):925-934. Epub 2017 May 15.

Research Institute of the McGill University Health Centre, Montréal, QC, Canada.

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http://dx.doi.org/10.1002/pds.4223DOI Listing
August 2017

A Mendelian Randomization Study of the Effect of Type-2 Diabetes and Glycemic Traits on Bone Mineral Density.

J Bone Miner Res 2017 May 12;32(5):1072-1081. Epub 2017 Jan 12.

Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1002/jbmr.3063DOI Listing
May 2017

Genetically Driven Hyperglycemia Increases Risk of Coronary Artery Disease Separately From Type 2 Diabetes.

Diabetes Care 2017 05 15;40(5):687-693. Epub 2017 Mar 15.

Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA

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http://dx.doi.org/10.2337/dc16-2625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399655PMC
May 2017

Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci.

Diabetes 2016 10 14;65(10):3200-11. Epub 2016 Jul 14.

Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA Department of Medicine, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.2337/db16-0199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033262PMC
October 2016

Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.

Authors:
Ching-Ti Liu Sridharan Raghavan Nisa Maruthur Edmond Kato Kabagambe Jaeyoung Hong Maggie C Y Ng Marie-France Hivert Yingchang Lu Ping An Amy R Bentley Anne M Drolet Kyle J Gaulton Xiuqing Guo Loren L Armstrong Marguerite R Irvin Man Li Leonard Lipovich Denis V Rybin Kent D Taylor Charles Agyemang Nicholette D Palmer Brian E Cade Wei-Min Chen Marco Dauriz Joseph A C Delaney Todd L Edwards Daniel S Evans Michele K Evans Leslie A Lange Aaron Leong Jingmin Liu Yongmei Liu Uma Nayak Sanjay R Patel Bianca C Porneala Laura J Rasmussen-Torvik Marieke B Snijder Sarah C Stallings Toshiko Tanaka Lisa R Yanek Wei Zhao Diane M Becker Lawrence F Bielak Mary L Biggs Erwin P Bottinger Donald W Bowden Guanjie Chen Adolfo Correa David J Couper Dana C Crawford Mary Cushman John D Eicher Myriam Fornage Nora Franceschini Yi-Ping Fu Mark O Goodarzi Omri Gottesman Kazuo Hara Tamara B Harris Richard A Jensen Andrew D Johnson Min A Jhun Andrew J Karter Margaux F Keller Abel N Kho Jorge R Kizer Ronald M Krauss Carl D Langefeld Xiaohui Li Jingling Liang Simin Liu William L Lowe Thomas H Mosley Kari E North Jennifer A Pacheco Patricia A Peyser Alan L Patrick Kenneth M Rice Elizabeth Selvin Mario Sims Jennifer A Smith Salman M Tajuddin Dhananjay Vaidya Mary P Wren Jie Yao Xiaofeng Zhu Julie T Ziegler Joseph M Zmuda Alan B Zonderman Aeilko H Zwinderman Adebowale Adeyemo Eric Boerwinkle Luigi Ferrucci M Geoffrey Hayes Sharon L R Kardia Iva Miljkovic James S Pankow Charles N Rotimi Michele M Sale Lynne E Wagenknecht Donna K Arnett Yii-Der Ida Chen Michael A Nalls Michael A Province W H Linda Kao David S Siscovick Bruce M Psaty James G Wilson Ruth J F Loos Josée Dupuis Stephen S Rich Jose C Florez Jerome I Rotter Andrew P Morris James B Meigs

Am J Hum Genet 2016 Jul 16;99(1):56-75. Epub 2016 Jun 16.

Division of General Internal Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005440PMC
July 2016

Type 2 Diabetes Genetic Predisposition, Obesity, and All-Cause Mortality Risk in the U.S.: A Multiethnic Analysis.

Diabetes Care 2016 Apr 16;39(4):539-46. Epub 2016 Feb 16.

Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA Harvard Medical School, Boston, MA

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc15-208
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http://dx.doi.org/10.2337/dc15-2080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806775PMC
April 2016

Hypoglycemia in Diabetes Mellitus as a Coronary Artery Disease Risk Factor in Patients at Elevated Vascular Risk.

J Clin Endocrinol Metab 2016 Feb 16;101(2):659-68. Epub 2015 Dec 16.

Division of General Internal Medicine (A.L., S.A.B., V.A.T., B.P., W.H., S.J.A., D.J.W., J.B.M.), Massachusetts General Hospital, Boston, Massachusetts 02114-2698; Harvard Medical School (A.L., S.A.B., V.A.T., S.J.A., J.B.M.), Boston, Massachusetts 02115; and Diabetes Center (S.A.B., D.J.W.), Massachusetts General Hospital, Boston, Massachusetts 02114.

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http://dx.doi.org/10.1210/jc.2015-3169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880119PMC
February 2016

Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study.

PLoS Med 2015 Aug 25;12(8):e1001866. Epub 2015 Aug 25.

Centre for Clinical Epidemiology, Department of Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada; Department of Medicine, McGill University, Montreal, Quebec, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Department of Human Genetics, McGill University, Montreal, Quebec, Canada; Department of Twin Research and Genetic Epidemiology, King's College London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pmed.1001866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549308PMC
August 2015

A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease.

Nat Commun 2015 May 28;6:7060. Epub 2015 May 28.

1] Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec H3A 0G4, Canada [2] Department of Medicine, McGill University, Montreal, Quebec H3A 0G4, Canada [3] Department of Human Genetics, McGill University, Montréal, Québec H3A 0G4, Canada [4] Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.

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http://dx.doi.org/10.1038/ncomms8060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458864PMC
May 2015

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.

Authors:
Jennifer Wessel Audrey Y Chu Sara M Willems Shuai Wang Hanieh Yaghootkar Jennifer A Brody Marco Dauriz Marie-France Hivert Sridharan Raghavan Leonard Lipovich Bertha Hidalgo Keolu Fox Jennifer E Huffman Ping An Yingchang Lu Laura J Rasmussen-Torvik Niels Grarup Margaret G Ehm Li Li Abigail S Baldridge Alena Stančáková Ravinder Abrol Céline Besse Anne Boland Jette Bork-Jensen Myriam Fornage Daniel F Freitag Melissa E Garcia Xiuqing Guo Kazuo Hara Aaron Isaacs Johanna Jakobsdottir Leslie A Lange Jill C Layton Man Li Jing Hua Zhao Karina Meidtner Alanna C Morrison Mike A Nalls Marjolein J Peters Maria Sabater-Lleal Claudia Schurmann Angela Silveira Albert V Smith Lorraine Southam Marcus H Stoiber Rona J Strawbridge Kent D Taylor Tibor V Varga Kristine H Allin Najaf Amin Jennifer L Aponte Tin Aung Caterina Barbieri Nathan A Bihlmeyer Michael Boehnke Cristina Bombieri Donald W Bowden Sean M Burns Yuning Chen Yii-DerI Chen Ching-Yu Cheng Adolfo Correa Jacek Czajkowski Abbas Dehghan Georg B Ehret Gudny Eiriksdottir Stefan A Escher Aliki-Eleni Farmaki Mattias Frånberg Giovanni Gambaro Franco Giulianini William A Goddard Anuj Goel Omri Gottesman Megan L Grove Stefan Gustafsson Yang Hai Göran Hallmans Jiyoung Heo Per Hoffmann Mohammad K Ikram Richard A Jensen Marit E Jørgensen Torben Jørgensen Maria Karaleftheri Chiea C Khor Andrea Kirkpatrick Aldi T Kraja Johanna Kuusisto Ethan M Lange I T Lee Wen-Jane Lee Aaron Leong Jiemin Liao Chunyu Liu Yongmei Liu Cecilia M Lindgren Allan Linneberg Giovanni Malerba Vasiliki Mamakou Eirini Marouli Nisa M Maruthur Angela Matchan Roberta McKean-Cowdin Olga McLeod Ginger A Metcalf Karen L Mohlke Donna M Muzny Ioanna Ntalla Nicholette D Palmer Dorota Pasko Andreas Peter Nigel W Rayner Frida Renström Ken Rice Cinzia F Sala Bengt Sennblad Ioannis Serafetinidis Jennifer A Smith Nicole Soranzo Elizabeth K Speliotes Eli A Stahl Kathleen Stirrups Nikos Tentolouris Anastasia Thanopoulou Mina Torres Michela Traglia Emmanouil Tsafantakis Sundas Javad Lisa R Yanek Eleni Zengini Diane M Becker Joshua C Bis James B Brown L Adrienne Cupples Torben Hansen Erik Ingelsson Andrew J Karter Carlos Lorenzo Rasika A Mathias Jill M Norris Gina M Peloso Wayne H-H Sheu Daniela Toniolo Dhananjay Vaidya Rohit Varma Lynne E Wagenknecht Heiner Boeing Erwin P Bottinger George Dedoussis Panos Deloukas Ele Ferrannini Oscar H Franco Paul W Franks Richard A Gibbs Vilmundur Gudnason Anders Hamsten Tamara B Harris Andrew T Hattersley Caroline Hayward Albert Hofman Jan-Håkan Jansson Claudia Langenberg Lenore J Launer Daniel Levy Ben A Oostra Christopher J O'Donnell Stephen O'Rahilly Sandosh Padmanabhan James S Pankow Ozren Polasek Michael A Province Stephen S Rich Paul M Ridker Igor Rudan Matthias B Schulze Blair H Smith André G Uitterlinden Mark Walker Hugh Watkins Tien Y Wong Eleftheria Zeggini Markku Laakso Ingrid B Borecki Daniel I Chasman Oluf Pedersen Bruce M Psaty E Shyong Tai Cornelia M van Duijn Nicholas J Wareham Dawn M Waterworth Eric Boerwinkle W H Linda Kao Jose C Florez Ruth J F Loos James G Wilson Timothy M Frayling David S Siscovick Josée Dupuis Jerome I Rotter James B Meigs Robert A Scott Mark O Goodarzi

Nat Commun 2015 Jan 29;6:5897. Epub 2015 Jan 29.

1] Department of Medicine and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA [2] Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.

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http://dx.doi.org/10.1038/ncomms6897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311266PMC
January 2015

Weight gain after orthotopic liver transplantation: is nonalcoholic fatty liver disease cirrhosis a risk factor for greater weight gain?

Liver Transpl 2014 Oct;20(10):1266-74

Division of Endocrinology, Department of Medicine, Royal Victoria Hospital, McGill University Hospital Center, Montreal, Canada.

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http://dx.doi.org/10.1002/lt.23951DOI Listing
October 2014

The causal effect of vitamin D binding protein (DBP) levels on calcemic and cardiometabolic diseases: a Mendelian randomization study.

PLoS Med 2014 Oct 28;11(10):e1001751. Epub 2014 Oct 28.

Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada; Department of Medicine, McGill University, Montreal, Quebec, Canada; Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pmed.1001751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211663PMC
October 2014

Group-based activities with on-site childcare and online support improve glucose tolerance in women within 5 years of gestational diabetes pregnancy.

Cardiovasc Diabetol 2014 Jun 30;13:104. Epub 2014 Jun 30.

Division of Clinical Epidemiology, Department of Medicine, McGill University Health Centre, 687 Pine Avenue West, H3A 1A1, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1186/1475-2840-13-104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227099PMC
June 2014

Spousal diabetes as a diabetes risk factor: a systematic review and meta-analysis.

BMC Med 2014 Jan 24;12:12. Epub 2014 Jan 24.

Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1186/1741-7015-12-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900990PMC
January 2014

Coexistence of malignant struma ovarii and cervical papillary thyroid carcinoma.

J Clin Endocrinol Metab 2013 Dec 11;98(12):4599-605. Epub 2013 Nov 11.

MD, Division of Endocrinology and Metabolism, McGill University Health Centre, 687 Pine Avenue West, M9.05, Montreal, Canada QC H3A 1A1.

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http://dx.doi.org/10.1210/jc.2013-1782DOI Listing
December 2013

The cardiovascular effects of peroxisome proliferator-activated receptor agonists.

Am J Med 2012 Feb;125(2):126-33

Division of Cardiology, Jewish General Hospital/McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.amjmed.2011.08.025DOI Listing
February 2012

Is there a need for neonatal screening of glucose-6-phosphate dehydrogenase deficiency in Canada?

Authors:
Aaron Leong

Mcgill J Med 2007 Jan;10(1):31-4

Physiology, McGill University, 1537 Summerhill Ave, Apt #208, Montreal, Quebec.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323536PMC
January 2007