Aaron D Gitler

Aaron D Gitler

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Aaron D Gitler

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Axons Gonna Ride 'til They Can't No More.

Neuron 2019 Oct;104(2):179-181

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.09.029DOI Listing
October 2019

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.

Acta Neuropathol 2019 Jun 29;137(6):961-980. Epub 2019 Mar 29.

Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, M322 Alway Building, Stanford, CA, 94305-5120, USA.

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http://dx.doi.org/10.1007/s00401-019-01995-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531417PMC
June 2019

Identification and functional analysis of novel mutations in the gene in Chinese patients with amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2019 05 19;20(3-4):222-228. Epub 2019 Mar 19.

a Department of Neurology and Institute of Neurology , First Affiliated Hospital Fujian Medical University , Fuzhou , China.

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http://dx.doi.org/10.1080/21678421.2019.1582668DOI Listing
May 2019

In search of lost trafficking.

Brain 2018 12;141(12):3282-3285

Department of Genetics, Stanford University School of Medicine, Stanford, CA USA.

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/brain/awy294DOI Listing
December 2018

Pour Some Sugar on TDP(-43).

Mol Cell 2018 09;71(5):649-651

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.08.032DOI Listing
September 2018

The epidemiology and genetics of Amyotrophic lateral sclerosis in China.

Brain Res 2018 08 1;1693(Pt A):121-126. Epub 2018 Mar 1.

Department of Neurology, Peking University Third Hospital, Beijing 100191, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2018.02.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486791PMC
August 2018

These violent repeats have violent extends.

Neurol Genet 2018 Aug 1;4(4):e247. Epub 2018 Aug 1.

Department of Genetics, Stanford University School of Medicine, CA.

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http://dx.doi.org/10.1212/NXG.0000000000000247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089690PMC
August 2018

A matter of balance.

Elife 2018 08 21;7. Epub 2018 Aug 21.

Department of Neuroscience, Mayo Clinic, Jacksonville, United States.

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http://dx.doi.org/10.7554/eLife.40034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103765PMC
August 2018

Targeted next-generation sequencing improves diagnosis of hereditary spastic paraplegia in Chinese patients.

J Mol Med (Berl) 2018 07 11;96(7):701-712. Epub 2018 Jun 11.

Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, China.

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http://dx.doi.org/10.1007/s00109-018-1655-4DOI Listing
July 2018

Yeast screen for modifiers of C9orf72 poly(glycine-arginine) dipeptide repeat toxicity.

FEMS Yeast Res 2018 06;18(4)

Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, M322 Alway Building, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1093/femsyr/foy024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946852PMC
June 2018

Hunting the G-unit in Huntington's.

Brain 2018 06;141(6):1586-1589

Department of Genetics, Stanford University School of Medicine, Stanford, CA USA.

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http://dx.doi.org/10.1093/brain/awy112DOI Listing
June 2018

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport.

Cell 2018 05 5;173(4):958-971.e17. Epub 2018 Apr 5.

Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA; Cellular and Molecular Medicine Program, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA; Solomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183030
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http://dx.doi.org/10.1016/j.cell.2018.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083872PMC
May 2018

Phosphorylation Leads the Way for Protein Aggregate Disassembly.

Dev Cell 2018 05;45(3):279-281

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.04.017DOI Listing
May 2018

Ataxin-2 Is Droppin' Some Knowledge.

Neuron 2018 05;98(4):673-675

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.05.002DOI Listing
May 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

Internalization, axonal transport and release of fibrillar forms of alpha-synuclein.

Neurobiol Dis 2018 Jan 16;109(Pt B):219-225. Epub 2017 Mar 16.

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5120, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2017.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600643PMC
January 2018

Distinct repertoires of microRNAs present in mouse astrocytes compared to astrocyte-secreted exosomes.

PLoS One 2017 2;12(2):e0171418. Epub 2017 Feb 2.

Department of Genetics, Stanford University School of Medicine, Stanford, CA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171418PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289606PMC
August 2017

Efficient Prevention of Neurodegenerative Diseases by Depletion of Starvation Response Factor Ataxin-2.

Trends Neurosci 2017 08 3;40(8):507-516. Epub 2017 Jul 3.

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.tins.2017.06.004DOI Listing
August 2017

Glycolytic Enzymes Coalesce in G Bodies under Hypoxic Stress.

Cell Rep 2017 07;20(4):895-908

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.06.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586494PMC
July 2017

Neurodegenerative disease: models, mechanisms, and a new hope.

Dis Model Mech 2017 05;10(5):499-502

Department of Biochemistry & Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

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http://dx.doi.org/10.1242/dmm.030205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451177PMC
May 2017

Unlocking the Mystery of ALS.

Sci Am 2017 May;316(6):46-51

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http://dx.doi.org/10.1038/scientificamerican0617-46DOI Listing
May 2017

Old moms say, no Sir.

Science 2017 03 16;355(6330):1126-1127. Epub 2017 Mar 16.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1126/science.aam9740DOI Listing
March 2017

Raise the Roof: Boosting the Efficacy of a Spinal Muscular Atrophy Therapy.

Neuron 2017 Jan;93(1):3-5

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.12.029DOI Listing
January 2017

Defects in trafficking bridge Parkinson's disease pathology and genetics.

Nature 2016 11;539(7628):207-216

Department of Genetics, Stanford University, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/nature20414DOI Listing
November 2016

Susan Lee Lindquist (1949-2016).

Nature 2016 11;540(7631):40

Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1038/540040aDOI Listing
November 2016

There has been an awakening: Emerging mechanisms of C9orf72 mutations in FTD/ALS.

Brain Res 2016 09 6;1647:19-29. Epub 2016 Apr 6.

Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori, Mizuhoku, Nagoya, Aichi 467-8603, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2016.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003651PMC
September 2016

Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations.

ACS Chem Biol 2016 09 11;11(9):2428-37. Epub 2016 Jul 11.

Department of Biochemistry and Program in Structural Biology, Weill Cornell Medical College , New York, New York 10065, United States.

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http://dx.doi.org/10.1021/acschembio.6b00539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240779PMC
September 2016

Nuclear transport dysfunction: a common theme in amyotrophic lateral sclerosis and frontotemporal dementia.

J Neurochem 2016 08 15;138 Suppl 1:134-44. Epub 2016 Jun 15.

Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1111/jnc.13642DOI Listing
August 2016

Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis.

Neuron 2016 07 16;91(1):41-55. Epub 2016 Jun 16.

Department of Pathology, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA; Pathology Service 113B, VA Medical Center, San Francisco, CA 94121, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938715PMC
July 2016

Regrowing axons with alternative splicing.

Elife 2016 07 15;5. Epub 2016 Jul 15.

Department of Genetics, Stanford University School of Medicine, Stanford, United States.

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http://dx.doi.org/10.7554/eLife.18707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946881PMC
July 2016

Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1.

Acta Neuropathol 2016 Apr 28;131(4):539-48. Epub 2016 Jan 28.

Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305-5120, USA.

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http://dx.doi.org/10.1007/s00401-016-1538-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789229PMC
April 2016

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia.

Nat Commun 2016 Apr 15;7:11253. Epub 2016 Apr 15.

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.

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http://dx.doi.org/10.1038/ncomms11253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835537PMC
April 2016

Analysis of COPII Vesicles Indicates a Role for the Emp47-Ssp120 Complex in Transport of Cell Surface Glycoproteins.

Traffic 2016 Mar 10;17(3):191-210. Epub 2016 Jan 10.

Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA.

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http://dx.doi.org/10.1111/tra.12356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767645PMC
March 2016

It's all starting to come together.

Elife 2015 Aug 5;4. Epub 2015 Aug 5.

Department of Genetics, Stanford University School of Medicine, Stanford, United States.

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http://dx.doi.org/10.7554/eLife.09853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525470PMC
August 2015

Neurodegeneration: A Leg Up on TDP-43.

Curr Biol 2015 Aug;25(16):R728-31

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2015.06.064DOI Listing
August 2015

Targeted exon capture and sequencing in sporadic amyotrophic lateral sclerosis.

PLoS Genet 2014 Oct 9;10(10):e1004704. Epub 2014 Oct 9.

Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191946PMC
October 2014

The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.

Hum Mol Genet 2014 Sep 11;23(17):4491-509. Epub 2014 Apr 11.

Laboratory of Molecular and Chemical Biology of Neurodegeneration, Ecole Polytechnique Fédérale de Lausanne, Station 19, CH-1015 Lausanne, Switzerland

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http://dx.doi.org/10.1093/hmg/ddu165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119404PMC
September 2014

Cell Biology. Clogging information flow in ALS.

Science 2014 Sep;345(6201):1118-9

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1126/science.1259461DOI Listing
September 2014

Congenital muscular dystrophy and generalized epilepsy caused by GMPPB mutations.

Brain Res 2014 Aug 26;1575:66-71. Epub 2014 Apr 26.

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2014.04.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108529PMC
August 2014

Yeast genetic screen reveals novel therapeutic strategy for ALS.

Rare Dis 2013 27;1:e24420. Epub 2013 Mar 27.

Department of Genetics, Stanford University School of Medicine, Stanford, CA.

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http://dx.doi.org/10.4161/rdis.24420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933050PMC
July 2014

A cellular system that degrades misfolded proteins and protects against neurodegeneration.

Mol Cell 2014 Jul 29;55(1):15-30. Epub 2014 May 29.

Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.04.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445634PMC
July 2014

Evaluating noncoding nucleotide repeat expansions in amyotrophic lateral sclerosis.

Neurobiol Aging 2014 Apr 23;35(4):936.e1-4. Epub 2013 Oct 23.

Department of Genetics, Stanford University School of Medicine, Standford, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.09.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880650PMC
April 2014

TDP-43 in ALS: stay on target…almost there.

Neuron 2014 Feb;81(3):463-5

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.01.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962496PMC
February 2014

A template for new drugs against Alzheimer's disease.

Cell 2013 Sep;154(6):1182-4

Institute of Neuropathology, University Hospital Zurich, 8091 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2013.08.049DOI Listing
September 2013

Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways.

J Neurosci 2013 Jun;33(25):10348-61

Department of Developmental Biology and Pathology, Stanford University Medical School, Stanford, California 94305, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1258-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685834PMC
June 2013

RNA-binding proteins with prion-like domains in ALS and FTLD-U.

Prion 2011 Jul-Sep;5(3):179-87. Epub 2011 Jul 1.

Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.4161/pri.5.3.17230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226045PMC
April 2013

Stress granules as crucibles of ALS pathogenesis.

J Cell Biol 2013 Apr;201(3):361-72

Medical Scientist Training Program and, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1083/jcb.201302044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639398PMC
April 2013

Parallel PARKing: Parkinson's genes function in common pathway.

Neuron 2013 Feb;77(3):377-9

Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.neuron.2013.01.014DOI Listing
February 2013

TDP-43 and FUS/TLS yield a target-rich haul in ALS.

Authors:
Aaron D Gitler

Nat Neurosci 2012 Nov;15(11):1467-9

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http://dx.doi.org/10.1038/nn.3243DOI Listing
November 2012

Compartmentalization of superoxide dismutase 1 (SOD1G93A) aggregates determines their toxicity.

Proc Natl Acad Sci U S A 2012 Sep 11;109(39):15811-6. Epub 2012 Sep 11.

Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1073/pnas.1205829109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465386PMC
September 2012

The role of the Parkinson's disease gene PARK9 in essential cellular pathways and the manganese homeostasis network in yeast.

PLoS One 2012 23;7(3):e34178. Epub 2012 Mar 23.

Department of Genetics, Stanford University School of Medicine, Stanford University, Stanford, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034178PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311584PMC
August 2012

Distinct TDP-43 pathology in ALS patients with ataxin 2 intermediate-length polyQ expansions.

Acta Neuropathol 2012 Aug 21;124(2):221-30. Epub 2012 Apr 21.

Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, M322 Alway Building, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1007/s00401-012-0985-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543833PMC
August 2012

ALS-associated ataxin 2 polyQ expansions enhance stress-induced caspase 3 activation and increase TDP-43 pathological modifications.

J Neurosci 2012 Jul;32(27):9133-42

Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0996-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418890PMC
July 2012

Modeling human disease.

Science 2012 Jul;337(6092):269

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http://dx.doi.org/10.1126/science.1227179DOI Listing
July 2012

The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease.

Brain Res 2012 Jun 21;1462:61-80. Epub 2012 Jan 21.

Boston Biomedical Research Institute, 64 Grove St., Watertown, MA 02472, USA.

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http://dx.doi.org/10.1016/j.brainres.2012.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372647PMC
June 2012

The modulation of Amyotrophic Lateral Sclerosis risk by ataxin-2 intermediate polyglutamine expansions is a specific effect.

Neurobiol Dis 2012 Jan 25;45(1):356-61. Epub 2011 Aug 25.

Experimental Neurology, Goethe University Medical School, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.nbd.2011.08.021DOI Listing
January 2012

Model organisms reveal insight into human neurodegenerative disease: ataxin-2 intermediate-length polyglutamine expansions are a risk factor for ALS.

J Mol Neurosci 2011 Nov 10;45(3):676-83. Epub 2011 Jun 10.

Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s12031-011-9548-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207127PMC
November 2011

Neuroscience. Another reason to exercise.

Authors:
Aaron D Gitler

Science 2011 Nov;334(6056):606-7

Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/science.1214714DOI Listing
November 2011

Local RNA translation at the synapse and in disease.

J Neurosci 2011 Nov;31(45):16086-93

Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4105-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241995PMC
November 2011

High-throughput yeast plasmid overexpression screen.

J Vis Exp 2011 Jul 27(53). Epub 2011 Jul 27.

Neuroscience Graduate Group, University of Pennsylvania School of Medicine, USA.

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http://dx.doi.org/10.3791/2836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197441PMC
July 2011

Ataxin-2 intermediate-length polyglutamine expansions in European ALS patients.

Hum Mol Genet 2011 May 3;20(9):1697-700. Epub 2011 Feb 3.

Department of Cell and Developmental Biology, the University of Pennsylvania School of Medicine, 1109 BRB II/III, 421 Curie Blvd., Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1093/hmg/ddr045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071667PMC
May 2011

Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS.

PLoS Biol 2011 Apr 26;9(4):e1000614. Epub 2011 Apr 26.

Department of Cell and Developmental Biology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1000614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082519PMC
April 2011

TDP-43 toxicity in yeast.

Methods 2011 Mar 27;53(3):238-45. Epub 2010 Nov 27.

Neuroscience Graduate Group, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.ymeth.2010.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073690PMC
March 2011

Prion-like disorders: blurring the divide between transmissibility and infectivity.

J Cell Sci 2010 Apr;123(Pt 8):1191-201

Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 805b Stellar-Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1242/jcs.051672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848109PMC
April 2010

GTPase activity plays a key role in the pathobiology of LRRK2.

PLoS Genet 2010 Apr 8;6(4):e1000902. Epub 2010 Apr 8.

NeuroRegeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851569PMC
April 2010

Disease models and mechanisms in the classroom.

Authors:
Aaron D Gitler

Dis Model Mech 2009 Mar-Apr;2(3-4):103-6

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http://dx.doi.org/10.1242/dmm.002600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650211PMC
August 2009

TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity.

J Biol Chem 2009 Jul 22;284(30):20329-39. Epub 2009 May 22.

Department of Cell and Developmental Biology, the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M109.010264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740458PMC
July 2009

Evidence that alpha-synuclein does not inhibit phospholipase D.

Biochemistry 2009 Feb;48(5):1077-83

Department of Neurology, Harvard Medical School and Brigham & Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1021/bi801871hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683767PMC
February 2009